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公开(公告)号：US11927530B2
公开(公告)日：2024-03-12
申请号：US17278450
申请日：2019-09-30
Applicant: Nicoya Lifesciences, Inc.
Inventor： Ryan Denomme , Shawn Fitzpatrick , Jason Garr , Krishna Iyer , Gordon Hall , Champika Samarasekera
IPC: G01N21/552 , G01N21/05
CPC classification number: G01N21/553 , G01N21/05 , G01N2201/0438 , G01N2201/062
Abstract: A plasmon resonance (PR) system, instrument, and/or device and configurations thereof for measuring molecular interactions is disclosed. In some embodiments, the PR system, instrument, and/or device is a localized surface plasmon resonance (LSPR) system, instrument, and/or device. In other embodiments, the PR system, instrument, and/or device is a surface plasmon resonance (SPR) system, instrument. The PR system, instrument, and/or device may include, for example, force feedback for reliable flow cell sealing, optical feedback for reliable flow cell sealing, local thermal control of an LSPR chip (e.g., a ring Peltier, a continuous Peltier), dual displacement pumps for constant flow delivery to a microfluidic device, a dual channel LSPR sensor, and any combinations thereof.
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公开(公告)号：US20170191941A1
公开(公告)日：2017-07-06
申请号：US15461745
申请日：2017-03-17
Applicant: Sysmex Corporation
Inventor： Atsushi HOSOTANI , Daigo TAKAHASHI , Motohiro ODA
IPC: G01N21/77 , G01N33/493
CPC classification number: G01N21/77 , G01N21/78 , G01N21/8483 , G01N33/493 , G01N35/00029 , G01N2021/7769 , G01N2035/00039 , G01N2035/00118 , G01N2201/0438 , G01N2201/12
Abstract: A testing unit to test a liquid sample applied on a measurement surface in an indicator section on a test piece by using a brightness distribution. The testing unit comprises an irradiation part that irradiates the measurement surface with light; an imaging part that obtains images of the measurement surface; a generating part that generates a determination index based on the imaging data; and a determination part that executes determination on a measurement item, using the determination index. The determination index is based on a brightness of the measurement surface when the measurement surface does not include a specular reflection region. The determination index is based on a brightness of a remnant region of the measurement surface excluding the specular reflection region when it is determined that the measurement surface includes a specular reflection region.
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公开(公告)号：US20150276612A1
公开(公告)日：2015-10-01
申请号：US14646354
申请日：2013-12-03
Applicant: F. HOFFMAN-LA ROCHE AG
Inventor： Christof Fattinger
IPC: G01N21/75
CPC classification number: G01N21/75 , G01N21/552 , G01N21/7703 , G01N21/774 , G01N33/54373 , G01N2021/752 , G01N2021/7776 , G01N2021/7793 , G01N2201/0438
Abstract: A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines. The predetermined straight lines (7) are arranged at an angle relative to the direction of propagation of the evanescent field (11) such that the coherent light (12) diffracted by the target samples bound to the binding sites impinges under a diffraction angle relative to the straight lines onto a further optical coupler (8) arranged in a portion (10) of the planar waveguide (2) outside the beam of coherent light propagating through the planar waveguide. The further optical coupler (8) couples the diffracted coherent light (13) out of the planar waveguide (2) such as to interfere at a predetermined detection location (9) with a difference in optical path length which is an integer multiple of the predetermined wavelength.
Abstract translation: 一种用于检测结合亲和力的装置，所述装置包括布置在基板（3）上的平面波导（2），并且还包括具有预定长度的光耦合器（41），用于耦合相干光（1） 预定波长进入平面波导（2），使得相干光的平行光通过平面波导（2）的外表面（21）的相干光的消逝场（11）传播通过平面波导（2） ）。 平面波导（2）的外表面（21）包括其上能够将目标样品结合到结合位点的结合位点，使得消逝场（11）的光被结合到结合位点的靶样品衍射。 绑定位置沿着彼此平行延伸的多条预定的直线（7）布置，在相邻的直线之间具有恒定的距离。 预定的直线（7）相对于ev逝场（11）的传播方向以一定角度排列，使得被绑定位置的目标样本衍射的相干光（12）相对于 布置在平面波导（2）的部分（10）中的另外的光耦合器（8）上的直线穿过平面波导传播的相干光束之外。 另外的光耦合器（8）将衍射相干光（13）耦合到平面波导（2）之外，以便在预定的检测位置（9）处干涉光路长度的差异，该光程长度是预定的 波长。
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公开(公告)号：US20150219611A1
公开(公告)日：2015-08-06
申请号：US14412616
申请日：2013-07-05
Applicant: Moba Group B.V.
