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    SURFACE TREATED BIOERODIBLE METAL ENDOPROSTHESES
    23.
    发明申请
    SURFACE TREATED BIOERODIBLE METAL ENDOPROSTHESES 失效
    表面处理的生物可降解金属内切酶

    公开(公告)号：US20110238151A1

    公开(公告)日：2011-09-29

    申请号：US13053791

    申请日：2011-03-22

    Applicant: Torsten Scheuermann ,  Jan Weber ,  Charles Deng ,  Jonathan S. Stinson ,  Steven R. Larsen ,  Dennis A. Boismier ,  Jacob D. Edick

    Inventor： Torsten Scheuermann ,  Jan Weber ,  Charles Deng ,  Jonathan S. Stinson ,  Steven R. Larsen ,  Dennis A. Boismier ,  Jacob D. Edick

    IPC: A61F2/82

    CPC classification number: A61L31/148 ,  A61F2/91 ,  A61F2210/0004 ,  A61L31/022 ,  A61L31/088

    Abstract: An endoprosthesis includes an expandable tubular body defined by a plurality of struts. In some embodiments, the expandable tubular body includes a bioerodible metal that has at least a first surface region and a second surface region. The first and second surface regions can have different surface oxide compositions. In some embodiments, the first portion has a thermally altered microstructure and the second portion has a wrought microstructure. The thermally altered microstructure can be a cast microstructure comprising dendritic grains. The first portion forms at least a portion of an outer surface of the expandable tubular body. In some embodiments, the expandable tubular body includes iron or a bioerodible iron alloy and at least one surface of the expandable tubular body includes a substantially uniform coating of iron(III) oxide.

    Abstract translation: 内假体包括由多个支柱限定的可扩张管状体。 在一些实施例中，可扩张管状体包括具有至少第一表面区域和第二表面区域的生物浸渍金属。 第一和第二表面区域可以具有不同的表面氧化物组成。 在一些实施例中，第一部分具有热改变的微结构，第二部分具有锻造微结构。 热改变的微结构可以是包含树枝状晶粒的铸造微结构。 第一部分形成可扩张管状体的外表面的至少一部分。 在一些实施例中，可膨胀管状体包括铁或生物腐蚀性铁合金，并且可膨胀管体的至少一个表面包括基本均匀的氧化铁（III）涂层。

    Catheter tip
    24.
    发明授权
    Catheter tip 有权
    导管尖

    公开(公告)号：US07972350B2

    公开(公告)日：2011-07-05

    申请号：US10767675

    申请日：2004-01-29

    Applicant: Thomas McHale ,  Jan Weber

    Inventor： Thomas McHale ,  Jan Weber

    IPC: A61M25/10

    CPC classification number: A61M25/0068 ,  A61F2/958 ,  A61F2002/9583 ,  A61F2250/0098 ,  A61M25/001 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/0069 ,  A61M25/008 ,  A61M25/0108 ,  A61M25/0127 ,  A61M25/1027 ,  A61M2025/1079 ,  A61M2025/1093 ,  A61M2205/32

    Abstract: A catheter tip may be coupled to a catheter shaft. The catheter tip may include markers, such as radiopaque markers and MRI markers, securement hubs, recessed portions, a radiused tip, and varying axial flexibility. The catheter tip may be a molded tip, and the markers may be insert molded. Recessed portions and raised securement hubs may be formed during the molding process. The raised hubs may be integrally formed and made from the same material as the catheter tip.

    Abstract translation: 导管尖端可以联接到导管轴。 导管尖端可以包括标记，例如不透射线标记和MRI标记，固定轮毂，凹陷部分，圆角末端和变化的轴向柔性。 导管尖端可以是模制尖端，并且标记可以是嵌入模制的。 嵌入部分和凸起的固定轮毂可以在模制过程中形成。 凸起的轮毂可以由与导管尖端相同的材料一体地形成并制成。

    Endoprosthesis
    25.
    发明申请
    Endoprosthesis 审中-公开
    内假体

    公开(公告)号：US20110160839A1

    公开(公告)日：2011-06-30

    申请号：US12649007

    申请日：2009-12-29

    Applicant: Jan Weber ,  Liliana Atanasoska ,  Rajesh Radhakrishnan

    Inventor： Jan Weber ,  Liliana Atanasoska ,  Rajesh Radhakrishnan

    IPC: A61F2/82 ,  B05D3/00

    CPC classification number: A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2250/0067

    Abstract: An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits.

    Abstract translation: 内表假体，例如生物可蚀塑的支架，其通过等离子体浸没离子注入在表面上和任选地在本体中进行处理。 可释放的治疗剂，药物或药物活性化合物可以并入内用假体的经处理的表面以提供所需的医疗益处。

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    29.
    发明授权
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效
    用于与电力源一起递送治疗剂的内部医疗装置

    公开(公告)号：US07850645B2

    公开(公告)日：2010-12-14

    申请号：US11055930

    申请日：2005-02-11

    Applicant: Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    Inventor： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC: A61M29/00

    CPC classification number: A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    Abstract: The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    Abstract translation: 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

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