公开(公告)号：US6167293A

公开(公告)日：2000-12-26

申请号：US635078

申请日：1996-04-19

Applicant: Thomas Leonard Chenevert ,  Thomas Kwok-Fah Foo ,  Martin R. Prince

Inventor： Thomas Leonard Chenevert ,  Thomas Kwok-Fah Foo ,  Martin R. Prince

IPC: A61B5/055 ,  G01R33/28 ,  G01R33/48 ,  G01R33/561 ,  G01R33/563

CPC classification number: G01R33/563 ,  G01R33/281 ,  G01R33/56308

Abstract: A 3DFT MRA dynamic study is performed using a contrast agent to enhance image contrast. A monitor pulse sequence is performed at a high temporal rate to monitor the magnitude of the NMR signal produced in a monitor region after the contrast agent is injected into the patient. When the monitor signal reaches a threshold value, the patient is signaled and the 3DFT image data set is acquired.

Abstract translation: 使用造影剂进行3DFT MRA动态研究以增强图像对比度。 以高时间速率执行监视脉冲序列，以监测将造影剂注射到患者体内后的监测区域中产生的NMR信号的大小。 当监视信号达到阈值时，通知患者并获取3DFT图像数据集。

公开(公告)号：US5924987A

公开(公告)日：1999-07-20

申请号：US944426

申请日：1997-10-06

Applicant: James F. M. Meaney ,  Martin R. Prince

Inventor： James F. M. Meaney ,  Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

公开(公告)号：US5762065A

公开(公告)日：1998-06-09

申请号：US705818

申请日：1996-08-30

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

Abstract translation: 本发明是一种用于相对于相邻静脉和背景组织提供感兴趣的动脉的优先增强的方法和装置。 所述方法和装置使最大或基本上提高的输注速率的时间适应与对应于k空间中心的图像数据的收集相关。 技术和设备根据感兴趣的动脉的位置，感兴趣的动脉的大小，患者的身体状况，时间上相关联的最大或基本上升高的输注速率的时间和k空间的映射 由于造影剂传送系统的配置引起的时间延迟和/或成像装置采用的脉冲序列的类型。 适应最大或基本上提高的输注速率的时间与对应于k空间中心的图像数据的收集相关联，提供在收集期间相对于相邻静脉的感兴趣动脉中的最大或基本上升高的对比浓度的周期 的图像数据的至少一部分对应于k空间的中心。

公开(公告)号：US5133709A

公开(公告)日：1992-07-28

申请号：US484181

申请日：1990-02-23

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B18/22 ,  A61B18/24 ,  G02B6/255 ,  G02B6/26

CPC classification number: G02B6/2552 ,  A61B18/245 ,  G02B6/262 ,  A61B2018/2266

Abstract: An apparatus for delivery of high intensity laser radiation of large spot size into arteries and a method for making same are disclosed. An optical radiating apparatus is formed on one end of a light-conducting optical fiber such that high intensity laser radiation leaves the optical radiation apparatus with a spot size that is expanded to a diameter significantly larger than the optical fiber diameter. The apparatus comprises a small diameter, flexible fiber which tapers to a large diameter, smooth, rounded ball tip. The taper allows the beam to expand to several millimeters in diameter and thereby ablate a large channel through an occluded artery. The smooth ball tip minimizes the chance of mechanical dissection or perforation. The fiber material is continuous such that there are no optical interfaces. The light radiation apparatus is manufactured to ensure uniformity of light intensity and the ability to transmit intense light without developing regions of mechanical, thermal or optical damage to the apparatus.

Abstract translation: 公开了一种用于将大斑点的高强度激光辐射输送到动脉中的装置及其制造方法。 在导光光纤的一端形成光辐射装置，使得高强度激光辐射离开光辐射装置，其光点尺寸扩大到明显大于光纤直径的直径。 该装置包括一个小直径的柔性纤维，其逐渐变细到大直径，平滑的圆形球头。 锥形允许束扩张至直径几毫米，从而通过闭塞动脉消融大通道。 平滑的球头使机械夹层或穿孔的机会最小化。 纤维材料是连续的，使得没有光学界面。 制造光辐射装置以确保光强度的均匀性和传递强光的能力，而不会对该装置发生机械，热或光学损伤的区域。

公开(公告)号：US11678890B2

公开(公告)日：2023-06-20

申请号：US13482348

申请日：2012-05-29

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B17/135 ,  A61B17/132 ,  A61B5/055 ,  A61B90/00

CPC classification number: A61B17/135 ,  A61B17/1322 ,  A61B17/1355 ,  A61B5/055 ,  A61B2090/374

Abstract: A thigh compression device and technique to control, time, delay and/or prevent excessive early venous enhancement relative to arterial enhancement and thereby improve and/or enhance MRA images, including peripheral MRA images, is disclosed. In one embodiment, the present invention uses a curved strip of material which is longer on the superior edge and shorter along the inferior edge. When wrapped around the conical shape of the thigh of a subject, for example, a human, the thigh compression device more uniformly conforms to and/or fits around the thigh, providing more even/uniform compression as well as reducing, minimizing and/or eliminating significant movement of the thigh compression device towards the knees of the subject. A snug fit on the thighs may also enable the thigh compression device to be inflated with less fluid, which is faster and less cumbersome for the operator.

