公开(公告)号：US20080198555A1

公开(公告)日：2008-08-21

申请号：US11933695

申请日：2007-11-01

Applicant: Kenji YAMASHITA ,  Hiroyuki Kageyama ,  Seiichi Moriyama

Inventor： Kenji YAMASHITA ,  Hiroyuki Kageyama ,  Seiichi Moriyama

IPC: H05K7/20

CPC classification number: H01L23/4006 ,  H01L23/36 ,  H01L23/3672 ,  H01L23/50 ,  H01L2023/405 ,  H01L2023/4062 ,  H01L2224/32 ,  H01L2924/3011

Abstract: The present invention provides a semiconductor device comprising a semiconductor element, a single-layer wiring board on which the semiconductor element is mounted, a connector section located at an end of the single-layer wiring board, a thermally and electrically conductive radiator plate, a relay electrode section formed on the single-layer wiring board, and a connecting member that electrically connects the radiator plate and the relay electrode section together. The single-layer wiring board is structured so that a power supply potential and/or a ground potential received by the connector section is transmitted through a path comprising the radiator plate, the relay electrode section, and the connecting member to the semiconductor element.

Abstract translation: 本发明提供一种半导体器件，包括半导体元件，安装有半导体元件的单层布线板，位于单层布线板的端部的连接器部，导热散热板， 形成在单层布线板上的继电器电极部分和将散热板和继电器电极部分电连接在一起的连接部件。 单层布线板被构造成使得由连接器部分接收的电源电位和/或接地电位通过包括散热板，继电器电极部分和连接部件的路径传输到半导体元件。

公开(公告)号：US20070031894A1

公开(公告)日：2007-02-08

申请号：US10571268

申请日：2004-09-10

Applicant: Tomoko Syofuda ,  Yonehiro Kanemura ,  Jun Miyake ,  Hideo Niwa ,  Kenji Yamashita

Inventor： Tomoko Syofuda ,  Yonehiro Kanemura ,  Jun Miyake ,  Hideo Niwa ,  Kenji Yamashita

IPC: G01N33/567 ,  C07K14/475 ,  C07K16/22 ,  C07H21/04

CPC classification number: G01N33/5058 ,  C12Q1/6876 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5073 ,  G01N2500/00

Abstract: It is an object of the present invention to provide a method for detecting nerve stem cells/progenitor cells among a tissue or a mass of cells as constituted of a plurality of cell species, and a method for screening for a drug functioning as a nerve differentiation factor or the like by using the above-mentioned detection method. It was found in this invention that the expression of the NC1 gene was high in undifferentiated nerve stem cells and said expression decreased with an advance of differentiation. Furthermore in this invention, by using the NC1 gene, the product thereof (NC1 protein) and the base sequences or the amino acid sequences thereof, antibodies or the like, it became possible to detect nerve stem cells/progenitor cells by way of various methods, so that a novel method for screening for a drug functioning as a nerve differentiation factor or the like was provided.

Abstract translation: 本发明的目的是提供一种由多种细胞种组成的组织或大量细胞中的神经干细胞/祖细胞的检测方法，以及筛选作为神经分化的药物的方法 因子等通过使用上述检测方法。 在本发明中发现NC1基因的表达在未分化神经干细胞中高，并且所述表达随着分化的进展而降低。 此外，在本发明中，通过使用NC1基因，其产物（NC1蛋白）及其碱基序列或其氨基酸序列，抗体等，可以通过各种方法检测神经干细胞/祖细胞 ，因此提供了筛选用作神经分化因子等的药物的新方法。

公开(公告)号：US08390559B2

公开(公告)日：2013-03-05

申请号：US13155786

申请日：2011-06-08

Applicant: Seiichi Moriyama ,  Satoshi Endou ,  Kenji Yamashita ,  Hiroyuki Kageyama

Inventor： Seiichi Moriyama ,  Satoshi Endou ,  Kenji Yamashita ,  Hiroyuki Kageyama

IPC: G09G3/38 ,  G09G3/28 ,  G06F3/038

CPC classification number: G09G3/20 ,  G09G3/288 ,  G09G3/296 ,  G09G2310/027 ,  G09G2320/103 ,  G09G2330/021 ,  G09G2330/025 ,  G09G2330/028 ,  G09G2330/06 ,  H04N5/66

Abstract: A display driving apparatus according to an implementation of the present invention includes: a first delay circuit that generates latch control signals changing with different timings; a second delay circuit that generates falling delay signals and rising delay signals by delaying the latch control signals; a delay selection circuit that (i) selects the falling delay signals or the rising delay signals when pixel data for adjacent display output terminals have changed in different directions and (ii) selects the latch control signals when pixel data for adjacent display output terminals have changed in the same direction; and a step control circuit that drives the display output terminals with timings of the signals selected by the delay signal circuit.

