公开(公告)号：US20060219971A1

公开(公告)日：2006-10-05

申请号：US11096244

申请日：2005-03-31

Applicant: James Pearson ,  Robert Van der Linde ,  Thomas Davern

Inventor： James Pearson ,  Robert Van der Linde ,  Thomas Davern

IPC: F16K1/22

CPC classification number: F16K1/221 ,  F16K31/5282 ,  F24F13/1426 ,  F24F2013/1473 ,  F25D17/045

Abstract: A damper assembly that produces bi-directional damper door movement from a single-direction motor is provided. Bi-directional rotation of the damper door is enabled by a cam slot on an end of the damper door that is engaged by a motor-driven drive cam having a drive pin extending into the cam slot. As the single-direction motor collectively rotates the drive cam and the drive pin, the drive pin reciprocates within the cam slot. This causes sealing flanges and the damper from the damper door to alternatively engage under a positive pressure and disengage from one another as the damper door is rotated bi-directionally.

Abstract translation: 提供了从单向电动机产生双向阻尼器门运动的阻尼器组件。 阻尼器门的双向旋转由阻尼器门的端部上的凸轮槽实现，其由具有延伸到凸轮槽中的驱动销的电动驱动驱动凸轮接合。 当单向马达共同旋转驱动凸轮和驱动销时，驱动销在凸轮槽内往复运动。 这使得密封凸缘和阻尼器从阻尼器门交替地接合在正压力下并且当阻尼器门双向旋转时彼此脱离。

公开(公告)号：US20060202563A1

公开(公告)日：2006-09-14

申请号：US11075205

申请日：2005-03-08

Applicant: James Pearson

Inventor： James Pearson

IPC: H01H33/59

CPC classification number: D06F39/005 ,  D06F2212/04 ,  H01H2043/108 ,  Y10T307/957

Abstract: A timer control apparatus for use in an appliance is provided. The timer control apparatus includes a timer having a timing motor, a user interface including a setting indicator and option switches, and a delay circuit associated with the timing motor. The delay circuit is operable to halt the timing motor and to start the timing motor such that the timer control apparatus delays progression of the timing motor. The delay circuit can halt and start the timing motor at regular intervals, irregular intervals, according to a timing pattern, based on the setting indicator, and/or based the option switches. By delaying the timing motor, travel or progression of the setting indicator between settings is reduced.

公开(公告)号：US20050234244A1

公开(公告)日：2005-10-20

申请号：US10979794

申请日：2004-11-01

Applicant: Wilmin Bartolini ,  Brian Cali ,  Barbara Chen ,  Yueh-Tyng Chien ,  Mark Currie ,  G. Milne ,  James Pearson ,  John Talley ,  Craig Zimmerman

Inventor： Wilmin Bartolini ,  Brian Cali ,  Barbara Chen ,  Yueh-Tyng Chien ,  Mark Currie ,  G. Milne ,  James Pearson ,  John Talley ,  Craig Zimmerman

IPC: C07D209/18 ,  C07D209/26 ,  C07D209/28 ,  C07D409/06 ,  C07D43/02

CPC classification number: C07D209/18 ,  C07D209/26 ,  C07D209/28 ,  C07D409/06

Abstract: Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

Abstract translation: 描述了制备有用的COX-2抑制剂和可用于这些方法的中间体的吲哚的方法。

公开(公告)号：US12228214B2

公开(公告)日：2025-02-18

申请号：US17686641

申请日：2022-03-04

Applicant: Shubhada Surve ,  James Pearson

Inventor： Shubhada Surve ,  James Pearson

IPC: F16K11/08 ,  F16K11/085 ,  F16K27/06

Abstract: A multiport valve has a stemshell rotatable within a valve body with two columns of ports arranged in a planar array. An extra port extends external to the array and inlet ports communicate with selected outlet ports. The stemshell has lateral channels and longitudinal channels which cooperate with the ports at selected angular positions to provide desired inlet/outlet flows while preventing intermixing within the valve.

公开(公告)号：US20220316607A1

公开(公告)日：2022-10-06

申请号：US17686641

申请日：2022-03-04

Applicant: Shubhada Surve ,  James Pearson

Inventor： Shubhada Surve ,  James Pearson

IPC: F16K11/085 ,  F16K27/06

Abstract: A multiport valve has a stemshell rotatable within a valve body with two columns of ports arranged in a planar array. An extra port extends external to the array and inlet ports communicate with selected outlet ports. The stemshell has lateral channels and longitudinal channels which cooperate with the ports at selected angular positions to provide desired inlet/outlet flows while preventing intermixing within the valve.

