公开(公告)号：US20150099906A1

公开(公告)日：2015-04-09

申请号：US14046068

申请日：2013-10-04

Applicant: Bayer MaterialScience AG

Inventor： Thomas Knauf ,  Jurgen Munnig ,  Joerg Schmiedler

IPC: C07C201/08

CPC classification number: C07C201/08 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention relates to a method for producing nitrobenzene, in which the waste gas streams accruing in the process and containing benzene and (traces of) nitrobenzene, possibly low- and medium-boiling components, possibly non-condensable gases and possibly water, optionally after removal of nitrogen oxides, are scrubbed in an absorption column with nitrobenzene, which comprises only very small amounts (maximum 50 ppm) of benzene and is distributed by means of a liquid distributor at a rate of 50 to 200 drip points per square metre, preferably 60 to 120 drip points per square metre, wherein (i) a liquid stream containing benzene and nitrobenzene, possibly organic low- and medium-boiling components and additionally containing sulfuric acid if sulfuric acid is used as the scrubbing agent and (ii) waste gas depleted in benzene and possibly in organic low- and medium-boiling components are obtained. A waste gas purified by the method according to the invention is particularly suitable for burning in a thermal exhaust air treatment process.

公开(公告)号：US20150057452A1

公开(公告)日：2015-02-26

申请号：US14390735

申请日：2013-04-04

Applicant: Catylix, Inc.

Inventor： James David Rozzell ,  Raymond McCague

IPC: C07C255/60 ,  C07C317/46 ,  C07C315/02 ,  C07D233/86 ,  C07C17/32 ,  C07C253/14 ,  C07C209/74 ,  C07C201/08 ,  C07C209/36 ,  C07C253/30 ,  C07C319/20

CPC classification number: C07C255/60 ,  C07C17/32 ,  C07C201/08 ,  C07C209/365 ,  C07C209/74 ,  C07C253/14 ,  C07C253/30 ,  C07C315/02 ,  C07C317/46 ,  C07C319/20 ,  C07D233/86

Abstract: Compounds having therapeutic potential as androgen receptor modulators, and methods of making such compounds, are provided. The compounds are structurally related to bicalutamide but bear at least one difluoromethyl or C2 to C5 perfluoroalkyl group instead of a trifluoromethyl group.

Abstract translation: 提供具有作为雄激素受体调节剂的治疗潜力的化合物，以及制备这些化合物的方法。 这些化合物在结构上与比卡鲁胺有关，但至少含有一个二氟甲基或C2至C5全氟烷基而不是三氟甲基。

公开(公告)号：US20140357905A1

公开(公告)日：2014-12-04

申请号：US14374665

申请日：2013-01-28

Applicant: Bayer Intellectual Property GmbH

Inventor： Bernd Pennemann ,  Juergen Munnig ,  Wulf Dietrich ,  Andreas Karl Rausch

IPC: C07C201/08 ,  C07C205/06

CPC classification number: C07C201/08 ,  C01B17/88 ,  C01B17/94 ,  C07C205/06

Abstract: The present invention relates to a process and a plant for the production, in particular the continuous production, of nitrobenzene by means of adiabatic nitration of benzene with nitric acid in the presence of sulfuric acid, in which, following the nitration, a multi-stage concentration of the sulfuric acid is carried out by means of heating at a pressure that is reduced as compared with ambient pressure, and wherein the heating takes place using the heat generated in the adiabatic nitration of benzene.

Abstract translation: 本发明涉及在硫酸存在下通过苯与硝酸的绝热硝化来生产，特别是连续生产硝基苯的方法和设备，其中在硝化之后，进行多阶段 通过在与环境压力相比降低的压力下加热进行硫酸的浓度，并且其中使用在苯的绝热硝化中产生的热量进行加热。

公开(公告)号：US20110218368A1

公开(公告)日：2011-09-08

申请号：US13129023

申请日：2008-11-14

Applicant: Sergio Berretta ,  David A. Boyd

Inventor： Sergio Berretta ,  David A. Boyd

IPC: C07C201/08 ,  B01J19/00

CPC classification number: C07C201/08 ,  B01J2219/00006 ,  C07C205/06

Abstract: A method for making mononitrobenzene using a plug flow reactor train. Benzene, nitric acid and sulfuric acid are introduced into the reactor and produced mononitrobenzene is removed at an outlet end. All of the benzene and at least part of the sulfuric acid are introduced at the inlet end of the reactor. A first portion of the nitric acid is introduced by a first nitric acid feed into the inlet end and a second portion of the nitric acid is introduced at one or more additional feeds that are spaced between the inlet end and the outlet end. The method results in reduced formation of by-product dinitrobenzene, improving the reaction yield of mononitrobenzene while avoiding the need for a distillation step.