Inventor： Edwin Van Wegen , Josse De Baerdemaeker , Bart Kemps , Jeroen Evert Jan Brunnenkreef , Bart De Ketelaere
CPC classification number: G01N33/08 , A01K43/00 , G01N21/13 , G01N21/55 , G01N21/95 , G01N2201/0438 , G01N2201/06113 , G01N2201/12
Abstract: This invention relates to a method and an apparatus for characterizing eggshells of eggs, the eggs being supported, comprising:—deforming the eggshell,—scanning the eggshell with a laser beam of a Self Mixing Laser Vibrometer (SMLV) with scanning signals, whereby a reflection light signal of reflection light is obtained,—processing scanning signal and the reflection signal with the SMLV, whereby a mixed signal with crack information is obtained,—during scanning moving the eggs relative to the SMLV,—comparing the signals with preset criteria and characteristics of such eggs, whereby comparative data are obtained, and—characterizing the eggshells on the basis of the comparative data.
Abstract translation: 本发明涉及一种用于表征蛋的蛋壳的方法和装置，所述蛋被支撑，包括：用扫描信号的自混合激光测振仪（SMLV）的激光束扫描蛋壳 - 扫描蛋壳，由此 获得反射光的反射光信号，利用SMLV处理扫描信号和反射信号，从而获得具有裂纹信息的混合信号， - 扫描移动卵相对于SMLV， - 以预设标准比较信号， 获得比较数据的这种蛋的特征，并且基于比较数据来表征蛋壳。
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公开(公告)号：US20130222803A1
公开(公告)日：2013-08-29
申请号：US13818188
申请日：2011-09-09
Applicant: Matthias Hartrumpf
Inventor： Matthias Hartrumpf
IPC: G01N21/21
CPC classification number: G01N21/21 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N21/84 , G01N2015/144 , G01N2021/845 , G01N2201/0438 , G01N2201/06113
Abstract: The present invention relates to a device for optical characterisation of a sample and/or of the material/materials of the same having an illumination unit which is orientated or can be orientated to illuminate with incident light a sample spatial portion into which the sample can be introduced, a detection unit which is orientated or can be orientated to image the sample introduced into the sample spatial portion by receiving light reflected by the sample, and which is configured to detect at least two different, preferably two orthogonal, polarisation components in the reflected light, and an evaluation unit with which, in the imaging data recorded by the detection unit, those imaged surface elements (reflection elements) of the sample can be identified, the reflected, received light of which is based on a reflection of the incident light on the sample, and with which the detected different polarisation components for these reflection elements can be evaluated for optical characterisation.
Abstract translation: 本发明涉及一种用于光学表征样品和/或其材料/材料的装置，该装置具有照明单元，照明单元被定向或可被定向以用入射光照射样品空间部分 引入了一种检测单元，其被定向或可以被定向以通过接收由样本反射的光来对引入到样本空间部分的样品成像，并且被配置为检测反射的至少两个不同的，优选两个正交的偏振分量 光和评估单元，其中在由检测单元记录的成像数据中，能够识别样品的那些成像表面元件（反射元件），其反射的接收光基于入射光的反射 对于这些反射元件，检测出的不同的偏振分量可以被评估为光学特性 ation。
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Patent Agency Ranking
公开(公告)号：US20090218513A1
公开(公告)日：2009-09-03
申请号：US12092767
申请日：2006-11-07
Applicant: Daniel Bec , Vincent Paveau , Stephane Le Brun
Inventor： Daniel Bec , Vincent Paveau , Stephane Le Brun
CPC classification number: G01N21/6452 , G01N21/6458 , G01N2201/0438 , G01N2201/0492 , G01N2201/101 , G02B21/0076
Abstract: A device for analysing a specimen by fluorescence includes a confocal microscope, illumination means capable of emitting a light beam that converges, by means of an objective, on a focal spot, means for successively positioning the focal spot at various points on the specimen during analysis. The confocal microscope includes an objective mounted on a movable rapid-scan carriage driven in a reciprocating linear movement along a traverse direction by a rotating motor by means of a device of the connecting rod type. The specimen is placed on a movable support driven in a longitudinal movement and is able to move along the axis of the objective of the microscope in order to position the specimen relative to the focal spot. The excitation light spectrum is spread over the surface of the specimen in such a way that the excitation light reflected by the specimen and corresponding to the wavelengths close to fluorescence converge on points that are sufficiently distant from a diaphragm positioned in front of a device for measuring the fluorescence.