公开(公告)号：US20120209413A1

公开(公告)日：2012-08-16

申请号：US13162459

申请日：2011-06-16

Applicant: Lejie Xu ,  Peter John Torr ,  Mei L. Wilson ,  Rachel Jiang ,  Bryan Welbourne Nealer ,  Eric H. Bie ,  Christopher James Pearson ,  William G. Patton, III ,  Yensheng Wang

Inventor： Lejie Xu ,  Peter John Torr ,  Mei L. Wilson ,  Rachel Jiang ,  Bryan Welbourne Nealer ,  Eric H. Bie ,  Christopher James Pearson ,  William G. Patton, III ,  Yensheng Wang

IPC: G06F17/00

CPC classification number: H04W52/0264 ,  G06F9/5011 ,  G06F9/546 ,  H04L41/0893 ,  H04N21/233 ,  H04N21/4126 ,  H04N21/439 ,  H04N21/6175 ,  H04W4/50 ,  H04W4/60 ,  Y02D70/00 ,  Y02D70/12 ,  Y02D70/124 ,  Y02D70/142 ,  Y02D70/144 ,  Y02D70/146 ,  Y02D70/164 ,  Y02D70/23 ,  Y02D70/26

Abstract: The subject disclosure is directed towards a technology in which a mobile device service plays background audio as instructed by a third party audio player application. The service continues to play background audio after the audio player application is deactivated from the foreground, e.g., as another application becomes the foreground application. Also described is launching agents to obtain additional information and/or to handle custom audio formats, and handling of user requests from a universal (system) volume control or the audio player application (when in the foreground).

Abstract translation: 本发明涉及一种技术，其中移动设备服务按照第三方音频播放器应用程序的指示播放背景音频。 在音频播放器应用程序从前台停用之后，服务继续播放背景音频，例如当另一个应用程序成为前台应用程序时。 还描述了启动代理以获得附加信息和/或处理定制音频格式，以及处理来自通用（系统）音量控制或音频播放器应用（当前景时）的用户请求。

公开(公告)号：US20070231839A1

公开(公告)日：2007-10-04

申请号：US11220224

申请日：2005-09-06

Applicant: Andrew Kende ,  Barbara Iglewski ,  Roger Smith ,  Richard Phipps ,  James Pearson

Inventor： Andrew Kende ,  Barbara Iglewski ,  Roger Smith ,  Richard Phipps ,  James Pearson

IPC: G01N33/554 ,  G01N33/569 ,  C07K16/12 ,  C07K16/46

CPC classification number: C07D207/273 ,  A61K39/385 ,  A61K2039/505 ,  A61K2039/6081 ,  C07D263/26 ,  C07D307/33 ,  C07D333/36 ,  C07K16/1203 ,  C07K16/1214 ,  G01N33/56911 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S530/806 ,  Y10S530/808

Abstract: The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples. TABLE OF CONTENTS Page 1. FIELD OF THE INVENTION1 2. BACKGROUND OF THE INVENTION1 3. SUMMARY OF THE INVENTION4 4. BRIEF DESCRIPTION OF THE DRAWINGS7 5. DETAILED DESCRIPTION OF THE INVENTION7   5.1 Isolation and Synthesis of Homoserine Lactones7   5.2 Bacterial Autoinducer Conjugation to a Carrier17   5.3 Generation of Antibodies to BAI Immunogenic conjugates19   5.4 Therapeutic Uses of Immunogenic conjugates22     or Antibodies Thereto     5.4.1 Administration and Formulation22     5.4.2 Effective Dose25     5.5 Diagnostic Methods27 6. EXAMPLE: SYNTHESIS32   Preparation of Compound C32   Preparation of Compound D32   Preparation of Compound 532   Preparation of Compound 633   Preparation of Compound 733   Preparation of Compound 833   Preparation of Compound 1034   Preparation of Compound 1134   Preparation of Compound 1335   Preparation of Compound 1235   Preparation of Compound 1435   Preparation of Compound 1536   Preparation of Compound 1736   Preparation of Compound 2137   Preparation of Compound 2237   Preparation of Compound 2438   Preparation of Compound 2538   Preparation of Compound 2738   Preparation of Compound 2939 7. EXAMPLE: PRODUCTION OF BAI ANTIBODIES39   7.1 PAI'S Role In Virulence39   7.2 Anti-PAI Polyclonal Antibodies40   7.3 Neutralization of PAI With Antibodies40

