公开(公告)号：US07741488B2

公开(公告)日：2010-06-22

申请号：US11883624

申请日：2006-02-10

Applicant: Klaus Pekari ,  Mathias Schmidt ,  Thomas Bär ,  Thomas Beckers ,  Björn Bartels

Inventor： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bär ,  Thomas Beckers ,  Björn Bartels

IPC: C07D471/02

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。

公开(公告)号：US20100061039A1

公开(公告)日：2010-03-11

申请号：US12205551

申请日：2008-09-05

Applicant: Emery Sanford ,  Stephen Brian Lynch ,  Anthony Sagala Montevirgen ,  Fletcher Rothkopf ,  Mathias Schmidt ,  Hamid Mohammadinia ,  R. Sean Murphy

Inventor： Emery Sanford ,  Stephen Brian Lynch ,  Anthony Sagala Montevirgen ,  Fletcher Rothkopf ,  Mathias Schmidt ,  Hamid Mohammadinia ,  R. Sean Murphy

IPC: H05K7/00 ,  B23P11/00

CPC classification number: H05K5/0013 ,  Y10T29/49826 ,  Y10T428/24628

Abstract: Apparatus and methods for assembling an electronic device and components thereof are provided. The electronic device may include a housing and a cover inserted into an opening in the housing. The electronic device may also include a first assembly that may be inserted into the housing through a first end, and a second assembly that may be inserted into the housing through a second end. The electronic device may also include end cap assemblies. In some embodiments, the electronic device may include an input mechanism coupled to the housing and a plate coupled to the housing. In some embodiments, a connector of the electronic device may be mounted on a circuit board by inserting a fixture into the connector, mounting the connector to a portion of the circuit board, removing the fixture from the connector, and separating the portion of the circuit board from another portion of the circuit board.

Abstract translation: 提供了用于组装电子设备及其组件的装置和方法。 电子设备可以包括壳体和插入壳体中的开口中的盖子。 电子设备还可以包括可以通过第一端插入壳体的第一组件和可以经由第二端插入壳体中的第二组件。 电子设备还可以包括端盖组件。 在一些实施例中，电子设备可以包括联接到壳体的输入机构和联接到壳体的板。 在一些实施例中，电子设备的连接器可以通过将固定装置插入到连接器中来安装在电路板上，将连接器安装到电路板的一部分上，从连接器移除固定装置，并将电路的一部分 板从电路板的另一部分。

公开(公告)号：US20090227577A1

公开(公告)日：2009-09-10

申请号：US12411486

申请日：2009-03-26

Applicant: Klaus PEKARI ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

Inventor： Klaus PEKARI ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

IPC: A61K31/4365 ,  A61P25/00 ,  A61K31/506 ,  A61K31/5377

CPC classification number: C07D495/04

Abstract: The invention relates to compounds of formula I, wherein Ra is —C(O)ORI, in which R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and either Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, or Q is optionally substituted by Rca and/or Rcb, and is Has, or Q is optionally substituted by Rda and/or Rdb, and is Het, or Q is optionally substituted by Rea and/or Reb, and is 3-7C-cycloalkyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.

Abstract translation: 本发明涉及式I化合物，其中R a为-C（O）ORI，其中R 1为1-7C-烷基，3-7C-环烷基或被一至四个取代基取代的1-7C-烷基，所述取代基独立地选自 R2，Rb是-TQ，其中T是1-6C-亚烷基或3-7C-亚环烷基，并且Q任选地被Rba和/或Rbb和/或Rbc取代，并且是苯基或萘基，或Q是任选的 被Rca和/或Rcb取代，并且是或者是Q被Rda和/或Rdb任选取代，并且是Het，或Q任选地被Rea和/或Reb取代，并且是3-7C-环烷基，它们是 可用于治疗过度增殖性疾病，特别是人类癌症。

公开(公告)号：US20080260749A1

公开(公告)日：2008-10-23

申请号：US11920501

申请日：2006-05-24

Applicant: Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Petra Gimmnich

Inventor： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Petra Gimmnich

IPC: A61K31/4365 ,  A61P35/00 ,  A61K31/444 ,  A61K39/395 ,  A61K31/70 ,  A61K31/4439 ,  C07D495/04

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

公开(公告)号：US20080096914A1

公开(公告)日：2008-04-24

申请号：US11883596

申请日：2006-02-08

Applicant: Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

Inventor： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

IPC: A61K31/4743 ,  C07D498/02

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。

公开(公告)号：US20070244112A1

公开(公告)日：2007-10-18

申请号：US11597142

申请日：2005-05-25

Applicant: Klaus Pekari ,  Thomas Baer ,  Bjorn Bartels ,  Mathias Schmidt ,  Thomas Beckers

Inventor： Klaus Pekari ,  Thomas Baer ,  Bjorn Bartels ,  Mathias Schmidt ,  Thomas Beckers

