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公开(公告)号：US08658081B2
公开(公告)日：2014-02-25
申请号：US12845536
申请日：2010-07-28
Applicant: David C. Gale , Bin Huang , Timothy Limon , Vincent J. Gueriguian
Inventor： David C. Gale , Bin Huang , Timothy Limon , Vincent J. Gueriguian
IPC: B29C49/08
CPC classification number: A61F2/915 , A61F2/90 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/9522 , A61F2210/0004 , A61F2220/0016 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4273 , B29C49/4823 , B29C55/22 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , Y10T156/1026 , C08L67/04
Abstract: Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
Abstract translation: 公开了制造具有增强的断裂韧性的支架的支架和方法。
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公开(公告)号：US08585731B2
公开(公告)日：2013-11-19
申请号：US12334382
申请日：2008-12-12
Applicant: Anthony J. Abbate , Bin Huang , Gail M. Zaler , David C. Gale , Richard E. Kaufman
Inventor： Anthony J. Abbate , Bin Huang , Gail M. Zaler , David C. Gale , Richard E. Kaufman
CPC classification number: A61L31/022 , A61B17/24 , A61B17/3468 , A61B17/3478 , A61B2017/3454 , A61F2/04 , A61F2/18 , A61F2/186 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/95 , A61F5/08 , A61F2002/048 , A61F2002/91508 , A61F2002/9522 , A61F2210/0004 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2230/0091 , A61F2240/001 , A61F2250/003 , A61F2250/006 , A61F2250/0067 , A61K9/70 , A61L31/10 , A61L31/148 , A61L31/16 , A61M29/00
Abstract: Described here are self-expanding devices and methods of using and making them. The devices may be useful in a variety of locations within the body, for a number of different uses. In some variations, the devices have a first compressed configuration enabling low profile delivery through a delivery device, a second expanded configuration for apposition against tissue, and comprise either a single continuous filament or at least two non-intersecting filaments. In some variations, the device is formed into a shape having a series of peaks and valleys. At least one of the peaks and valleys may have a loop at then end thereof. At least a portion of these devices may be capable of biodegrading over a predetermined period of time, and the devices may be configured for drug delivery. Methods of treating one or more sinus cavities are also described here.
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公开(公告)号：US08377356B2
公开(公告)日：2013-02-19
申请号：US13481518
申请日：2012-05-25
Applicant: Bin Huang , David C. Gale
Inventor： Bin Huang , David C. Gale
CPC classification number: A61F2/82 , A61L31/127 , A61L31/128 , A61L31/148 , B29C47/0007 , B29C47/0014 , B29C47/0021 , B29C47/0023 , Y10S977/753 , Y10S977/776 , Y10S977/831 , Y10S977/931
Abstract: Methods relating to polymer-bioceramic composite implantable medical devices are disclosed.
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24.发明授权Method of making Polymer-bioceramic composite implantable medical devices 有权制备聚合物 - 生物陶瓷复合植入式医疗器械的方法公开(公告)号：US08309114B2
公开(公告)日：2012-11-13
申请号：US13101920
申请日：2011-05-05
Applicant: David C. Gale , Yunbing Wang , Syed Faiyaz Ahmed Hossainy , Bin Huang , Garth L. Wilkes , Vincent J. Gueriguian
Inventor： David C. Gale , Yunbing Wang , Syed Faiyaz Ahmed Hossainy , Bin Huang , Garth L. Wilkes , Vincent J. Gueriguian
CPC classification number: A61F2/82 , A61L31/127 , A61L31/128 , A61L31/148 , B29C47/0007 , B29C47/0014 , B29C47/0021 , B29C47/0023 , Y10S977/753 , Y10S977/776 , Y10S977/831 , Y10S977/931
Abstract: Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.
Abstract translation: 公开了与聚合物 - 生物陶瓷复合植入式医疗装置有关的方法和装置。
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25.发明申请METHOD OF FABRICATING AN IMPLANTABLE MEDICAL DEVICE WITH BIAXIALLY ORIENTED POLYMERS 有权用双向聚合物制作可植入医疗器械的方法公开(公告)号：US20120217672A1
公开(公告)日：2012-08-30
申请号：US13463562
申请日：2012-05-03
Applicant: Bin Huang , Stephen Schaible , Richard Kaufman , Jim Kennedy , David C. Gale , Suresh Amin , John Guardiano
Inventor： Bin Huang , Stephen Schaible , Richard Kaufman , Jim Kennedy , David C. Gale , Suresh Amin , John Guardiano
CPC classification number: A61F2/82 , A61F2/91 , A61F2002/825 , A61L31/148 , B23K2103/42 , B23K2103/50 , B29C47/0023 , B29C47/0057 , B29C47/24 , B29C49/786 , B29L2031/7534
Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Methods of inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer are disclosed.