公开(公告)号：US20130030284A1

公开(公告)日：2013-01-31

申请号：US13482348

申请日：2012-05-29

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B17/135 ,  A61B5/055 ,  A61B17/1322 ,  A61B17/1355 ,  A61B2090/374

Abstract: A thigh compression device and technique to control, time, delay and/or prevent excessive early venous enhancement relative to arterial enhancement and thereby improve and/or enhance MRA images, including peripheral MRA images, is disclosed. In one embodiment, the present invention uses a curved strip of material which is longer on the superior edge and shorter along the inferior edge. When wrapped around the conical shape of the thigh of a subject, for example, a human, the thigh compression device more uniformly conforms to and/or fits around the thigh, providing more even/uniform compression as well as reducing, minimizing and/or eliminating significant movement of the thigh compression device towards the knees of the subject. A snug fit on the thighs may also enable the thigh compression device to be inflated with less fluid, which is faster and less cumbersome for the operator.

Abstract translation: 公开了一种大腿压缩装置和技术，用于控制，时间，延迟和/或防止相对于动脉增强的过度的早期静脉增强，从而改善和/或增强包括外围MRA图像在内的MRA图像。 在一个实施例中，本发明使用弯曲的材料条，其在上边缘上较长并且沿着下边缘较短。 当围绕受试者的大腿的圆锥形形状（例如人）缠绕时，大腿压缩装置更均匀地适应和/或配合大腿周围，提供更均匀/均匀的压缩以及减少，最小化和/或 消除大腿压缩装置朝向受试者的膝盖的显着运动。 在大腿上贴合适合也可以使大腿压缩装置以更少的流体充气，这对于操作者而言更快且不那么麻烦。

公开(公告)号：US08190236B2

公开(公告)日：2012-05-29

申请号：US11331519

申请日：2006-01-13

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B17/135 ,  A61B5/055 ,  A61B17/1322 ,  A61B17/1355 ,  A61B2090/374

Abstract: There are many inventions described herein as well as many aspects and embodiments of those inventions. A thigh compression device and technique to control, time, delay and/or prevent excessive early venous enhancement relative to arterial enhancement and thereby improve and/or enhance MRA images, including peripheral MRA images. In one embodiment, the present invention uses a curved strip of material which is longer on the superior edge and shorter along the inferior edge. When wrapped around the conical or conal-like shape of the thigh of a subject (for example, a human), the thigh compression device more uniformly conforms to and/or fits around the thigh, providing more even/uniform compression as well as reducing, minimizing and/or eliminating significant movement of the thigh compression device towards the knees of the subject. Notably, a snug fit on the thighs may also enable the thigh compression device to be inflated with less fluid (for example, air) which is faster and less cumbersome for the operator.

Abstract translation: 这里描述了许多发明以及这些发明的许多方面和实施例。 一种大腿压缩装置和技术，用于相对于动脉增强来控制，时间，延迟和/或预防过度的早期静脉增强，从而改善和/或增强MRA图像，包括外围MRA图像。 在一个实施例中，本发明使用弯曲的材料条，其在上边缘上较长并且沿着下边缘较短。 当围绕受试者（例如人）的大腿的锥形或锥形形状缠绕时，大腿压缩装置更均匀地适应和/或适合大腿周围，提供更均匀/均匀的压缩以及减少 ，最大限度地减少和/或消除大腿压缩装置朝向受试者的膝盖的显着运动。 值得注意的是，大腿上的紧贴配合还可以使得较少的流体（例如，空气）使大腿压缩装置膨胀，这对于操作者而言更快且不那么麻烦。

公开(公告)号：US20110054301A1

公开(公告)日：2011-03-03

申请号：US12750027

申请日：2010-03-30

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: Systems and methods for contrast-enhanced magnetic resonance angiography in which both arterial-phase image data and post-contrast image data is collected.

Abstract translation: 用于对比度增强的磁共振血管造影术的系统和方法，其中收集动脉相位图像数据和造影后图像数据。

公开(公告)号：US20100240985A1

公开(公告)日：2010-09-23

申请号：US12791488

申请日：2010-06-01

Applicant: James F.M. Meaney ,  Martin R. Prince

Inventor： James F.M. Meaney ,  Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Abstract translation: 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US07545967B1

公开(公告)日：2009-06-09

申请号：US10664425

申请日：2003-09-17

Applicant: Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

Inventor： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

IPC: G06K9/00

CPC classification number: G06T5/50 ,  G06K2209/05 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30101 ,  Y10S128/92 ,  Y10S128/922

Abstract: In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.

Abstract translation: 在时间分辨的对比度增强磁共振血管造影术中，量化图像质量的度量为通过促进选择掩模和用于减法的动脉相位图像生成线性滤波的复合图像提供了基础。 通过使像素强度的时间行为表示为动脉，静脉或背景组织，对时间序列图像中的各个像素进行滤波，从而在单个图像中提供增强的对比度。 通过重新注册顺序图像来抑制运动伪影，在平均和减法之前调整加权并对傅立叶数据进行滤波以消除由运动或其他现象损坏的数据。