公开(公告)号：US20200330492A1

公开(公告)日：2020-10-22

申请号：US16303131

申请日：2017-05-19

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Elison

IPC: A61K31/702 ,  A61P1/00 ,  A61P25/00

Abstract: The application relates to synthetic compositions containing one or more human milk oligosaccharides for treating serotonin and/or tryptophan dysregulation.

公开(公告)号：US10800802B2

公开(公告)日：2020-10-13

申请号：US15703551

申请日：2017-09-13

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: A23L33/195 ,  B01D15/36 ,  B01D61/02 ,  B01D61/14 ,  B01D61/16 ,  B01D61/58 ,  C07H1/06 ,  C07H1/08 ,  C07H13/02 ,  C07H13/04 ,  C07H23/00 ,  C08B37/00 ,  C12P19/04 ,  C12P19/18

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US10780103B2

公开(公告)日：2020-09-22

申请号：US15771652

申请日：2016-10-28

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Emma Elison ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/15 ,  A61P25/22 ,  A61P25/24

Abstract: A synthetic composition for use in treating or improving one or more emotion and/or mood disorders in a patient, characterised in that the composition contains an effective amount of one or more neutral human milk oligosaccharides, is disclosed.

公开(公告)号：US20200163982A1

公开(公告)日：2020-05-28

申请号：US16613082

申请日：2018-05-09

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  A61K9/00 ,  A61K35/745 ,  A61P1/00

Abstract: The invention relates to a composition comprising one or more human milk oligosaccharides (HMOs) for use in stimulating the production of butyrate in the gastro-intestinal tract of a non-infant human and obtaining delayed increase in the level of butyrate in the gastro-intestinal tract of the non-infant human, and methods for their use.

公开(公告)号：US20200069709A1

公开(公告)日：2020-03-05

申请号：US16490027

申请日：2018-03-01

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  A61K31/7004 ,  A23L33/125 ,  A61P1/00 ,  A23L33/135

Abstract: The invention relates to a method and composition for modulating the microbiota in the gastro-intestinal tracts of non-infant humans, particularly for increasing the abundance of Bifidobacterium longum and/or Bifidobacterium bifidum in the gut microbiota of non-infant humans.

公开(公告)号：US10415021B2

公开(公告)日：2019-09-17

申请号：US15521580

申请日：2015-10-23

Applicant: Glycom A/S

Inventor： Elise Champion ,  Andreas Vogel ,  Sebastian Bartsch ,  Gyula Dekany

IPC: C12N9/26 ,  C12N15/00 ,  C12P19/18 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C12N9/10 ,  C12N9/24 ,  C12P19/04

Abstract: Mutated fucosidases are provided demonstrating improved properties in terms of thermal stability and transfucosidase synthetic performance compared with a wild type transfucosidase isolated from Bifidobacterium longum subsp. infantis.

公开(公告)号：US10407516B2

公开(公告)日：2019-09-10

申请号：US15799386

申请日：2017-10-31

Applicant: Glycom A/S

Inventor： Pierre Chassagne ,  Nikolay Khanzhin ,  Agnese Maggi

IPC: C08B37/00 ,  A23L33/125 ,  A23L33/00

Abstract: Crystalline pLNnH, useful in a pharmaceutical or nutritional composition, is disclosed.

公开(公告)号：US10314852B2

公开(公告)日：2019-06-11

申请号：US15521582

申请日：2015-10-23

Applicant: Glycom A/S

Inventor： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC: C12P19/18 ,  C12P19/26 ,  A61K31/702 ,  C07H5/06 ,  A61K31/715 ,  A61K31/7016

Abstract: The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

公开(公告)号：US09834574B2

公开(公告)日：2017-12-05

申请号：US14442017

申请日：2013-09-19

Applicant: Glycom A/S

Inventor： Martin Matwiejuk ,  Gyula Dekany

IPC: C07H3/06 ,  C07H1/06 ,  A23L33/10 ,  A23L33/00

CPC classification number: C07H3/06 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H1/06

Abstract: Crystalline 3-O-fucosyllactose, useful in a pharmaceutical composition and a nutritional formulation, is disclosed.

公开(公告)号：US09816122B2

公开(公告)日：2017-11-14

申请号：US14430930

申请日：2013-09-25

Applicant: Glycom A/S

Inventor： Pauline Peltier-Pain ,  Gyula Dekany ,  Christophe Pain ,  Pierre Chassagne ,  Nicolas Fierfort ,  Dóra Molnàr-Gàbor

IPC: C12P19/18 ,  C12P19/44 ,  C07H15/08 ,  C07H13/04 ,  C07H15/04 ,  C07H15/26

CPC classification number: C12P19/44 ,  C07H13/04 ,  C07H15/04 ,  C07H15/08 ,  C07H15/26 ,  C12P19/18

Abstract: The invention relates to a method for producing a glycoconjugate comprising an oligosaccharide part covalently linked to a non-sugar moiety selected from the group consisting of amino acids, peptides, proteins, lipids, longer alkyl groups, polyethylene glycols, α,β-unsaturated amido group and polyvinyl alcohols, using a genetically modified cell.