Abstract translation: 本文描述了用于制造可植入医疗装置（例如支架）的方法和系统，其具有期望的机械性质（例如改善的周向强度和刚度）的管。 可以通过在用于制造可植入医疗装置的材料中诱导分子取向来获得改善的周向强度和刚性。 公开了通过在熔融聚合物中引起圆周流动而导致圆周分子取向的方法。
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Patent Agency Ranking
公开(公告)号：US20120024474A1
公开(公告)日：2012-02-02
申请号：US13267829
申请日：2011-10-06
Applicant: Bin Huang , Daniel Castro , David C. Gale , Yunbing Wang
Inventor： Bin Huang , Daniel Castro , David C. Gale , Yunbing Wang
IPC: B32B37/06
CPC classification number: A61F2/958 , A61F2002/9522 , A61F2002/9583 , A61F2210/0004 , A61F2240/001 , A61F2250/0067
Abstract: Methods for improved stent retention on an expandable member during delivery are disclosed. Methods include fabricating delivery systems including a retention layer over the stent, the expandable member, or both for improving retention of the stent on the expandable member during delivery.
Abstract translation: 公开了在递送期间改善可扩张构件上的支架保持性的方法。 方法包括制造输送系统，包括在支架上方的保留层，可膨胀构件或两者，用于在输送期间改善支架在可扩张构件上的保持力。
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公开(公告)号：US20110313510A1
公开(公告)日：2011-12-22
申请号：US13117550
申请日：2011-05-27
Applicant: David C. Gale , Bin Huang , John M. Capek
Inventor： David C. Gale , Bin Huang , John M. Capek
IPC: A61F2/82
CPC classification number: A61L31/148 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61F2250/0098 , A61L31/028 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/604 , A61L2300/606 , A61L2400/12 , C08L67/04
Abstract: A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device. A further aspect of the invention includes device and a method of manufacturing the device that includes a mixture of a biodegradable polymer and bioerodable metallic particles. The mixture may be used to fabricate an implantable medical device or to coat an implantable medical device. In some embodiments, the metallic particles are metallic nanoparticles.
Abstract translation: 这里描述了一种制造植入式医疗装置（例如支架）的装置和方法。 该装置包括由生物侵蚀金属组成的金属区域和由与金属区域接触的可生物降解的聚合物组成的聚合物区域。 当暴露于体液时，当暴露于体液时，金属区域可能以不同于聚合物区域的速度侵蚀。 在某些实施方案中，聚合物区域是外层，金属区域是该装置的内层。 本发明的另一方面包括装置和制造该装置的方法，该装置包括可生物降解的聚合物和可生物侵蚀的金属颗粒的混合物。 混合物可用于制造可植入医疗装置或涂覆可植入医疗装置。 在一些实施方案中，金属颗粒是金属纳米颗粒。
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公开(公告)号：US08062465B1
公开(公告)日：2011-11-22
申请号：US11890170
申请日：2007-08-02
Applicant: Bin Huang , Daniel Castro , David C. Gale , Yunbing Wang
Inventor： Bin Huang , Daniel Castro , David C. Gale , Yunbing Wang
IPC: B29C65/00
CPC classification number: A61F2/958 , A61F2002/9522 , A61F2002/9583 , A61F2210/0004 , A61F2240/001 , A61F2250/0067
Abstract: Methods for improved stent retention on an expandable member during delivery are disclosed. Methods include fabricating delivery systems including a retention layer over the stent, the expandable member, or both for improving retention of the stent on the expandable member during delivery.
Abstract translation: 公开了在递送期间改善可扩张构件上的支架保持性的方法。 方法包括制造输送系统，包括在支架上方的保留层，可膨胀构件或两者，用于在输送期间改善支架在可扩张构件上的保持力。
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公开(公告)号：US08062350B2
公开(公告)日：2011-11-22
申请号：US12035391
申请日：2008-02-21
Applicant: David C. Gale , Bin Huang , Kleine Klaus
Inventor： David C. Gale , Bin Huang , Kleine Klaus
IPC: A61F2/06
CPC classification number: A61L31/047 , A61L31/10 , C08L71/02
Abstract: Provided herein is a method of using a bioabsorbable medical device that includes RGD attached to the device via a spacer compound. The method comprises implanting in a human being a bioaborbable device, e.g., a bioabsorbable stent, including a chemo-attractant for endothelial progenitor cells (EPCs).
Abstract translation: 本文提供了一种使用生物可吸收的医疗装置的方法，其包括经由间隔物化合物附着于该装置的RGD。 该方法包括在人体中植入生物可吸收装置，例如生物可吸收支架，包括内皮祖细胞（EPCs）的化学引诱剂。
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公开(公告)号：US20110265426A1
公开(公告)日：2011-11-03
申请号：US13179473
申请日：2011-07-08
Applicant: Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
Inventor： Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
CPC classification number: A61L2/08 , A61L2/081 , A61L2/082 , A61L2/085 , A61L2/087 , A61L2/10 , A61L2202/23 , A61L2202/24 , B65B55/00 , B65B55/16
Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.
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