Abstract translation: 根据本发明的实施例的显示驱动装置包括：产生以不同定时改变的锁存控制信号的第一延迟电路; 第二延迟电路，通过延迟所述锁存控制信号来产生下降的延迟信号和上升的延迟信号; 延迟选择电路，其特征在于：（i）当相邻显示输出端子的像素数据在不同方向上发生变化时，选择下降延迟信号或上升延迟信号;（ii）当相邻显示输出端子的像素数据发生变化时选择锁存控制信号 在同一个方向; 以及步进控制电路，用延迟信号电路选择的信号的定时来驱动显示输出端。

公开(公告)号：US08284315B2

公开(公告)日：2012-10-09

申请号：US12132963

申请日：2008-06-04

Applicant: Kenji Yamashita

Inventor： Kenji Yamashita

IPC: H04N9/66

CPC classification number: H04N9/66 ,  H04N9/646 ,  H04N9/78

Abstract: A PAL signal demodulating apparatus comprises BPF filters that perform band pass filtering to pass a chroma band for frames 1 to 5, thereby producing the BPF output signals for the frames, a 3D color phase distortion correcting color signal acquiring unit that calculates correlations between frames 1 and 3 and between frames 3 and 5 and takes a weighted average of the BPF output signals for frames 2 and 4 with weights according to the two calculated correlations, thereby producing a 3D color phase distortion correcting color signal N, and a carrier chrominance signal extracting unit that takes the addition/subtraction of the BPF output signal for frame 3 and the 3D color phase distortion correcting color signal, thereby extracting carrier chrominance signals, to perform correctly U/V separation for a line different in color from its preceding and following lines in the same frame.

Abstract translation: PAL信号解调装置包括执行带通滤波以通过帧1至5的色度带的BPF滤波器，从而产生用于帧的BPF输出信号; 3D彩色相位失真校正颜色信号获取单元，其计算帧1之间的相关性 3和帧3和5之间，并且根据两个计算的相关值对具有权重的帧2和4的BPF输出信号进行加权平均，从而产生3D彩色相位失真校正颜色信号N和载波色度信号提取 对帧3的BPF输出信号进行相加/减法的单元，以及3D彩色相位失真校正颜色信号，从而提取载波色度信号，以便对与之前和之后的行不同的行进行正确的U / V分离 在同一帧。

公开(公告)号：US20110234578A1

公开(公告)日：2011-09-29

申请号：US13155786

申请日：2011-06-08

Applicant: Seiichi MORIYAMA ,  Satoshi ENDOU ,  Kenji YAMASHITA ,  Hiroyuki KAGEYAMA

Inventor： Seiichi MORIYAMA ,  Satoshi ENDOU ,  Kenji YAMASHITA ,  Hiroyuki KAGEYAMA

IPC: G09G5/00

CPC classification number: G09G3/20 ,  G09G3/288 ,  G09G3/296 ,  G09G2310/027 ,  G09G2320/103 ,  G09G2330/021 ,  G09G2330/025 ,  G09G2330/028 ,  G09G2330/06 ,  H04N5/66

Abstract: A display driving apparatus according to an implementation of the present invention includes: a first delay circuit that generates latch control signals changing with different timings; a second delay circuit that generates falling delay signals and rising delay signals by delaying the latch control signals; a delay selection circuit that (i) selects the falling delay signals or the rising delay signals when pixel data for adjacent display output terminals have changed in different directions and (ii) selects the latch control signals when pixel data for adjacent display output terminals have changed in the same direction; and a step control circuit that drives the display output terminals with timings of the signals selected by the delay signal circuit.

Abstract translation: 根据本发明的实施例的显示驱动装置包括：产生以不同定时改变的锁存控制信号的第一延迟电路; 第二延迟电路，通过延迟所述锁存控制信号来产生下降的延迟信号和上升的延迟信号; 延迟选择电路，其特征在于：（i）当相邻显示输出端子的像素数据在不同方向上发生变化时，选择下降延迟信号或上升延迟信号;（ii）当相邻显示输出端子的像素数据发生变化时选择锁存控制信号 在同一个方向; 以及步进控制电路，用延迟信号电路选择的信号的定时来驱动显示输出端。

公开(公告)号：US07445793B2

公开(公告)日：2008-11-04

申请号：US10527075

申请日：2003-09-09

Applicant: Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

Inventor： Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

IPC: A61F2/02 ,  A61F2/00 ,  A61F2/28 ,  A61K9/14 ,  A61K48/00

CPC classification number: A61L27/3895 ,  A61L27/3852 ,  A61L27/56 ,  A61L2430/06 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/40

Abstract: The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation.The present invention relates to a 3-dimensional porous scaffold for tissue regeneration which comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 μm to not more than 500 μm and pore length of not less than 20 μm to not more than 1 cm being juxtaposedly arranged obtained by a production process comprising rapid freeze-drying as a key technology. Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.

