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21.发明授权公开(公告)号：US10073086B2
公开(公告)日：2018-09-11
申请号：US14376270
申请日：2013-01-29
Applicant: HORIBA ABX SAS
Inventor： Jèrôme Bibette , Philippe Nerin , Jean-Philippe Gineys , Gilles Cauet
CPC classification number: G01N33/5094 , G01N1/38 , G01N35/0098 , G01N35/10 , G01N2015/1486 , G01N2021/825 , G01N2333/46 , G01N2333/4737
Abstract: The present invention concerns a device for analyzing biological parameters from a sample (6) comprising (i) first transferring means (5, 20, 25), (ii) first preparing means (7), (iii) means for measuring cellular components (8), (iv) second preparing means (10, 11, 22, 23, 24) capable of carrying out, on a sample from the first preparing means (7), at least one dilution with an assay reagent (R3) comprising particles functionalized at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means (30, 31) capable of assaying at least one analyte of interest by measuring the aggregation of functionalized particles, said device further comprising (i) second transferring means (4, 21, 22, 26) at least partially separate from the first transferring means (5, 20, 25) and (ii) means for applying a magnetic field (28) capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalized particles, which comprise magnetic colloidal particles. The invention also concerns a method implemented in said device.
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公开(公告)号：US20150060614A1
公开(公告)日：2015-03-05
申请号：US14386964
申请日：2013-03-14
Applicant: HORIBA ABX SAS
Inventor： Nathalie Henon
CPC classification number: F16M11/043 , G01B5/0004 , G01N15/0205 , G01N15/1459 , G01N35/085 , G01N2015/149
Abstract: The subject of the invention is a device for positioning an object in space, comprising at least 4 plates, each one able to move with respect to another of said plates which is contiguous with it along one of the 3 axes of space, it being possible for the movement of one plate with respect to another plate to be guided by a tenon/mortise assembly in which said tenon is secured to one of the plates and its mortise is produced in the other plate, the spatial orientation of each of the tenon/mortise assemblies being different from the other 2 and along one of the 3 axes of space.
Abstract translation: 本发明的主题是用于将物体定位在空间中的装置，包括至少4个板，每个板能够相对于沿着3个空间轴之一与其相邻的另一个板移动，这是可能的 对于一个板相对于另一个板的运动，由榫头/榫组件引导，其中所述榫头固定到其中一个板，并且在另一个板中产生其榫眼，每个榫头/ 榫眼组件与其他2和沿着3个空间轴之一不同。
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公开(公告)号：US12196662B2
公开(公告)日：2025-01-14
申请号：US17606101
申请日：2020-04-24
Applicant: HORIBA ABX SAS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , UNIVERSITE DE MONTPELLIER
Inventor： Pierre Taraconat , Damien Isebe , Simon Mendez , Franck Nicoud
Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).
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公开(公告)号：US12135273B2
公开(公告)日：2024-11-05
申请号：US17414801
申请日：2019-12-16
Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , HORIBA ABX SAS , IPRASENSE SAS
Inventor： Pierre Blandin , Cédric Allier , Olivier Cioni , Lionel Herve , Pierre Joly , Jean-Marc Dinten
IPC: G01N15/1434 , G03H1/08
Abstract: A method for characterizing a particle present in a sample, the sample lying between an image sensor and a light source and the sensor lying in a detection plane, includes illuminating the sample with the light source which emits an incident light wave propagating along a propagation axis, and acquiring an image of the sample with the sensor. The sensor is exposed to an exposure light wave. The image includes a plurality of elementary diffraction patterns each corresponding to one particle. The method also includes reconstructing a complex image representative of a complex amplitude of the light wave on a reconstruction surface passing through the sample, based on the acquired image; selecting a region of interest of the complex image corresponding to a particle of interest; forming an extracted image based on the region of interest; and characterizing the particle of interest depending on the extracted region of interest.
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25.发明公开公开(公告)号：US20240182990A1
公开(公告)日：2024-06-06
申请号：US18549058
申请日：2021-03-09
Applicant: Etablissement Français du Sang , Université de Montpellier , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , HORIBA ABX SAS
Inventor： Chantal FOURNIER-WIRTH , Fanny LEON , Jean-François CANTALOUBE , Jean-Pierre MOLÈS , Elena PINCHON , Aurélien DAYNÈS , Charly MAYRAN
IPC: C12Q1/70 , C12Q1/6804 , C12Q1/6844 , C12Q1/689
CPC classification number: C12Q1/701 , C12Q1/6804 , C12Q1/689 , C12Q1/6844
Abstract: The present invention concerns a method for the molecular detection of an infectious agent based on isothermal amplification by recombinase polymerase amplification (RPA) combined with a Magnetic Field-Enhanced Agglutination (MFEA) readout.
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Patent Agency Ranking
公开(公告)号：US20230066255A1
公开(公告)日：2023-03-02
申请号：US17793208
申请日：2021-01-15
Applicant: HORIBA ABX SAS , UNIVERSITE DE MONTPELLIER , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventor： Pierre TARACONAT , Damien ISEBE , Simon MENDEZ , Franck NICOUD
IPC: G01N15/12 , G01N33/487
Abstract: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.
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公开(公告)号：US20220196538A1
公开(公告)日：2022-06-23
申请号：US17606101
申请日：2020-04-24
Applicant: HORIBA ABX SAS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , UNIVERSITE DE MONTPELLIER
Inventor： Pierre TARACONAT , Damien ISEBE , Simon MENDEZ , Franck NlCOUD
Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).
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公开(公告)号：US20220018756A1
公开(公告)日：2022-01-20
申请号：US17414801
申请日：2019-12-16
Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , HORIBA ABX SAS , IPRASENSE SAS
Inventor： Pierre BLANDIN , Cédric ALLIER , Olivier CIONI , Lionel HERVE , Pierre JOLY , Jean-Marc DINTEN
Abstract: A method for characterizing a particle present in a sample, the sample lying between an image sensor and a light source and the sensor lying in a detection plane, includes illuminating the sample with the light source which emits an incident light wave propagating along a propagation axis, and acquiring an image of the sample with the sensor. The sensor is exposed to an exposure light wave. The image includes a plurality of elementary diffraction patterns each corresponding to one particle. The method also includes reconstructing a complex image representative of a complex amplitude of the light wave on a reconstruction surface passing through the sample, based on the acquired image; selecting a region of interest of the complex image corresponding to a particle of interest; forming an extracted image based on the region of interest; and characterizing the particle of interest depending on the extracted region of interest.
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公开(公告)号：US20210387190A1
公开(公告)日：2021-12-16
申请号：US17291139
申请日：2019-11-07
Inventor： Yves FOUILLET , Anais ALI-CHERIF
Abstract: A device for preparing a solution from a sample and a reagent, the device includes a microfluidic array having a sample supply inlet, a reagent supply inlet, a discharge outlet, a solution collection outlet, a sampling zone to which the inlets are connected, first and second preparation chambers connected to the sampling zone, arranged to either side of the sampling zone such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone, the first preparation chamber having a volume that is variable between a minimum volume and a calibrated volume. The device includes valves interrupting the flow of the fluid at least at the two inlets and the collection and discharge outlets.
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公开(公告)号：US20210131944A1
公开(公告)日：2021-05-06
申请号：US16471429
申请日：2017-12-20
Inventor： Pierre BLANDIN , Anais ALI-CHERIF , Estelle GREMION , Sebastien RAIMBAULT , Oliver CIONI , Aurelien DAYNES
IPC: G01N15/14
Abstract: The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.
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