公开(公告)号：US1981311A

公开(公告)日：1934-11-20

申请号：US67734233

申请日：1933-06-23

Applicant: DU PONT

Inventor： DAHLEN MILES A ,  FOOHEY WILLIAM L

IPC: C07C201/08 ,  C07C201/16 ,  C07C205/12

CPC classification number: C07C201/08 ,  C07C201/16 ,  C07C205/12

公开(公告)号：US1640737A

公开(公告)日：1927-08-30

申请号：US57532822

申请日：1922-07-15

Applicant: DU PONT

Inventor： TAYLOR GUY B ,  RICHARDSON ALBERT S

IPC: C07B43/02 ,  C07C201/08 ,  C07C205/06

CPC classification number: C07B43/02 ,  C07C201/08 ,  C07C205/06

公开(公告)号：US11820724B2

公开(公告)日：2023-11-21

申请号：US17296544

申请日：2020-09-10

Applicant: ACCELA CHEMBIO CO., LTD. ,  QIDONG ACCELA CHEMBIO CO., LTD.

Inventor： Yang Liu ,  Duoqing Xue ,  Yong Wu ,  Lihuang Chen ,  Lianhua Zhai

IPC: C07C201/08 ,  C07C201/12

CPC classification number: C07C201/08 ,  C07C201/12

Abstract: The present disclosure provides a method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, including: (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone; (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene; (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene, to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene; and (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene.

公开(公告)号：US11542277B2

公开(公告)日：2023-01-03

申请号：US16451509

申请日：2019-06-25

Applicant: Angus Chemical Company

Inventor： Daniel M. Trauth ,  George D. Green ,  Raymond J. Swedo ,  Richard L. James ,  Ian A. Tomlinson

IPC: C07C201/12 ,  C07C201/08 ,  C07C215/28 ,  C07C215/20 ,  C07C215/08 ,  C07C215/42 ,  C07C205/05 ,  C07C205/04 ,  C07C205/16 ,  C07C205/15 ,  C07C205/18 ,  C07C205/02 ,  C07C205/06 ,  A01N43/76 ,  A01N43/90 ,  C07D263/04 ,  C07D263/52 ,  C07D498/04 ,  C07D498/10 ,  C07C239/10 ,  C08G18/32

Abstract: Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

公开(公告)号：US20220298099A1

公开(公告)日：2022-09-22

申请号：US17690729

申请日：2022-03-09

Applicant: Amgen Inc.

Inventor： Sebastien CAILLE ,  James MURRAY ,  Kyle QUASDORF ,  Hannah NGUYEN ,  Maria Victoria SILVA ELIPE ,  Ari Elizabeth ERICSON

IPC: C07C201/08

Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

公开(公告)号：US20220024850A1

公开(公告)日：2022-01-27

申请号：US17296544

申请日：2020-09-10

Applicant: ACCELA CHEMBIO CO., LTD. ,  QIDONG ACCELA CHEMBIO CO., LTD.

Inventor： Yang LIU ,  Duoqing XUE ,  Yong WU ,  Lihuang CHEN ,  Lianhua ZHAI

IPC: C07C201/08 ,  C07C201/12

Abstract: The present disclosure provides a method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, including: (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone; (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene; (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene, to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene; and (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene.

