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21.发明授权Method of treating psoriasis by administering IL-22 antibodies, or binding fragments thereof 失效通过施用IL-22抗体或其结合片段治疗牛皮癣的方法公开(公告)号：US07951372B1
公开(公告)日：2011-05-31
申请号：US11896363
申请日：2007-08-31
Applicant: Kenneth Jacobs , Debra D. Pittman , Lynette Fouser , Vikki Spaulding , Dejun Xuan
Inventor： Kenneth Jacobs , Debra D. Pittman , Lynette Fouser , Vikki Spaulding , Dejun Xuan
IPC: A61K39/395 , A61K39/00
CPC classification number: C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
Abstract: Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
Abstract translation: 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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公开(公告)号：US20090232809A1
公开(公告)日：2009-09-17
申请号：US12232542
申请日：2008-09-18
Applicant: Wei Liu , Lynette Fouser , Vikki Spaulding
Inventor： Wei Liu , Lynette Fouser , Vikki Spaulding
IPC: A61K39/395 , C12N15/11 , C12N15/00 , C12N5/00 , C07K14/00 , A61K38/16 , C07K16/18 , C12Q1/68 , G01N33/53
CPC classification number: C07K14/7155 , A61K38/00 , C07K14/7158 , C07K2319/00
Abstract: The present invention provides novel isolated CRF2-13 polynucleotides and polypeptides encoded by the CRF2-13 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-13 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the CRF2-13 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-13 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
Abstract translation: 本发明提供了由CRF2-13多核苷酸编码的新型分离的CRF2-13多核苷酸和多肽。 还提供免疫特异性结合CRF2-13多肽或CRF2-13多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。 本发明还提供了其中CRF2-13多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US07307161B1
公开(公告)日：2007-12-11
申请号：US09561811
申请日：2000-04-28
Applicant: Kenneth Jacobs , Lynette Fouser , Vikki Spaulding , Dejun Xuan
Inventor： Kenneth Jacobs , Lynette Fouser , Vikki Spaulding , Dejun Xuan
CPC classification number: C07K14/5428 , A61K38/00 , A61K2039/505
Abstract: Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.
Abstract translation: 公开了与白细胞介素-10（IL-10）高度同源的新型人GIL-19 / AE289蛋白。 编码这种蛋白质的多核苷酸也被封闭。
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公开(公告)号：US07279559B2
公开(公告)日：2007-10-09
申请号：US10256977
申请日：2002-09-27
Applicant: Kenneth Jacobs , Debra D. Pittman , Lynette Fouser , Vikki Spaulding , Dejun Xuan
Inventor： Kenneth Jacobs , Debra D. Pittman , Lynette Fouser , Vikki Spaulding , Dejun Xuan
CPC classification number: C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
Abstract: Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
Abstract translation: 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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公开(公告)号：US20050238648A1
公开(公告)日：2005-10-27
申请号：US11157387
申请日：2005-06-20
Applicant: Kenneth Jacobs , Debra Pittman , Lynette Fouser , Vikki Spaulding , Dejun Xuan
Inventor： Kenneth Jacobs , Debra Pittman , Lynette Fouser , Vikki Spaulding , Dejun Xuan
IPC: A61K38/00 , A61K38/20 , C07K14/54 , C07K16/24 , A61K39/395
CPC classification number: C07K16/244 , A61K38/20 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/76 , C12N2799/022 , A61K2300/00
Abstract: Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.
Abstract translation: 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎症性疾病。
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Patent Agency Ranking
26.发明申请公开(公告)号：US20050153400A1
公开(公告)日：2005-07-14
申请号：US11013741
申请日：2004-12-17
Applicant: Kenneth Jacobs , Lynette Fouser , Vikki Spaulding , Dejun Xuan
Inventor： Kenneth Jacobs , Lynette Fouser , Vikki Spaulding , Dejun Xuan
CPC classification number: C07K14/5428 , A61K38/00 , A61K2039/505
Abstract: Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.
Abstract translation: 公开了与白细胞介素-10（IL-10）高度同源的新型人GIL-19 / AE289蛋白。 编码这种蛋白质的多核苷酸也被封闭。
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公开(公告)号：US5969125A
公开(公告)日：1999-10-19
申请号：US721924
申请日：1996-09-27
Applicant: Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding
Inventor： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding
IPC: C12N15/09 , A61K38/00 , A61K48/00 , A61P3/02 , A61P7/02 , A61P7/08 , A61P35/00 , A61P37/00 , C07K14/47 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/10
CPC classification number: C07K14/47 , Y10S530/85 , Y10S530/851
Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
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公开(公告)号：US5965397A
公开(公告)日：1999-10-12
申请号：US14969
申请日：1998-01-28
Applicant: Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
Inventor： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding , Michael J. Agostino
IPC: C12N15/09 , A61K38/00 , A61K48/00 , A61P3/04 , A61P7/00 , A61P7/02 , A61P15/08 , A61P17/02 , A61P19/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , C07K14/47 , C12N5/10 , C12N15/12 , C12N15/00
CPC classification number: C07K14/47
Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
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公开(公告)号：US5837490A
公开(公告)日：1998-11-17
申请号：US739775
申请日：1996-10-30
Applicant: Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding
Inventor： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Racie , David Merberg , Maurice Treacy , Vikki Spaulding
IPC: C12N15/09 , A61K38/00 , A61K48/00 , A61P7/02 , A61P7/04 , A61P7/08 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/47 , C07K14/52 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12N15/00
Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
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30.发明授权Human GIL-19/AE289 polynucleotides and methods of producing the encoded polypeptides 失效人GIL-19 / AE289多核苷酸和产生编码多肽的方法公开(公告)号：US07585646B2
公开(公告)日：2009-09-08
申请号：US11013920
申请日：2004-12-17
Applicant: Kenneth Jacobs , Lynette Fouser , Vikki Spaulding , Dejun Xuan
Inventor： Kenneth Jacobs , Lynette Fouser , Vikki Spaulding , Dejun Xuan
CPC classification number: C07K14/5428 , A61K38/00 , A61K2039/505
Abstract: Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.
Abstract translation: 公开了与白细胞介素-10（IL-10）高度同源的新型人GIL-19 / AE289蛋白。 编码这种蛋白质的多核苷酸也被封闭。
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