IPC: A61K31/44 ,  A61K31/497 ,  A61K31/535 ,  A61P35/00 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。

公开(公告)号：US5942602A

公开(公告)日：1999-08-24

申请号：US800198

申请日：1997-02-13

Applicant: Winfried S. Wels ,  Mathias Schmidt ,  Evangelia Vakalopoulou ,  Douglas W Schneider

Inventor： Winfried S. Wels ,  Mathias Schmidt ,  Evangelia Vakalopoulou ,  Douglas W Schneider

IPC: A61K38/00 ,  A61K47/48 ,  C07K16/28 ,  C12N15/13 ,  C07K16/30

CPC classification number: C07K16/2863 ,  A61K47/48561 ,  A61K2039/505 ,  A61K38/00 ,  C07K2317/622 ,  C07K2319/00

Abstract: The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating and diagnosing the status of pathological conditions such as cancer and cellular hyper proliferation.

Abstract translation: 本发明涉及EGF受体的单链和双链抗体。 本发明还涉及这种抗体的毒素缀合物。 这些抗体可用于治疗和诊断病理状况如癌症和细胞超增殖的状况。

公开(公告)号：US10301257B2

公开(公告)日：2019-05-28

申请号：US14344391

申请日：2012-09-14

Applicant: Erwin Hacker ,  Georg Bonfig-Picard ,  Stefan Lehr ,  Udo Bickers ,  Martin Hess ,  Klaus Trabold ,  Mathias Schmidt ,  Frank Ziemer ,  Juan Pedro Ruiz-Santaella Moreno

Inventor： Erwin Hacker ,  Georg Bonfig-Picard ,  Stefan Lehr ,  Udo Bickers ,  Martin Hess ,  Klaus Trabold ,  Mathias Schmidt ,  Frank Ziemer ,  Juan Pedro Ruiz-Santaella Moreno

IPC: A01N41/06 ,  A01N43/653 ,  A01N39/04 ,  A01N37/50 ,  A01N25/00 ,  C07C311/38 ,  C07D405/06

Abstract: Compounds (A) can be used for increasing the yield of useful plants or crop plants with respect to their harvested plant organs, wherein the Compound (A) is selected from compounds of the formula (I) or salts thereof, wherein the symbols are defined as in claim 1, preferably cyprosulfamide [Compound (A1)].

公开(公告)号：US20150291518A1

公开(公告)日：2015-10-15

申请号：US14344391

申请日：2012-09-14

Applicant: Erwin Hacker ,  Georg Bonfig-Picard ,  Stefan Lehr ,  Udo Bickers ,  Martin Hess ,  Klaus Trabold ,  Mathias Schmidt ,  Frank Ziemer ,  Juan Pedro Ruiz-Santaella Moreno

Inventor： Erwin Hacker ,  Georg Bonfig-Picard ,  Stefan Lehr ,  Udo Bickers ,  Martin Hess ,  Klaus Trabold ,  Mathias Schmidt ,  Frank Ziemer ,  Juan Pedro Ruiz-Santaella Moreno

IPC: C07C311/38 ,  C07D405/06 ,  A01N43/653 ,  A01N41/06

CPC classification number: C07C311/38 ,  A01N25/00 ,  A01N39/04 ,  A01N41/06 ,  A01N43/653 ,  C07D405/06 ,  Y02A40/143 ,  A01N37/50 ,  A01N2300/00

Abstract: Compounds (A) can be used for increasing the yield of useful plants or crop plants with respect to their harvested plant organs, wherein the Compound (A) is selected from compounds of the formula (I) or salts thereof, wherein the symbols are defined as in claim 1, preferably cyprosulfamide [Compound (A1)].

Abstract translation: 化合物（A）可用于相对于其收获的植物器官增加有用植物或作物的产量，其中化合物（A）选自式（I）的化合物或其盐，其中符号被定义 权利要求1中，优选环丙磺酰胺[化合物（A1）]。

公开(公告)号：US08610522B2

公开(公告)日：2013-12-17

申请号：US13409193

申请日：2012-03-01

Applicant: Erhard Deylitz ,  Björn Gehrke ,  Pierre Lamoth ,  Mathias Schmidt

Inventor： Erhard Deylitz ,  Björn Gehrke ,  Pierre Lamoth ,  Mathias Schmidt

IPC: H01H9/20

CPC classification number: H01H9/223 ,  H01H71/04

Abstract: An electrical switch is disclosed for switching an electric current, the switch being suitable for being inserted into a switch holding device. In at least one embodiment, the switch includes a locking device which, in the event of an overcurrent, moves a locking element of the locking device to a position which mechanically locks the switch in the switch holding device.

Abstract translation: 公开了用于切换电流的电开关，该开关适于插入开关保持装置。 在至少一个实施例中，开关包括锁定装置，在过电流的情况下，锁定装置将锁定装置的锁定元件移动到将开关机械地锁定在开关保持装置中的位置。