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    Reagent cuvette
    12.
    发明授权
    Reagent cuvette 失效
    试剂比色杯

    公开(公告)号：US07645424B2

    公开(公告)日：2010-01-12

    申请号：US11434211

    申请日：2006-05-16

    Applicant: Michael O'Donovan

    Inventor： Michael O'Donovan

    IPC: B01L3/00 ,  B01L3/02 ,  C12M1/34 ,  C12M3/00 ,  C12M3/04 ,  C12M1/24

    CPC classification number: B01L3/50825 ,  B01L3/502 ,  B01L3/5082 ,  B01L3/5635 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2400/0683 ,  G01N21/03 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0364 ,  G01N2201/0245

    Abstract: A reagent cuvette has a first chamber with an inspection part and a socket, and a second chamber. The socket has four spikes at its base. Both chambers are sealed with a membrane. At the point-of-care the foil membrane of the first chamber is peeled away by the therapist (typically general practitioner doctor). A sample, such as blood, is added to the chamber using a pipette or other device to provide a verifiable quantity of sample. This provides a mixture of a buffer reagent supplied in the chamber and the sample injected into the inspection chamber at the point of care. The chamber is then inserted into the socket by gently pressing it down so that its foil membrane is broken by the spikes. This causes the starter reagent to drop down from within the second chamber into the inspection part of the first chamber. The inspection part is then inserted into an optical inspection instrument for analysis of the two reagents and the sample mixed together.

    Abstract translation: 试剂池具有具有检查部分和插座的第一室和第二室。 插座在其底部有四个尖峰。 两个室都用膜密封。 在护理点，第一室的箔膜由治疗师（通常是全科医生）剥离。 使用移液管或其他装置将诸如血液的样品加入到腔室中以提供可验证量的样品。 这提供了在室内提供的缓冲试剂和在注意点处注入检查室的样品的混合物。 然后通过轻轻地将其插入插座中，使其箔片被尖钉破坏。 这使起动剂试剂从第二室内下降到第一室的检查部分。 然后将检查部件插入光学检查仪器中，分析两种试剂和样品混合在一起。

    Flow-through apparatus for microscopic investigation of dissolution pharmaceutical solids
    13.
    发明申请
    Flow-through apparatus for microscopic investigation of dissolution pharmaceutical solids 有权
    用于溶出药物固体的微观研究的流通装置

    公开(公告)号：US20080138261A1

    公开(公告)日：2008-06-12

    申请号：US11635312

    申请日：2006-12-07

    Applicant: Robin H. Bogner ,  Theodore L. Bergman ,  Kristyn Greco ,  Derek J. Michaels ,  Szymon J. Chawarski

    Inventor： Robin H. Bogner ,  Theodore L. Bergman ,  Kristyn Greco ,  Derek J. Michaels ,  Szymon J. Chawarski

    IPC: B01D11/02

    CPC classification number: G01N21/05 ,  G01N21/0317 ,  G01N21/0332 ,  G01N21/09 ,  G01N21/272 ,  G01N2021/0342 ,  G01N2021/056 ,  G01N2201/0245

    Abstract: The present disclosure is directed to an apparatus and method for studying dissolution of a compact sample. The compact sample is typically a pharmaceutical drug sample. A flow-through apparatus includes a frame defining a flow-through channel, a removable insert having a drug sample, the insert positioned within the frame such that a fluid interacts with the sample when the fluid passes through the flow channel. The frame has an opening on the top side to allow a glass plate, typically a microscope cover slip to be positioned within the frame and allow viewing of the fluid flow and interaction with the drug sample. The hydrodynamics of the fluid flow are either known or computed. Thus, dissolution can be studied and observed in view of hydrodynamic characteristics. Typically, only a small amount of sample is necessary for a study. The flow-through apparatus is designed to fit on a microscopy stage and allow visual observation of the fluid/sample interaction.

