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公开(公告)号：US20250161281A1
公开(公告)日：2025-05-22
申请号：US18832691
申请日：2023-01-23
Applicant: BIOGEN MA INC.
Inventor： Felix Gonzalez Lopez de Turiso , Martin Himmelbauer , Zhili Xin , Nupur Bansal , TeYu Chen , John Howard Jones , Edward Yin Shiang Lin
IPC: A61K31/439 , C07D451/04
Abstract: Provided are compounds of the Formula (I): (I), or pharmaceutically acceptable salts thereof, which are useful for the inhibition of EBP and in the treatment of a variety of EBP mediated conditions or diseases, such as multiple sclerosis.
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公开(公告)号：US12180205B2
公开(公告)日：2024-12-31
申请号：US17276502
申请日：2019-09-18
Applicant: BIOGEN MA INC.
Inventor： Nathan Genung , Kevin M. Guckian , Jeffrey Vessels , Lei Zhang , Ryan Gianatassio , Edward Yin Shiang Lin , Zhili Xin
IPC: C07D417/14 , A61P25/28 , C07D417/06
Abstract: Described herein are compounds represented by formulas (IA) or (IB) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R1, R3, R4, Y1, Y2, Ar, Z and n are as defined herein.
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公开(公告)号：US11999715B2
公开(公告)日：2024-06-04
申请号：US17267631
申请日：2019-08-13
Applicant: BIOGEN MA INC.
Inventor： Felix Gonzalez Lopez de Turiso , Zhili Xin , Martin Himmelbauer , John H. Jones
IPC: C07D401/14 , C07D405/14
CPC classification number: C07D401/14 , C07D405/14
Abstract: Provided are compounds of Formula (I): Formula (I), including compounds of Formulas (II), (III), (IV), (V) and (VI), wherein X, R1, R2, R3, R4 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).
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公开(公告)号：US20240109867A1
公开(公告)日：2024-04-04
申请号：US18377125
申请日：2023-10-05
Applicant: BIOGEN MA INC.
Inventor： Felix Gonzalez Lopez de Turiso , Michael Dechantsreiter , Zhili Xin , John H. Jones , Martin Himmelbauer
IPC: C07D401/14
CPC classification number: C07D401/14
Abstract: Provided are compounds of Formula (I):
including compounds of Formulas (II), (III) and (IV), wherein X, R1, R2, R3 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).-
公开(公告)号：US20230117898A1
公开(公告)日：2023-04-20
申请号：US17894461
申请日：2022-08-24
Applicant: BIOGEN MA INC.
Inventor： Nathan Genung , Kevin M. Guckian , Jeffrey Vessels , Lei Zhang , Ryan Gianatassio , Edward Yin Shiang Lin , Zhili Xin
IPC: C07D417/14 , C07D417/06 , C07D471/04
Abstract: Described herein are compounds represented by formula (I″) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, Ra, Rb, m, n, Y, Y2, R3 and R4 are defined herein.
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Patent Agency Ranking
公开(公告)号：US20220106305A1
公开(公告)日：2022-04-07
申请号：US17428323
申请日：2020-02-03
Applicant: BIOGEN MA INC.
Inventor： Nathan Genung , Kevin M. Guckian , Jeffrey Vessels , Lei Zhang , Ryan Gianatassio , Edward Yin Shiang Lin , Zhili Xin
IPC: C07D417/14 , C07D495/04 , C07D487/04 , C07D491/048 , C07D471/04
Abstract: Described herein are compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R4, Y1, Y2, n and p are as defined herein.
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公开(公告)号：US20220017506A1
公开(公告)日：2022-01-20
申请号：US17311232
申请日：2019-12-04
Applicant: BIOGEN MA INC.
Inventor： Nathan Genung , Kevin M. Guckian , Jeffrey Vessels , Lei Zhang , Ryan Gianatassio , Edward Yin Shiang Lin , Zhili Xin
IPC: C07D417/12 , C07D417/14
Abstract: Described herein are compounds represented by formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R4, Y1, Y2, m, n, and p are as defined herein.
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公开(公告)号：US09771326B2
公开(公告)日：2017-09-26
申请号：US14443944
申请日：2013-11-20
Applicant: BIOGEN MA INC.
Inventor： Hairuo Peng , Zhili Xin , Lihong Sun , Timothy Chan , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07D211/62 , C07D401/10 , C07D237/14 , C07D215/14 , C07D401/04 , C07D239/34 , C07D417/04 , C07D417/06 , C07C229/14 , C07D249/06 , C07C229/48 , C07C229/50 , C07D487/04 , C07D205/04 , C07D207/16 , C07D277/28 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06
CPC classification number: C07D211/62 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06 , C07B2200/07 , C07C229/14 , C07C229/48 , C07C229/50 , C07C2601/14 , C07C2602/44 , C07D205/04 , C07D207/16 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , C07D215/14 , C07D237/14 , C07D239/34 , C07D249/06 , C07D277/28 , C07D401/04 , C07D401/10 , C07D417/04 , C07D417/06 , C07D487/04
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US20170174710A1
公开(公告)日：2017-06-22
申请号：US15368454
申请日：2016-12-02
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Zhili Xin , Lei Zhang
IPC: C07F7/08 , C07C229/50 , A61K31/196 , C07D215/12 , A61K31/47 , C07D401/04 , A61K31/4545 , A61K31/506 , C07D295/096 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D239/42 , C07D241/20 , A61K31/497 , C07D211/14 , A61K31/451 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/4709 , C07D491/107 , C07D209/52 , A61K31/403 , C07D451/02 , A61K31/439 , A61K31/695 , C07C233/60 , C07D215/38 , C07D451/14 , A61K45/06
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US09555050B2
公开(公告)日：2017-01-31
申请号：US14417353
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D215/20 , A61K31/662 , A61K45/06 , C07D401/04 , C07D401/06 , C07C229/48 , C07D265/30 , C07D211/34 , C07D211/62 , C07D213/79 , C07D223/06 , C07C233/47 , C07D205/04 , C07D207/08 , C07D207/16 , C07C229/46 , C07F9/38 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , C07D213/80
CPC classification number: A61K31/662 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C229/46 , C07C229/48 , C07C233/47 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/26 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07D213/79 , C07D213/80 , C07D215/20 , C07D223/06 , C07D265/30 , C07D401/04 , C07D401/06 , C07F9/38 , C07F9/3808
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可调节自分泌素（ATX）的活性。
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