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    Moraxella (Branhamella) catarrhalis antigens
    25.
    发明授权
    Moraxella (Branhamella) catarrhalis antigens 失效

    公开(公告)号：US07410645B2

    公开(公告)日：2008-08-12

    申请号：US10477592

    申请日：2002-05-15

    Applicant: Denis Martin ,  Josée Hamel ,  Bernard R. Brodeur ,  Stéphane Rioux ,  Julie Couture

    Inventor： Denis Martin ,  Josée Hamel ,  Bernard R. Brodeur ,  Stéphane Rioux ,  Julie Couture

    IPC: A61K39/02 ,  A61K39/00 ,  A61K38/00 ,  C07H21/04 ,  C07K14/00 ,  C12P21/04

    CPC classification number: C07K14/212 ,  A61K39/00 ,  C07K2319/00

    Abstract: The present invention relates to polypeptides of Moraxella(Branhamella) catarrhalis which may be useful for prophylaxis, diagnosis and/or therapy purposes. 1ATGGACACTG ACATGAAACA TTTAACAAAA CATCGCCTAT CAGCTGCCAT 51CATTGGCGTT TTATTATTCA TTAGCCCATC AGTGCAAGCA AATACGACAC 101ACCATCACAC GCTAACCAGT AGCGAGCTTA AACTTGCTGA TGATAGTATT 151ATTGATAGTA TCAATCAATT GGGTGAGCTG ACCGTCAATA TTCCAAATAC 201ACAATATTTT CAAACCAACA ACGGTGTGAG CGTTGCTTTT ACGCCATTAC 251ATGAGCTGCC TATTGTCGAT ATCAGCTTGT ATTTTAATGC AGGGTCAGCG 301TATCACCATC AGGTTGGCAA ATCAGGCACG GCTAACATGG TTGCAACCAT 351GCTCACCCAA GGAACTGACA GCCTTTCTGA AGATGAGTTT GTTGCTGCCA 401AAGAGCGTCT TCGCATTCAT TTTACCAGTA CAGCAAATAA GGATAACTTA 451ACTTTATCAT TAAGAAGCTT GTCTGATCAA TCATTATTAA ATCAAGCCGC 501CGATTTAATG GTCGATGCTG TCACTCAACC TGCTTTTGAT GATAAGACTC 551TACAACGCAA CAAAAATCAG CTCATCACCA GTTTAAAACA AAAAAAGCAA 601AACCCTTATC ATGTAGCTTC TGTTGCTTAT CATCAAGCCG TATATGAAAA 651TCATCCTTAT GCACACGCAA CCACAGGCGA TGAAGATAGT ATTGCCAAAA 701TTGATCGTGA TGAGCTGCTT AATTTTTGGC ATACTTTTAT TAATGCAAAT 751AATGCGACAC TGCTGATTAC AGGTGATATG ACCGCCGAGC AAGCCAAATC 801ACTTGCCAAC CATCTGACCG CCAAATTACC CACAGGCAAG TCGTATAAAA 851ATACGCTGGA TTTGACAAAA CCAGTTAAGG CTCGTCATAT CCATATTCCT 901CACAACAGTA GTCAAACCCA AATCATCATC GGTCATCCCA CCAGTAAAGT 951ACGCACGGAC AAAGCAGGTC GTCAAGAGTT CAGCGATTTT TCATTAGCTA 1001ATGAAATTTT GGCAGGTGGT GATTTTAATG CCAGATTGAT GAAAACCATT 1051CGAGAGCAAA AAGGCTACAC TTATGGCATT TATGGCGGTA TGGAACGCCT 1101CAGAGCAGGT GGTAATTATG TGGTTGAATT TTCAACCGAT GGCGATAAAG 1151CAGCCGATGC CATTTTAGAG ACGCTACACA TCATTAATCA GTCGCTGAAT 1201GAAGGCATAA CCCAAGAAGA GCTTGAGTTG GTGCGTTTGG GCAATAAAAA 1251TGGTTTTGCC AATATTTTTT CAAGCAATGC CAGTATTCAT CGTGTCATTC 1301GTGCTTTATT TGTTGCCGAT TATCCAAAAG ATCATCTTAA CCATACGCTC 1351AATCGCTTGG ATAATGCCAC GATAAATAGT GTTAATACCG CACTGAACTT 1401GCGTATCAAG CCTGATGAAT TTATCATCAT CACCGTGGGT AAAACTAAGC 1451CAAATTTGGA CAAATAA

    Proteinase K resistant surface protein of neisseria meningitidis
    26.
    发明授权
    Proteinase K resistant surface protein of neisseria meningitidis 失效
    脑膜炎奈瑟氏球菌的蛋白酶K抗性表面蛋白

    公开(公告)号：US06287574B1

    公开(公告)日：2001-09-11

    申请号：US08913362

    申请日：1997-11-13

    Applicant: Bernard R. Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

    Inventor： Bernard R. Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

    IPC: A61K39095

    CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/522 ,  C07K14/22

    Abstract: A highly conserved, immunologically accessible antigen at the surface of Neisseria meningitidis organisms. Immunotherapeutic, prophylactic and diagnostic compositions and methods useful in the treatment, prevention an diagnosis of Neisseria meningitidis diseases. A proteinase K resistant Neisseria meningitidis surface protein having an apparent molecular weight of 22 kDa, the corresponding nucleotide and derived amino acid sequences (SEQ ID NO: 1, NO:3, NO:5 and NO:7: SEQ ID NO: 2, NO:4, NO:6, and NO:8), recombinant DNA methods for the production of the Neisseria meningitidis 22 kDA surface protein, and antibodies that bind to the Neisseria meningitidis 22 kDA surface protein.

