公开(公告)号：US20120202816A1

公开(公告)日：2012-08-09

申请号：US13346968

申请日：2012-01-10

Applicant: Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

Inventor： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  C. Dutt ,  Vijay Chauthaiwale

IPC: A61K31/415 ,  C07D403/06 ,  A61K31/4155 ,  C07D409/04 ,  C07D413/06 ,  A61K31/4245 ,  C07D413/04 ,  A61K31/5377 ,  A61P3/04 ,  A61P5/48 ,  A61P3/10 ,  A61P3/06 ,  A61P3/00 ,  A61P5/14 ,  A61P3/08 ,  A61P25/24 ,  A61P9/00 ,  A61P17/00 ,  C07D231/18

CPC classification number: C07D403/06 ,  C07D231/12 ,  C07D231/14 ,  C07D231/18 ,  C07D403/10 ,  C07D403/12 ,  C07D409/04 ,  C07D413/06

Abstract: The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.

Abstract translation: 本发明公开了一种新颖的甲状腺样化合物，其中R1 R2，R3，R4和Z如本说明书中所定义，其制备方法，含有这些化合物的组合物以及这些化合物的用途和作为药物的组合物。 此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。 本发明还涉及式（I）化合物在制备用于治疗各种疾病状况如肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。

公开(公告)号：US20100154394A1

公开(公告)日：2010-06-24

申请号：US12318133

申请日：2008-12-22

Applicant: Randall D. Partridge ,  Ramesh Gupta ,  Kouseki Sugiyama

Inventor： Randall D. Partridge ,  Ramesh Gupta ,  Kouseki Sugiyama

IPC: F01N3/02 ,  F28D7/00

CPC classification number: F28D15/0275 ,  F01N5/02 ,  F01N2240/02 ,  F02M1/165 ,  F02M31/005 ,  F02M31/20 ,  F02M37/0064 ,  F28D21/0003 ,  F28F1/12 ,  Y02T10/126 ,  Y02T10/16

Abstract: An exhaust heat recovery system 25 provided with a plurality of heat pipes 60, 61 provided with heat recovery parts 60a, 61a and heat exchange parts 60b, 61b. The heat pipes recover heat from exhaust gas exhausted from an internal combustion engine at the heat recovery parts and transfer this recovered heat to an object to be heated at the heat exchange parts. The heat recovery part 60a of the first heat pipe 60 recovers heat from the exhaust gas at an exhaust purification catalyst 20′ provided in an engine exhaust passage or its upstream side. The heat recovery part 61b of the second heat pipe 61 recovers heat from the exhaust gas at the downstream side of the exhaust purification catalyst. Due to this, there is provided an exhaust heat recovery system which can recover at least a fixed amount of exhaust heat at all times while maintaining a warm-up performance of the exhaust purification catalyst.

Abstract translation: 具有设置有热回收部60a，61a和热交换部60b，61b的多个热管60,61的排气热回收系统25。 热管从热回收部分的内燃机排出的废气中回收热量，并将该回收的热量传递到在热交换部件处被加热的物体。 第一热管60的热回收部60a在设置在发动机排气通路或其上游侧的排气净化催化剂20'处从废气中回收热量。 第二热管61的热回收部61b从排气净化催化剂的下游侧的排气回收热量。 因此，提供了一种废气热回收系统，其能够在保持排气净化催化剂的预热性能的同时始终恢复至少一定量的排气热。

公开(公告)号：US20100116553A1

公开(公告)日：2010-05-13

申请号：US12691783

申请日：2010-01-22

Applicant: Paul Matthew Spiecker ,  Pavlin B. Entchev ,  Ramesh Gupta ,  Richard Polizzotti ,  Barbara Carstensen ,  Dennis G. Peiffer ,  Norman Pokutylowicz

Inventor： Paul Matthew Spiecker ,  Pavlin B. Entchev ,  Ramesh Gupta ,  Richard Polizzotti ,  Barbara Carstensen ,  Dennis G. Peiffer ,  Norman Pokutylowicz

IPC: C09K8/02

CPC classification number: E21B21/002 ,  E21B21/00 ,  E21B21/062 ,  E21B21/066 ,  Y10S507/906

Abstract: A method and system for drilling a wellbore is described. The system includes a wellbore with a variable density drilling mud, drilling pipe, a bottom hole assembly disposed in the wellbore and a drilling mud processing unit in fluid communication with the wellbore. The variable density drilling mud has compressible particles and drilling fluid. The bottom hole assembly is coupled to the drilling pipe, while the drilling mud processing unit is configured to separate the compressible particles from the variable density drilling mud. The compressible particles in this embodiment may include compressible hollow objects filled with pressurized gas and configured to maintain the mud weight between the fracture pressure gradient and the pore pressure gradient. In addition, the system and method may also manage the use of compressible particles having different characteristics, such as size, during the drilling operations.

