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公开(公告)号:US20140316442A1
公开(公告)日:2014-10-23
申请号:US14358136
申请日:2012-11-16
Applicant: Stichting VU-VUMC
IPC: A61B17/04
CPC classification number: A61B17/0469 , A61B2017/047 , A61B2017/0472 , F04C2270/0421
Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.
Abstract translation: 缝合装置包括在至少插入位置和针转移位置之间相对于壳体纵向移动的针操作装置。 针操作装置包括从壳体的远端延伸到壳体近端或靠近壳体近端的细长操作元件。 连接在操作元件的远端处的针保持器保持两个或更多针,其自由端朝向近端方向。 保持器在至少保护自由端的保护位置与保护装置的非保护位置之间相对于保护装置可移动。 当操作装置移动到转移位置时,在壳体的远端处的针接收装置接收自由端。 在至少插入位置中,保持器和保护装置与壳体纵向隔开以在其间接收组织。
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公开(公告)号:US12285408B2
公开(公告)日:2025-04-29
申请号:US17744502
申请日:2022-05-13
Applicant: Liverpool School of Tropical Medicine , Stichting VU
Inventor: Nicholas Casewell , Laura-Oana Albulescu , Jeroen Kool
IPC: A61K31/405 , A61K31/10 , A61K31/16 , A61P39/02
Abstract: The disclosure herein are materials and methods for the treatment of snake bite. Aspects of the disclosure includes pharmaceutical compositions, and kits, both of which may be of use in the treatment of snake bite.
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公开(公告)号:US11944701B2
公开(公告)日:2024-04-02
申请号:US17592162
申请日:2022-02-03
Applicant: STICHTING VU
Inventor: Floris Jacob Bikker , Engelmundus Cornelis Ignatius Veerman , Marianne Valentijn-Benz , Willem Van 'T Hof
IPC: A61K8/55 , A23L33/10 , A61C13/08 , A61K8/24 , A61K8/41 , A61K8/42 , A61K8/68 , A61Q11/00 , A61Q11/02
CPC classification number: A61K8/55 , A23L33/10 , A61C13/08 , A61K8/24 , A61K8/41 , A61K8/42 , A61K8/68 , A61Q11/00 , A61Q11/02 , A23V2002/00
Abstract: The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.
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公开(公告)号:US20220345600A1
公开(公告)日:2022-10-27
申请号:US17232760
申请日:2019-10-18
Applicant: Stichting VU
Abstract: An imaging system (100) comprises a multimode waveguide (Wm) configured to receive input light (Li) from a light source (20) into its proximal side (13p) and output a corresponding speckle pattern (Pn) based on the input light (Li) out of its distal side (13d) for illuminating a sample (S) to be imaged. A single-mode waveguide (Ws) is connected to the multimode waveguide (Wm) for coupling the input light (Li) from the light source (20) to the multimode waveguide (Wm). The multimode waveguide (Wm) has a relatively short length (Zm) and relatively high flexural rigidity (R) for maintaining a unique relation between the input characteristic (λ,A) of the input light (Li) into the multimode waveguide (Wm) and a spatial distribution (Ixy) of the speckle pattern (Pn). The single-mode waveguide (Ws) may be relatively long and flexible (F) for allowing movement of the short rigid multimode waveguide (Wm).
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公开(公告)号:US11035860B2
公开(公告)日:2021-06-15
申请号:US15528322
申请日:2015-11-18
Applicant: Stichting Katholieke Universiteit , Stichting VU-Vumc
IPC: C12Q1/68 , G01N33/574 , C12Q1/6886 , C07K14/71 , C12Q1/6883 , G01N33/74 , A61K39/00 , C07K16/28
Abstract: The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.
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公开(公告)号:US10710870B2
公开(公告)日:2020-07-14
申请号:US15370919
申请日:2016-12-06
Applicant: Stichting VU-VUMC , FOM-Nikhef
Inventor: Eric Hennes , Alessandro Bertolini , Johannes Franciscus Van Den Brand
IPC: G01P15/13 , G01P15/125 , B81B3/00 , G01P15/08 , G01P15/09
Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to the support structure; and, a proof mass flexibly suspended by the suspension springs; wherein at least one of the suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.
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27.
公开(公告)号:US20190265028A1
公开(公告)日:2019-08-29
申请号:US16277317
申请日:2019-02-15
Applicant: Stichting VU , Stichting Nederlandse Wetenschappelijk Onderzoek Instituten , Universiteit van Amsterdam , ASML Netherlands B.V.
Inventor: Patricius Aloysius Jacobus TINNEMANS , Vasco Tomas Tenner , Arie Jeffrey Den Boef , Hugo Augustinus Joseph Cramer , Patrick Warnaar , Grzegorz Grzela , Martin Jacobus Johan Jak
Abstract: Disclosed is a method and associated apparatus for measuring a characteristic of interest relating to a structure on a substrate. The method comprises calculating a value for the characteristic of interest directly from the effect of the characteristic of interest on at least the phase of illuminating radiation when scattered by the structure, subsequent to illuminating said structure with said illuminating radiation.
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公开(公告)号:US20190233886A1
公开(公告)日:2019-08-01
申请号:US16202474
申请日:2018-11-28
Applicant: STICHTING VU-VUmc , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Inventor: Thomas Wurdinger , Rolf Jonas Nilsson
IPC: C12Q1/6834 , C12Q1/6886
CPC classification number: C12Q1/6834 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.
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公开(公告)号:US20190094240A1
公开(公告)日:2019-03-28
申请号:US16123955
申请日:2018-09-06
Applicant: Cambridge Enterprise Limited , Stichting VU
Inventor: Sabine Bahn , Emanuel Schwarz , Brenda Penninx , Nicole Vogelzangs
IPC: G01N33/68 , G01N33/573
Abstract: The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.
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公开(公告)号:US20170252131A1
公开(公告)日:2017-09-07
申请号:US15512841
申请日:2014-09-19
Applicant: Stichting VU-VUMC
Inventor: Daniel KOOPS
Abstract: The present invention provides a kit for use for the implantation of a dental implant, comprising an implant guide comprising a proximal end and a distal end, wherein the distal end is configured to be detachably attached to a dental implant, said implant guide comprising a cylindrical body, wherein the cylindrical body comprises a cylindrical outer surface and a circumferential groove in the outer surface, and a template configured to be arranged at a predetermined location with respect to a jaw, wherein the template comprises at least one implantation channel to guide the cylindrical body of the implant guide in a desired implantation direction during implantation of a dental implant in the jaw, and a stop surface at an end of the implantation channel.The kit comprises a stop element comprising a first part and a second part, wherein the first part and the second part are configured to be movable between a first state, in which the first part and the second part are spaced at a first distance, and a second state, in which the first part and the second part are spaced at a second distance, wherein the first distance is smaller than the second distance, and wherein the first and second parts are biased to the first state, wherein the second distance is the same or larger than a distance between diametrically opposite sides of the outer surface of the implant guide, such that, before implantation, the first part and the second part can be arranged, in the second state, on diametrically opposite sides of the outer surface, and that during movement in the implantation direction of the dental implant into the jaw, the stop surface of the implantation channel will push the stop element towards the groove until the groove will allow the first and second part to move towards the first state and the stop element will be caught by the groove, therewith blocking further movement of the implant guide in the implantation direction.
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