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公开(公告)号：US11938164B2
公开(公告)日：2024-03-26
申请号：US17714295
申请日：2022-04-06
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Gerald V. Denis , Louis C. Gerstenfeld , Naser Jafari , Tova Meshulam
CPC classification number: A61K38/005 , A61K38/217 , A61K45/06 , A61P35/00
Abstract: The technology described herein is directed to methods of treating and diagnosing cancer, e.g, by measuring the expression of certain genes in exosomes.
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公开(公告)号：US11933864B2
公开(公告)日：2024-03-19
申请号：US18199185
申请日：2023-05-18
Applicant: Trustees of Boston University
Inventor： Joshua Javor , David Bishop , David Campbell , Matthias Imboden
IPC: G01R33/022 , G01R33/00 , G01R33/038
CPC classification number: G01R33/022 , G01R33/0052 , G01R33/038 , G01R33/0385
Abstract: A system and method of effectively measuring a change in a gradient of a magnetic field. The systems include a first magnet and a second magnet mechanically coupled together and aligned along a polarization axis. The first magnet and the second magnet are positioned such that a pair of like magnetic poles of the first magnet and the second magnet face in opposite directions. Further, the first magnet and the second magnet are configured to move along the polarization axis in response to a magnetic field. A sensing system is configured to measure a change in a gradient of the magnetic field based on the movement of the first magnet and second magnet along the polarization axis in response to the magnetic field.
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公开(公告)号：US11846217B2
公开(公告)日：2023-12-19
申请号：US17112833
申请日：2020-12-04
Applicant: Trustees of Boston University
Inventor： Xin Zhang , Reza Ghaffarivardavagh , Stephan Anderson
Abstract: A bilayler metamaterial silencer allows substantial fluid through the apparatus, while mitigating the propagation of sound through the apparatus, and while providing a form factor that is significantly more compact than previously-known devices. Moreover, illustrative embodiments allow a designer to specify one or both of the frequency or frequencies at which the apparatus mitigates sound propagation, and/or the bandwidth around the frequency or frequencies at which the apparatus mitigates sound propagation.
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公开(公告)号：US11841265B2
公开(公告)日：2023-12-12
申请号：US16598468
申请日：2019-10-10
Inventor： Stephen Brown , Thomas Szabo , Daniel R. Burns , Michael Fehler
CPC classification number: G01H9/002 , G01S13/86 , G01S13/885 , G01V1/003 , G01V3/12 , G01V11/00 , G01V2210/1299
Abstract: A system for near-surface subsurface imaging for detecting and characterizing subsurface heterogeneities comprises a non-contact acoustic source that senses a plurality of acoustic waves that travel through a surface; an instrument that outputs probing electromagnetic signals through the surface that interact and are affected by scattered signals of the acoustic waves and further senses vibrational modes of a subsurface below the surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.
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公开(公告)号：US20230381142A1
公开(公告)日：2023-11-30
申请号：US18201938
申请日：2023-05-25
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Scott E. SCHAUS , Lauren E. BROWN , Mark W. GRINSTAFF , Danielle M. FITZGERALD , Diana L. DIAZ , John A. KAVOURIS , Jair LAGE DE SIQUEIRA-NETO , James MCKERROW , Camila INDIANI DE OLIVEIRA
IPC: A61K31/4162 , A61K9/16 , A61K31/4178 , A61K31/4439 , A61K31/437 , A61K31/454 , A61K31/427 , A61K31/506 , A61K31/501 , A61P33/02
CPC classification number: A61K31/4162 , A61K9/1647 , A61K31/4178 , A61K31/4439 , A61K31/437 , A61K31/454 , A61K31/427 , A61K31/506 , A61K31/501 , A61P33/02
Abstract: Provided herein are antileishmanial compounds, compositions comprising the antileishmanial compounds, and use thereof.
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Patent Agency Ranking
公开(公告)号：US11813604B2
公开(公告)日：2023-11-14
申请号：US17740014
申请日：2022-05-09
Applicant: Trustees of Boston University , Fraunhofer USA, Inc.