    Abstract translation: 本公开涉及用于研究紧凑样品的溶解的装置和方法。 紧凑型样品通常是药物药物样品。 流通装置包括限定流通通道的框架，具有药物样本的可移除插入件，插入件定位在框架内，使得流体在流体通过流动通道时与样品相互作用。 框架在顶侧具有开口，以允许玻璃板，通常是显微镜盖滑动件定位在框架内，并允许观察流体流动和与药物样品的相互作用。 流体流动的流体动力学是已知的或计算的。 因此，考虑到流体动力特性，可以研究和观察溶解。 通常，研究只需要少量样品。 流通装置设计成适合于显微镜台上，并允许目视观察流体/样品相互作用。

    Reagent cuvette
    15.
    发明申请
    Reagent cuvette 失效
    试剂比色杯

    公开(公告)号：US20060210450A1

    公开(公告)日：2006-09-21

    申请号：US11434211

    申请日：2006-05-16

    Applicant: Michael O'Donovan

    Inventor： Michael O'Donovan

    IPC: B01L3/00

    CPC classification number: B01L3/50825 ,  B01L3/502 ,  B01L3/5082 ,  B01L3/5635 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2400/0683 ,  G01N21/03 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0364 ,  G01N2201/0245

    Abstract: A reagent cuvette (1) has a first chamber (2) with an inspection part (5) and a socket (6), and a second chamber (3). The socket (6) has four spikes (20) at its base. Both chambers are sealed with a membrane. At the point-of-care the foil membrane (7) of the first chamber (2) is peeled away by the therapist (typically general practitioner doctor). A sample, such as blood, is added to the chamber (2) using a pipette or other device to provide a verifiable quantity of sample. This provides a mixture of a buffer reagent supplied in the chamber (2) and the sample injected into the inspection chamber 2 at the point of care. The chamber (3) is then inserted into the socket (6) by gently pressing it down so that its foil membrane is broken by the spikes (20). This causes the starter reagent to drop down from within the second chamber (3) into the inspection part (5) of the first chamber (2). The inspection part (5) is then inserted into an optical inspection instrument for analysis of the two reagents and the sample mixed together.

    Abstract translation: 试剂池（1）具有具有检查部（5）和插座（6）的第一室（2）和第二室（3）。 插座（6）在其底部具有四个钉（20）。 两个室都用膜密封。 在护理点，第一室（2）的箔膜（7）由治疗师（通常是全科医生）去除。 使用移液管或其他装置将诸如血液的样品加入到腔室（2）中以提供可验证量的样品。 这提供了在室（2）中提供的缓冲试剂和在注意点处注入检查室2的样品的混合物。 然后将腔室（3）通过轻轻地向下压入插座（6），使得其膜片被钉（20）破坏。 这使得起动剂从第二室（3）内下降到第一室（2）的检查部分（5）中。 然后将检查部件（5）插入光学检查仪器中，以分析两种试剂并将样品混合在一起。

    Novel device, system and method for fluorescence detection
    16.
    发明申请
    Novel device, system and method for fluorescence detection 审中-公开
    用于荧光检测的新型装置，系统和方法

    公开(公告)号：US20050109951A1

    公开(公告)日：2005-05-26

    申请号：US10500186

    申请日：2002-12-26

    Applicant: Falk Fish ,  Zvi Greenberg ,  Ouriel Faktor

    Inventor： Falk Fish ,  Zvi Greenberg ,  Ouriel Faktor

    IPC: G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N21/86

    CPC classification number: G01N21/645 ,  G01N21/64 ,  G01N21/8483 ,  G01N33/549 ,  G01N2021/6439 ,  G01N2021/757 ,  G01N2021/7759 ,  G01N2021/7763 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2201/0245 ,  G01N2201/062 ,  G01N2201/0628

    Abstract: A device, system and method for portable fluorescence detection. The portable device of the present invention features a low power light, in which a wavelength range is defined as at least one wavelength of light. The light source is preferably highly energy efficient, such that a majority of the electrical power which is consumed is then converted into transmitted light. The emitted light from the excited fluorophore is then preferably detected with any low cost and low power photodetector. Although optionally a highly sensitive optical detector may be used, preferably fluorescence is detected with any light sensing device, such as a regular photodiode or a CCD (charge-coupled device) sensor for example.

    Abstract translation: 用于便携式荧光检测的装置，系统和方法。 本发明的便携式装置具有低功率光，其中波长范围被定义为至少一个波长的光。 光源优选地是高能量的，使得消耗的大部分电功率然后被转换成透射光。 然后优选用任何低成本和低功率光电检测器检测来自激发的荧光团的发射光。 尽管可选地使用高灵敏度的光学检测器，但是优选地，例如使用诸如常规光电二极管或CCD（电荷耦合器件）传感器的任何光感测装置来检测荧光。

    Tray assembly for optical inspection apparatus
    17.
    发明申请
    Tray assembly for optical inspection apparatus 有权
    光学检测仪器托盘组件

