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21.发明申请公开(公告)号：US20150165346A1
公开(公告)日：2015-06-18
申请号：US14243469
申请日：2014-04-02
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Jason Louis Davis , Jason M. Nichols
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A system is provided for separating particulates dispersed within a base fluid wherein at least one of the particulates and the base fluid is an organic liquid. The system relies on a microfluidic separation device comprising a microchannel in fluid communication across a microporous body with a collection chamber. Particulates and a portion of the base fluid traverse the microporous body under the influence of an external force field and are collected in the collection chamber. A first fluid flow having a first flow rate through the microchannel together with the microporous body operationally generate a second fluid flow within the collection chamber as base fluid and particulates traverse the microporous body and enter the collection chamber, and as base fluid re-traverses the microporous body and re-enters the microchannel, the second fluid flow having a flow rate which is a fraction of the first flow rate.
Abstract translation: 提供一种用于分离分散在基础流体中的微粒的系统，其中至少一个微粒和基础流体是有机液体。 该系统依赖于微流体分离装置，其包括跨越微孔体与收集室流体连通的微通道。 基体液体的一部分在外力场的影响下穿过微孔体并被收集在收集室中。 具有与微孔体一起通过微通道的第一流速的第一流体流动可操作地在收集室内产生作为基础流体的第二流体流，并且微粒穿过微孔体并进入收集室，并且当基础流体重新穿过 微孔体并重新进入微通道，第二流体流的流速是第一流量的一部分。
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公开(公告)号：US20150050654A1
公开(公告)日：2015-02-19
申请号：US13970315
申请日：2013-08-19
Applicant: General Electric Company
Inventor： Erin Jean Finehout , Christopher Michael Puleo , Ralf Lenigk , Jason M. Nichols , John Nelson
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6816 , C12Q1/6851 , C12Q2565/137 , C12Q2565/625 , C12Q2527/113 , C12Q2565/133 , C12Q2545/114
Abstract: The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.
Abstract translation: 本公开涉及通过多孔底物中的扩增检测来表征生物样品。 举例来说，多孔底物可以包括配置成在放大期间释放时提供信号的扩增试剂。 当应用样品时，从应用点开始发生波前放大，波前在多孔基底上达到距离的时间与施加样品的初始浓度有关。 通过在一个或多个时间点检测扩增产物行进的距离，可以估计样品的初始浓度。
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23.发明申请METHOD AND DEVICE FOR COLLECTION AND AMPLIFICATION OF CIRCULATING NUCLEIC ACIDS 有权用于收集和放大循环核酸的方法和装置公开(公告)号：US20150031035A1
公开(公告)日：2015-01-29
申请号：US13952173
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Erik Leeming Kvam , John Richard Nelson , Gregory Andrew Grossmann , Ryan Charles Heller , Erin Jean Finehout , Christopher Michael Puleo , William Patrick Waters
IPC: C12Q1/68
CPC classification number: C12N15/1017 , B01L7/52 , B01L2300/0681 , C12Q1/68 , C12Q1/6844 , C12Q1/6806 , C12Q2521/501 , C12Q2531/125
Abstract: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library. Devices for the collection of a non-cellular fraction from a biological sample are also provided. The device includes a filtration membrane and a dry solid matrix, which is in direct contact with the filtration membrane.
Abstract translation: 本文提供了从生物样品的非细胞部分收集和扩增循环核酸的方法。 从非细胞级分提取循环核酸，并进行环化以产生单链核酸环，然后通过使用随机引物的滚动循环扩增产生扩增文库，然后扩增其。 还提供了用于从生物样品中收集非细胞级分的装置。 该装置包括与过滤膜直接接触的过滤膜和干燥固体基质。
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公开(公告)号：US12257457B2
公开(公告)日：2025-03-25
申请号：US17864212
申请日：2022-07-13
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
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公开(公告)号：US20240318225A1
公开(公告)日：2024-09-26
申请号：US18293305
申请日：2022-07-29
Inventor： Christopher Michael Puleo , Erik Leeming Kvam , Pak Kin Wong , Peter Torab , Christine Lynne Surrette
CPC classification number: C12Q1/24 , C12Q1/18 , G01N33/491
Abstract: The subject matter of the present disclosure generally relates to techniques for isolating bacterial cells from a biological sample comprising red blood cells. Using an aggregating agent and an anticoagulant during sedimentation permits separation of bacterial pathogens in the sample from red blood cells. The separated sedimentation layer, which is enriched in any bacterial pathogens, can be centrifuged and resuspended to concentrate the bacteria for additional analysis, such as bacterial identification and/or antibiotic susceptibility tests.
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Patent Agency Ranking
公开(公告)号：US20240115886A1
公开(公告)日：2024-04-11
申请号：US18481700
申请日：2023-10-05
Applicant: General Electric Company
Inventor： Christine A. Morton , Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero
IPC: A61N7/02
CPC classification number: A61N7/02 , A61N2007/0017
Abstract: The present approaches are generally directed to facilitating healing of wounds, including chronic wounds typically associated with slow heal times or which are persistent. In one embodiment, a method of promoting wound healing comprises positioning an ultrasound transducer at a stimulation site on a subject having a wound. Pulsed focused ultrasound (pFUS) is non-invasively applies using the transducer to cause modulation of a target anatomic site containing resident or circulating immune cells. Modulation of the target anatomic site of the subject causes migration of one or more of monocytes, macrophages, or neutrophils to a wound bed of the wound.
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公开(公告)号：US11883689B2
公开(公告)日：2024-01-30
申请号：US17722948
申请日：2022-04-18
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Lakshmi Sireesha Kaanumalle , Victoria Eugenia Cotero , John Frederick Graf
CPC classification number: A61N7/00 , A61N1/36189 , G01N33/68 , A61N2007/0004
Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
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公开(公告)号：US11602331B2
公开(公告)日：2023-03-14
申请号：US16567996
申请日：2019-09-11
Applicant: General Electric Company
Inventor： Asha Singanamalli , David Andrew Shoudy , Jeffrey Michael Ashe , Christopher Michael Puleo
Abstract: Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.
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公开(公告)号：US20210205636A1
公开(公告)日：2021-07-08
申请号：US17208547
申请日：2021-03-22
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero
IPC: A61N7/00
Abstract: The subject matter of the present disclosure generally relates to techniques for applying mechanical or ultrasound energy to a region of interest in a subject to induce modulation of one or more nerve pathways. The region of interest may include at least a portion of a nerve ganglion.
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公开(公告)号：US20200346043A1
公开(公告)日：2020-11-05
申请号：US16399692
申请日：2019-04-30
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Victoria Eugenia Cotero , Jeffrey Michael Ashe , John Frederick Graf
Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.
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