Abstract translation: 描述了钻井井的方法和系统。 该系统包括具有可变密度钻井泥浆，钻井管，设置在井筒中的井底组件和与井筒流体连通的钻井泥浆处理单元的井筒。 可变密度钻井泥浆具有可压缩颗粒和钻井液。 井底组件联接到钻井管道，而钻井泥浆处理单元构造成将可压缩颗粒与可变密度钻井泥浆分开。 该实施例中的可压缩颗粒可以包括填充有加压气体的可压缩中空物体，并且被配置为保持裂缝压力梯度和孔隙压力梯度之间的泥浆重量。 此外，该系统和方法还可以在钻井操作期间管理具有不同特征的尺寸的可压缩颗粒的使用。

公开(公告)号：US20050092654A1

公开(公告)日：2005-05-05

申请号：US10938301

申请日：2004-09-10

Applicant: Edward Ellis ,  Ramesh Gupta ,  William Novak

Inventor： Edward Ellis ,  Ramesh Gupta ,  William Novak

IPC: C10G65/04 ,  C10G69/02

CPC classification number: C10G65/043

Abstract: A distillate fuel feed is hydrotreated to remove heteroatoms and then separated into light and heavy hydrotreated fractions, with the heavy fraction catalytically dewaxed to improve low temperature properties. The hydrotreating and dewaxing are conducted in separate stages, which may be in the same reactor vessel. Fresh hydrogen may be passed into the dewaxing stage, with the dewaxing stage gaseous effluent then passed into the hydrotreating stage to provide hydrogen for the hydrotreating. Existing hydrotreating reaction vessels and facilities may be retrofitted to add one or more dewaxing stages.

Abstract translation: 将馏出物燃料进料加氢处理以除去杂原子，然后分离成轻重和加氢处理的馏分，重馏分催化脱蜡以改善低温性能。 加氢处理和脱蜡在不同的阶段进行，可以在同一个反应器容器中。 新鲜的氢气可以进入脱蜡阶段，脱蜡阶段的气态流出物然后进入加氢处理阶段以提供氢气用于加氢处理。 现有的加氢处理反应容器和设备可以被改装以加入一个或多个脱蜡阶段。

公开(公告)号：US06689329B2

公开(公告)日：2004-02-10

申请号：US09974561

申请日：2001-10-10

Applicant: Ramesh Gupta ,  Salvatore Joseph Rossetti

Inventor： Ramesh Gupta ,  Salvatore Joseph Rossetti

IPC: B01J804

CPC classification number: B01J8/008 ,  B01J8/025 ,  B01J8/0278 ,  B01J2208/00707 ,  C10G49/002

Abstract: The invention is directed to a bypass device for extending the operating life of fixed bed reactors. The device may be placed within a fixed catalyst bed to partition the bed into a first top bed and a second virtual bed. The bypass device allows any fluid feedstock to bypass the first top bed of the fixed catalyst bed as it fouls and enter the second virtual bed under conditions that promote depositing any foulants contained in the bypass flow on the top surface of the second virtual bed rather than in the interstices of the second virtual bed. The invention also relates to an improved fixed bed reactor comprising the inventive bypass device and a method for extending the operating life of a fixed bed reactor that employs the inventive bypass device.

