公开(公告)号：US20060041256A1

公开(公告)日：2006-02-23

申请号：US11254951

申请日：2005-10-20

Applicant: Stuart Edwards ,  David Utley

Inventor： Stuart Edwards ,  David Utley

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00553

Abstract: A method of forming a composite lesion pattern in a tissue region at or near a sphincter comprising providing a catheter having a plurality of energy delivery devices coupled to the catheter. The catheter is introduced at least partially into the sphincter. Energy is delivered from the energy delivery devices to produce the composite lesion pattern. The composite lesion pattern comprises a radial distribution of lesions about the tissue region and a longitudinal distribution of lesions along the tissue region.

Abstract translation: 在括约肌处或附近在组织区域中形成复合损伤图案的方法，包括提供具有耦合到导管的多个能量输送装置的导管。 将导管至少部分地引入括约肌。 能量从能量输送装置输送以产生复合损伤模式。 复合损伤图案包括围绕组织区域的损伤的径向分布和沿着组织区域的损伤的纵向分布。

公开(公告)号：US20050245926A1

公开(公告)日：2005-11-03

申请号：US11175471

申请日：2005-07-06

Applicant: Stuart Edwards ,  David Utley ,  Ronald Lax ,  Theodore Kucklick ,  Peter Muller

Inventor： Stuart Edwards ,  David Utley ,  Ronald Lax ,  Theodore Kucklick ,  Peter Muller

IPC: A61B18/00 ,  A61B18/14

CPC classification number: A61B18/14 ,  A61B17/32 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00916 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1472 ,  A61B2018/183 ,  A61B2090/3614 ,  A61B2090/3782

Abstract: A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.

Abstract translation: 括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。 引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。 能量输送装置联接到引入构件。 保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。

公开(公告)号：US20050203503A1

公开(公告)日：2005-09-15

申请号：US11034503

申请日：2005-01-12

Applicant: Stuart Edwards ,  James Baker ,  Hugh Sharkey ,  Ronald Lax

Inventor： Stuart Edwards ,  James Baker ,  Hugh Sharkey ,  Ronald Lax

IPC: A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18 ,  A61B18/22 ,  A61M3/02 ,  A61M25/00 ,  A61N1/40 ,  A61N5/04 ,  C22C1/04 ,  C22C14/00 ,  C22F1/18

Abstract: An infusion array ablation apparatus includes an elongated delivery device having a lumen and an infusion array positionable in the lumen. The infusion array includes an RF electrode and at least a first and a second infusion member. Each infusion member has a tissue piercing distal portion and an infusion lumen. At least one of the first or second infusion members is positionable in the elongated delivery device in a compacted state and deployable from the elongated delivery device with curvature in a deployed state. Also, at least one of the first or second infusion members exhibits a changing direction of travel when advanced from the elongated delivery device to a selected tissue site. At least one infusion port is coupled to one of the elongated delivery device, the infusion array, the first infusion member or the second infusion member.

Abstract translation: 输液阵列消融装置包括细长递送装置，其具有可定位在内腔中的内腔和输液排列。 输注阵列包括RF电极和至少第一和第二输注构件。 每个输注构件具有组织穿刺远端部分和输注腔。 第一或第二输注构件中的至少一个可以处于压实状态的细长输送装置中定位并且可以从伸长的输送装置以部署状态的曲率展开。 此外，第一或第二输注构件中的至少一个表现出当从细长递送装置前进到选定的组织部位时改变的行进方向。 至少一个输注端口连接到细长递送装置，输注阵列，第一输注构件或第二输注构件中的一个。

公开(公告)号：US20050183732A1

公开(公告)日：2005-08-25

申请号：US11043902

申请日：2005-01-26

Applicant: Stuart Edwards

Inventor： Stuart Edwards

IPC: A61B18/00 ,  A61B18/14 ,  A61F2/958 ,  A61F5/00 ,  A61N1/06 ,  A61N1/36 ,  A61B19/00 ,  A61B18/18

CPC classification number: A61F5/0026 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00238 ,  A61B2018/00261 ,  A61B2018/00482 ,  A61B2018/00654 ,  A61B2018/00797 ,  A61B2018/1467 ,  A61B2218/002 ,  A61B2218/007 ,  A61M25/1011 ,  A61M2025/105 ,  A61M2210/1053 ,  A61N1/0509 ,  A61N1/06 ,  A61N1/36007 ,  A61N1/36014