Inventor： Christine McBeth , Kirsten Borchers , Achim Weber , Daniel Zontar
IPC: B01L3/00 , C12Q1/6837 , B01L7/00 , C12Q1/6848 , C12Q1/6876
CPC classification number: B01L3/5027 , C12Q1/6837 , B01J2219/00529 , B01J2219/00576 , B01J2219/00626 , B01L7/52 , C12Q1/6848 , C12Q1/6876 , C12Q2565/60 , C12Q2565/607
Abstract: Disclosed is a biogel nanosensor for detection of an analyte that includes an acryloyl or methacryloyl modified hydrogel and nucleic acid amplification reagents in picoliter or nanoliter volume in the form of microarray. Also disclosed are methods of making the disclosed biogel nanosensor, and methods of using the biogel nanosensors.
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公开(公告)号：US11801000B2
公开(公告)日：2023-10-31
申请号：US17734042
申请日：2022-04-30
Applicant: Trustees of Boston University
Inventor： James Galagan , Uros Kuzmanovic , Abdurrahman Addokhi
IPC: A61B5/145 , A61B5/1477 , A61B5/1486
CPC classification number: A61B5/14546 , A61B5/1451 , A61B5/1477 , A61B5/1486 , A61B5/14517
Abstract: Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.
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公开(公告)号：US20230335445A1
公开(公告)日：2023-10-19
申请号：US18300278
申请日：2023-04-13
Applicant: Brown University , Trustees of Boston University
Inventor： Jacob K. Rosenstein , Kangping Hu , Joseph W. Larkin
IPC: H01L21/8238 , C12M1/12 , C12M1/34 , H01L21/84 , H01L27/146
CPC classification number: H01L21/8238 , C12M1/3407 , C12M25/14 , H01L21/84 , H01L27/14603 , H01L2933/0016
Abstract: Described herein are devices that relate to sensor, data, and interactive interfaces between micro or nano electronics and biofilms, which optionally include an added extracellular matrix. Biofilms in the interfaces can include adherent cells or microorganisms, for example, fungi, bacteria, and the biofilms may include viruses. Computational capability, circuitry, and methods are provided for interactive measurements/processing between the electronics and biofilms.
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公开(公告)号：US20230305082A1
公开(公告)日：2023-09-28
申请号：US18199185
申请日：2023-05-18
Applicant: Trustees of Boston University
Inventor： Joshua Javor , David Bishop , David Campbell , Matthias Imboden
IPC: G01R33/022 , G01R33/038 , G01R33/00
CPC classification number: G01R33/022 , G01R33/038 , G01R33/0052 , G01R33/0385
Abstract: A system and method of effectively measuring a change in a gradient of a magnetic field. The systems include a first magnet and a second magnet mechanically coupled together and aligned along a polarization axis. The first magnet and the second magnet are positioned such that a pair of like magnetic poles of the first magnet and the second magnet face in opposite directions. Further, the first magnet and the second magnet are configured to move along the polarization axis in response to a magnetic field. A sensing system is configured to measure a change in a gradient of the magnetic field based on the movement of the first magnet and second magnet along the polarization axis in response to the magnetic field.
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公开(公告)号：US20230296633A1
公开(公告)日：2023-09-21
申请号：US17431584
申请日：2020-02-28
Applicant: Unchained Labs , Trustees of Boston University
Inventor： John Connor , Shinichiro Kurosawa , Deborah Stearns-Kurosawa , George G. Daaboul
CPC classification number: G01N33/86 , G01N21/6428 , G01N21/6456 , G01N2021/6439 , G01N2333/75
Abstract: Systems and methods for imaging and tracking fibrin formation via interaction of a test sample with a clotting agent or for imaging and tracking fibrin removal by an anti-clotting agent are described.In certain embodiments, the systems (200) comprise a planar reflective substrate (222, 224) comprising one or more capture agents and/or one or more fibrin reference regions; a mount for holding the substrate; an illumination light source (201) for directing illumination light toward a top surface of the substrate with fibrin (226)formed thereon; an image detector (232, 234) aligned with respect to the mount for detecting a portion of the illumination light that is scattered by the fibrin, and/or reflected by the reflective substrate, thereby obtaining a label-free image of fibrin formation or fibrin removal; a processor of a computing device (240); and a memory having instructions stored thereon, wherein the instructions, when executed by the processor, cause the processor to: receive and/or access data corresponding to the one or more label free images, and use the one or more label-free images to determine one or more measures of fibrin formation or fibrin removal.
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