公开(公告)号：US20210325412A1

公开(公告)日：2021-10-21

申请号：US17258873

申请日：2019-07-10

Applicant: NanoCytomics, LLC ,  Northwestern University

Inventor： Hariharan Subramanian ,  Michael Verleye ,  Micah Litow ,  Justin R. Derbas ,  Sergey Rozhok ,  John Hart ,  Chester Henderson ,  Rebecca Bartel ,  Nathan Ray ,  Anthony White

IPC: G01N35/00 ,  G01N1/28 ,  G01N1/31 ,  G01N35/10

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

公开(公告)号：US20180127833A1

公开(公告)日：2018-05-10

申请号：US15727924

申请日：2017-10-09

Applicant: Northwestern University ,  NorthShore University HealthSystem

Inventor： Vadim Backman ,  Hariharan Subramanian ,  Dhwanil Damania ,  Hemant Roy ,  Dhananjay Kunte ,  Mart Angelo De la Cruz

IPC: C12Q1/6886 ,  G01N21/64 ,  G01N33/574 ,  G01N21/41 ,  C12Q1/6806

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  G01N21/41 ,  G01N21/64 ,  G01N21/6486 ,  G01N33/57407 ,  G01N33/57411 ,  G01N33/57419 ,  G01N33/57484

Abstract: The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.