    公开(公告)号：US20040247491A1

    公开(公告)日：2004-12-09

    申请号：US10821441

    申请日：2004-04-09

    Inventor： David A. Brock ,  Donald R. Hesser ,  Gary H. Krauth ,  Jack L. Zuidema ,  David L. Boger ,  Kevin J. Sheldrake

    IPC: B01L003/00

    CPC classification number: G01N21/8483 ,  B01L9/52 ,  B01L2300/0825 ,  G01J2003/2866 ,  G01N21/274 ,  G01N21/4738 ,  G01N21/78 ,  G01N2021/0325 ,  G01N2201/0245 ,  G01N2201/12792

    Abstract: A tray assembly for use with an apparatus adapted to inspect a liquid sample, including a support tray insertable within an inspection location within the liquid sample inspection apparatus so that a light source of the apparatus illuminates a liquid sample carried on the support tray and a detector of the apparatus receives light from the liquid sample when the support tray is positioned at the inspection location, and an insert supported within the support tray and having a first surface adapted to receive a first type of liquid carrier and a second surface adapted to receive a second type of liquid carrier different from the first type of liquid carrier.

    Abstract translation: 一种用于与适于检查液体样品的设备一起使用的托盘组件，包括可插入在液体样品检查设备内的检查位置内的支撑托盘，使得设备的光源照亮承载在支撑托盘上的液体样品和检测器 当所述支撑托盘位于所述检查位置时，所述设备从所述液体样品接收光，以及插入件，其被支撑在所述支撑托盘内并且具有适于接纳第一类型的液体载体的第一表面和适于接收 第二类液体载体不同于第一类液体载体。

    OPTICAL FLOW CELL FOR BIOPROCESSING
    18.
    发明公开
    OPTICAL FLOW CELL FOR BIOPROCESSING 审中-公开

    公开(公告)号：US20230221241A1

    公开(公告)日：2023-07-13

    申请号：US17997644

    申请日：2021-06-10

    Applicant: CYTIVA SWEDEN AB

    Inventor： Hanno Ehring ,  Klaus Gebauer

    IPC: G01N21/05 ,  G01N21/15

    CPC classification number: G01N21/05 ,  G01N21/15 ,  G01N2021/052 ,  G01N2201/0245

    Abstract: Disclosed is an optical flow cell (100, 300) and a method (400) for bioprocessing applications. The optical flow cell (100, 300) comprises a fluid inlet (102, 302), a fluid outlet (104, 304), and a fluid flow channel (106, 306) provided between said fluid inlet (102, 302) and said fluid outlet (104, 304). The optical flow cell (100, 300) also comprises an output optical waveguide (108, 308) configured to emit light into said fluid flow channel (106, 306), and a collector optical waveguide (110, 310) configured to collect light from said fluid flow channel (106, 306). An optical pathlength adjuster (120, 320) for varying the optical pathlength (130, 330) between said output optical waveguide (108, 308) and said collector optical waveguide (110, 310) is also provided.

    METHOD AND SYSTEM FOR MULTIPLEXED TIME-RESOLVED FLUORESCENCE DETECTION
    20.
    发明申请
    METHOD AND SYSTEM FOR MULTIPLEXED TIME-RESOLVED FLUORESCENCE DETECTION 审中-公开
    多时间分辨荧光检测方法与系统

    公开(公告)号：US20160299076A1

    公开(公告)日：2016-10-13

    申请号：US14682026

    申请日：2015-04-08

    Applicant: Molecular Devices, LLC

    Inventor： Michael Katzlinger ,  Evan F. Cromwell ,  Vanitha Thulasiraman

    IPC: G01N21/64

    CPC classification number: G01N21/6408 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0245

    Abstract: The present invention is directed to a novel method to multiplex long lifetime fluorescent dyes using time-resolved fluorescence (TRF) detection. A combination of spectral and temporal differences in fluorescence emission is used to enhance the ability to separate signals in an assay from multiple dyes. Multiplexed TRF detection apparatuses and systems configured for performing all or part of any of the methods disclosed herein are also provided, particularly apparatuses and systems incorporating cartridge-based multi-mode readers.

    Abstract translation: 本发明涉及使用时间分辨荧光（TRF）检测来复用长寿命荧光染料的新方法。 使用荧光发射的光谱和时间差异的组合来增强分析中的信号与多种染料的能力。 还提供了被配置用于执行本文公开的任何方法的全部或部分的多路复用的TRF检测装置和系统，特别是包含基于盒式多模式读取器的装置和系统。

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