中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

332 records (took 0.017 seconds)

    Osmotic devices having vapor-permeable coatings
    221.
    发明授权
    Osmotic devices having vapor-permeable coatings 失效
    具有透气性涂层的渗透装置

    公开(公告)号：US5827538A

    公开(公告)日：1998-10-27

    申请号：US571980

    申请日：1996-01-17

    Applicant: Edward L. Cussler ,  Scott M. Herbig ,  Kelly L. Smith ,  Paul van Eikeren

    Inventor： Edward L. Cussler ,  Scott M. Herbig ,  Kelly L. Smith ,  Paul van Eikeren

    IPC: C07C201/08 ,  A61K9/00 ,  A61K9/32 ,  C07C201/12 ,  C07C205/11 ,  C07C205/19 ,  C07C205/23 ,  C07C205/26 ,  C07C205/34 ,  C07C205/42 ,  C07C215/14 ,  C07C271/08 ,  C07C301/00 ,  C07C309/67 ,  C07C309/73 ,  C07C319/14 ,  C07C323/16 ,  C07C323/25 ,  C07C323/29 ,  C08G18/38 ,  C08G59/50 ,  C08G63/685 ,  C08L101/00 ,  C09D163/00 ,  G03F7/00 ,  G03F7/004 ,  G03F7/039 ,  G03F7/16 ,  A61K9/24

    CPC classification number: C07C205/11 ,  A61K9/0004 ,  C07C205/19 ,  C07C205/26 ,  C07C215/14 ,  C07C323/25 ,  C08G18/384 ,  C08G59/50 ,  C08G59/504 ,  C08G63/6856 ,  C09D163/00 ,  G03F7/0045 ,  G03F7/039 ,  G03F7/164

    Abstract: An osmotic device that, following the imbibement of water vapor, provides for the controlled release of a beneficial agent to an aqueous environment. The device comprises a hydrophilic formulation including a beneficial agent, and if needed, an osmagent, surrounded by a wall. The wall is formed at least in part of a semipermeable hydrophobic membrane having an average pore size between about 0.1 .mu.m and 30 .mu.m. The pores are substantially filled with a gas phase. The hydrophobic membrane is permeable to water in the vapor phase and the hydrophobic membrane is impermeable to an aqueous medium at a pressure less than about 100 Pa. The beneficial agent is released, for example, by osmotic pumping or osmotic bursting upon imbibement of sufficient water vapor into the device core. These devices minimize incompatibilities between the beneficial agent and ions (such as hydrogen or hydroxyl) or other dissolved or suspended materials in the aqueous medium, since contact between the beneficial agent and the aqueous medium does not occur until after the beneficial agent is released. This results from the semipermeable membrane's selective permeability for water vapor. In addition, the high water fluxes attendant with these vapor-permeable membranes facilitate the delivery of beneficial agents having low solubilities, and the delivery of high dosages of beneficial agents.

    Abstract translation: PCT No.PCT / IB94 / 00114 Sec。 371日期1996年1月17日 102（e）日期1996年1月17日PCT 1994年5月19日PCT PCT。 公开号WO95 / 03033 日期1995年2月2日渗透装置在水蒸汽吸收之后提供有益剂控制释放到含水环境中。 该装置包括亲水性制剂，其包括有益剂，并且如果需要，包含被壁围绕的渗透剂。 所述壁至少部分形成有平均孔径在约0.1μm至30μm之间的半透性疏水膜。 孔基本上充满气相。 疏水膜在气相中是透水的，并且疏水膜在低于约100Pa的压力下对水介质是不可渗透的。有益剂例如通过渗透泵送或渗透的足够的水渗透渗出来释放 蒸汽进入设备核心。 这些装置使有益剂和离子（例如氢或羟基）或水性介质中的其它溶解或悬浮物质之间的不兼容性最小化，因为有益剂和水性介质之间的接触直到有益剂被释放才会发生。 这是由半透膜对水蒸汽的选择性渗透性产生的。 此外，伴随这些透气膜的高水通量促进了具有低溶解度的有益试剂的递送和高剂量的有益试剂的输送。

