公开(公告)号：US20100219034A1

公开(公告)日：2010-09-02

申请号：US12067135

申请日：2006-09-25

Applicant: Jonathan Charles Wheals ,  Nicholas Jackson

Inventor： Jonathan Charles Wheals ,  Nicholas Jackson

IPC: F16D21/00 ,  F16D19/00

CPC classification number: F16D28/00 ,  F16D21/06 ,  F16D23/12 ,  F16D2021/0646 ,  F16D2021/0661 ,  F16D2023/123

Abstract: A control assembly (10) for controlling the actuation of two clutch packs (50, 52) includes a motor (12) for driving an annular gear wheel (24). Radial pins (30) project from the gear wheel to engage concentric pistons (34, 36) arranged for linear movement relative to one another along the axis of rotation of the gear wheel. Each piston includes slots (40) which define cam surfaces for engagement by the drive pins. Rotation of the gear wheel in first direction causes the pins to drive against cam surfaces on the inner piston, to drive the inner piston towards the inner clutch. Rotation of the gear wheel in the opposite direction causes the pins to drive against cam surfaces on the outer piston, to drive the outer piston towards the outer clutch.

Abstract translation: 用于控制两个离合器组件（50,52）的致动的控制组件（10）包括用于驱动环形齿轮（24）的马达（12）。 径向销（30）从齿轮突出以接合被布置为沿着齿轮的旋转轴线相对于彼此线性运动的同心活塞（34,36）。 每个活塞包括限定用于由驱动销接合的凸轮表面的槽（40）。 齿轮在第一方向上的旋转使销钉驱动抵靠内活塞上的凸轮表面，以驱动内活塞朝向内离合器。 齿轮沿相反方向的旋转使得销钉驱动抵靠外活塞上的凸轮表面，以驱动外活塞朝向外离合器。

公开(公告)号：US20080089909A1

公开(公告)日：2008-04-17

申请号：US11757550

申请日：2007-06-04

Applicant: Kalpana Gupta ,  Nicholas Jackson

Inventor： Kalpana Gupta ,  Nicholas Jackson

IPC: A61K31/70 ,  A61K39/21 ,  A61P31/18 ,  C07H21/04 ,  C12N7/04 ,  C12Q1/70

CPC classification number: C12Q1/703 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

Abstract: The present invention relates to consensus nucleotide and protein sequences for HIV-1 Clade A antigens, and to nucleotide and protein sequences for Clade A antigens from circulating HIV-1 field isolates wherein the antigen sequences are closely related to the these consensus sequences. In a preferred embodiment, the present invention relates to HIV-1 Clade A transgenes that are derived from such sequences, and that encode either HIV-1 Clade A Gag, Pol (RT and Int), and Nef (referred to as “GRIN”), HIV-1 Clade A Gag, RT, and Nef (referred to as (“GRN”), or HIV-1 Clade A Env. The invention also relates to vectors containing such transgenes, including in preferred embodiment, adenovirus vectors containing such transgenes. The invention also relates to immunogenic compositions comprising the HIV-1 Clade A antigens, nucleotide sequences, vectors, or transgenes of the invention, and to methods of generating an immune response against HIV in a subject by administering an effective amount of such immunogenic compositions.

Abstract translation: 本发明涉及用于HIV-1进化枝A抗原的共有核苷酸和蛋白质序列，以及来自循环HIV-1场分离株的克隆A抗原的核苷酸和蛋白质序列，其中所述抗原序列与这些共有序列密切相关。 在一个优选的实施方案中，本发明涉及从这样的序列衍生的编码HIV-1 Clade A Gag，Pol（RT和Int）和Nef（称为“GRIN”）的HIV-1克隆A转基因， ），HIV-1克隆A Gag，RT和Nef（称为“GRN”）或HIV-1进化链A环。本发明还涉及含有这种转基因的载体，包括在优选实施方案中，含有这种转基因的腺病毒载体 本发明还涉及包含本发明的HIV-1进化枝A抗原，核苷酸序列，载体或转基因的免疫原性组合物，以及通过施用有效量的这种免疫原性产生针对HIV的免疫应答的方法 组合物。

公开(公告)号：US07294257B2

公开(公告)日：2007-11-13

申请号：US10466533

申请日：2001-12-14

Applicant: Nicholas Jackson

Inventor： Nicholas Jackson

IPC: B01D29/11 ,  B01D29/68 ,  A01K63/04

CPC classification number: B01D29/114 ,  A01K63/045 ,  B01D29/58 ,  B01D29/682 ,  B01D2201/583 ,  C02F1/001 ,  C02F1/008 ,  C02F1/02 ,  C02F1/32 ,  C02F1/38 ,  C02F3/00 ,  C02F2103/007 ,  C02F2103/42 ,  C02F2209/40 ,  C02F2209/42

Abstract: A filter unit for filtering particulates and other foreign matter from a water supply, comprising a filtering chamber. At least a portion of an exterior of the filtering chamber being provided with filtering chamber in use. The mesh being sized to filter particulates and other foreign matter from the water. The filter unit further comprising an outlet through which filtered water exits the filter unit, and a rotatable member located within the filtering chamber, the rotatable member having at least one outlet spaced from an internal face of a mesh. The axis of rotation of the rotatable member being such that the at least one outlet traverses at least a substantial portion of the internal face of a mesh. The filter unit further comprising a dedicated pump having an inlet communicating with the filtering chamber and an outlet communicating solely with the rotatable member such that operation of the pump causes filtered water from within the filtering chamber to be pumped through the rotatable member to exit the at least one outlet and impinge on the internal face of the mesh so as to cause particulates and other foreign matter located on an external face of the mesh to be dislodged.

Abstract translation: 一种用于从供水中过滤颗粒物和其它异物的过滤单元，包括过滤室。 过滤室的外部的至少一部分在使用中设有过滤室。 筛网尺寸适于从水中过滤颗粒物和其他异物。 过滤器单元还包括出口，过滤水通过该出口离开过滤器单元，以及位于过滤室内的可旋转构件，可旋转构件具有与网的内表面间隔开的至少一个出口。 可旋转构件的旋转轴线使得至少一个出口横过网状物的内表面的至少大部分。 过滤器单元还包括专用泵，其具有与过滤室连通的入口和仅与可旋转构件连通的出口，使得泵的操作使得过滤室内的过滤水被泵送通过可旋转构件以退出 至少一个出口并撞击在网的内表面上，以便使位于网的外表面上的颗粒和其它异物移动。

公开(公告)号：US5161759A

公开(公告)日：1992-11-10

申请号：US716301

申请日：1991-06-17

Applicant: Timothy J. Burns ,  Lawrence J. Higgins ,  Nicholas Jackson ,  Nicholas M. Benedetti

Inventor： Timothy J. Burns ,  Lawrence J. Higgins ,  Nicholas Jackson ,  Nicholas M. Benedetti

IPC: B60R16/02 ,  B65D67/02 ,  F16L3/08 ,  F16L3/23 ,  H02G3/30

CPC classification number: F16L3/23 ,  B60R16/0215 ,  H02G3/26

Abstract: A retainer which will secure a wire bundle to a panel like the retainer is hinged U shaped portions which can be releasably closed to clamp the bundle between deflectable pair of spreadable wings.