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    MOLECULARLY IMPRINTED POLYMERS HAVING AFFINITY FOR NATRIURETIC PEPTIDES
    21.
    发明申请
    MOLECULARLY IMPRINTED POLYMERS HAVING AFFINITY FOR NATRIURETIC PEPTIDES 有权
    具有自由基亲和力的分子印迹聚合物

    公开(公告)号：US20130330384A1

    公开(公告)日：2013-12-12

    申请号：US14000326

    申请日：2012-02-24

    Applicant: Subhra Mohapatra ,  Chunyan Wang

    Inventor： Subhra Mohapatra ,  Chunyan Wang

    IPC: C08F220/06

    CPC classification number: C08F220/06 ,  A61K38/00 ,  B82Y5/00 ,  C07K14/58 ,  G01N33/74 ,  G01N2333/58 ,  G01N2600/00 ,  Y10T428/24802

    Abstract: The present invention concerns molecularly imprinted polymers (MIPs) having an affinity for natriuretic peptides, such as atrial natriuretic peptide (ANP). In some embodiments, the MIP is a nanoparticle (a molecularly imprinted polymeric nanoparticle (MIPNP)). Other aspects of the invention include methods of preparing an MIP having affinity for a natriuretic peptide, methods for binding a natriuretic peptide in vitro or in vivo using an MIP of the invention, methods for interfering with the binding of a natriuretic peptide with its receptor in vivo, methods for reducing inflammation, cell growth, cell differentiation, or a cell proliferation disorder, methods for detecting natriuretic peptides, and devices and kits for sequestering and/or detecting natriuretic peptides.

    Abstract translation: 本发明涉及对钠尿肽具有亲和力的分子印迹聚合物（MIP），例如心房钠尿肽（ANP）。 在一些实施方案中，MIP是纳米颗粒（分子印迹聚合物纳米颗粒（MIPNP））。 本发明的其它方面包括制备对利尿钠肽具有亲和性的MIP的方法，使用本发明的MIP在体外或体内结合利尿钠肽的方法，用于干扰利尿钠肽与其受体的结合的方法 体内，减少炎症，细胞生长，细胞分化或细胞增殖障碍的方法，检测利尿钠肽的方法，以及用于隔离和/或检测利尿钠肽的装置和试剂盒。

    MICELLE COMPOSITIONS AND METHODS FOR THEIR USE
    22.
    发明申请
    MICELLE COMPOSITIONS AND METHODS FOR THEIR USE 审中-公开
    MICELLE组合物及其使用方法

    公开(公告)号：US20130243867A1

    公开(公告)日：2013-09-19

    申请号：US13773749

    申请日：2013-02-22

    Applicant: Subhra Mohapatra ,  Shyam S. Mohapatra ,  Mark Christian Howell ,  Suraj Kishore Dixit ,  Chunyan Wang

    Inventor： Subhra Mohapatra ,  Shyam S. Mohapatra ,  Mark Christian Howell ,  Suraj Kishore Dixit ,  Chunyan Wang

    IPC: A61K9/16 ,  A61K31/7088

    CPC classification number: A61K9/167 ,  A61K9/1075 ,  A61K31/7088 ,  A61K47/6909 ,  A61K49/1809 ,  A61K49/1821

    Abstract: Provided herein is a micelle composition comprising a polyethylene glycol (PEG), a DC-cholesterol, and a dioleoylphosphatidyl-ethanolamine (DOPE) and either or both a pharmaceutical compound core and a polynucleotide coating. Also provided herein is a method of administering one or more compounds to a cell comprising administering to the cell a micelle composition comprising 1) PEG-PE, a DC-cholesterol, and DOPE, and 2) the one or more compounds, wherein the compounds are selected from the group consisting of a polynucleotide and a pharmaceutical composition. Further provided are methods for detecting the micelle composition.

    Abstract translation: 本文提供了包含聚乙二醇（PEG），DC-胆固醇和二油酰磷脂酰乙醇胺（DOPE）以及药物化合物核心和多核苷酸涂层中的任一种或两者的胶束组合物。 本文还提供了向细胞施用一种或多种化合物的方法，包括向细胞施用包含1）PEG-PE，DC-胆固醇和DOPE的胶束组合物，和2）一种或多种化合物，其中化合物 选自多核苷酸和药物组合物。 还提供了用于检测胶束组合物的方法。

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