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公开(公告)号：US07927847B2
公开(公告)日：2011-04-19
申请号：US12429516
申请日：2009-04-24
Applicant: Robert DiCosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
Inventor： Robert DiCosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
CPC classification number: C12N9/78 , C12N9/96 , C12P7/42 , C12Y305/05001
Abstract: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.
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公开(公告)号：US07919286B2
公开(公告)日：2011-04-05
申请号：US12429543
申请日：2009-04-24
Applicant: Robert DiCosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
Inventor： Robert DiCosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
CPC classification number: C12N9/78 , C12N9/96 , C12P7/42 , C12Y305/05001
Abstract: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.
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公开(公告)号：US07871802B2
公开(公告)日：2011-01-18
申请号：US11931069
申请日：2007-10-31
Applicant: Robert DiCosimo , Anna Panova , Henry Keith Chenault , Samuel David Arthur
Inventor： Robert DiCosimo , Anna Panova , Henry Keith Chenault , Samuel David Arthur
CPC classification number: C12N9/78 , C12N9/96 , C12P7/42 , C12Y305/05001
Abstract: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.
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公开(公告)号：US07863027B2
公开(公告)日：2011-01-04
申请号：US12429526
申请日：2009-04-24
Applicant: Robert DiCosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
Inventor： Robert DiCosimo , Anna Panova , Samuel D. Arthur , Henry Keith Chenault
CPC classification number: C12N9/78 , C12N9/96 , C12P7/42 , C12Y305/05001
Abstract: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.
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公开(公告)号：US07829315B2
公开(公告)日：2010-11-09
申请号：US12538555
申请日：2009-08-10
Applicant: Robert DiCosimo , John Edward Gavagan , Mark Payne
Inventor： Robert DiCosimo , John Edward Gavagan , Mark Payne
CPC classification number: A01N37/02 , A01N37/16 , A01N37/36 , A01N59/00 , A61L2/186 , C12P7/40 , C12P7/62 , A01N63/02 , A01N2300/00
Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.
Abstract translation: 提供了从羧酸酯制备过氧羧酸的方法。 更具体地说，羧酸酯与无机过氧化物如过氧化氢在具有过水解活性的酶催化剂存在下反应。 基于保守的结构特征，本发明的过水解酶催化剂被分类为碳水化合物酯酶家族7（CE-7）的成员。 此外，提供包含通过本文所述方法生产的过酸的消毒剂制剂。
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Patent Agency Ranking
公开(公告)号：US20100240110A1
公开(公告)日：2010-09-23
申请号：US12429516
申请日：2009-04-24
Applicant: ROBERT DICOSIMO , Anna Panova , Henry Keith Chenault , Samuel David Arthur
Inventor： ROBERT DICOSIMO , Anna Panova , Henry Keith Chenault , Samuel David Arthur
IPC: C12P7/42
CPC classification number: C12N9/78 , C12N9/96 , C12P7/42 , C12Y305/05001
Abstract: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.
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公开(公告)号：US07741083B2
公开(公告)日：2010-06-22
申请号：US12189869
申请日：2008-08-12
Applicant: Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
Inventor： Robert DiCosimo , Anna Panova , Jeffery Scott Thompson , Robert D. Fallon , F. Glenn Gallagher , Thomas Foo , Xu Li , George C. Fox , Joseph J. Zaher , Mark S. Payne , Daniel P. O'Keefe
CPC classification number: C07C51/48 , C07C51/42 , C07C51/487 , C12P7/42 , C07C59/06
Abstract: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.
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公开(公告)号：US07695945B2
公开(公告)日：2010-04-13
申请号：US11930550
申请日：2007-10-31
Applicant: Robert Dicosimo , Arie Ben-Bassat
Inventor： Robert Dicosimo , Arie Ben-Bassat
CPC classification number: C12N9/78 , C12N11/06 , C12N11/10 , C12P7/42 , Y02P20/584 , Y02P20/588
Abstract: The present invention provides a process for preparing an enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid with improved retention of recovered catalyst activity in consecutive batch reactions with catalyst recycle, said process comprising pretreating the enzyme catalyst with glutaraldehyde. The glutaraldehyde-pretreated enzyme catalyst has improved specific activity when compared to non-glutaraldehyde-pretreated enzyme catalysts, and thereby, has improved overall catalyst activity and productivity.
Abstract translation: 本发明提供一种制备具有腈水解酶活性的酶催化剂的方法，所述酶催化剂具有乙醇腈水解为乙醇酸的酶催化剂，其具有在催化剂再循环的连续间歇反应中具有回收的催化剂活性的保持性，所述方法包括用戊二醛预处理酶催化剂。 与非戊二醛预处理的酶催化剂相比，戊二醛预处理的酶催化剂具有改善的比活性，从而改善了总的催化剂活性和生产率。
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公开(公告)号：US20100087528A1
公开(公告)日：2010-04-08
申请号：US12572059
申请日：2009-10-01
Applicant: Robert DiCosimo , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Richard Alan Reynolds
Inventor： Robert DiCosimo , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Richard Alan Reynolds
CPC classification number: C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
Abstract: Disclosed herein are two-component enzymatic peracid generation systems and methods of using such systems wherein the first component comprises a formulation of at least one enzyme catalyst having perhydrolysis activity, a carboxylic acid ester substrate, and a cosolvent and wherein the second component comprises a source of peroxygen in water. The two components are combined to produce an aqueous peracid formulation useful as, e.g., a disinfecting or bleaching agent. Specifically, organic cosolvents are used to control the viscosity of a substrate-containing component and to enhance the solubility of the substrate in an aqueous reaction formulation without causing substantial loss of perhydrolytic activity of the enzyme catalyst.
Abstract translation: 本文公开了双组分酶过酸生成系统和使用这种系统的方法，其中第一组分包含至少一种具有过水解活性的酶催化剂的制剂，羧酸酯底物和共溶剂，并且其中第二组分包含来源 的过氧在水中。 将两种组分组合以产生用作例如消毒剂或漂白剂的含水过酸制剂。 具体地说，使用有机共溶剂来控制含底物的组分的粘度，并提高底物在水性反应制剂中的溶解度，而不会引起酶催化剂的过水解活性的显着损失。
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公开(公告)号：US20100086621A1
公开(公告)日：2010-04-08
申请号：US12572107
申请日：2009-10-01
Applicant: Robert DiCosimo , Arie Ben-Bassat , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Mark S. Payne , Richard Alan Reynolds , Raymond Richard Zolandz
Inventor： Robert DiCosimo , Arie Ben-Bassat , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Mark S. Payne , Richard Alan Reynolds , Raymond Richard Zolandz
CPC classification number: C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
Abstract: Disclosed herein are multi-component peroxycarboxylic acid generation systems for enzymatically producing aqueous formulations of peroxycarboxylic acids suitable for use in, e.g., disinfectant and/or bleaching applications. The multi-component peroxycarboxylic acid generation systems comprise at least one carbohydrate esterase family 7 enzyme having perhydrolytic activity.
Abstract translation: 本文公开了用于酶促生产适用于例如消毒剂和/或漂白应用的过氧羧酸的水性制剂的多组分过氧羧酸生成系统。 多组分过氧羧酸生成系统包含至少一种具有过水解活性的碳水化合物酯酶家族7酶。
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