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公开(公告)号：US20180194856A1
公开(公告)日：2018-07-12
申请号：US15741590
申请日：2016-07-06
Applicant: UCB Biopharma SPRL
Inventor： Robert Anthony GRIFFIN , David Paul HUMPHREYS , Shirley Jane PETERS
CPC classification number: C07K16/32 , A61P35/00 , C07K16/2887 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/64 , C07K2317/734 , C07K2317/76 , C07K2317/94 , C07K2319/00
Abstract: The invention relates to fusion proteins which bind to human Fc-receptors. The fusion proteins are initially produced as monomers, and are capable of assembly into multimers at a target site of interest. The invention also relates to therapeutic compositions comprising the fusion proteins, and their widespread use in the treatment of diseases.
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公开(公告)号：US20180172701A1
公开(公告)日：2018-06-21
申请号：US15736558
申请日：2015-10-22
Applicant: UCB Biopharma SPRL , SANOFI
Inventor： James Philip O'CONNELL , John Robert PORTER , Alastair LAWSON , Tracy Lynn ARAKAKI , Daniel John LIGHTWOOD , Rebecca Jayne WOOTTON
IPC: G01N33/68 , C07D401/14 , C07D239/26 , C07D235/04 , C07D213/72 , C07K14/525 , C07K14/705 , C07K16/24 , C07D471/04
CPC classification number: G01N33/6845 , A61K47/6425 , A61P35/00 , A61P37/00 , C07D213/72 , C07D235/04 , C07D239/26 , C07D401/14 , C07D471/00 , C07D471/04 , C07K14/525 , C07K14/70575 , C07K16/241 , C07K2317/55 , C07K2317/92 , G01N33/6854 , G01N33/6863 , G01N2333/525 , G01N2500/02
Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
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公开(公告)号：US20180134774A1
公开(公告)日：2018-05-17
申请号：US15795874
申请日：2017-10-27
Applicant: UCB Biopharma SPRL
Inventor： Ralph ADAMS , Pallavi BHATTA , Sam Philip HEYWOOD , David Paul HUMPHREYS
CPC classification number: C07K16/18 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/624 , C07K2317/92
Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.
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公开(公告)号：US09969729B2
公开(公告)日：2018-05-15
申请号：US15100915
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437
Abstract: A series of substituted 1H imidazo[4,5-b]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09957320B2
公开(公告)日：2018-05-01
申请号：US15180916
申请日：2016-06-13
Applicant: UCB BIOPHARMA SPRL
Inventor： Neil Gozzard , Alastair David Griffiths Lawson , Daniel John Lightwood , Roger Thomas Palframan , Bryan John Smith , Kerry Louise Tyson
IPC: C07K16/24 , A61K39/395 , A61K9/00 , A61K39/00
CPC classification number: C07K16/244 , A61K9/0078 , A61K39/395 , A61K39/3955 , A61K2039/505 , A61K2039/544 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing antibody molecules.
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Patent Agency Ranking
公开(公告)号：US20180100007A1
公开(公告)日：2018-04-12
申请号：US15566231
申请日：2016-04-20
Applicant: UCB BIOPHARMA SPRL
Inventor： SAM PHILIP HEYWOOD , GAVIN BARRY WILD
CPC classification number: C07K16/065 , C07K1/22 , C07K16/18 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/62 , C07K2317/622 , C07K2317/624
Abstract: The present invention provides a method for recovering a human VH3 domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human VH3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.
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公开(公告)号：US20180028652A1
公开(公告)日：2018-02-01
申请号：US15549528
申请日：2016-02-05
Applicant: UCB Biopharma SPRL
Inventor： Michael Joseph Edouard BOONEN , Claude PEERBOOM
IPC: A61K39/395 , A61K47/12 , A61K47/26 , C07K16/28 , A61K47/18
CPC classification number: A61K39/39591 , A61K9/0019 , A61K9/08 , A61K47/12 , A61K47/183 , A61K47/26 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
Abstract: The current invention relates to a new pharmaceutical formulation, in particular to a pharmaceutical formulation comprising a protein, more particularly an antibody as an active ingredient.
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公开(公告)号：US20180022748A1
公开(公告)日：2018-01-25
申请号：US15547980
申请日：2016-01-29
Applicant: UCB Biopharma SPRL
Inventor： Joel Mercier , Laurent Provins , Celine Vermeiren , Yogesh Anil Sabnis
IPC: C07D471/14 , A61K51/04 , C07B59/00
CPC classification number: C07D471/14 , A61K51/0455 , A61K51/0459 , A61K51/0463 , C07B59/002 , C07B2200/05
Abstract: The invention relates to 9H-pyrrolo-dipyridine derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of Tau aggregates.
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公开(公告)号：US09868749B2
公开(公告)日：2018-01-16
申请号：US15100825
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
Inventor： Rikki Peter Alexander , Jonathan Mark Bentley , Gareth Neil Brace , Daniel Christopher Brookings , Prafulkumar Tulshibhai Chovatia , Hervé Jean Claude Deboves , Craig Johnstone , Elizabeth Pearl Jones , Boris Kroeplien , Fabien Claude Lecomte , James Madden , Craig Miller , John Robert Porter , Matthew Duncan Selby , Michael Alan Shaw , Darshan Gunvant Vaidya , Ian Andrew Yule
IPC: C07D519/00 , C07D471/04 , A61K31/4355 , A61K31/4709 , A61K31/538 , A61K31/5383
CPC classification number: C07D519/00 , A61K31/4355 , A61K31/4709 , A61K31/538 , A61K31/5383 , C07D471/04
Abstract: A series of substituted benzimidazole, imidazo[1,2-a]pyridine and pyrazolo[1,5-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09850240B2
公开(公告)日：2017-12-26
申请号：US15101044
申请日：2014-12-08
Applicant: UCB BIOPHARMA SPRL
IPC: C07D471/04 , A61K31/506 , A61K31/437 , A61K31/5377
CPC classification number: C07D471/04 , A61K31/437 , A61K31/506 , A61K31/5377
Abstract: A series of substituted [1,2,4]triazolo[4,3-a]pyridine derivatives, being potent modulators of human TNF activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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