Abstract translation: 本发明涉及一种用于延长固定床反应器的使用寿命的旁路装置。 该装置可以放置在固定的催化剂床内以将床分隔成第一顶床和第二虚拟床。 旁路装置允许任何流体原料绕其固定的催化剂床的第一顶层，因为它在有助于沉积在第二虚拟床的顶表面上的旁路流中的任何污染物的条件下进入第二虚拟床，而不是 在第二个虚拟床的空隙中。 本发明还涉及一种改进的固定床反应器，其包括本发明的旁路装置和用于延长采用本发明旁路装置的固定床反应器的使用寿命的方法。

公开(公告)号：US06495029B1

公开(公告)日：2002-12-17

申请号：US09385644

申请日：1999-08-27

Applicant: James J. Schorfheide ,  Edward S. Ellis ,  Michele S. Touvelle ,  Ramesh Gupta

Inventor： James J. Schorfheide ,  Edward S. Ellis ,  Michele S. Touvelle ,  Ramesh Gupta

IPC: C10G4500

CPC classification number: C10G25/003 ,  C10G45/10 ,  C10G65/04 ,  C10G67/06

Abstract: A process for the hydrodesulfurization (HDS) of the multiple condensed ring heterocyclic organosulfur compounds present in petroleum and chemical streams. The stream is passed through at least one reaction zone countercurrent to the flow of a hydrogen-containing treat gas, and through at least one sorbent zone. The reaction zone contains a bed of Group VIII metal-containing hydrodesulfurization catalyst and the sorbent zone contains a bed of hydrogen sulfide sorbent material.

Abstract translation: 石油和化学物流中存在的多重稠环杂环有机硫化合物的加氢脱硫（HDS）的方法。 该物流通过与含氢处理气体的流动逆流的至少一个反应区，并通过至少一个吸附区。 反应区含有含Ⅷ族金属的加氢脱硫催化剂床，吸附剂区含有硫化氢吸附剂材料床。

公开(公告)号：US06224749B1

公开(公告)日：2001-05-01

申请号：US09073415

申请日：1998-05-06

Applicant: Ramesh Gupta ,  Henry Jung ,  Edward S. Ellis ,  Gerald E. Markley

Inventor： Ramesh Gupta ,  Henry Jung ,  Edward S. Ellis ,  Gerald E. Markley

IPC: C10G6502

CPC classification number: C10G65/00 ,  B01J8/04 ,  B01J8/0488 ,  B01J2208/00283

Abstract: A three stage hydroprocessing process includes two liquid and one vapor reaction stages, both of which produce an effluent comprising liquid and vapor. Both vapor effluents comprise vaporized hydrocarbonaceous material. Fresh hydrogen is used for the hydroprocessing in both liquid stages. The second stage liquid effluent comprises the product liquid. The first stage liquid effluent is the feed for the second stage. The first stage vapor effluent is hydroprocessed in the vapor stage and then cooled to condense and recover at least a portion of the processed vapor as additional product liquid.

Abstract translation: 三级加氢处理方法包括两个液体和一个蒸气反应阶段，二者都产生包含液体和蒸汽的流出物。 两种蒸汽流出物都包含蒸发的含烃材料。 新鲜氢气用于两个液体阶段的加氢处理。 第二级液体流出物包括产物液体。 第一阶段液体流出物是第二阶段的进料。 第一级蒸汽流出物在蒸气阶段加氢处理，然后冷却以冷凝并回收至少一部分经处理的蒸气作为另外的产物液体。

公开(公告)号：US6153086A

公开(公告)日：2000-11-28

申请号：US73414

申请日：1998-05-06

Applicant: Ramesh Gupta ,  Henry Jung ,  Edward S. Ellis ,  James J. Schorfheide ,  Larry L. Iaccino

Inventor： Ramesh Gupta ,  Henry Jung ,  Edward S. Ellis ,  James J. Schorfheide ,  Larry L. Iaccino

IPC: C10G65/12 ,  C10G45/00 ,  C10G47/00 ,  C10G65/00 ,  C10G65/02 ,  C10G69/04 ,  C10G69/06

CPC classification number: C10G65/12 ,  C10G65/00 ,  C10G69/04 ,  C10G69/06 ,  C10G2300/202 ,  C10G2300/207

Abstract: A hydroprocessing process includes a cocurrent flow liquid reaction stage, a countercurrent flow liquid reaction stage and a vapor reaction stage in which feed components are catalytically hydroprocessed by reacting with hydrogen. Both liquid stages both produce a liquid and a vapor effluent, with the cocurrent stage liquid effluent the feed for the countercurrent stage and the countercurrent stage liquid effluent the hydroprocessed product liquid. Both liquid stage vapor effluents are combined and catalytically reacted with hydrogen in a vapor reaction stage, to form a hydroprocessed vapor. This vapor is cooled to condense and recover a portion of the hydroprocessed hydrocarbonaceous vapor components as additional product liquid. The uncondensed vapor is rich in hydrogen and is cleaned up if necessary, to remove contaminants, and then recycled back into the cocurrent stage as hydrogen-containing treat gas. Fresh hydrogen is introduced into the countercurrent stage and the countercurrent stage effluent contains sufficient, and preferably all of the hydrogen for the vapor stage reaction.

