公开(公告)号：US06298112B1

公开(公告)日：2001-10-02

申请号：US09472530

申请日：1999-12-27

Applicant: Kishore Acharya ,  Sandeep Dutta ,  Jiang Hsieh

Inventor： Kishore Acharya ,  Sandeep Dutta ,  Jiang Hsieh

IPC: A61B603

CPC classification number: A61B6/032 ,  A61B6/027 ,  A61B6/4085 ,  A61B6/548 ,  A61B6/581 ,  G06T11/005 ,  Y10S378/901

Abstract: A method for producing a base tomographic image and a subsequent tomographic image of an object using projection data acquired in a scan with a system which includes an x-ray source and a detector array which includes a plurality of detectors. The method includes applying a segmentation algorithm to the projection data to generate base image data comprising a plurality of segments; generating image data for each segment; generate subsequent image data based on image data of each segment; and communicating image data, segments, subsequent image data, or base image data to a remote facility via a network. The remote facility provides remote services.

Abstract translation: 一种使用包括X射线源和包括多个检测器的检测器阵列的系统在扫描中获取的投影数据来产生物体的基础断层图像和后续断层图像的方法。 该方法包括将分割算法应用于投影数据以产生包括多个片段的基本图像数据; 生成每个段的图像数据; 基于每个段的图像数据生成后续图像数据; 以及经由网络将图像数据，段，后续图像数据或基本图像数据传送到远程设施。 远程设施提供远程服务。

公开(公告)号：US08854355B2

公开(公告)日：2014-10-07

申请号：US12635879

申请日：2009-12-11

Applicant: John Skinner ,  Sandeep Dutta ,  Bernice E. Hoppel

Inventor： John Skinner ,  Sandeep Dutta ,  Bernice E. Hoppel

IPC: G06T15/00 ,  G06T11/00 ,  G06T11/20 ,  G06T19/00

CPC classification number: G06T11/206 ,  G06T11/008 ,  G06T19/00

Abstract: An imaging system includes a detector configured to receive data that can be reconstructed into a three-dimensional (3D) image of an object, and a computer programmed to obtain 3D image data of the object, the 3D image data including an internal structure of the object, define a longitudinal dimension of the internal structure from the 3D image data along a length of the structure, extract a first set of parameter-of-interest data related to the internal structure from the 3D image data along a first ray extending from a first location along the length of the structure and at a first angular orientation with respect to a base vector that is generally perpendicular to the longitudinal dimension, and plot the extracted first set of parameter-of-interest data at a pixel location of a two-dimensional (2D) plot that corresponds to the first location and corresponds to the first angular orientation.

Abstract translation: 成像系统包括检测器，其被配置为接收可以被重构成物体的三维（3D）图像的数据，以及被编程为获得对象的3D图像数据的计算机，3D图像数据包括内部结构 对象，沿着结构的长度从3D图像数据定义内部结构的纵向维度，沿着从3D图像数据延伸的第一射线从3D图像数据提取与内部结构相关的第一组感兴趣参数数据 沿着结构长度的第一位置和相对于大致垂直于纵向尺寸的基本向量以第一角度取向，并且将所提取的第一组感兴趣参数数据绘制在二维图像的像素位置处， 对应于第一位置并对应于第一角度取向的二维（2D）绘图。

公开(公告)号：US08542893B2

公开(公告)日：2013-09-24

申请号：US12705672

申请日：2010-02-15

Applicant: Arunabha Roy ,  Sandeep Dutta ,  Srikanth Suryanarayanan ,  Umesha Perdoor Srinivas Adiga

Inventor： Arunabha Roy ,  Sandeep Dutta ,  Srikanth Suryanarayanan ,  Umesha Perdoor Srinivas Adiga

IPC: G06K9/00

CPC classification number: G06T7/0012 ,  G06T5/008 ,  G06T7/187 ,  G06T2207/10081 ,  G06T2207/20036 ,  G06T2207/30061

Abstract: A system and method includes acquisition of a set of image data comprising a plurality of image voxels and isolation of a set of pulmonary emboli candidates from the plurality of image voxels. The system and method also includes application of a non-linear contrast enhancement to the set of pulmonary emboli candidates, filtration of the enhanced set of pulmonary emboli candidates, output of a final set of pulmonary emboli candidates, and creation of an image comprising the final set of pulmonary emboli candidates.