Abstract: This invention provides a method and system for the curative treatment of obesity. A first aspect of this invention is that it enables identification of the nerves responsible for the relaxation of the stomach muscles that occurs prior to and during eating. A second aspect of the invention is that it allows the physician to identify focal nerve sites in the stomach and upper duodenum that are associated with producing sensations of hunger and satiety. Nervous transmission from these sites can be modulated or blocked all together so as to minimize the sensation of hunger. A third aspect of this invention is that allows a physician to shrink selected portions of the innermost oblique muscle and middle circular muscle layers of the stomach. This can be performed in a physician's office using local anesthesia. Shrinkage of these muscles produces a feeling of satiety that enhances the patient's efforts to restrict his caloric intake.

Abstract translation: 本发明提供了治疗肥胖症的方法和系统。 本发明的第一方面是能够识别在进食之前和期间发生的负责放松胃肌肉的神经。 本发明的第二方面是其允许医师识别与产生饥饿感和饱腹感相关的胃和上十二指肠中的局灶性神经部位。 这些地点的神经传播可以一起被调制或阻挡，以便最大限度地减少饥饿感。 本发明的第三方面是允许医师收缩胃的最内倾斜肌肉和中间圆形肌肉层的选定部分。 这可以在医生办公室使用局部麻醉进行。 这些肌肉的收缩会产生饱腹感，从而增强患者的限制热量摄取的努力。

公开(公告)号：US06464697B1

公开(公告)日：2002-10-15

申请号：US09304737

申请日：1999-05-04

Applicant: Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Chin

Inventor： Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Chin

IPC: A61B1818

CPC classification number: A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Systems and methods treat a tissue region. In one arrangement, the systems and methods deploy an electrode on a support structure in a tissue region at or near the cardia of the stomach. The support structure has a proximal region and a distal region. The proximal region is enlarged in comparison to the distal region, and the electrode is carried by the enlarged proximal surface. The systems and methods advance the electrode in a path to penetrate the tissue region and couple the electrode to a source of radio frequency energy to ohmically heat tissue and create a lesion in the tissue region. In another arrangement, the systems and methods treat abnormal epithelium tissue at or near the lower esophageal sphincter by bringing an array of surface electrodes into contact with abnormal epithelium tissue. The systems and methods couple the surface electrodes to a source of radio frequency energy to ohmically heat tissue and cause necrosis of the abnormal epithelium tissue.

Abstract translation: 系统和方法处理组织区域。 在一种布置中，系统和方法将电极部署在胃贲门处或附近的组织区域中的支撑结构上。 支撑结构具有近端区域和远侧区域。 近端区域与远侧区域相比放大，并且电极由扩大的近侧表面承载。 系统和方法使电极在路径中前进以穿透组织区域并将电极耦合到射频能量源以欧姆加热组织并在组织区域中产生损伤。 在另一种布置中，系统和方法通过使表面电极阵列与异常上皮组织接触来治疗食管下括约肌或其附近的异常上皮组织。 系统和方法将表面电极耦合到射频能量源以欧姆加热组织并引起异常上皮组织的坏死。

公开(公告)号：US06355031B1

公开(公告)日：2002-03-12

申请号：US09304733

申请日：1999-05-04

Applicant: Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

Inventor： Stuart Edwards ,  John Gaiser ,  David S Utley ,  Scott West ,  Jay Qin

IPC: A61B1818

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Multiple electrodes are coupled together in monopolar or bipolar arrays to form lesion patterns in tissue regions at or near a sphincter. A controller couples the electrodes to a generator so that a single power channel serves more than a single electrode.

Abstract translation: 多个电极以单极或双极阵列耦合在一起，以在括约肌处或附近的组织区域中形成病变图案。 控制器将电极耦合到发生器，使得单个功率通道服务于单个电极。

公开(公告)号：US06325798B1

公开(公告)日：2001-12-04

申请号：US09304743

申请日：1999-05-04

Applicant: Stuart Edwards ,  John Gaiser ,  David Utley ,  Scott West ,  Jay Chin ,  Ronald Lax

Inventor： Stuart Edwards ,  John Gaiser ,  David Utley ,  Scott West ,  Jay Chin ,  Ronald Lax

IPC: A61B1818

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2017/22067 ,  A61B2017/308 ,  A61B2017/3488 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/036 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Systems and methods treat a tissue region at or near a sphincter by deploying a carrier, which carries an electrode that can be advanced to penetrate tissue. Negative pressure is applied through a suction port on the carrier near the electrode, to draw tissue in the tissue region inward against the carrier. The systems and methods advance the electrode to penetrate tissue drawn against the carrier. The vacuum anchors the surrounding tissue and mediates against the “tenting” of tissue during electrode penetration. Without tenting, the electrode penetrates mucosal tissue fully, to obtain a desired depth of penetration.