公开(公告)号：US11231727B2

公开(公告)日：2022-01-25

申请号：US16878923

申请日：2020-05-20

Applicant: Covestro Deutschland AG

Inventor： Bernd Pennemann ,  Erwin Dieterich ,  Heinz-Josef Hamacher

IPC: G05D7/06 ,  C07C201/08 ,  B01J19/00 ,  F16K31/02 ,  G05B11/42 ,  C07C205/06

Abstract: A method for continuously producing a product (A1) by way of at least two coupled-together chemical reactions (C1, C2), wherein at least two input substances (E1, E2) are fed to a first chemical reaction (C1), wherein a plurality of intermediate substances (Z1, Z2) are produced from the input substances (E1, E2) by the first chemical reaction (C1), wherein at least one of the intermediate substances (Z2) is fed to a second chemical reaction (C2), wherein the at least one fed intermediate substance (Z2) is further processed by the second chemical reaction (C2), in particular using at least one further substance (W1, W2) in a second chemical reaction (C2) to form a plurality of output substances (A1, A2), that is to say to form the chemical product (A1) and at least one further output substance (A2), wherein the flow rates (Fi) of the fed substances (E1, E2, Z1, W1, W2, A2) that are fed to one of the reactions (C1, C2) are set by a respective actuating element (VE1, VE2, VW1, VW 2, VZ 2, VA1), wherein each of the fed substances is assigned a separate actuating element, wherein a manipulated variable (SE2,R, Si,R) that is stipulated by a controller (RE2, Ri) is respectively applied to at least one of the actuating elements, wherein, for changing the production rate of the chemical product (A1), a temporary manipulated variable (SE2,temp, Si,temp) is respectively applied during a transient phase (II, III) to at least one of these actuating elements (VE2, Vi) instead of the manipulated variables (SE2, R, Si,R) stipulated by the respective controllers (RE2, Ri), wherein the temporary manipulated variable (SE2,temp, Si,temp) or the temporary manipulated variables is/are generated by at least one control unit (SE) in dependence on a default value (NV).

公开(公告)号：US11136285B2

公开(公告)日：2021-10-05

申请号：US16009396

申请日：2018-06-15

Applicant: Covestro Deutschland AG

Inventor： Thomas Knauf ,  Peter Drinda

IPC: B01J19/24 ,  B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  B01J19/18

Abstract: The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

公开(公告)号：US10717700B2

公开(公告)日：2020-07-21

申请号：US15550233

申请日：2016-01-18

Applicant: Arizona Board of Regents for the University of Arizona ,  Bhumasamudram Jagadish ,  Eugene Mash

Inventor： Bhumasamudram Jagadish ,  Eugene Mash

IPC: C07C201/08

Abstract: The present invention provides a process for nitrating aromatic compounds without the need for a solid catalyst and/or any organic solvents and/or any other additives. A typical process includes combining or admixing a nitric acid and an anhydride compound under conditions sufficient to produce a reactive intermediate. The aromatic compound to be nitrated is then added to this reactive intermediate to produce a nitroaromatic compound. The nitroaromatic compound can be substituted with one or more, typically, one to three, and often one or two nitrate (—NO2) groups.

公开(公告)号：US10698424B2

公开(公告)日：2020-06-30

申请号：US15526871

申请日：2015-11-17

Applicant: Covestro Deutschland AG

Inventor： Bernd Pennemann ,  Erwin Dieterich ,  Heinz-Josef Hamacher

IPC: G05D7/06 ,  C07C201/08 ,  B01J19/00 ,  F16K31/02 ,  C07C205/06 ,  G05B11/42

Abstract: A method for continuously producing a product (A1) by way of at least two coupled-together chemical reactions (C1, C2), wherein at least two input substances (E1, E2) are fed to a first chemical reaction (C1), wherein a plurality of intermediate substances (Z1, Z2) are produced from the input substances (E1, E2) by the first chemical reaction (C1), wherein at least one of the intermediate substances (Z2) is fed to a second chemical reaction (C2), wherein the at least one fed intermediate substance (Z2) is further processed by the second chemical reaction (C2), in particular using at least one further substance (W1, W2) in a second chemical reaction (C2) to form a plurality of output substances (A1, A2), that is to say to form the chemical product (A1) and at least one further output substance (A2), wherein the flow rates (Fi) of the fed substances (E1, E2, Z1, W1, W2, A2) that are fed to one of the reactions (C1, C2) are set by a respective actuating element (VE1, VE2, VW1, VW 2, VZ 2, VA1), wherein each of the fed substances is assigned a separate actuating element, wherein a manipulated variable (SE2,R, Si,R) that is stipulated by a controller (RE2, Ri) is respectively applied to at least one of the actuating elements, wherein, for changing the production rate of the chemical product (A1), a temporary manipulated variable (SE2,temp, Si,temp) is respectively applied during a transient phase (II, III) to at least one of these actuating elements (VE2, Vi) instead of the manipulated variables (SE2,R, Si,R) stipulated by the respective controllers (RE2, Ri), wherein the temporary manipulated variable (SE2,temp, Si,temp) or the temporary manipulated variables is/are generated by at least one control unit (SE) in dependence on a default value (NV).