公开(公告)号：US20170081629A1

公开(公告)日：2017-03-23

申请号：US15371037

申请日：2016-12-06

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Jason Barnes ,  Dane Mealey ,  Walter M. Presz, JR. ,  Stanley Kowalski, III ,  Louis Masi ,  Thomas J. Kennedy, III ,  Brian McCarthy ,  Ben Ross-Johnsrud

IPC: C12M1/00 ,  B01D21/28 ,  C12M1/26

CPC classification number: C12M47/02 ,  A61M1/3678 ,  B01D21/0045 ,  B01D21/283 ,  B06B1/06 ,  C12M33/08 ,  C12M47/10

Abstract: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.

公开(公告)号：US20160370287A1

公开(公告)日：2016-12-22

申请号：US15186302

申请日：2016-06-17

Applicant: FloDesign Sonics, Inc.

Inventor： Jason Barnes ,  Dane Mealey ,  Jeffrey King

IPC: G01N21/53 ,  G01N1/20

CPC classification number: G01N21/532 ,  G01N1/2035 ,  G01N21/05 ,  G01N2201/06153

Abstract: Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.

Abstract translation: 公开了用于提高浊度传感器精度的系统和方法。 该系统包括浊度传感器和具有专门流路的流量模块，浊度传感器与流量模块接合，使得浊度传感器的测量区域设置在流动模块的流动路径内， 流量模块不通过测量区域。 所述方法包括将含有气泡的流体流入将流动模块中的流体分离成包含相对较多气泡的第一流体流和含有相对较少气泡的第二流体流的系统中，第一流流过旁路路径， 不通过测量区，第二条流通过浊度传感器的测量区。

公开(公告)号：US20160361670A1

公开(公告)日：2016-12-15

申请号：US15249129

申请日：2016-08-26

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Walter M. Presz, JR. ,  Jeffrey King ,  Jason Barnes ,  Dane Mealey ,  Brian McCarthy ,  Ben Ross-Johnsrud ,  Kedar Chitale

IPC: B01D21/28 ,  B06B1/06 ,  C12M1/00 ,  C02F1/36 ,  B01D21/00

CPC classification number: B01D21/283 ,  B01D21/0042 ,  B01D21/0045 ,  B01D21/0087 ,  B01D21/2422 ,  B06B1/06 ,  C02F1/36 ,  C12M47/02

Abstract: Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.

Abstract translation: 公开了用于从第二流体或颗粒分离主体流体的装置。 这些装置包括声室，在声腔的顶端处的流体出口，在声腔的底端处的浓缩物出口，以及在声室的第一侧端上的入口。 超声波换能器和反射器在声室中产生多维声驻波，其将微粒（例如电池）与主流体捕获并分离。 主流体通过流体出口收集，微粒通过浓缩物出口收集。 该装置是能够处理升/小时，并具有大的内部容积的大型装置。

公开(公告)号：US20160089620A1

公开(公告)日：2016-03-31

申请号：US14870952

申请日：2015-09-30

Applicant: FloDesign Sonics, Inc.

Inventor： Bart Lipkens ,  Jeff King ,  David Sokolowski ,  Anthony B. Masi ,  Brian T. Kennedy ,  Brian McCarthy ,  Benjamin Ross-Johnsrud ,  Jason Dionne ,  Dane Mealey ,  Jason Barnes

IPC: B01D21/28 ,  B06B1/06 ,  B01J19/10 ,  C12N13/00 ,  C12M1/00

CPC classification number: B01D21/283 ,  B01D17/044 ,  B01D17/06 ,  B01D19/0078 ,  B06B1/06 ,  B06B1/0622 ,  B06B1/0644 ,  B06B2201/71 ,  C12M47/04 ,  C12N13/00

Abstract: Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.

Abstract translation: 公开了用于从非流动主流体分离颗粒的声学装置。 这些装置包括基本上声透明的容器和分离单元，容器被放置在分离单元内。 分离单元中的超声波换能器在容器内产生平面或多维声驻波，捕获设置在非流动流体内的颗粒，并使其聚结或附聚，然后由于浮力或重力而分离。