公开(公告)号：US20070110680A1

公开(公告)日：2007-05-17

申请号：US11480286

申请日：2006-06-30

Applicant: David Davies ,  John Costerton ,  Matthew Parsek ,  E. Greenberg ,  James Pearson ,  Barbara Iglewski

Inventor： David Davies ,  John Costerton ,  Matthew Parsek ,  E. Greenberg ,  James Pearson ,  Barbara Iglewski

IPC: A61K8/49 ,  A61K31/381 ,  A61K31/365

CPC classification number: C02F1/50 ,  A01N43/08 ,  A01N61/00 ,  A61K8/4973 ,  A61K8/69 ,  A61K31/365 ,  A61K31/381 ,  A61L2/18 ,  A61L2/22 ,  A61L2/23 ,  A61Q11/00 ,  C11D1/146 ,  C11D3/0078 ,  C11D3/30 ,  C11D3/3481 ,  C11D3/48 ,  A01N2300/00

Abstract: A method of cleaning or protecting surfaces by treatment with compositions comprising N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) blocking compounds and/or N-butyryl-L-homoserine lactone (BHL) analogs, either in combination or separately.

Abstract translation: 通过用包含N-（3-氧代十二烷酰基）-L-高丝氨酸内酯（OdDHL）封闭化合物和/或N-丁酰基-L-高丝氨酸内酯（BHL）类似物的组合物处理组合或分开地清洁或保护表面的方法 。

公开(公告)号：US20060163044A1

公开(公告)日：2006-07-27

申请号：US11040884

申请日：2005-01-21

Applicant: James Pearson ,  Robert Van der Linde ,  Thomas Davern

Inventor： James Pearson ,  Robert Van der Linde ,  Thomas Davern

IPC: H01H19/00

CPC classification number: H01H43/125 ,  H01H43/022 ,  H01H43/106

Abstract: A motor driven appliance timer utilizing a cam program disk and snap action switches is provided. The motor may be externally energized, or may be energized based on integrated electronics within the appliance timer. Rotation of the program disk by a user to allow selection of a desired appliance cycle is accommodated by a clutch subassembly that allows bidirectional rotation of the program disk without requiring that the user pull or push the control shaft before rotating the program disk. The timer of the present invention may utilize either impulse or constant drive mechanisms to rotate the program disk. The use of snap action switches minimizes the possibility of tack weld failures due to switch teasing.

Abstract translation: 提供了一种使用凸轮程序盘和快动动作开关的马达驱动器具计时器。 电机可以被外部供电，或者可以基于设备定时器内的集成电子装置通电。 由使用者旋转程序盘以允许选择期望的器具循环由离合器子组件容纳，该离合器子组件允许程序盘的双向旋转，而不需要用户在旋转程序盘之前拉或者按下控制轴。 本发明的定时器可以利用脉冲或恒定驱动机构来旋转程序盘。 使用快速动作开关可以最大限度地减少由于开关调节引起的焊接故障的可能性。

公开(公告)号：US20050250841A1

公开(公告)日：2005-11-10

申请号：US11030569

申请日：2005-01-05

Applicant: James Pearson ,  Kendall Gray ,  Luciano Passador ,  Kenneth Tucker ,  Anatol Eberhard ,  Barbara Iglewski ,  Everett Greenberg

Inventor： James Pearson ,  Kendall Gray ,  Luciano Passador ,  Kenneth Tucker ,  Anatol Eberhard ,  Barbara Iglewski ,  Everett Greenberg

IPC: A61K31/366 ,  A61K31/381 ,  A61K31/382 ,  A61K31/4015 ,  C12N1/00 ,  C12N1/20 ,  C12N1/38 ,  C12N9/00

CPC classification number: A61K31/366 ,  A61K31/381 ,  A61K31/382 ,  A61K31/4015 ,  C12N1/38 ,  Y02A50/473 ,  Y10S435/874 ,  Y10S435/875

Abstract: Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.