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21.发明授权公开(公告)号：US11090375B2
公开(公告)日：2021-08-17
申请号：US16899738
申请日：2020-06-12
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US20170224804A1
公开(公告)日：2017-08-10
申请号：US15347034
申请日：2016-11-09
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K39/09
CPC classification number: A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20150216996A1
公开(公告)日：2015-08-06
申请号：US14420822
申请日：2013-08-12
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , A. Krishna Prasad , Yu-ying Yang
CPC classification number: A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
Abstract translation: 本发明提供了包含通过（2 - （（2-氧代乙基）硫基）乙基）氨基甲酸酯（eTEC）间隔物共价结合载体蛋白质的糖的eTEC连接的糖缀合物，包含这种糖缀合物的免疫原性组合物，以及制备和使用 这样的糖缀合物和免疫原性组合物。
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24.发明授权公开(公告)号：US11872274B2
公开(公告)日：2024-01-16
申请号：US17194224
申请日：2021-03-06
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-Ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
CPC classification number: A61K39/092 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , Y02A50/30
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US20230355735A1
公开(公告)日：2023-11-09
申请号：US18338961
申请日：2023-06-21
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06
CPC classification number: A61K39/095 , A61K47/646 , A61K47/64 , A61K39/092 , A61K45/06 , A61K47/6415 , A61K2039/6068
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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Patent Agency Ranking
公开(公告)号：US11426456B2
公开(公告)日：2022-08-30
申请号：US17060337
申请日：2020-10-01
Applicant: Pfizer Inc.
Inventor： Jianxin Gu , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad , Yu-Ying Yang
IPC: A61K39/09 , A61K39/385 , A61K39/39 , A61K39/00
Abstract: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.
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公开(公告)号：US11110160B2
公开(公告)日：2021-09-07
申请号：US16774309
申请日：2020-01-28
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06 , A61K39/00
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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28.发明申请公开(公告)号：US20210196810A1
公开(公告)日：2021-07-01
申请号：US17194224
申请日：2021-03-06
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US10946086B2
公开(公告)日：2021-03-16
申请号：US16245378
申请日：2019-01-11
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Amardeep Singh Bhupender Bhalla , Robert G. K. Donald , Jianxin Gu , Kathrin Ute Jansen , Rajesh Kumar Kainthan , Lakshmi Khandke , Jin-Hwan Kim , Paul Liberator , Avvari Krishna Prasad , Mark Edward Ruppen , Ingrid Lea Scully , Suddham Singh , Cindy Xudong Yang
Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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30.发明申请公开(公告)号：US20200306357A1
公开(公告)日：2020-10-01
申请号：US16899738
申请日：2020-06-12
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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