Abstract translation: 一种系统和方法包括获取包括多个图像体素的一组图像数据并从多个图像体素中分离一组肺栓塞候选物。 该系统和方法还包括对一组肺栓塞候选者应用非线性对比度增强，过滤增强的肺栓塞候选者组，输出最终的肺栓塞候选者，以及创建包括最终 一套肺栓塞候选人。

公开(公告)号：US08466159B2

公开(公告)日：2013-06-18

申请号：US13603022

申请日：2012-09-04

Applicant: Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

Inventor： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

IPC: A61K31/4965 ,  A61K31/33 ,  A61K31/505 ,  A61K31/47 ,  A61K31/415 ,  A61K31/40

CPC classification number: A61K38/07 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/513 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/05 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.

公开(公告)号：US08406488B2

公开(公告)日：2013-03-26

申请号：US11563025

申请日：2006-11-23

Applicant: Saad Ahmed Sirohey ,  Gopal B. Avinash ,  Sandeep Dutta ,  John V. Skinner ,  Patricia Le Nezet

Inventor： Saad Ahmed Sirohey ,  Gopal B. Avinash ,  Sandeep Dutta ,  John V. Skinner ,  Patricia Le Nezet

IPC: G06K9/00

CPC classification number: G06T7/0012 ,  G06K9/34 ,  G06K2209/05 ,  G06T7/143 ,  G06T2207/30101

Abstract: Systems, methods and apparatus are provided through which coronary plaque is classified in an image and visually displayed using an iterative adaptive process, such as an expectation maximization process.

Abstract translation: 提供了系统，方法和装置，通过该系统，方法和装置将冠状动脉斑块分类到图像中，并使用迭代自适应过程（例如期望最大化过程）进行视觉显示。

公开(公告)号：US08309910B2

公开(公告)日：2012-11-13

申请号：US12968393

申请日：2010-12-15

Applicant: Sandeep Dutta ,  Naveen Chandra ,  Toshihiro Rifu

Inventor： Sandeep Dutta ,  Naveen Chandra ,  Toshihiro Rifu

IPC: G12B13/00 ,  G01D18/00

CPC classification number: A61B6/583 ,  A61B6/032 ,  A61B6/06 ,  A61B6/4266 ,  A61B6/482

Abstract: A phantom includes a housing enclosing an interior volume and having a plurality of passages formed therein, wherein each passage is fluidly isolated from the interior volume. First and second inserts are included and configured to be positioned in a first passage of the plurality of passages and include materials having a known material density. The material is selected from iodine, hydroxyapatite (HAP), tricalcium phosphate (TCP), body fat, fatty plaque, sodium chloride (NaCl), gold (Au), and iron (Fe). The material of the inserts can be different materials or the same material at different densities.

Abstract translation: 体模包括封闭内部容积并具有形成在其中的多个通道的壳体，其中每个通道与内部容积流体隔离。 第一和第二插入件被包括并构造成定位在多个通道的第一通道中并且包括具有已知材料密度的材料。 该材料选自碘，羟基磷灰石（HAP），磷酸三钙（TCP），体脂肪，脂肪斑块，氯化钠（NaCl），金（Au）和铁（Fe）。 插入物的材料可以是不同的材料或不同密度的相同材料。

公开(公告)号：US20110229526A1

公开(公告)日：2011-09-22

申请号：US12984373

申请日：2011-01-04

Applicant: Joerg Rosenberg ,  Gerd H. Woehrle ,  Thomas Y. Kessler ,  Joerg Breitenbach ,  Salih Durak ,  Friedrich W. Richter ,  Wei Liu ,  Sandeep Dutta

Inventor： Joerg Rosenberg ,  Gerd H. Woehrle ,  Thomas Y. Kessler ,  Joerg Breitenbach ,  Salih Durak ,  Friedrich W. Richter ,  Wei Liu ,  Sandeep Dutta

IPC: A61K9/00 ,  A61K31/485 ,  A61P29/00 ,  A61P25/04

CPC classification number: A61K9/28 ,  A61K9/0053 ,  A61K9/209 ,  A61K31/167 ,  A61K31/192 ,  A61K31/485 ,  A61K2300/00

Abstract: The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

Abstract translation: 本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。 这些制剂减少了滥用的可能性。 在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。 更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。 在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。 本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