    Abstract translation: 脑膜炎奈瑟氏球菌生物体表面高度保守，免疫可及的抗原。 用于治疗，预防脑膜炎奈瑟菌病的诊断的免疫治疗，预防和诊断组合物和方法。 具有表观分子量22kDa的蛋白酶K抗性脑膜炎奈瑟氏球菌表面蛋白，相应的核苷酸和衍生氨基酸序列（SEQ ID NO：1，NO：3，NO：5和NO：7：SEQ ID NO：2， NO：4，NO：6和NO：8），用于产生脑膜炎奈瑟氏球菌22kDA表面蛋白质的重组DNA方法和结合脑膜炎奈瑟氏球菌22kDA表面蛋白的抗体。

    Method of forming photovoltaic quality amorphous alloys by passivating defect states
    27.
    发明授权
    Method of forming photovoltaic quality amorphous alloys by passivating defect states 失效
    通过钝化缺陷状态形成光伏质量非晶态合金的方法

    公开(公告)号：US4569697A

    公开(公告)日：1986-02-11

    申请号：US526831

    申请日：1983-08-26

    Applicant: Raphael Tsu ,  Stanford R. Ovshinsky ,  Jesus Hernandez ,  Denis Martin

    Inventor： Raphael Tsu ,  Stanford R. Ovshinsky ,  Jesus Hernandez ,  Denis Martin

    IPC: H01L31/04 ,  H01L21/205 ,  H01L31/20 ,  H01L21/203 ,  H01L31/18

    CPC classification number: H01L31/208 ,  H01L31/202 ,  Y02E10/50 ,  Y02P70/521

    Abstract: Relatively dense, photovoltaic quality amorphous alloys which are characterized by reduced density of defect states in the band gaps thereof and which are particularly suited for use in tandem photovoltaic devices are formed by evaporating amorphous germanium and amorphous silicon in an ultrahigh vacuum environment, diffusing a density of states reducing element into and through the amorphous material, and finally annealing the resultant amorphous alloy to complete the diffusion process. The amorphous alloy, so formed, is a substantially contaminant-free, substantially tetrahedrally coordinated material. Fluorine is the preferred density of states reducing element which is added to the amorphous material for reducing the density of states through compensation, and for orbital promotion and expansion.

    Abstract translation: 通过在超高真空环境中蒸发无定形锗和非晶硅，形成特征在于其带隙中缺陷状态密度降低并且特别适用于串联光伏器件的相对致密的光伏质量非晶合金，其扩散密度 的状态将元素还原并通过非晶材料，并且最终对所得到的非晶合金进行退火以完成扩散过程。 如此形成的非晶合金是基本上无污染的，基本上四面体配位的材料。 氟是优选的状态还原元素的密度，其被添加到无定形材料中以通过补偿降低状态密度，以及用于轨道促进和膨胀。

    Proteinase K resistant surface protein of Neisseria meningitidis
    30.
    发明授权
    Proteinase K resistant surface protein of Neisseria meningitidis 失效
    脑膜炎奈瑟氏球菌的蛋白酶K抗性表面蛋白

    公开(公告)号：US07833717B2

    公开(公告)日：2010-11-16

    申请号：US11929893

    申请日：2007-10-30

    Applicant: Bernard R. Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

    Inventor： Bernard R. Brodeur ,  Denis Martin ,  Josee Hamel ,  Clement Rioux

    IPC: C12Q1/68

    CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/522 ,  C07K14/22

    Abstract: The identification of a highly conserved, immunologically accessible antigen at the surface of Neisseria facilitates treatment, prophylaxis, and diagnosis of Neisseria diseases. This antigen is highly resistant to Proteinase K and has an apparent molecular weight of 22 kDa on SDS-PAGE. Specific polynucleotides encoding proteins of this class have been isolated from three Neisseria meningitidis strains and from one Neisseria gonorrhoeae strain. These polynucleotides have been sequenced, and the corresponding full-length amino acid sequences of the encoded polypeptides have been deduced. Recombinant DNA methods for the production of the Neisseria surface protein, and antibodies that bind to this protein are also disclosed.

    Abstract translation: 在奈瑟氏球菌表面鉴定高度保守的，免疫可及的抗原有助于治疗，预防和诊断奈瑟氏球菌病。 该抗原对蛋白酶K具有高度抗性，并且在SDS-PAGE上具有22kDa的表观分子量。 已经从三种脑膜炎奈瑟菌菌株和一种淋病奈瑟菌菌株分离了编码该类蛋白质的特异性多核苷酸。 已经对这些多核苷酸进行了测序，并且已推导出编码多肽的相应全长氨基酸序列。 也公开了用于产生奈纹球菌表面蛋白质的重组DNA方法和结合该蛋白质的抗体。

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