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公开(公告)号：US20050000900A1
公开(公告)日：2005-01-06
申请号：US10874103
申请日：2004-06-21
Applicant: Jiang Huang , Hou-Pu Chou , Marc Unger
Inventor： Jiang Huang , Hou-Pu Chou , Marc Unger
CPC classification number: B01D15/08 , G01N30/6065 , G01N30/6095 , G01N2030/387 , G01N2030/521 , Y10T137/86863 , Y10T436/2575
Abstract: The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same. Preferably, the chromatography column comprises an OTLC, PCLC, or combinations thereof.
Abstract translation: 本发明涉及包含微流体输送系统和与流体输送系统流体连通的色谱柱的微流体色谱装置及其制造和使用方法。 优选地，色谱柱包括OTLC，PCLC或其组合。
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公开(公告)号：US08828663B2
公开(公告)日：2014-09-09
申请号：US11912502
申请日：2006-03-20
Applicant: Marc Unger , Lincoln McBride , Geoffrey Facer , Michael Lucero , Hany Ramez Nassef
Inventor： Marc Unger , Lincoln McBride , Geoffrey Facer , Michael Lucero , Hany Ramez Nassef
IPC: C12Q1/68 , C12P19/34 , G01N27/453 , B01L3/00
CPC classification number: C12Q1/686 , B01L3/502738 , B01L7/52 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2300/1805 , B01L2300/1827 , B01L2400/0481 , B01L2400/0655 , G01N27/453 , C12Q2565/629
Abstract: Devices and methods for performing the relative concentration of a target in a sample, the sample containing both target and non-target components, the method performed by partitioning the sample into a large number of reaction volumes such that the target is concentrated relative to the non-target, and performing a detection assay upon each reaction volume to detect the target.
Abstract translation: 用于执行样品中靶标相对浓度的装置和方法，含有靶和非目标成分的样品，通过将样品分成大量反应体积进行的方法，使得靶相对于非目标成分集中 并且在每个反应体积上进行检测测定以检测目标。
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23.发明申请INTEGRATED CHIP CARRIERS WITH THERMOCYCLER INTERFACES AND METHODS OF USING THE SAME 有权具有热交换器接口的集成芯片载体及其使用方法公开(公告)号：US20110265304A1
公开(公告)日：2011-11-03
申请号：US12987787
申请日：2011-01-10
Applicant: Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
Inventor： Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
IPC: B23P11/00
CPC classification number: C12M1/00 , B01J2219/00317 , B01J2219/00495 , B01L3/0293 , B01L3/06 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/5635 , B01L3/565 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0816 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , C30B7/00 , C30B29/58 , Y10T29/49826 , Y10T436/25
Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
Abstract translation: 提供方法和系统用于在选定的温度或时间范围内进行反应。 提供阵列装置。 阵列装置包含单独的反应室，并且由多层形成为弹性体块。 至少一个层具有至少一个凹部，该凹部具有至少一个与该凹部一体的可偏转膜。 阵列装置具有靠近至少一个反应室的热转印装置。 热转印装置形成为接触热控制源。 用于进行所需反应的试剂被引入阵列装置。 阵列装置与热控制装置接触，使得热控制装置与热控制源热连通，使得至少一个反应室中的反应温度由于温度变化而改变 的热控制源。
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公开(公告)号：US08007746B2
公开(公告)日：2011-08-30
申请号：US11929660
申请日：2007-10-30
Applicant: Marc Unger , Jiang Huang , Emerson Quan
Inventor： Marc Unger , Jiang Huang , Emerson Quan
IPC: B01L3/00
CPC classification number: B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , C12Q1/686
Abstract: An M.times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
Abstract translation: 一种用于执行反应矩阵的M.times.N矩阵微流体装置，该装置具有多个反应池，其通过形成在装置的弹性体块内的通孔与样品入口或试剂入口之一连通。 提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。
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25.发明授权Integrated chip carriers with thermocycler interfaces and methods of using the same 有权具有热循环器接口的集成芯片载体及其使用方法公开(公告)号：US07867763B2
公开(公告)日：2011-01-11
申请号：US11058106
申请日：2005-02-14
Applicant: Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
Inventor： Geoffrey Facer , Robert Grossman , Marc Unger , Phillip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
CPC classification number: C12M1/00 , B01J2219/00317 , B01J2219/00495 , B01L3/0293 , B01L3/06 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/5635 , B01L3/565 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0816 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , C30B7/00 , C30B29/58 , Y10T29/49826 , Y10T436/25
Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
Abstract translation: 提供方法和系统用于在选定的温度或时间范围内进行反应。 提供阵列装置。 阵列装置包含单独的反应室，并且由多层形成为弹性体块。 至少一个层具有至少一个凹部，该凹部具有至少一个与该凹部一体的可偏转膜。 阵列装置具有靠近至少一个反应室的热转印装置。 热转印装置形成为接触热控制源。 用于进行所需反应的试剂被引入阵列装置。 阵列装置与热控制装置接触，使得热控制装置与热控制源热连通，使得至少一个反应室中的反应温度由于温度变化而改变 的热控制源。
