公开(公告)号：US5792056A

公开(公告)日：1998-08-11

申请号：US777347

申请日：1996-12-27

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B3/055

CPC classification number: A61K49/18 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/5635 ,  A61B5/201 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

公开(公告)号：US5520178A

公开(公告)日：1996-05-28

申请号：US332715

申请日：1994-11-01

Applicant: Michael S. Dahn ,  M. Patricia Lange

Inventor： Michael S. Dahn ,  M. Patricia Lange

IPC: A61B5/00 ,  A61B5/0275 ,  A61M25/01 ,  A61M25/08

CPC classification number: A61B5/6855 ,  A61B5/0275 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/201 ,  A61B5/412 ,  A61M25/0105 ,  A61M25/0116

Abstract: A multifunctional visceral catheter having a self-guiding system in the form of a pair of electrochemical sensors which are sensitive to a predetermined analyte, the analyte being one which is removed from the vascular circuit of interest to a high degree, such as galactose in the hepatic venous system or creatinine in the renal venous system. One of the sensors is disposed on the catheter so as to be positioned within the venous system of interest, while the other sensor remains outside the venous system in the inferior vena cava. A substantial difference between analyte concentration values as measured via the two sensors provides immediate confirmation that the catheter is properly positioned, eliminating the need for fluoroscopy or other x-ray techniques. In addition to being self-guiding, the catheter provides for direct sampling of venous blood; is capable of continuously monitoring oxygen saturation in the hepatic or renal venous blood; and is capable of measuring absolute hepatic or renal blood flow using a tracer clearance technique.

Abstract translation: 一种多功能内脏导管，其具有对预定分析物敏感的一对电化学传感器形式的自我引导系统，所述分析物是高度感兴趣的血管回路中的分析物，例如半乳糖 肝静脉系统或肌酐在肾静脉系统中。 其中一个传感器设置在导管上，以便定位在感兴趣的静脉系统内，而另一个传感器保留在下腔静脉中的静脉系统的外部。 通过两个传感器测量的分析物浓度值之间的显着差异提供了立即确认导管被适当定位，消除了对透视或其它x射线技术的需要。 除了自我引导之外，导管还提供静脉血的直接取样; 能够连续监测肝或肾静脉血中的氧饱和度; 并且能够使用示踪剂清除技术测量绝对的肝或肾血流量。

公开(公告)号：US5476434A

公开(公告)日：1995-12-19

申请号：US284260

申请日：1994-08-02

Applicant: Irvin M. Kalb ,  Robert H. Shaw ,  Michael J. Ram

Inventor： Irvin M. Kalb ,  Robert H. Shaw ,  Michael J. Ram

IPC: A61M39/00 ,  A61B5/20 ,  A61F2/00 ,  A61F2/48 ,  A61F5/37 ,  A61M1/00 ,  A61M25/00 ,  A61F2/02

CPC classification number: A61B5/14539 ,  A61B5/14507 ,  A61B5/20 ,  A61B5/201 ,  A61B5/202 ,  A61B5/205 ,  A61F2/0009 ,  A61M25/0017 ,  A61M2205/3324 ,  A61M2205/3344 ,  A61M2205/3368 ,  Y10S128/903

Abstract: A system for controlling drainage of the female bladder comprising a valved catheter, a stylet for placing the catheter in the female urethra, and a spike for opening the valve in the catheter to allow voiding of the contents of the bladder which also includes sensing and transmission means incorporated therein. The valve which may be integral with the shaft or located in a cap on the shaft may be manually operated or opened electronically by a signal transmitted from an external source.

Abstract translation: 一种用于控制阴囊的排水的系统，包括：阀导管，用于将导管放置在女性尿道中的探针，以及用于打开导管中的阀的尖峰，以允许膀胱内容物的排空，其还包括感测和传输 并入其中。 可以与轴一体或位于轴上的盖中的阀可以通过从外部源传输的信号以电子方式手动操作或打开。

公开(公告)号：US5335660A

公开(公告)日：1994-08-09

申请号：US105239

申请日：1993-08-12

Applicant: Charles L. Dumoulin

Inventor： Charles L. Dumoulin

IPC: G01R33/50 ,  G01R33/563 ,  A61B5/055

CPC classification number: G01R33/563 ,  G01R33/50 ,  A61B5/201

Abstract: A magnetic resonance imaging system employs a sequence of radio frequency pulses and magnetic field gradients to detect and measure the spin-relaxation time of moving blood within a subject. Spin-lattice relaxation times are determined by first inverting longitudinal spin magnetization and then detecting the recovery of this magnetization with a series of detection radio frequency pulses. The inversion pulse is applied to the entire subject, but the detection pulses are applied only to a selection portion of the subject. Blood motion causes the blood in the detection region to be replaced for each detection pulse, thereby increasing the accuracy of the measurement and permitting the use of multiple detection pulses after a single inversion pulse. In-vivo application of this invention can be used to assess renal function in individual kidneys.