Abstract translation: 加氢处理方法包括并流流动液体反应阶段，逆流流动反应阶段和蒸气反应阶段，其中进料组分通过与氢反应进行催化加氢处理。 两个液相都产生液体和蒸汽流出物，并流阶段液体流出物是逆流阶段的进料和逆流阶段液体流出加氢产物液体。 两个液相蒸气流出物在蒸气反应阶段中与氢组合并催化反应，形成加氢处理的蒸汽。 将该蒸气冷却以冷凝并回收一部分加氢处理的含烃蒸汽组分作为另外的产物液体。 未冷凝的蒸汽富含氢气，如果需要，将其清除，以除去污染物，然后再循环回到并流阶段作为含氢处理气体。 将新鲜氢气引入逆流阶段，逆流阶段流出物含有足够的，优选全部用于蒸气阶段反应的氢气。

公开(公告)号：US6123830A

公开(公告)日：2000-09-26

申请号：US222863

申请日：1998-12-30

Applicant: Ramesh Gupta ,  Edward S. Ellis

Inventor： Ramesh Gupta ,  Edward S. Ellis

IPC: C10G69/04 ,  C10G69/02

CPC classification number: C10G69/04

Abstract: Disclosed is a catalytic cracking process that includes more than one catalytic cracking reaction step. The process integrates catalytic cracking steps with hydroprocessing in order to maximize olefins production, distillate quality and octane level of the overall cracked product. Preferably, one hydroprocessing step is included between the cat cracking reaction steps, and a portion of the hydroprocessed products, i.e., a naphtha and mid distillate fraction, is combined with cracked product for further separation and hydroprocessing. It is also preferred that the first catalytic cracking reaction step be a short contact time reaction step.

Abstract translation: 公开了包括多于一个催化裂化反应步骤的催化裂化方法。 该方法将催化裂化步骤与加氢处理相结合，以使烯烃的产生最大化，馏出物质量和整个裂解产物的辛烷值达到最大。 优选地，在催化裂化反应步骤和一部分加氢处理产物（即石脑油和中间馏分馏分）之间包括一个加氢处理步骤，与裂化产物结合进一步分离和加氢处理。 还优选的是，第一催化裂化反应步骤是短接触时间反应步骤。

公开(公告)号：US6036844A

公开(公告)日：2000-03-14

申请号：US73413

申请日：1998-05-06

Applicant: Ramesh Gupta ,  Henry Jung ,  Edward S. Ellis ,  Gerald E. Markley

Inventor： Ramesh Gupta ,  Henry Jung ,  Edward S. Ellis ,  Gerald E. Markley

IPC: C10G51/02 ,  C10G35/00 ,  C10G35/10 ,  C10G45/00 ,  C10G55/02 ,  C10G57/00 ,  C10G65/00 ,  C10G65/02 ,  C10G69/02

CPC classification number: C10G65/00 ,  C10G65/02

Abstract: A three stage hydroprocessing process includes two liquid and one vapor reaction stages, with a hydrogen containing vapor effluent produced in both liquid stages. The second liquid stage vapor effluent comprises part of the first liquid stage feed and the first liquid stage vapor effluent is the feed for the vapor stage. At least a portion of the hydrogen for the first liquid stage and vapor stage reactions is respectively provided by the hydrogen in the second and first liquid stage vapor effluents.

Abstract translation: 三级加氢处理方法包括两个液相和一个蒸气反应阶段，在两个液相中产生含氢气的蒸气流出物。 第二液相蒸气流出物包括第一液相进料的一部分，第一液段蒸气流出物是用于蒸气阶段的进料。 用于第一液段和蒸气阶段反应的氢的至少一部分分别由第二和第一液相蒸气流出物中的氢提供。