中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

55 records (took 0.032 seconds)

    Methods and systems for generating peptides
    22.
    发明授权
    Methods and systems for generating peptides 失效
    产生肽的方法和系统

    公开(公告)号：US07603239B2

    公开(公告)日：2009-10-13

    申请号：US11123399

    申请日：2005-05-05

    Applicant: Gregory Stephanopoulos ,  Christopher R. Loose ,  Kyle Jensen

    Inventor： Gregory Stephanopoulos ,  Christopher R. Loose ,  Kyle Jensen

    IPC: G06F19/00

    CPC classification number: C07K1/00 ,  G06F19/22 ,  G06F19/24

    Abstract: Antimicrobial peptides are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and that they may form the basis for a novel class of therapeutics. Systems and methods may treat the amino acid sequences of these peptides as a formal language and build a set of right-linear grammars that describe this language. These grammars may allow for rationally designed novel antimicrobial peptides in silico. These peptides conform to the syntax of natural antimicrobial peptides lack significant homology to any natural sequences, thus populating a previously unexplored region of protein sequence space. Synthesis of these peptides, leads to de novo AmPs.

    Abstract translation: 抗微生物肽是先天免疫系统用于防治多细胞真核生物细菌感染的小蛋白质。 有越来越多的证据表明，这些肽比传统抗生素对细菌耐药性较不敏感，并且它们可能形成新型治疗剂的基础。 系统和方法可以将这些肽的氨基酸序列视为形式语言，并构建描述此语言的一组右线性语法。 这些语法可以允许合理设计的新型抗微生物肽。 这些肽符合天然抗微生物肽的语法，与任何天然序列缺乏显着的同源性，从而填充了以前未探索的蛋白质序列空间区域。 这些肽的合成，导致从头AmPs。

    Promoter engineering and genetic control
    24.
    发明申请
    Promoter engineering and genetic control 有权
    启动子工程和遗传控制

    公开(公告)号：US20070009932A1

    公开(公告)日：2007-01-11

    申请号：US11411212

    申请日：2006-04-26

    Applicant: Gregory Stephanopoulos ,  Hal Alper ,  Curt Fischer ,  Elke Nevoigt

    Inventor： Gregory Stephanopoulos ,  Hal Alper ,  Curt Fischer ,  Elke Nevoigt

    IPC: C40B30/06 ,  C40B50/06 ,  C40B40/08

    CPC classification number: C12N15/1086

    Abstract: The present invention relates to expression cassettes libraries of expression vectors comprising the same, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose sequence is randomly mutated with respect to that of another in the library and cells comprising the same. Methods utilizing either the libraries or cells of this invention, in optimizing gene expression, protein expression, or optimized gene or protein delivery are described.

    Abstract translation: 本发明涉及包含该表达载体的表达载体的表达盒文库，其中每个载体包含至少一个目的基因和可操作地连接到其上的启动子，其中每个启动子包含核酸，其序列相对于另一个的序列是随机突变的 在图书馆和包含它的细胞中。 描述了利用本发明的文库或细胞，优化基因表达，蛋白质表达或优化的基因或蛋白质递送的方法。

    Monolith reactor containing a plurality of flow passages and method for carrying out biological reactions
    26.
    发明授权
    Monolith reactor containing a plurality of flow passages and method for carrying out biological reactions 失效
    包含多个流动通道的整体反应器和进行生物反应的方法

    公开(公告)号：US4948728A

    公开(公告)日：1990-08-14

    申请号：US166258

    申请日：1988-03-10

    Applicant: Gregory Stephanopoulos ,  Julia A. Kornfield ,  Gerald E. Voecks

    Inventor： Gregory Stephanopoulos ,  Julia A. Kornfield ,  Gerald E. Voecks

    IPC: C12M1/40

    CPC classification number: C12M47/10 ,  C12M23/20 ,  C12M23/24 ,  C12M29/04 ,  Y10S435/813 ,  Y10S435/818

    Abstract: Biological reactions are carried out with a unitary structure, preferably formed of a ceramic material, having a plurality of flow passages including first and second sets of flow passages arranged so that individual passages of the first set are adjacent individual passages of the second set and are separated by walls formed of the ceramic material. The ceramic material is porous to provide mass transfer of gaseous oxygen and biological reaction products while containing liquid in the second set of passages. Walls of the passages may be covered with a gaseous oxygen permeable membrane. Inside walls of the second set of passages may coated with a compound adapted to immobilize biological reaction materials. In a biological reaction, the first set of passages are contacted with a fluid such as an air stream to provide gaseous oxygen, and a fluid flow such as a nutrient medium is established through the second set of flow passages whereby an oxygen flow producing gradient is produced through the porous ceramic material between the first and second sets of flow passages to supply oxygen for cells immobilized on inside walls of the second set of flow passages.

    Abstract translation: 生物反应采用整体结构进行，优选由陶瓷材料形成，其具有多个流动通道，其包括第一组和第二组流动通道，其布置成使得第一组的各个通道相邻于第二组的各个通道，并且分别是 由陶瓷材料形成的壁分隔开。 陶瓷材料是多孔的，以提供气态氧和生物反应产物的质量传递，同时在第二组通道中含有液体。 通道的壁可以用气体氧气渗透膜覆盖。 第二组通道的内壁可涂覆有适于固定生物反应材料的化合物。 在生物反应中，第一组通道与诸如空气流的流体接触以提供气态氧，并且通过第二组流动通道建立流体流如营养培养基，由此产生氧气的梯度为 通过第一组和第二组流动通道之间的多孔陶瓷材料产生，以便为固定在第二组流动通道的内壁上的细胞供应氧气。

Patent Agency Ranking