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公开(公告)号：US11543349B2
公开(公告)日：2023-01-03
申请号：US17321907
申请日：2021-05-17
Applicant: GEN-PROBE INCORPORATED
Inventor： Norbert D. Hagen , David Opalsky , George T. Walker , Byron J. Knight
Abstract: Method for calibrating or monitoring performance of an optical measurement device that includes using a robotic arm to move a reference device having an optical reference material into a signal-detecting position of the optical measurement device. With the optical measurement device, detecting an emission emitted by the optical reference material of the reference device in the signal-detecting position. Then generating a reference signal representing a characteristic of the emission detected by the optical measurement device and comparing the reference signal to an expected reference signal for the emission to calibrate or monitor the performance of the optical measurement device.
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公开(公告)号：US11511283B2
公开(公告)日：2022-11-29
申请号：US16811772
申请日：2020-03-06
Applicant: Gen-Probe Incorporated
Inventor： David H. Combs , David A. Buse , Norbert D. Hagen , David Opalsky , Jin Chen
Abstract: A system and method provides a supply of consumables to a processing instrument that uses one or more of the consumables for each of a plurality of processes performed by the instrument. The system includes a loading drawer holding a carrier for receiving a plurality of consumables and an input module for holding a carrier supporting a plurality of consumables thereon and presenting the consumables for access by the instrument. A transporter includes a vertical elevator and a lateral actuator for moving a lift platform vertically and laterally and for transporting carriers on the lift platform with or without consumables supported thereon between the loading drawer and the input module, between the loading drawer and one or more holding shelves, or between the input module and one or more holding shelves. A carrier includes parallel support rails for holding multiple receptacle units and retainer tabs for retaining the units on the support rails.
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公开(公告)号：US20220364154A1
公开(公告)日：2022-11-17
申请号：US17878491
申请日：2022-08-01
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , Norbert D. Hagen , David Opalsky
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
Abstract: A reagent pack changer includes a reagent pack input device, a reagent pack storage compartment, a reagent pack storage carousel disposed within the storage compartment, and a rotary distributor. The input device includes a reagent pack input carousel rotatable about an axis of rotation, with reagent pack stations for holding reagent packs disposed around the axis of rotation of the carousel. The reagent pack storage carousel is rotatable about an axis of rotation with reagent pack stations for holding reagent packs disposed around the axis of rotation. The rotary distributor is configured to move a reagent pack between the reagent pack input carousel and the reagent pack storage carousel.
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公开(公告)号：US11434521B2
公开(公告)日：2022-09-06
申请号：US17668775
申请日：2022-02-10
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , David Howard Combs , Byron J. Knight , Norbert D. Hagen , David Opalsky , Jason F. Rhubottom , Keith Moravick , Tyler Moore , Anita Prasad , Bruce Richardson
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.
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公开(公告)号：US11345946B2
公开(公告)日：2022-05-31
申请号：US15934339
申请日：2018-03-23
Applicant: GEN-PROBE INCORPORATED
Inventor： David Opalsky , David Buse , James T. Tuggle , Alexander Navarro , Patrick Sheehan
IPC: B01L3/00 , C12Q1/6806 , G01F23/263 , G01N35/04 , G01N35/10 , C12Q1/686
Abstract: A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.
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Patent Agency Ranking
公开(公告)号：US11279967B2
公开(公告)日：2022-03-22
申请号：US17036730
申请日：2020-09-29
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , David Howard Combs , Byron J. Knight , Norbert D. Hagen , David Opalsky , Jason F. Rhubottom , Keith Moravick , Tyler Moore , Anita Prasad , Bruce Richardson
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
Abstract: A system for performing a nucleic acid amplification assay that includes a receptacle holder formed from a thermally conductive material and having a receptacle well for receiving a lower portion of a vial; a thermal element for cycling the temperature of the receptacle holder; a signal detection module in optical communication with the receptacle well; and a robotic pipettor. The receptacle holder supports a capped vial having a plastic, opaque cap in a snap-fit with a single plastic vial containing a nucleic acid amplification reagent. An upper portion of the cap includes a probe recess that is configured to be removably engaged by an end of a probe of the robotic pipettor. A lower portion of the vial is contained within the receptacle well, and the cap is situated above a top surface of the receptacle holder.
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公开(公告)号：US11098343B2
公开(公告)日：2021-08-24
申请号：US16011229
申请日：2018-06-18
Applicant: GEN-PROBE INCORPORATED
Inventor： David A. Buse , David Opalsky , Jason F. Rhubottom , Norbert D. Hagen , Jennifer L. Tidd
IPC: C12Q1/6806 , B01L3/00 , B01L7/00 , C12Q1/686 , G01N35/04
Abstract: A processing module is configured to extend the capabilities of an analyzer configured to process substances within each of a plurality of receptacles. The module includes a container transport configured to transport a container from a location within the processing module to a location within the analyzer that is accessible to a substance transfer device of the analyzer. A receptacle distribution system is configured to receive a receptacle from the analyzer, transfer the receptacle into the processing module, and to move the receptacle between different locations within the analyzer. A substance transfer device of the module is configured to dispense substances into or remove substances from the receptacle within the processing module. A reagent card exchanger provides an input device for inserting reagent cards into and removing reagent cards from the module, stores reagent cards within the module, and transfers reagent cards to different location within the module.
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公开(公告)号：US10969336B2
公开(公告)日：2021-04-06
申请号：US15176867
申请日：2016-06-08
Applicant: Gen-Probe Incorporated
Inventor： Norbert D. Hagen , David Opalsky , George T. Walker , Byron J. Knight
Abstract: An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.
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公开(公告)号：US10961572B2
公开(公告)日：2021-03-30
申请号：US16434910
申请日：2019-06-07
Applicant: Gen-Probe Incorporated
Inventor： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore
Abstract: A thermally conductive receptacle holder includes a plurality of wells that each receive a receptacle. A cross-brace is mounted to a support to exert a force onto an outer surface of a compressive housing such that the compressive housing exerts a force onto the receptacle holder. An optical fiber associated with each well provides optical communication between the receptacle well and an excitation signal source and/or an emission signal detector.
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公开(公告)号：US20210017579A1
公开(公告)日：2021-01-21
申请号：US17036730
申请日：2020-09-29
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , David Howard Combs , Byron J. Knight , Norbert D. Hagen , David Opalsky , Jason F. Rhubottom , Keith Moravick , Tyler Moore , Anita Prasad , Bruce Richardson
IPC: C12Q1/6806 , G01N35/04 , B01L3/00 , B01L7/00 , C12Q1/686
Abstract: A system for performing a nucleic acid amplification assay comprises a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.
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