    Nitration process which employs water tolerant Lewis acid catalysts
    222.
    发明授权
    Nitration process which employs water tolerant Lewis acid catalysts 失效
    采用耐水路易斯酸催化剂的硝化工艺

    公开(公告)号：US5728901A

    公开(公告)日：1998-03-17

    申请号：US720938

    申请日：1996-10-04

    Applicant: Dorai Ramprasad ,  Francis Joseph Waller ,  Anthony Gerard Barrett ,  David Christopher Braddock

    Inventor： Dorai Ramprasad ,  Francis Joseph Waller ,  Anthony Gerard Barrett ,  David Christopher Braddock

    IPC: C07B43/02 ,  C07C201/08 ,  C07C205/06 ,  C07C205/00

    CPC classification number: C07B43/02 ,  C07C201/08

    Abstract: A process for preparing a nitrated arene which comprises reacting an arene and nitric acid in the presence of a water tolerant Lewis acid catalyst under process conditions sufficient to form the nitrated arene and recovering the nitrated arene. Suitable Lewis acid catalysts are represented by the formula M.sup.n (A.sub.1).sub.x (A.sub.2).sub.n-x wherein M is selected from the group consisting of La, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm, Yb, Sc, Hf, Lu and Li; A.sub.1 and A.sub.2 are independently selected from a perfluoroalkylsulfonate, a fluorosulfonate, a hexafluorophosphate or a nitrate; n is the common oxidation state of M and x is 1, 2, 3 or 4 with the proviso that x is never greater than n. The catalysts of the process are isolatable from water and can be recycled for subsequent process cycles.

    Abstract translation: 一种制备硝化芳烃的方法，其包括在耐水性路易斯酸催化剂存在下使芳烃和硝酸与足以形成硝化芳烃并回收硝化芳烃的工艺条件下反应。 合适的路易斯酸催化剂由式Mn（A1）x（A2）nx表示，其中M选自La，Pr，Nd，Sm，Eu，Gd，Dy，Ho，Er，Tm，Yb，Sc ，Hf，Lu和Li; A1和A2独立地选自全氟烷基磺酸盐，氟磺酸盐，六氟磷酸盐或硝酸盐; n是M的常见氧化态，x是1,2,3或4，条件是x不能大于n。 该方法的催化剂可与水分离，可循环使用，用于后续工艺循环。

    Process for the adiabatic preparation of mononitrohalogenobenzenes
    223.
    发明授权
    Process for the adiabatic preparation of mononitrohalogenobenzenes 失效
    绝热制备单硝基卤代苯的工艺

    公开(公告)号：US5714647A

    公开(公告)日：1998-02-03

    申请号：US785577

    申请日：1997-01-21

    Applicant: Heinz Ulrich Blank ,  Helmut Judat ,  Bernd-Michael Konig

    Inventor： Heinz Ulrich Blank ,  Helmut Judat ,  Bernd-Michael Konig

    IPC: C07C201/08 ,  C07C201/16 ,  C07C205/12 ,  C07C205/00

    CPC classification number: C07C201/08

    Abstract: Mononitrohalogenobenzenes can be prepared by mixing halogenobenzene, nitric acid, sulphuric acid and water intensively with one another, simultaneously or in succession in their total quantity, and by redispersing them at least twice in the case of continuous preparation, applying a mixing energy of 1-40 watts per liter of the overall reaction mixture, preferably 3-30 W/l, largely suppressing back-mixing in the continuous procedure, and observing adiabatic reaction conditions.