Abstract translation: 使用活塞流反应器列车制备单硝基苯的方法。 将苯，硝酸和硫酸引入反应器中，并在出口端除去产生的单硝基苯。 所有的苯和至少一部分硫酸在反应器的入口端引入。 硝酸的第一部分通过第一硝酸进料引入入口端，并且硝酸的第二部分被引入在入口端和出口端之间间隔开的一个或多个另外的进料处。 该方法导致副产物二硝基苯的形成减少，提高了单硝基苯的反应产率，同时避免了蒸馏步骤的需要。

公开(公告)号：US20050080262A1

公开(公告)日：2005-04-14

申请号：US10502734

申请日：2003-01-28

Applicant: Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Hiroyuki Oda ,  Takeshi Takahashi ,  Shinobu Suzuki

Inventor： Shigeyoshi Nishino ,  Kenji Hirotsu ,  Hidetaka Shima ,  Takashi Harada ,  Hiroyuki Oda ,  Takeshi Takahashi ,  Shinobu Suzuki

IPC: C07C201/08 ,  C07C205/59 ,  C07C205/60 ,  C07C227/04 ,  C07C229/56 ,  C07C229/64 ,  C07D239/88 ,  C07D239/90 ,  C07D239/72

CPC classification number: C07D239/88 ,  C07C67/31 ,  C07C69/92 ,  C07C201/08 ,  C07C205/59 ,  C07C205/60 ,  C07C227/04 ,  C07C229/56 ,  C07C229/64 ,  C07D239/90

Abstract: A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.

Abstract translation: 制备具有下式的喹唑啉-4-酮化合物的方法：其中R 1，R 2，R 3和R 4各自表示不参与下述反应的基团，和 R 1，R 2，R 3和R 4可以组合在一起形成环]，其包括使具有下式的邻氨基苯甲酸衍生物：其中R 5是氢原子或 烃基]与甲酸衍生物在羧酸铵存在下反应。

公开(公告)号：US06861527B1

公开(公告)日：2005-03-01

申请号：US10048157

申请日：2000-07-05

Applicant: Kai Fabian ,  Joeran Stoldt ,  Hanns Wurziger ,  Norbert Schwesinger

Inventor： Kai Fabian ,  Joeran Stoldt ,  Hanns Wurziger ,  Norbert Schwesinger

IPC: B01J19/00 ,  C07B43/02 ,  C07C201/08 ,  C07C205/06 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D307/82 ,  C07D201/08

CPC classification number: B01J19/0093 ,  B01J2219/00889 ,  C07B43/02 ,  C07C201/08 ,  C07D217/02 ,  C07D217/04 ,  C07C205/06

Abstract: The present invention relates to a novel process for the nitration of organic compounds, preferably of aromatic and heteroaromatic compounds, using nitrating reagents which are known from the literature and new types of nitrating reagents.

Abstract translation: 本发明涉及使用从文献中已知的硝化试剂和新型硝化试剂来硝化有机化合物，优选芳族和杂芳族化合物的新方法。

公开(公告)号：US5963878A

公开(公告)日：1999-10-05

申请号：US126087

申请日：1998-07-30

Applicant: Clive M. H. Brereton ,  Alfred A. Guenkel

Inventor： Clive M. H. Brereton ,  Alfred A. Guenkel

IPC: C07C201/08 ,  C07C205/06 ,  C07C205/00

CPC classification number: C07C201/08

Abstract: A continuous process to nitrate a nitratable aromatic compound utilizing nitric acid and sulfuric acid feed stocks is described. The process includes the collecting of NO.sub.x O gases with water under pressure to and treating the NO.sub.x gases with water under pressure to produce weak nitric acid which is recycled to the nitric acid feed stock. The process is efficient, permitting the venting of NO.sub.x free gases to the atmosphere.

Abstract translation: 描述了使用硝酸和硫酸原料硝化可硝化芳族化合物的连续方法。 该方法包括将NO x O气体与压力下的水一起收集并在压力下用水处理NOx气体，以产生再循环至硝酸原料的弱硝酸。 该过程是有效的，允许将NO x释放的气体排放到大气中。

公开(公告)号：US5847231A

公开(公告)日：1998-12-08

申请号：US838672

申请日：1997-04-09

Applicant: Hideki Kanno ,  Hiroyuki Chida ,  Yurie Otani

Inventor： Hideki Kanno ,  Hiroyuki Chida ,  Yurie Otani

IPC: C07B43/02 ,  C07C201/08 ,  C07C201/12 ,  C07C205/22 ,  C07C205/23 ,  C07C205/26 ,  C07C205/37 ,  C07C205/43 ,  C07C205/44 ,  C07C205/45 ,  C07C205/59 ,  C07C231/12 ,  C07C235/46 ,  C07C253/30 ,  C07C255/53 ,  C07C205/00

CPC classification number: C07C253/30 ,  C07B43/02 ,  C07C201/08

Abstract: Process for preparing 4-nitrophenol derivatives of formula (IV) with high selectivity, which comprises converting phenols to diphenyl oxalate derivatives of formula (III) and conducting nitration reaction and hydrolysis to give said 4-nitrophenol derivatives. ##STR1## In the above formulae, R is, the same or different from each other, an alkyl group having 1 to 4 carbon atoms; a halogen atom; an alkoxy group having 1 to 4 carbon atoms; a formyl group; a nitrile group; --COOR.sup.1 (R.sup.1 is an alkyl group having 1 to 4 carbon atoms); --CONR.sup.2 R.sup.3 (R.sup.2 and R.sup.3 are, the same or different from each other, hydrogen atom(s) or alkyl group(s) having 1 to 4 carbon atoms); or --COR.sup.4 (R.sup.4 is an alkyl group having 1 to 4 carbon atoms), and R is not substituted at the 4-position of the phenyl ring and not substituted at the 2- and 6-positions of the phenyl ring at the same time, and, n is 1, 2 or 3.