Abstract translation: 用于通过荧光分析样品的装置包括共聚焦显微镜，能够发射通过物镜会聚在焦点上的光束的照明装置，用于在分析期间将焦斑连续地定位在样品上的各个点处的装置 。 共焦显微镜包括安装在可移动快速扫描托架上的物镜，该移动快速扫描托架借助于连杆型的装置沿着横动方向由旋转马达沿往复线性运动驱动。 样本被放置在以纵向运动驱动的可移动支撑上，并且能够沿着显微镜的物镜的轴线移动，以便使样本相对于焦点定位。 激发光谱以试样的反射并对应于接近荧光的波长的激发光在测量装置前方的光阑上充分远离的位置上分散在试样的表面上， 荧光。
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公开(公告)号：US20050281715A1
公开(公告)日：2005-12-22
申请号：US10870107
申请日：2004-06-17
Applicant: Merrit Jacobs , Robert Burkovich , David Johnson
Inventor： Merrit Jacobs , Robert Burkovich , David Johnson
CPC classification number: G01N21/13 , G01N21/0303 , G01N21/253 , G01N2021/0357 , G01N2021/0367 , G01N2021/0371 , G01N2201/0438
Abstract: A device and method solves the problems of improving precision, in particular in reducing movement of a cuvette, particularly lateral or side to side movement of a cuvette, during the measurement process. The device, which stabilizes a cuvette during a measurement read in an analyzer having a cuvette path of travel, includes: a fixed support located on a first side of the path of travel and abutting a side of the cuvette at a location that does not interfere with an optical window on the cuvette on which the measurement read takes place; and a movable support located on a second side of the path of travel and biased against a side of the cuvette at a location that does not interfere with the optical window on the cuvette on which the measurement read takes place, and which is opposite the side abutting the fixed support.
Abstract translation: 一种装置和方法解决了在测量过程中提高精度的问题，特别是在减小试管的运动，特别是比色杯的侧向或侧向运动。 在具有运动的比色皿路径的分析器中读取测量期间使测定杯稳定的装置包括：位于行进路径的第一侧的固定支撑件，并且在不干扰的位置处邻接比色杯的一侧 在其上进行测量读取的比色皿上具有光学窗口; 以及可移动支撑件，其位于行进路径的第二侧，并且在不影响在其上进行测量读取的比色皿上的光学窗口的位置处抵靠所述比色皿的侧面偏压，并且与所述侧面相对的位置 抵靠固定支架。
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18.发明授权
公开(公告)号：US5595708A
公开(公告)日：1997-01-21
申请号：US341825
申请日：1994-11-18
Applicant: Klaus W. Berndt
Inventor： Klaus W. Berndt
CPC classification number: G01N21/253 , C12M41/46 , G01N2021/7786 , G01N2035/00752 , G01N21/6408 , G01N2201/0438 , G01N2201/101 , G01N35/028 , Y10S435/808
Abstract: A system for detecting the presence of bacterial growth in a plurality of sample vials incorporates a single test station moveable along each of the plurality of sample vials. In one embodiment, the sensor station is movably mounted on a rod, and that rod is movably mounted on a pair of spaced rods. The rod which carries the test station may move along the spaced rods to change the location of the test station in a first dimension and the test station is moveable along its rod to change location in a second dimension. In this way, the test station may be moved through two dimensions to move serially to the location of each of the plurality of sample vials. In another aspect of this invention, a bar code is associated with each of the sample vials, and the test station makes a reading of that bar code concurrent with a determination being made as to whether there is any bacterial growth in the sample vial. In this way, it is ensured that the results of the evaluation of whether bacterial growth is ongoing will be associated with the proper sample vial. In a third aspect of this invention, the sample vial incorporates a plurality of distinct types of bacterial sensors. Thus, the advantages of each of several types of bacterial sensors may be incorporated into a single sample vial.