Abstract translation: 本发明提供了一种支架，其中细胞可以在培养物中以均匀的分布状态稳定地保持和接枝，可以确保优选的增殖能力和活力，特别是在软骨的情况下，可以进行诸如缝合的定影处理 在培养后移植到受影响的部位，并且在移植的初始阶段提供可持续的（加权）压缩的机械强度。 本发明涉及用于组织再生的三维多孔支架，其包括由垂直长孔形成的结构，其孔径不小于10μm至不大于500μm，孔长度不小于20μm 通过包括快速冷冻干燥作为关键技术的生产方法并排布置而不超过1cm。 此外，本发明涉及上述三维多孔支架，其中通过分离操作，表面部分的盐洗脱操作或这些操作的组合，通过单侧面的孔扩大处理来提高细胞的接种性能 。 可以通过将来自该支架中的组织的细胞或前体细胞接种，并在人造环境和/或生物体中进行培养，来生产具有优异的组织形成程度和医疗效果的3维细胞组合。

公开(公告)号：US20060127368A1

公开(公告)日：2006-06-15

申请号：US10527075

申请日：2003-09-09

Applicant: Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

Inventor： Hideo Niwa ,  Takeshi Fukuchi ,  Ichiro Shimizu ,  Masao Sato ,  Akiko Nishi ,  Kenji Yamashita ,  Tadashi Kaneko ,  Hajime Ohgushi ,  Koji Hattori ,  Kota Uematsu

IPC: A61K35/12 ,  C12N5/00

CPC classification number: A61L27/3895 ,  A61L27/3852 ,  A61L27/56 ,  A61L2430/06 ,  C12N5/0068 ,  C12N5/0655 ,  C12N2533/40

Abstract: The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation. The present invention relates to a 3-dimensional porous scaffold for tissue regeneration which comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 μm to not more than 500 μm and pore length of not less than 20 μm to not more than 1 cm being juxtaposedly arranged obtained by a production process comprising rapid freeze-drying as a key technology. Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.

Abstract translation: 本发明提供了一种支架，其中细胞可以在培养物中以均匀的分布状态稳定地保持和接枝，可以确保优选的增殖能力和活力，特别是在软骨的情况下，可以进行诸如缝合的定影处理 在培养后移植到受影响的部位，并且在移植的初始阶段提供可持续的（加权）压缩的机械强度。 本发明涉及用于组织再生的三维多孔支架，其包括由垂直长孔形成的结构，其孔径不小于10μm至不大于500μm，孔长度不小于20μm 通过包括快速冷冻干燥作为关键技术的生产方法并排布置而不超过1cm。 此外，本发明涉及上述三维多孔支架，其中通过分离操作，表面部分的盐洗脱操作或这些操作的组合，通过单侧面的孔扩大处理来提高细胞的接种性能 。 可以通过将来自该支架中的组织的细胞或前体细胞接种，并在人造环境和/或生物体中进行培养，来生产具有优异的组织形成程度和医疗效果的3维细胞组合。

公开(公告)号：US20060057645A1

公开(公告)日：2006-03-16

申请号：US10507876

申请日：2003-03-06

Applicant: Hideo Niwa ,  Kenji Yamashita

Inventor： Hideo Niwa ,  Kenji Yamashita

IPC: G01N33/567 ,  C07H21/04 ,  C12N5/08 ,  C07K16/26

CPC classification number: C12Q1/6883 ,  C07K14/47

Abstract: The object of the present invention is to detect and select insulin-producing cells capable of proliferating, and further to differentiate/proliferate insulin-producing cells and precursory thereof, or cells related thereto. The present invention was made by finding three species of novel genes by detecting genes specifically expressed in pancreases of PHHI patients which are regarded as a model of spontaneous proliferation of pancreatic β cells, and searching for base sequence data bases. According to the present invention, proliferating insulin-producing cells can be detected using these genes, gene products or gene sequences by, for example, Northern analysis or RT-PCR. Furthermore, these genes can be differentiated into insulin-producing cells by introducing these genes into appropriate cells in genetic engineering manner.