Abstract translation: 系统和方法通过展开携带可以被推进穿透组织的电极的载体来处理括约肌处或附近的组织区域。 通过电极附近的载体上的吸入口施加负压，将组织区域中的组织向内抵靠载体。 这些系统和方法使电极移动以穿透抵靠载体的组织。 真空锚定周围的组织，并在电极穿透期间抵抗组织的“隆起”进行介导。 没有隆起，电极完全渗透粘膜组织，以获得所需的穿透深度。

公开(公告)号：US1222337A

公开(公告)日：1917-04-10

申请号：US1914830575

申请日：1914-04-09

Applicant: STUART EDWARDS B

Inventor： STUART EDWARDS B

CPC classification number: B65G65/00

公开(公告)号：US20070112340A1

公开(公告)日：2007-05-17

申请号：US11431213

申请日：2006-05-10

Applicant: Simon Thomas ,  Peter Edelstein ,  John To ,  Benjamin Nordell ,  Stuart Edwards

Inventor： Simon Thomas ,  Peter Edelstein ,  John To ,  Benjamin Nordell ,  Stuart Edwards

IPC: A61B18/04

CPC classification number: A61B18/00 ,  A61B17/0625 ,  A61B18/02 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2017/00805 ,  A61B2017/00867 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00178 ,  A61B2018/00285 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00916 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2218/007 ,  A61N1/06 ,  A61N7/022 ,  C08L2201/12

Abstract: Apparatus and methods are provided for treating female urinary incontinence by applying a form of energy to tissue in the vicinity of the urethra and/or bladder outlet to change tissue compliance without substantially narrowing the urethral and/or bladder outlet lumen. The apparatus comprises an elongated shaft having a means for treating urethral tissue and an expandable member deployable distal of the means for treating. The expandable member is configured to be anchored against the bladder outlet to dispose the means for treating at a desired treatment site in the urethra using only tactile feedback. The means for treating may include a needleless RF electrode, an ultrasound transducer, or a cryogenic probe configured to be advanced through a hollow needle, each of which are designed to reduce or eliminate symptoms associated with urinary incontinence.

Abstract translation: 提供了用于通过向尿道和/或膀胱出口附近的组织施加能量来改变组织依从性而不使尿道和/或膀胱出口腔基本上变窄来治疗女性尿失禁的装置和方法。 该装置包括细长轴，其具有用于治疗尿道组织的装置和可展开装置的可扩展构件。 可膨胀构件被构造成锚固在膀胱出口上，以仅使用触觉反馈来将用于治疗的装置设置在尿道中的期望的治疗部位。 用于治疗的装置可以包括无针RF电极，超声换能器或构造成通过中空针前进的低温探针，每个都被设计为减少或消除与尿失禁相关的症状。

公开(公告)号：US20060259029A1

公开(公告)日：2006-11-16

申请号：US11420714

申请日：2006-05-26

Applicant: David Utley ,  John Gaiser ,  Stuart Edwards ,  Scott West ,  Jay Qin

Inventor： David Utley ,  John Gaiser ,  Stuart Edwards ,  Scott West ,  Jay Qin

IPC: A61B18/18

CPC classification number: A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/0066 ,  A61B2018/00702 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002 ,  A61B2218/007

Abstract: Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting an operative element into an alimentary canal such that the proximate to a portion of the alimentary canal having tissue to be ablated; and (ii) using the operative element to apply cryogenic ablation to a site of abnormal tissue.

Abstract translation: 提供了在消化道中获取和消融异常上皮组织的方法。 所述方法可以包括以下步骤：（i）将操作元件插入消化道，使得靠近消化道的一部分具有要消融的组织; 和（ii）使用手术元件将低温消融应用于异常组织的部位。