Abstract translation: 具有高选择性制备式（IV）的4-硝基苯酚衍生物的方法，其包括将酚转化为式（III）的草酸二苯酯衍生物并进行硝化反应和水解，得到所述4-硝基苯酚衍生物。 上述式中，R为相同或不同的含有1〜4个碳原子的烷基; 卤素原子; 具有1至4个碳原子的烷氧基; 甲酰基; 腈基; -COOR1（R1为碳原子数1〜4的烷基）。 -CONR2R3（R2和R3彼此相同或不同，具有1至4个碳原子的氢原子或烷基）; 或-COR 4（R4为碳原子数为1〜4的烷基），并且R在苯环的4-位未被取代，并且在苯环的2位和6位不同时被取代 ，n为1,2或3。

公开(公告)号：US5763687A

公开(公告)日：1998-06-09

申请号：US763146

申请日：1996-12-10

Applicant: Jyoji Morisaki ,  Masaaki Iijima ,  Kouki Oogaki ,  Hiroaki Matsuno ,  Takashi Yamaguchi ,  Katsuharu Miyata

Inventor： Jyoji Morisaki ,  Masaaki Iijima ,  Kouki Oogaki ,  Hiroaki Matsuno ,  Takashi Yamaguchi ,  Katsuharu Miyata

IPC: B01J19/24 ,  C07C201/08 ,  C07C205/06 ,  C07C205/12 ,  C07C205/00 ,  C07C201/00

CPC classification number: C07C201/08 ,  B01J19/2415 ,  B01J2219/00186

Abstract: An improved preparation process for an aromatic mononitro compound comprising reacting an aromatic compound with mixed acid consisting of nitric acid, sulfuric acid or phosphoric acid and water, wherein these flow to react with each other in a reactor comprising a tube inside of which more than one twisted tabular members are aligned in sequence in a manner that a front margin of a twisted tabular member is substantially perpendicular to an back margin of the preceding member, can resolve a number of problems such as an inadequate mixing efficiency, reduction of a reaction rate, associated voluminal increase/complication of a reactor and difficulty in securing safety as well as provide the aromatic mononitro compound with minimal amount of by-products in a considerably short period.

Abstract translation: 一种改进的芳族单硝基化合物的制备方法，包括使芳族化合物与硝酸，硫酸或磷酸和水组成的混合酸反应，其中这些流动在包含管内的多个反应器的反应器中彼此反应 扭曲的平板状构件按照使得扭曲的平板状构件的前缘基本上垂直于前一构件的后缘的方式顺序排列，可以解决许多问题，例如不充分的混合效率，降低反应速率， 相关的体积增加/反应器的并发症和难以确保安全性，以及在相当短的时间内提供芳香族单硝基化合物与最少量的副产物。

公开(公告)号：US5696305A

公开(公告)日：1997-12-09

申请号：US510888

申请日：1995-08-03

Applicant: Uwe Klingler ,  Thomas Schieb ,  Gerhard Wiechers ,  Jurgen Zimmermann

Inventor： Uwe Klingler ,  Thomas Schieb ,  Gerhard Wiechers ,  Jurgen Zimmermann

IPC: C07C201/08 ,  C07C205/06 ,  C07C205/12

CPC classification number: C07C201/08

Abstract: Nitroaromatic compounds are produced by continuously reacting an aromatic compound with nitrating acid. The reaction mixture is separated into an organic phase from which the desired nitroaromatic compound is recovered and an acid phase. The acid phase is subjected to flash evaporation to remove at least 5% by weight of the water present therein. The vapors generated during the flash evaporation are introduced into a jet spray of coolant to produce a condensate made up coolant, condensed vapors and suspended organic compounds. A portion of the condensate is subjected to phase separation to remove water and organic compounds present therein. The water and organic compounds may be reused. The process of the present invention is particularly advantageous in that deposits which block pipelines and interfere with heat transfer are not generated.

Abstract translation: 硝基芳族化合物是通过使芳族化合物与硝酸进行连续反应来制备的。 将反应混合物分离成有机相，从中回收所需的硝基芳族化合物和酸相。 将酸相进行闪蒸以除去其中存在的至少5重量％的水。 在闪蒸期间产生的蒸汽被引入冷却剂的喷射喷雾中以产生冷却剂，冷凝蒸汽和悬浮的有机化合物的冷凝物。 将一部分冷凝物进行相分离以除去其中存在的水和有机化合物。 水和有机化合物可以重复使用。 本发明的方法特别有利的是不产生堵塞管道并干扰热传递的沉积物。