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公开(公告)号：US08131372B2
公开(公告)日：2012-03-06
申请号：US11688178
申请日：2007-03-19
Applicant: Howard R. Levin , Mark Gelfand
Inventor： Howard R. Levin , Mark Gelfand
CPC classification number: A61B18/1492 , A61B18/04 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61M1/3627 , A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/05 , A61N1/0551 , A61N1/326 , A61N1/36007 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36135 , A61N1/3627 , A61N1/40 , A61N1/403 , A61N5/00
Abstract: A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based.
Abstract translation: 一种通过刺激肾神经来治疗心力衰竭，高血压和肾功能衰竭的方法和装置。 治疗的目的是减少肾神经的交感神经活动。 通过药物输注或电刺激至少部分阻断神经来完成治疗。 装置可以永久植入或基于导管。
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公开(公告)号：US20110208096A1
公开(公告)日：2011-08-25
申请号：US13046595
申请日：2011-03-11
Applicant: Denise Demarais , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
Inventor： Denise Demarais , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
CPC classification number: A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61F7/123 , A61F2007/126 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/28 , A61N1/32 , A61N1/326 , A61N1/36007 , A61N1/36017 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/403 , A61N5/045 , A61N7/02 , A61N2007/003
Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
Abstract translation: 提供了用于热诱导的肾神经调节的方法和装置。 热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。 在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。 在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。 在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。
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23.发明授权公开(公告)号：US07935071B2
公开(公告)日：2011-05-03
申请号：US11960145
申请日：2007-12-19
Applicant: Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
Inventor： Howard R. Levin , Mark Gelfand , John O'Mahony , Hans-Dietrich Polaschegg
CPC classification number: A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
Abstract: A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.
Abstract translation: 一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质， 以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。
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公开(公告)号：US07883500B2
公开(公告)日：2011-02-08
申请号：US10808397
申请日：2004-03-25
Applicant: Howard R. Levin , Mark Gelfand
Inventor： Howard R. Levin , Mark Gelfand
IPC: A61M31/00
CPC classification number: A61M25/02 , A61M25/1011 , A61M2025/0233 , A61M2210/122
Abstract: A method and apparatus for prevention and reduction of myocardial infarct expansion and heart remodeling by infusion of fluid into the pericardial space of the heart to created a hydraulic heart constraint. As a result of the constraint ventricular stress and dilation is reduced. Pressure in the pericardial sac is maintained at a safe level for the duration of treatment. Apparatus consists of a catheter and a fluid infusion system.
Abstract translation: 一种通过将流体输入心脏心包空间来预防和减少心肌梗塞扩张和心脏重建的方法和装置，以产生水力心脏约束。 由于受限制，心室应激和扩张减轻。 心包囊中的压力在治疗期间保持在安全水平。 装置由导管和流体输注系统组成。
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公开(公告)号：US07869874B2
公开(公告)日：2011-01-11
申请号：US11861019
申请日：2007-09-25
Applicant: Howard Levin , Mark Gelfand
Inventor： Howard Levin , Mark Gelfand
IPC: A61N1/365
CPC classification number: A61N1/3627 , A61B5/0452 , A61N1/3624 , A61N1/368 , A61N1/3684 , A61N1/37235
Abstract: A method and apparatus for treatment of hypertension and heart failure by increasing vagal tone and secretion of endogenous atrial hormones by excitory pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in atrial contraction against closed AV valves, and atrial contraction rate that is higher than the ventricular contraction rate. Pacing results in the increased atrial wall stress. An implantable device is used to monitor ECG and pace the atria in a nonphysiologic manner.
