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公开(公告)号：US20150125948A1
公开(公告)日：2015-05-07
申请号：US14533753
申请日：2014-11-05
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Jason Barnes , Dane Mealey , Walter M. Presz, JR. , Stanley Kowalski, III , Louis Masi , Thomas J. Kennedy, III
CPC classification number: C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
Abstract: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
Abstract translation: 公开了一种由模块化部件组成的消声器。 本文公开了多个模块，包括超声换能器模块，输入/输出模块，收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒（例如生物细胞）的适当流体动力学的不同系统。
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公开(公告)号：US11022551B2
公开(公告)日：2021-06-01
申请号：US16889170
申请日：2020-06-01
Applicant: FloDesign Sonics, Inc.
Inventor： Jason Barnes , Dane Mealey , Jeffrey King
Abstract: Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.
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公开(公告)号：US11007457B2
公开(公告)日：2021-05-18
申请号：US15960451
申请日：2018-04-23
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Ronald Musiak , Dane Mealey , Ali Shajii
IPC: B01D17/06 , B01D17/12 , B01D21/28 , B01D29/72 , C02F1/36 , H04R1/06 , H01L41/09 , H03H3/02 , H03H9/00 , B01D21/00 , B06B1/06 , C12M1/26 , C12M1/00 , A61M1/36
Abstract: Aspects of the disclosure are directed to an apparatus for separating a second fluid or a particulate from a host fluid. That apparatus comprises a flow chamber with at least one inlet and at least one outlet. A drive circuit configured to provide a drive signal to a filter circuit configured to receive the drive signal and provide a translated drive signal. An ultrasonic transducer is cooperatively arranged with the flow chamber, and transducer includes at least one piezoelectric element configured to be driven by the current drive signal to create an acoustic standing wave in the flow chamber. At least one reflector opposing the ultrasonic transducer to reflect acoustic energy.
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公开(公告)号：US10814253B2
公开(公告)日：2020-10-27
申请号：US15690263
申请日：2017-08-29
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
Abstract: Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号：US20200324225A1
公开(公告)日：2020-10-15
申请号：US16754065
申请日：2018-05-04
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Ronald E. Musiak , Dane Mealey , John Artis
IPC: B01D17/12 , B01D17/06 , B01D21/28 , B01D29/72 , C02F1/36 , H04R1/06 , H01L41/09 , H03H3/02 , H03H9/00 , B01D21/00 , B06B1/06 , C12M1/26 , C12M1/00 , A61M1/36
Abstract: An RF driver provides power to an acoustic transducer, which can be implemented as a piezoelectric element, which presents a reactive load. The driver can be a linear amplifier or a combination of a DC-DC converter and DC-AC inverter. A controller implements a control technique for efficient transducer operation. The control technique can locate a frequency for operation that is at a reactance minimum or maximum for the transducer to provide efficient operation of that transducer. An implementation of the controller can be provided in modular hardware.
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Patent Agency Ranking
公开(公告)号：US10670524B2
公开(公告)日：2020-06-02
申请号：US16443817
申请日：2019-06-17
Applicant: FloDesign Sonics, Inc.
Inventor： Jason Barnes , Dane Mealey , Jeffrey King
Abstract: Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.
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公开(公告)号：US20180207551A1
公开(公告)日：2018-07-26
申请号：US15872984
申请日：2018-01-16
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Ronald Musiak , Dane Mealey , John Artis , Ali Shajii
IPC: B01D17/04
CPC classification number: B01D17/04 , B01D17/06 , B01D21/00 , B01D21/283
Abstract: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, or cells entrained in a fluid, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water. A driver and controller for the acoustophoretic device accommodate variable loading as the components are separated, thereby improving separation efficiency.
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公开(公告)号：US09744483B2
公开(公告)日：2017-08-29
申请号：US15249129
申请日：2016-08-26
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
CPC classification number: B01D21/283 , B01D21/0042 , B01D21/0045 , B01D21/0087 , B01D21/2422 , B06B1/06 , C02F1/36 , C12M47/02
Abstract: Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号：US20170008029A1
公开(公告)日：2017-01-12
申请号：US15206244
申请日：2016-07-09
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Walter M Presz, JR. , Kedar Chitale , Thomas J Kennedy, III , Rudolf Gilmanshin , Dane Mealey , Brian Dutra , David Sokolowski
CPC classification number: B06B1/0238 , B01D21/0009 , B01D21/283 , B06B1/0644 , B06B3/04 , C12M47/02 , H03H9/17
Abstract: An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
Abstract translation: 公开了一种声学设备。 声波装置包括声室，超声波换能器和反射器。 超声波换能器包括由电压信号驱动的压电材料，以在从压电材料的非平面发出的声室中产生多维声驻波。 还公开了用于从主体流体分离第二流体或颗粒的方法。 该方法包括使混合物流过声波装置。 发送电压信号以驱动超声波换能器以在声学室中产生多维声驻波，使得第二流体或颗粒被连续捕获在驻波中，然后聚集，聚集，聚集或聚结在一起， 并随后由于浮力或重力而升高或沉降在主流体之外，并离开声室。
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公开(公告)号：US20170369865A1
公开(公告)日：2017-12-28
申请号：US15672288
申请日：2017-08-08
Applicant: FloDesign Sonics, Inc.
Inventor： Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
CPC classification number: C12N13/00 , B01D21/283
Abstract: An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
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