Abstract translation: 磁共振成像系统采用射频脉冲序列和磁场梯度来检测和测量受试者内移动血液的自旋弛豫时间。 旋转晶格弛豫时间通过首先反转纵向自旋磁化来确定，然后用一系列检测射频脉冲检测该磁化的恢复。 反转脉冲被施加到整个对象，但是检测脉冲仅被施加到被摄体的选择部分。 血液运动导致检测区域中的血液被替换为每个检测脉冲，从而提高了测量的准确度，并允许在单次反转脉冲之后使用多个检测脉冲。 本发明的体内应用可用于评估个体肾脏中的肾功能。

公开(公告)号：US4532936A

公开(公告)日：1985-08-06

申请号：US295073

申请日：1981-08-21

Applicant: Eric G. LeVeen ,  Robert F. LeVeen

Inventor： Eric G. LeVeen ,  Robert F. LeVeen

IPC: G01F23/292 ,  A61B5/20 ,  A61M1/00 ,  G01F3/38 ,  G01N33/493

CPC classification number: A61B5/201 ,  A61B5/14507 ,  A61B5/208 ,  G01F3/38

Abstract: The present inventive apparatus measures the output of urine optically, totalizes it and prints it on a self-adherent paper which can easily be afixed to the hospital chart. The apparatus includes a measurement column, an optical sensor to determine when the measurement column is empty, a peristaltic pump to empty the measurement column at a known rate, into a collection bag or specimen bottle and control logic to determine the volume removed from the column based on the pump rate. A display is also provided for easy observation of current output statistics. Specimens can be collected under automatic or manual control for biochemical analysis without contamination by contact or alteration by electrical current. An alarm may be sounded when the collection bag is in need of replacement, or when the urine output falls or rises to predetermined rates.

Abstract translation: 本发明的装置以光学方式测量尿液的输出，将其累积并打印在可以容易地固定在医院图表上的自粘纸上。 该装置包括测量柱，用于确定测量柱何时为空的光学传感器，将蠕动泵以已知速率清空测量柱的收集袋或标本瓶和控制逻辑，以确定从柱移除的体积 基于泵速。 还提供了一个显示屏，便于观察当前的输出统计。 样品可以在自动或手动控制下进行生化分析，不受电流接触或变化的污染。 当收集袋需要更换时，或当尿液输出下降或上升到预定的速率时，可能会发出警报。

公开(公告)号：US4417585A

公开(公告)日：1983-11-29

申请号：US288658

申请日：1981-07-30

Applicant: Ulrich A. Frank

Inventor： Ulrich A. Frank

IPC: A61B5/20 ,  A61B5/00 ,  G01F3/24

CPC classification number: A61B5/201 ,  A61B5/208

Abstract: A device to digitally meter, monitor and collect liquid, such as urine, from a catheterized patient. As such it is the successor to and improvement upon U.S. Pat. No. 3,769,497. An optional part prevents the migration of bacteria from the monitoring and collecting devices to the patient's body cavity. The device comprises a plurality of uniquely shaped movable containers that empty their contents when filled to a predetermined volume, a catheter for delivering liquid to the containers, movement sensors for detecting container movement to determine the amount of fluid collected, patient isolating means for electrically isolating the sensors from the patient while delivering movement signals to the sensors, a final collection container for receiving liquid from the movable containers, supports for supporting the device, and controls and alarms for indicating an alarm condition.

Abstract translation: 一种从导管患者数字计量，监测和收集液体（如尿液）的装置。 因此，它是美国专利的继任者和改进者。 第3,769,497号。 可选部件可防止细菌从监测和收集装置迁移到患者的体腔。 该装置包括多个独特形状的可移动容器，其在填充到预定体积时将其内容物排空，用于将液体输送到容器的导管，用于检测容器运动以确定收集的流体量的运动传感器，用于电隔离的患者隔离装置 来自患者的传感器，同时向传感器传送运动信号，用于从可移动容器接收液体的最终收集容器，用于支撑装置的支撑件，以及用于指示报警状况的控制和报警。

公开(公告)号：US4343316A

公开(公告)日：1982-08-10

申请号：US150250

申请日：1980-05-16

Applicant: Chris A. Jespersen

Inventor： Chris A. Jespersen

IPC: A61B5/00 ,  A61B5/20 ,  A61B10/00 ,  A61M1/00 ,  G01F1/00 ,  G01F3/38 ,  G01F23/292

CPC classification number: A61B5/201 ,  A61B10/007 ,  A61B5/208 ,  G01F1/007 ,  G01F23/2921 ,  G01F3/38