Abstract translation: 一种通过增加迷走神经张力和通过心脏心房的兴奋性起搏分泌内源性心房激素来治疗高血压和心力衰竭的方法和装置。 心房起搏在心室不应期内完成，导致闭合性AV瓣膜的心房收缩，心房收缩率高于心室收缩率。 起搏导致心房壁压力增加。 可植入装置用于监测心电图并以非生理学方式对心房进行加速。
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Patent Agency Ranking
公开(公告)号：US20100234797A1
公开(公告)日：2010-09-16
申请号：US12800673
申请日：2010-05-20
Applicant: Mark Gelfand , Howard R. Levin
Inventor： Mark Gelfand , Howard R. Levin
IPC: A61M5/168
CPC classification number: A61M5/1723 , A61B5/201 , A61B5/208 , A61B5/4839 , A61M5/007 , A61M5/142 , A61M5/16895 , A61M5/365 , A61M2205/18 , A61M2205/3355 , A61M2205/3393 , G01G17/04
Abstract: A patient hydration system including an infusion device for administering hydration fluid to a patient, and a hydration fluid measurement device responsive to a source of hydration fluid, a patient urine output measurement device. A controller is responsive to the hydration fluid measurement device and the patient urine output measurement device. The controller operates the infusion device, in response to the patient urine output measurement device and the hydration fluid measurement device, to hydrate the patient based on the patient's urine output. The controller also monitors the operation history of the infusion device thereby providing redundancy in the measurement of the amount of hydration fluid administered to the patient.
Abstract translation: 一种患者水合系统，包括用于向患者施用水合流体的输注装置，以及响应于水合流体源的水合流体测量装置，患者尿液输出测量装置。 控制器响应于水合流体测量装置和患者尿液输出测量装置。 控制器响应于患者尿液输出测量装置和水合流体测量装置操作输液装置，以基于患者的尿液输出水合患者。 控制器还监测输注装置的操作历史，从而在测量给予患者的水合液量的量方面提供冗余。
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公开(公告)号：US20100222851A1
公开(公告)日：2010-09-02
申请号：US12777892
申请日：2010-05-11
Applicant: Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
Inventor： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
CPC classification number: A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
Abstract translation: 提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。 预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗 晚期肾脏疾病。 本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。
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公开(公告)号：US20100137952A1
公开(公告)日：2010-06-03
申请号：US12700524
申请日：2010-02-04
Applicant: Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
Inventor： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
IPC: A61F7/12
CPC classification number: A61N7/022 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/1492 , A61B2018/0022 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61F7/007 , A61F7/12 , A61F7/123 , A61F2007/126 , A61M5/44 , A61M2210/1082 , A61N1/28 , A61N1/36007 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/045 , A61N5/0603 , A61N7/00 , A61N7/02 , A61N2007/003 , A61N2007/0078
Abstract: Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.
Abstract translation: 提供了用于热诱导的肾神经调节的方法和装置。 热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。 在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。 在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。
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公开(公告)号：US20100125288A1
公开(公告)日：2010-05-20
申请号：US12620258
申请日：2009-11-17
Applicant: Mark Gelfand , Howard Levin
Inventor： Mark Gelfand , Howard Levin
IPC: A61B17/12
CPC classification number: A61B17/12 , A61B5/0031 , A61B5/0215 , A61B5/02241 , A61B5/201 , A61B5/6846 , A61B5/6876 , A61B5/6884 , A61B17/1355 , A61B2017/00221
Abstract: A method and apparatus for treatment of chronic renal failure by reducing renal perfusion pressure. Treatment is performed by partial occlusion of renal artery. A device to constrict the renal artery may be implanted in the body of a patient and include a renal pressure sensor and a mechanical control applied the renal artery to adjustably constrict a cross sectional area of the artery.
Abstract translation: 通过减少肾灌注压来治疗慢性肾功能衰竭的方法和装置。 通过部分闭塞肾动脉进行治疗。 用于收缩肾动脉的装置可以植入患者体内，并且包括肾脏压力传感器和施加肾动脉的机械控制以可调节地收缩动脉的横截面积。
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公开(公告)号：US20100094370A1
公开(公告)日：2010-04-15
申请号：US12555389
申请日：2009-09-08
Applicant: Howard Levin , Mark Gelfand
Inventor： Howard Levin , Mark Gelfand
IPC: A61N1/368
CPC classification number: A61N1/36542 , A61N1/36117 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/368 , A61N1/3684
Abstract: A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.
Abstract translation: 一种通过心脏心房起搏增加内源性心房激素分泌来治疗高血压和心力衰竭的方法和装置。 心房起搏在心室不应期内完成，导致心房收缩过早，不会导致心室收缩。 起搏导致心房壁压力，周围血管舒张，ANP分泌。 根据需要随机起搏来监测和控制心率的伴随降低。
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