Abstract translation: 用于检测多个样品瓶中细菌生长存在的系统结合了可沿多个样品瓶中的每一个移动的单个测试台。 在一个实施例中，传感器站可移动地安装在杆上，并且该杆可移动地安装在一对隔开的杆上。 携带测试台的杆可以沿着间隔开的杆移动，以便在第一维度上改变测试台的位置，并且测试台可沿其杆移动以在第二维度上改变位置。 以这种方式，测试台可以通过两个维度移动以连续地移动到多个样品瓶中的每一个的位置。 在本发明的另一方面，条形码与每个样品瓶相关联，并且测试台同时进行该条形码的读取，并确定样品瓶中是否存在细菌生长。 以这种方式，确保细菌生长是否正在进行的评估结果将与适当的样品瓶相关联。 在本发明的第三方面，样品瓶包含多种不同类型的细菌传感器。 因此，可以将几种类型的细菌传感器中的每一种的优点结合到单个样品瓶中。
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公开(公告)号：US20170336316A1
公开(公告)日：2017-11-23
申请号：US15670297
申请日：2017-08-07
Inventor： Matthias Hartrumpf
CPC classification number: G01N21/21 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N21/84 , G01N2015/144 , G01N2021/845 , G01N2201/0438 , G01N2201/06113
Abstract: The present invention relates to a device for optical characterisation of a sample and/or of the material(s) of the same having an illumination unit that can be orientated to illuminate with incident light a sample spatial portion into which the sample can be introduced, a detection unit which is orientated or can be orientated to image the sample introduced into the sample spatial portion by receiving light reflected by the sample, and which is configured to detect at least two different, preferably orthogonal, polarization components in the reflected light, and an evaluation unit with which, in the imaging data recorded by the detection unit, those imaged surface elements (reflection elements) of the sample can be identified, and with which the detected different polarization components for these reflection elements can be evaluated for optical characterisation.
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20.发明授权Non-contact egg identification system for determining egg viability using transmission spectroscopy, and associated method 有权使用透射光谱测定蛋活力的非接触式鸡蛋识别系统及相关方法公开(公告)号：US09513270B2
公开(公告)日：2016-12-06
申请号：US14536869
申请日：2014-11-10
Applicant: Zoetis Services LLC
Inventor： Joel James Walukas , Ramin Karimpour
IPC: G01N33/08 , G01N21/3563 , G01N21/25 , G01N21/64
CPC classification number: G01N33/085 , A01K43/00 , G01N21/255 , G01N21/3563 , G01N21/645 , G01N21/6486 , G01N2021/6417 , G01N2021/6491 , G01N2201/0438 , G01N2201/061
Abstract: An egg identification system for determining viability of an avian egg is provided. Such a system includes an emitter assembly configured to emit electromagnetic radiation toward an egg. A detector assembly is axially aligned with the emitter assembly to detect electromagnetic radiation transmitted through the egg. The detector assembly is spaced-apart from the egg during operation thereof such that the detector assembly does not contact the egg. The detected electromagnetic radiation is processed using transmission spectroscopy analysis to determine whether the egg is viable. An associated method is also provided.
Abstract translation: 提供了一种用于确定禽卵活力的鸡蛋识别系统。 这种系统包括被配置为朝向卵发射电磁辐射的发射器组件。 检测器组件与发射器组件轴向对准以检测通过卵传播的电磁辐射。 检测器组件在操作期间与蛋间隔开，使得检测器组件不接触蛋。 使用透射光谱分析处理检测到的电磁辐射，以确定鸡蛋是否存活。 还提供了相关联的方法。
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