Abstract: A urine flow monitor for displaying preferably in digital form total patient urine output and also urine flow rate. Urine from the patient passes through a catheter and into a calibrated volume chamber of special configuration which permits use even under conditions of vertical misalignment and wherein electronically controlled valve means are located both above and below the chamber and optical sensor means are provided above the chamber and below the top valve means. With the lower valve means closed, filling of the chamber takes place until the point where the urine level reaches the optical sensor at which time, by virtue of electronic control, the upper valve will close and the lower valve will open, allowing the urine to pass into a collection receptacle such as a urine drainage bag. Concurrently with the operation of the valve means, a signal is sent to a console monitor to record the volume dumped into the receptacle and also to commence operation of the flow rate recorder.

Abstract translation: 一种用于以数字形式显示总体患者尿量和尿流量的尿流量监测器。 来自患者的尿液通过导管并进入具有特殊构造的校准容积室，即使在垂直未对准的情况下也允许使用，并且其中电子控制阀装置位于腔室的上方和下方，并且光学传感器装置设置在腔室上方， 在顶部阀门下方。 随着下阀装置关闭，腔室的填充进行直到尿液到达光学传感器的点，此时由于电子控制，上阀将关闭，下阀将打开，允许尿液 进入诸如排尿袋的收集容器。 与阀装置的操作同时，将信号发送到控制台监视器以记录倾倒到容器中的体积，并开始操作流量记录器。

公开(公告)号：US20240354599A1

公开(公告)日：2024-10-24

申请号：US18304594

申请日：2023-04-21

Applicant: KAOHSIUNG MEDICAL UNIVERSITY ,  National Sun Yat-Sen University

Inventor： Hao-Wei Chen ,  Chung-Yao Kao ,  Jung-Ting Lee ,  Yu-Chen Chen

IPC: G06N5/022 ,  A61B5/20 ,  G16H50/30

CPC classification number: G06N5/022 ,  A61B5/201 ,  G16H50/30

Abstract: A method for determining a probability of a kidney stone in a subject being a uric-acid (UA) stone includes steps of: establishing, by using a machine learning algorithm, a prediction model based on a plurality of training data sets that are related to a plurality of patients, each of the plurality of training data sets at least including an estimated glomerular filtration rate (eGFR) and a value of urine pH; and feeding an input variable set into the prediction model so as to obtain the probability of the kidney stone in the subject being a UA stone. The input variable set is related to the subject and including an eGFR and a value of urine pH of the subject.

公开(公告)号：US12114978B2

公开(公告)日：2024-10-15

申请号：US17026058

申请日：2020-09-18

Applicant: Potrero Medical, Inc.

Inventor： Kelly Stanton ,  Saheel Sutaria ,  Dimitri Sokolov ,  Daniel R. Burnett

IPC: A61B5/20 ,  A61B5/00 ,  A61B5/01 ,  A61B5/024 ,  A61B5/08 ,  A61M1/00

CPC classification number: A61B5/201 ,  A61B5/01 ,  A61B5/024 ,  A61B5/08 ,  A61B5/208 ,  A61B5/6853 ,  A61M1/743 ,  A61M1/962 ,  A61B5/20 ,  A61B5/202 ,  A61B5/207

Abstract: Systems, devices and methods for draining and analyzing bodily fluids and assessing health are described and generally comprise a drainage tube in fluid communication with at least one opening near or at a distal end of a catheter, a pump in fluid communication with the drainage tube and configured to apply a negative pressure to the drainage tube, and a valve configured for unidirectional flow and in fluid communication with the drainage tube. A controller is configured to actuate the pump to apply the negative pressure for clearing an airlock and to monitor a urine output from the patient over a first predetermined period of time above a urine output threshold and over a second predetermined period of time below the urine output threshold. The controller may determine a risk of acute kidney injury if the urine output below the urine output threshold exceeds the second predetermined period of time.

公开(公告)号：US11986454B1

公开(公告)日：2024-05-21

申请号：US18340005

申请日：2023-06-22

Applicant: Axsome Malta Ltd.

Inventor： Katayoun Zomorodi

IPC: A61K31/27 ,  A61B5/00 ,  A61B5/20

CPC classification number: A61K31/27 ,  A61B5/201 ,  A61B5/4839

Abstract: The invention relates to methods for decreasing adverse effects associated with solriamfetol ([R]-2-amino-3-phenylpropylcarbamate) therapy in subjects with impaired renal function. In particular, the invention provides an optimized dose escalation scheme for subjects with moderate renal impairment which results in the subjects having increased tolerance to adverse effects associated with the administration of solriamfetol. The invention also provides adjusted dosing for safe therapeutic use of solriamfetol in subjects having severe renal impairment.