    Abstract translation: 一硝基卤代苯可以通过将卤代苯，硝酸，硫酸和水彼此同时或相继地以总量相互重叠混合，并且在连续制备的情况下将它们再分散至少两次来制备， 总体反应混合物为40瓦/升，优选为3-30W / l，在连续方法中大大抑制了反混合，并且观察绝热反应条件。

    Process for the production of dinitrotoluene
    224.
    发明授权
    Process for the production of dinitrotoluene 失效
    生产二硝基甲苯的方法

    公开(公告)号：US5679873A

    公开(公告)日：1997-10-21

    申请号：US510992

    申请日：1995-08-03

    Applicant: Uwe Klingler ,  Thomas Schieb ,  Gerhard Wiechers ,  Jurgen Zimmermann

    Inventor： Uwe Klingler ,  Thomas Schieb ,  Gerhard Wiechers ,  Jurgen Zimmermann

    IPC: C07C201/08 ,  C07C201/16 ,  C07C205/06

    CPC classification number: C07C201/08

    Abstract: Dinitrotoluene is produced in a two-stage process from toluene and nitric acid in the presence of sulfuric acid under adiabatic conditions in the presence of nitrating acids made up of specified components. The reaction product of the first phase is separated into an acid phase and an organic phase containing the mononitrotoluene. Some water is removed from the acid phase, nitric acid is added and the resultant mixture is recycled. The organic phase containing mononitrotoluene is further nitrated to produce the dinitrotoluene. This nitration mixture is also separated into an acid phase and an organic phase. The acid phase is treated to remove some water, nitric acid is added and the resultant acid mixture is recycled. Dinitrotoluene is recovered from the organic phase. This process is advantageous in that dilute nitric acid may be used and the heat of the nitration reaction is utilized.

    Abstract translation: 在绝酸条件下，在由特定组分组成的硝酸的存在下，在硫酸存在下，甲苯和硝酸二步法生产二硝基甲苯。 将第一相的反应产物分离成酸相和含有一硝基甲苯的有机相。 从酸相中除去一些水，加入硝酸并将所得混合物回收。 含有单硝基甲苯的有机相进一步硝化以产生二硝基甲苯。 该硝化混合物也分离成酸相和有机相。 处理酸相以除去一些水，加入硝酸并将所得酸混合物再循环。 从有机相回收二硝基甲苯。 该方法的优点在于可以使用稀硝酸并利用硝化反应的热。

    Process for the adiabatic preparation of mononitrotoluenes
    225.
    发明授权
    Process for the adiabatic preparation of mononitrotoluenes 失效
    制备单硝基甲苯的绝热方法

    公开(公告)号：US5648565A

    公开(公告)日：1997-07-15

    申请号：US679323

    申请日：1996-07-12

    Applicant: Bernd-Michael Konig ,  Helmut Judat ,  Heinz Ulrich Blank

    Inventor： Bernd-Michael Konig ,  Helmut Judat ,  Heinz Ulrich Blank

    IPC: C01B17/88 ,  C07C201/08 ,  C07C201/16 ,  C07C205/06 ,  C07C205/00

    CPC classification number: C07C201/08

    Abstract: Mononitrotoluenes can be prepared by intensively mixing together toluene, nitric acid, sulphuric acid and water, simultaneously or successively in their total amount, and, in the case of continuous preparation, redispersing the mixture at least twice, for which purpose a mixing energy of 1 to 40 watts per liter of the total reaction mixture, preferably 3 to 30 W/l, is employed per volume of the reactor, and, for the continuous procedure, the back mixing is substantially repressed. Adiabatic reaction conditions are maintained.

