公开(公告)号：US11230733B2

公开(公告)日：2022-01-25

申请号：US17025735

申请日：2020-09-18

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  B01L9/06

Abstract: Receptacles containing a reaction mixture are transported to receptacle wells of a thermally conductive receptacle holder, and the temperature of the holder is cycled with a thermoelectric device situated between a support and a first side of the holder while a first force is applied onto a second side of the holder. Optical communication between each well and an excitation signal source and an emission signal detector is established to determine whether an emission signal is emitted from any of the receptacles during temperature cycling as an indication of the presence of a target nucleic acid. The thermoelectric device may be situated between an upright portion of the support and the first side of the holder. A second force may be applied onto a top end of each receptacle in the holder by a cover moveable with respect to the receptacles between an open position and a closed position.

公开(公告)号：US11046101B2

公开(公告)日：2021-06-29

申请号：US16696611

申请日：2019-11-26

Applicant: Gen-Probe Incorporated

Inventor： Rolf Silbert ,  Robert J. Rosati ,  David Buse ,  Olev Tammer ,  Matthias Merten

IPC: B41J29/38 ,  G01N35/00 ,  B41J2/32 ,  B41J3/407 ,  G01N35/10

Abstract: A printing module configured to print a label on a curved surface of an article includes an expandable printing mechanism configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head and an article moving assembly configured to grasp and hold the article and effect relative movement between the curved surface and the print head. The printing mechanism includes contact elements, such as rollers, that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head during relative movement between the curved surface and the print head.

公开(公告)号：US10562329B2

公开(公告)日：2020-02-18

申请号：US15971660

申请日：2018-05-04

Applicant: Gen-Probe Incorporated

Inventor： Rolf Silbert ,  Robert J. Rosati ,  David Buse ,  Olev Tammer ,  Matthias Merten

IPC: B41J29/38 ,  B41J2/32 ,  B41J3/407 ,  G01N35/00 ,  G01N35/10

Abstract: A printing module configured to print a label on a curved surface of an article includes an expandable printing mechanism configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head and an article moving assembly configured to grasp and hold the article and effect relative movement between the curved surface and the print head. The printing mechanism includes contact elements, such as rollers, that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head during relative movement between the curved surface and the print head.

公开(公告)号：US09566582B2

公开(公告)日：2017-02-14

申请号：US14837647

申请日：2015-08-27

Applicant: GEN-PROBE INCORPORATED

Inventor： David Buse ,  Byron J. Knight

IPC: B01L3/00 ,  B65B69/00 ,  B65D39/00 ,  G01N35/02 ,  C12Q1/68 ,  G01N35/10 ,  B65D1/02 ,  B65D1/34 ,  G01N30/60

CPC classification number: B01L3/5085 ,  B01L3/502 ,  B01L3/5082 ,  B01L3/50825 ,  B01L3/50853 ,  B01L3/50855 ,  B01L3/523 ,  B01L3/527 ,  B01L2200/02 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0668 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0609 ,  B01L2300/0829 ,  B01L2300/0832 ,  B01L2300/0838 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/12 ,  B01L2400/0406 ,  B65B69/00 ,  B65D1/0207 ,  B65D1/34 ,  B65D1/36 ,  B65D17/50 ,  B65D39/0017 ,  B65D39/0029 ,  B65D2539/003 ,  C12Q1/686 ,  G01N30/6091 ,  G01N35/0099 ,  G01N35/026 ,  G01N35/10 ,  G01N35/1002 ,  G01N35/1079 ,  G01N2035/00287 ,  Y10T436/11

Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.

Abstract translation: 提供了用于执行基于自动化试剂的分析的系统，装置和方法。 还提供了用于将盖自动附接到反应容器的方法，以及从加盖的反应容器自动移除盖。

公开(公告)号：US12239989B2

公开(公告)日：2025-03-04

申请号：US18470927

申请日：2023-09-20

Applicant: GEN-PROBE INCORPORATED

Inventor： David Buse ,  Byron J. Knight

IPC: B01L3/00 ,  B65D51/00

Abstract: A container including a top wall and a fluid vessel depending from the top wall. The fluid vessel extends from a top wall aperture formed in the top wall to a bottom end of the fluid vessel. The container further includes gripping structures configured to enable an automated gripping mechanism to securely grip the container in a repeatable position and orientation with respect to the container-gripping components of the gripping mechanism.

公开(公告)号：US11788115B2

公开(公告)日：2023-10-17

申请号：US17033395

申请日：2020-09-25

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A receptacle cap includes a probe recess configured to receive a probe inserted therein to thereby frictionally secure the receptacle cap to the probe, and a closed lower end of the receptacle is insertable into an open end of a reaction receptacle to close the reaction receptacle. The receptacle cap and the reaction receptacle include interlocking features for securing the receptacle cap to the reaction receptacle.

公开(公告)号：US11090963B2

公开(公告)日：2021-08-17

申请号：US16696574

申请日：2019-11-26

Applicant: Gen-Probe Incorporated

Inventor： Rolf Silbert ,  Robert J. Rosati ,  David Buse ,  Olev Tammer ,  Matthias Merten

IPC: B41J29/38 ,  G01N35/00 ,  B41J2/32 ,  B41J3/407 ,  G01N35/10

Abstract: A printing module configured to print a label on a curved surface of an article includes an expandable printing mechanism configured to be expanded to an open configuration for receiving the article or contracted to a closed configuration placing the curved surface in an operative position with respect to a print head and an article moving assembly configured to grasp and hold the article and effect relative movement between the curved surface and the print head. The printing mechanism includes contact elements, such as rollers, that contact or otherwise engage the article when the printing mechanism is in the closed configuration and maintain the curved surface in the operative position with respect to the print head during relative movement between the curved surface and the print head.

公开(公告)号：US20210002704A1

公开(公告)日：2021-01-07

申请号：US17025735

申请日：2020-09-18

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64

Abstract: Receptacles containing a reaction mixture are transported to receptacle wells of a thermally conductive receptacle holder, and the temperature of the holder is cycled with a thermoelectric device situated between a support and a first side of the holder while a first force is applied onto a second side of the holder. Optical communication between each well and an excitation signal source and an emission signal detector is established to determine whether an emission signal is emitted from any of the receptacles during temperature cycling as an indication of the presence of a target nucleic acid. The thermoelectric device may be situated between an upright portion of the support and the first side of the holder. A second force may be applied onto a top end of each receptacle in the holder by a cover moveable with respect to the receptacles between an open position and a closed position.

公开(公告)号：US10065190B2

公开(公告)日：2018-09-04

申请号：US15604791

申请日：2017-05-25

Applicant: GEN-PROBE INCORPORATED

Inventor： David Buse ,  Byron J. Knight ,  Julian Groeli

IPC: B01L3/00 ,  B65D1/34 ,  B65D1/02 ,  B65D39/00 ,  B65B69/00 ,  G01N35/02 ,  G01N35/10 ,  G01N30/60 ,  G01N35/00 ,  C12Q1/686

Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.