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Patent Agency Ranking
公开(公告)号：US07820427B2
公开(公告)日：2010-10-26
申请号：US11531147
申请日：2006-09-12
Applicant: Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
Inventor： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
IPC: C12M1/38
CPC classification number: C12M1/38 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L2300/0627 , B01L2300/123 , B01L2400/06 , C12Q1/68 , C12Q1/6844 , C40B60/14 , F16K11/20 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T137/2076 , Y10T137/2496 , Y10T137/86292 , Y10T137/87249 , Y10T436/2575 , C12Q2565/501
Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
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公开(公告)号：US20100184202A1
公开(公告)日：2010-07-22
申请号：US12579347
申请日：2009-10-14
Applicant: Lincoln McBride , Geoffrey Facer , Marc Unger , Michael Lucero , Hany Ramez Nassef
Inventor： Lincoln McBride , Geoffrey Facer , Marc Unger , Michael Lucero , Hany Ramez Nassef
IPC: C12M1/34
CPC classification number: C12Q1/68 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/10 , B01L2200/142 , B01L2200/147 , B01L2300/06 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
Abstract: An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
Abstract translation: 一种用于执行反应矩阵的M×N矩阵微流体装置，所述装置具有多个反应池，其通过形成在装置的弹性体块内的通孔与样品入口或试剂入口之一连通。 提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。
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28.发明授权Integrated chip carriers with thermocycler interfaces and methods of using the same 有权具有热循环器接口的集成芯片载体及其使用方法公开(公告)号：US07704735B2
公开(公告)日：2010-04-27
申请号：US11740735
申请日：2007-04-26
Applicant: Geoffrey Facer , Robert Grossman , Marc Unger , Philip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
Inventor： Geoffrey Facer , Robert Grossman , Marc Unger , Philip Lam , Hou-Pu Chou , Jake Kimball , Martin Pieprzyk , Antoine Daridon
CPC classification number: C12M1/00 , B01J2219/00317 , B01J2219/00495 , B01L3/0293 , B01L3/06 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/5635 , B01L3/565 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0816 , B01L2300/0829 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , C30B7/00 , C30B29/58 , Y10T29/49826 , Y10T436/25
Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
Abstract translation: 提供方法和系统用于在选定的温度或时间范围内进行反应。 提供阵列装置。 阵列装置包含单独的反应室，并且由多层形成为弹性体块。 至少一个层具有至少一个凹部，该凹部具有至少一个与该凹部一体的可偏转膜。 阵列装置具有靠近至少一个反应室的热转印装置。 热转印装置形成为接触热控制源。 用于进行所需反应的试剂被引入阵列装置。 阵列装置与热控制装置接触，使得热控制装置与热控制源热连通，使得至少一个反应室中的反应温度由于温度变化而改变 的热控制源。
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公开(公告)号：US07691333B2
公开(公告)日：2010-04-06
申请号：US10819088
申请日：2004-04-05
Applicant: Lincoln McBride , Michael Lucero , Marc Unger , Hany Ramez Nassef , Geoffrey Facer , Yong Yi
Inventor： Lincoln McBride , Michael Lucero , Marc Unger , Hany Ramez Nassef , Geoffrey Facer , Yong Yi
IPC: B01L3/00
CPC classification number: B01L3/00 , B01F13/0059 , B01J2219/00337 , B01J2219/00353 , B01J2219/00403 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/0072 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/50851 , B01L2300/0627 , B01L2300/0883 , B01L2300/123 , B01L2400/06 , C12Q1/6844 , C40B60/08 , C40B60/14 , G01N35/00029 , G01N35/0098 , G01N2035/00366 , Y10T436/25 , C12Q2565/501
Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.
Abstract translation: 提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。 某些设备具有反应位置阵列以便于高通量分析。 一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经预先沉积。 一旦将样品引入反应部位，试剂就会悬浮。 该装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。
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公开(公告)号：US07604965B2
公开(公告)日：2009-10-20
申请号：US11084357
申请日：2005-03-18
Applicant: Lincoln McBride , Geoffrey Facer , Marc Unger , Michael Lucero , Hany Ramez Nassef
Inventor： Lincoln McBride , Geoffrey Facer , Marc Unger , Michael Lucero , Hany Ramez Nassef
CPC classification number: C12Q1/68 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/10 , B01L2200/142 , B01L2200/147 , B01L2300/06 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
Abstract: An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
Abstract translation: 一种用于执行反应矩阵的MxN矩阵微流体装置，所述装置具有多个反应池，其通过形成在所述装置的弹性体块内的通孔与样品入口或试剂入口之一连通。 提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。
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