公开(公告)号：US08476424B2

公开(公告)日：2013-07-02

申请号：US12403762

申请日：2009-03-13

Applicant: John Kerr ,  Robert Jansen ,  Christian J. Isaac ,  James Edwin Wiley, Jr. ,  Duane A. Leinhos

Inventor： John Kerr ,  Robert Jansen ,  Christian J. Isaac ,  James Edwin Wiley, Jr. ,  Duane A. Leinhos

IPC: C07H1/06 ,  C07H5/02

CPC classification number: C07C231/24 ,  B01D11/0426 ,  B01D11/0446 ,  B01D11/0476 ,  B01D11/0492 ,  C07H1/06 ,  C07H5/02 ,  C07H13/04 ,  C07C233/03

Abstract: A method of removing a carboxylic acid from a liquid that contains a tertiary amide solvent includes a step of contacting the liquid with an extraction medium comprising an amine. The amine is immiscible with both water and the tertiary amide solvent, and the contacting step forms a de-acidified phase containing the tertiary amide solvent and a phase containing the extraction medium and the carboxylic acid. Both the liquid that contains the tertiary amide solvent and the de-acidified phase may also contain a sucrose-6-acylate.

Abstract translation: 从含有叔酰胺溶剂的液体中除去羧酸的方法包括使液体与包含胺的萃取介质接触的步骤。 胺与水和叔酰胺溶剂不混溶，接触步骤形成含有叔酰胺溶剂的脱酸相和含有萃取介质和羧酸的相。 含有叔酰胺溶剂和脱酸相的液体也可以含有蔗糖-6-酰化物。

公开(公告)号：US20090247737A1

公开(公告)日：2009-10-01

申请号：US12409951

申请日：2009-03-24

Applicant: James Edwin Wiley, JR. ,  Duane A. Leinhos ,  David A. Dentel ,  John Kerr

Inventor： James Edwin Wiley, JR. ,  Duane A. Leinhos ,  David A. Dentel ,  John Kerr

IPC: C07H1/00

CPC classification number: C07H5/02 ,  C07H1/00

Abstract: The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate; (ii) quenching the product stream of (i) with an aqueous solution of a base to provide a sucralose-6-acylate and the chloride salt of said base, wherein the concentration of the aqueous solution of the base is sufficiently high such that at least a portion of the chloride salt of the base is formed as a precipitate; (iii) either: deacylating the sucralose-6-acylate by treating the product stream of (ii) with a base and thereafter removing precipitated salt to provide a product stream including sucralose; or: removing precipitated salt from the product stream of (ii) and thereafter deacylating the sucralose-6-acylate by treating with a base to provide a product stream including sucralose; and (iv) isolating sucralose from the product stream of (iii).

Abstract translation: 本发明提供了在反应载体中从包含蔗糖-6-酰化物的进料流中制备三氯半乳蔗糖的方法。 该方法包括：（i）使蔗糖-6-酰化物与氯化剂反应，以使蔗糖-6-酰化物的4,1'和6'位置氯化; （ii）用碱的水溶液淬灭（i）的产物流，得到三氯半乳蔗糖-6-酰化物和所述碱的氯化物盐，其中碱的水溶液的浓度足够高，使得在 至少一部分碱的氯化物盐形成沉淀物; （iii）：通过用碱处理（ii）的产物流，然后除去沉淀的盐以提供包含三氯蔗糖的产物流，使三氯蔗糖-6-酰化物脱酰化; 或者：从（ii）的产物流中除去沉淀的盐，然后用碱处理三氯半乳蔗糖-6-酰化物，以提供包含三氯蔗糖的产物流; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。