公开(公告)号：US07957574B2

公开(公告)日：2011-06-07

申请号：US11603490

申请日：2006-11-22

Applicant: Saad Ahmed Sirohey ,  Gopal B. Avinash ,  John V. Skinner ,  Sandeep Dutta ,  Patricia Le Nezet ,  Deann Marie Haas

Inventor： Saad Ahmed Sirohey ,  Gopal B. Avinash ,  John V. Skinner ,  Sandeep Dutta ,  Patricia Le Nezet ,  Deann Marie Haas

IPC: G06K9/00

CPC classification number: G06T7/0012 ,  G06T7/62 ,  G06T2207/10116 ,  G06T2207/30048 ,  G06T2207/30101

Abstract: A method for generating a score for soft plaque in coronary arteries includes using the computer to estimate the soft plaque content within at least one object depicted in a medical image, using the computer to determine a plaque score dependent upon the estimated soft plaque content of the at least one object, and using the computer to report the plaque score.

Abstract translation: 用于在冠状动脉中产生软斑块得分的方法包括使用该计算机估计在医学图像中描绘的至少一个物体内的软斑块含量，使用计算机来确定取决于所估计的软斑块含量的斑块得分 至少一个对象，并使用电脑报告斑块得分。

公开(公告)号：US07940974B2

公开(公告)日：2011-05-10

申请号：US11602909

申请日：2006-11-21

Applicant: John V. Skinner ,  Gopal B. Avinash ,  Patricia Le Nezet ,  Sandeep Dutta ,  Saad Ahmed Sirohey ,  Deann Marie Haas

Inventor： John V. Skinner ,  Gopal B. Avinash ,  Patricia Le Nezet ,  Sandeep Dutta ,  Saad Ahmed Sirohey ,  Deann Marie Haas

IPC: G06K9/00

CPC classification number: G06K9/34 ,  G06T7/12 ,  G06T2207/10081 ,  G06T2207/20096 ,  G06T2207/30101

Abstract: Method and system for processing an object within a diagnostic image comprises segmenting a three dimensional (3D) object within a diagnostic image. A contour of the object is fitted with a 3D mesh comprising splines in at least first and second directions. The splines provide a plurality of editable control points, and the splines in the first direction intersect with the splines in the second direction at intersection points. A position of at least one control point on the 3D mesh is adjusted based on a user input.

Abstract translation: 用于处理诊断图像内的对象的方法和系统包括分割诊断图像内的三维（3D）对象。 对象的轮廓装配有至少在第一和第二方向上包括花键的3D网格。 花键提供多个可编辑的控制点，并且第一方向上的花键在交叉点处与第二方向上的花键相交。 基于用户输入来调整3D网格上至少一个控制点的位置。

公开(公告)号：US20100054554A1

公开(公告)日：2010-03-04

申请号：US12198492

申请日：2008-08-26

Applicant: Sandeep Dutta ,  Beth Heckel ,  Maria-Magdalena Nay ,  Sardar Gautham

Inventor： Sandeep Dutta ,  Beth Heckel ,  Maria-Magdalena Nay ,  Sardar Gautham

IPC: G06K9/62

CPC classification number: G06T19/00 ,  G06T2210/41 ,  G06T2219/008 ,  G06T2219/028

Abstract: A system and method for analyzing three-dimensional image data are disclosed herein. The system includes a processor configured to generate an overview image of at least a portion of a patient. The processor is configured to generate a cross-sectional image including a cross-sectional view of the overview image. The processor is also configured to generate a statistical image showing a parameter value relating to the portion of the patient shown in the overview image. The system also includes a visual output device connected to the processor. The visual output device is configured to display the overview image, the cross-sectional image, and the statistical image generally simultaneously. Also, the overview image, the cross-sectional image, and the statistical image are interconnected such that an update, change, or input applied to any one of the images results in an update to one or more of the other images.

Abstract translation: 本文公开了一种用于分析三维图像数据的系统和方法。 该系统包括被配置为生成患者的至少一部分的概览图像的处理器。 处理器被配置为生成包括概览图像的横截面图的横截面图像。 处理器还被配置为生成显示与概览图像中显示的患者部分相关的参数值的统计图像。 该系统还包括连接到处理器的视觉输出设备。 视觉输出设备被配置为一般同时显示概览图像，横截面图像和统计图像。 此外，概览图像，横截面图像和统计图像被互连，使得应用于任何一个图像的更新，改变或输入导致对一个或多个其他图像的更新。