    Abstract translation: 单硝基甲苯可以通过将甲苯，硝酸，硫酸和水同时或相继浓缩在一起而制备，并且在连续制备的情况下，将混合物再分散至少两次，为此目的的混合能量为1 至40瓦/升的总反应混合物，优选3至30W / l，并​​且对于连续方法，背混合基本上被压制。 保持绝热反应条件。

    Non-pollutional process for producing aromatic nitro compounds without using a mineral acid
    228.
    发明授权
    Non-pollutional process for producing aromatic nitro compounds without using a mineral acid 失效
    不使用矿物酸生产芳香硝基化合物的非污染方法

    公开(公告)号：US5237077A

    公开(公告)日：1993-08-17

    申请号：US844587

    申请日：1992-03-27

    Applicant: Hitomi Suzuki ,  Takashi Murashima ,  Kenkichi Tsukamoto

    Inventor： Hitomi Suzuki ,  Takashi Murashima ,  Kenkichi Tsukamoto

    IPC: C07C201/08 ,  C07C205/06 ,  C07C205/12 ,  C07C205/47 ,  C07C205/57 ,  C07C231/12

    CPC classification number: C07C231/12 ,  C07C201/08 ,  C07C2103/24

    Abstract: The present invention relates to a process for producing an aromatic nitro compound by introducing a nitrogen oxide gas and ozone-containing oxygen or air into a halogenated organic solvent dissolving or suspending therein an aromatic compound, thereby subjecting the aromatic compound to nitration. By the use of a system comprising the nitrogen oxide and ozone-containing oxygen or air as the nitrating agent, the aromatic nitro compound can be produced under mild conditions without using any mineral acid. In addition, the various disadvantages due to the use of mineral acid in the conventional process can be avoided by the process of the present invention.

    Abstract translation: PCT No.PCT / JP91 / 01151 Sec。 371日期：1992年3月27日 102（e）1992年3月27日PCT PCT 1991年8月29日PCT公布。 出版物WO92 / 04313 本发明涉及通过将氮氧化物气体和含臭氧的氧气或空气引入溶解或悬浮在其中的芳族化合物的卤化有机溶剂中来制备芳族硝基化合物的方法，从而使芳族化合物 复合硝化。 通过使用包含氮氧化物和含臭氧的氧气或空气作为硝化剂的系统，芳族硝基化合物可以在温和条件下生产而不使用任何无机酸。 此外，通过本发明的方法可以避免在常规方法中使用无机酸的各种缺点。

    Preparation of 1,3,5-triamino-2,4,6-trinitrobenzene from 3,5-dichloroanisole
    229.
    发明授权
    Preparation of 1,3,5-triamino-2,4,6-trinitrobenzene from 3,5-dichloroanisole 失效
    从3,5-二氯苯甲醚制备1,3,5-三氨基-2,4,6-三硝基苯

    公开(公告)号：US4997987A

    公开(公告)日：1991-03-05

    申请号：US534896

    申请日：1990-06-08

    Applicant: Donald G. Ott ,  Theodore M. Benziger

    Inventor： Donald G. Ott ,  Theodore M. Benziger

    IPC: C07C201/08 ,  C07C205/12 ,  C07C205/37 ,  C07C209/10

    CPC classification number: C07C209/10 ,  C07C201/08 ,  C07C201/12

    Abstract: Preparation of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) from 3,5-dichloroanisole. Nitration of 3,5-dichloroanisole under relatively mild conditions gave 3,5-dichloro-2,4,6-trinitroanisole in high yield and purity. Ammonolysis of this latter compound gave the desired TATB. Another route to TATB was through the treatment of the 3,5-dichloro-2,4,6-trinitroanisole with thionyl chloride and dimethylformamide to yield 1,3,5-trichloro-2,4,6-trinitrobenzene. Ammonolysis of this product produced TATB.

    Abstract translation: 由3,5-二氯苯甲醚制备1,3,5-三氨基-2,4,6-三硝基苯（TATB）。 在相对温和的条件下硝化3,5-二氯苯甲醚，得到3,5-二氯-2,4,6-三硝基苯甲醚，产率高，纯度高。 该后一种化合物的溶解得到所需的TATB。 通过用亚硫酰氯和二甲基甲酰胺处理3,5-二氯-2,4,6-三硝基苯甲醚，得到1,3,5-三氯-2,4,6-三硝基苯，通过TATB的另一条路线。 该产品的解淀粉生成TATB。

Patent Agency Ranking