Abstract translation: 本发明的目的是检测和选择能够增殖的胰岛素生成细胞，并且进一步分化/增殖胰岛素产生细胞及其前体，或与其相关的细胞。 本发明是通过检测被认为是胰腺β细胞自发增殖的模型，以及寻找碱基序列数据库的PHHI患者胰腺特异性表达的基因来发现三种新型基因。 根据本发明，通过例如Northern分析或RT-PCR，可以使用这些基因，基因产物或基因序列检测增殖性胰岛素生成细胞。 此外，这些基因可以通过将这些基因以遗传工程方式引入合适的细胞中而分化成胰岛素生成细胞。

公开(公告)号：US4773810A

公开(公告)日：1988-09-27

申请号：US39262

申请日：1987-04-17

Applicant: Seiichiro Nishimura ,  Toshifumi Hata ,  Kenji Yamashita

Inventor： Seiichiro Nishimura ,  Toshifumi Hata ,  Kenji Yamashita

IPC: B29C33/02 ,  B29C33/44 ,  B29D30/00 ,  B65G1/00 ,  B65G37/00 ,  B65G1/10

CPC classification number: B29D30/0016 ,  B29D30/005 ,  B29D2030/0022 ,  B29D2030/0055 ,  B29D2030/0651 ,  Y10S414/121 ,  Y10S414/124

Abstract: An automatic transport system for green tires between a forming process and a vulcanizing process in a tire manufacturing installing in which different kinds of tires are manufactured through a forming process of making use of a plurality of forming machines and a subsequent vulcanizing process making use of a plurality of vulcanizing machines. The automatic transport system comprises pallets each adapted to be charged with four or more formed green tires and to be used for transporting them as one unit. A temporary storage is interposed between a forming machine group and a vulcanizing machine group for temporarily storing the pallets at predetermined locations. Forming side unmanned transport trucks circulate between the forming machine group and the temporary storage with the pallet loaded thereon. Vulcanizing side unmanned transport trucks circulate between the temporary storage and the vulcanizing machine group with the pallet loaded thereon. Associated with the respective forming machines, a device places green tires into the pallet and loads the pallet onto the forming side unmanned transport truck. Associated with the respective vulcanizing machines, a device unloads the pallet from the vulcanizing side unmanned transport truck and discharges green tires from the pallet. Associated with the temporary storage, a device carries a green tires from the forming side unmanned transport truck, and associated with the temporary storage another device carries green tires onto the vulcanizing side unmanned transport truck. A control system controls travel of the forming side unmanned transport truck and the vulcanizing side unmanned transport truck in response to truck demands issued form the respective forming machines and vulcanizig machines, independently of each other.

Abstract translation: 一种用于轮胎制造安装中的成型工艺和硫化工序之间的生轮胎的自动运送系统，其中通过使用多个成型机的成型工艺制造不同种类的轮胎，以及随后的使用 多台硫化机。 自动运送系统包括各自适于装满四个或更多个成形绿色轮胎的托盘，并用于将它们作为一个单元运输。 在成型机组和硫化机组之间插入临时储存器，用于在预定位置临时存放托盘。 成型机无人运输卡车在成型机组和临时存放处之间循环，托盘装载在其上。 硫化侧无人运输卡车在临时存储和硫化机组之间循环，托盘装载在其上。 与相应的成型机相关联，设备将绿色轮胎放置到托盘中并将托盘装载到成形侧无人运输卡车上。 与相应的硫化机相关联，装置从硫化侧无人运输车卸载托盘，并从托盘排出绿色轮胎。 与临时储存有关的装置，从成形侧无人运输卡车携带绿色轮胎，并与临时储存器相连，另一装置将绿色轮胎装载到硫化侧无人运输车上。 控制系统响应于彼此独立的相应成型机和硫化机产生的卡车需求，控制成形侧无人运输卡车和硫化侧无人运输车辆的行驶。

公开(公告)号：US08875891B2

公开(公告)日：2014-11-04

申请号：US13108685

申请日：2011-05-16

Applicant: Kenji Yamashita ,  Akiyoshi Yasusato ,  Tetsuya Yamashita ,  Kenji Hamada ,  Goro Kuratani ,  Masakazu Sugino ,  Yuko Hanazono ,  Yoshihiko Matsuoka

Inventor： Kenji Yamashita ,  Akiyoshi Yasusato ,  Tetsuya Yamashita ,  Kenji Hamada ,  Goro Kuratani ,  Masakazu Sugino ,  Yuko Hanazono ,  Yoshihiko Matsuoka

IPC: B65D83/04 ,  A61J1/03 ,  B65D75/32

CPC classification number: B65D75/327 ,  A61J1/035 ,  B65D83/0445 ,  Y10T29/49826

Abstract: A press-through package for articles such as medicines which can reliably prevent a recipient from accidentally swallowing the whole package without opening it, including solid medicines M stored in a plurality of pockets of a base sheet one by one and the pockets sealed by a cover film having attached to the rear surface of the base sheet, wherein the entire package of the press-through package is made in a cylindrical form which cannot allow a recipient from accidentally swallowing and from which the medicines can be taken out easily.

Abstract translation: 一种用于能够可靠地防止接收者意外吞咽整个包装而不打开它的物品的压穿包装，包括一个接一个地存储在基片的多个口袋中的固体药物M和由盖子封闭的口袋 薄膜附着在基片的后表面上，其中压入包装的整个包装制成圆柱形，不能容许接收者意外吞咽，并且药物可以容易地从中取出。