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21.发明授权公开(公告)号：US07795467B1
公开(公告)日：2010-09-14
申请号：US11115699
申请日：2005-04-26
Applicant: Stephen Dirk Pacetti , Charles Claude , Irina Astafieva
Inventor： Stephen Dirk Pacetti , Charles Claude , Irina Astafieva
IPC: C07C265/00 , C07C265/02 , C07C265/04 , C07C265/06 , C07C265/08 , C07C265/10 , C07C265/12 , C07C265/14
CPC classification number: C07C275/16
Abstract: Bioabsorbable, polyurethane-based stent coatings that comprise non-fouling coatings with polyethylene glycol and hyaluronic acid are disclosed. In addition to these coatings, medical devices comprising these coatings and methods of applying the coatings are disclosed.
Abstract translation: 公开了包含聚乙二醇和透明质酸的非结垢涂层的生物可吸收的基于聚氨酯的支架涂层。 除了这些涂层之外，还公开了包括这些涂层的医疗装置和施加涂层的方法。
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22.发明授权公开(公告)号：US07749263B2
公开(公告)日：2010-07-06
申请号：US11970490
申请日：2008-01-07
Applicant: Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC classification number: C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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公开(公告)号：US07673379B1
公开(公告)日：2010-03-09
申请号：US11801955
申请日：2007-05-11
Applicant: Stephen Dirk Pacetti
Inventor： Stephen Dirk Pacetti
CPC classification number: A61F2/958 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2002/9522 , A61F2240/001 , A61L31/022 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2420/06 , B05C11/00 , B21D39/048 , Y10T29/49863 , Y10T29/49865 , Y10T29/49925 , Y10T29/49927 , Y10T29/53996
Abstract: A method of producing a stent-balloon assembly is disclosed which includes providing a stent having a polymeric component; exposing the stent to a relative humidity of 20% to 100%; and crimping the stent on a balloon of a catheter assembly. The polymeric component could be at least part of the material from which the stent is made or could be a constituent of a coating for the stent, such as a drug delivery coating. In lieu of or in addition to the application of humidity, a plasticizing agent can be applied to the polymeric component. A crimping device is also disclosed which allows the stent to be exposed to humidity during the crimping process.
Abstract translation: 公开了一种制造支架 - 球囊组件的方法，其包括提供具有聚合物组分的支架; 将支架暴露于20％至100％的相对湿度; 并将支架卷曲在导管组件的气球上。 聚合物组分可以是制造支架的材料的至少一部分，或者可以是用于支架的涂层的成分，例如药物递送涂层。 除了施加湿度之外，还可以将增塑剂施加到聚合物组分上。 还公开了压接装置，其允许支架在压接过程期间暴露于湿度。
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公开(公告)号：US20080220055A1
公开(公告)日：2008-09-11
申请号：US11714439
申请日：2007-03-05
Applicant: Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Stephen Dirk Pacetti
CPC classification number: A61K9/0087 , A61K47/6907 , A61K47/6911 , A61K47/6913 , A61K47/6915 , A61K47/6935 , B82Y5/00
Abstract: A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed.
Abstract translation: 公开了包含对血小板具有结合亲和力的纳米颗粒的组合物，以及使用该组合物治疗血管疾病的方法。
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25.发明授权公开(公告)号：US09089627B2
公开(公告)日：2015-07-28
申请号：US11827180
申请日：2007-07-10
Applicant: Syed F. A. Hossainy , David C. Gale , Stephen Dirk Pacetti , Bin Huang
Inventor： Syed F. A. Hossainy , David C. Gale , Stephen Dirk Pacetti , Bin Huang
CPC classification number: A61F2/86 , A61F2210/0076 , A61F2230/0069 , A61L31/10 , A61L31/129
Abstract: Stents fabricated from polymer composites toughened by a dispersed phase are disclosed.
Abstract translation: 公开了由分散相增韧的聚合物复合材料制成的支架。
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Patent Agency Ranking
公开(公告)号：US20130165461A1
公开(公告)日：2013-06-27
申请号：US13332509
申请日：2011-12-21
Applicant: Stephen Dirk Pacetti , Jeffrey B. Huff , Paul Macke Consigny
Inventor： Stephen Dirk Pacetti , Jeffrey B. Huff , Paul Macke Consigny
IPC: A61K31/505 , A61P9/04 , A61M37/00 , A61K31/401
CPC classification number: A61K31/401 , A61K31/505 , A61K35/19
Abstract: Methods of treating heart failure by administration of beneficial agents to the heart.
Abstract translation: 通过向心脏施用有益药物治疗心力衰竭的方法。
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27.发明授权Poly(ester amide)-based drug delivery systems with controlled release rate and morphology 有权具有控制释放速率和形态的基于聚（酯酰胺）的药物递送系统公开(公告)号：US08377107B2
公开(公告)日：2013-02-19
申请号：US13037169
申请日：2011-02-28
Applicant: Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
Inventor： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
IPC: A61F2/06
CPC classification number: A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
Abstract: A method of forming a coating on a medical device having a controlled morphology is described. A medical device having a controlled morphology is described.
Abstract translation: 描述了在具有受控形态的医疗装置上形成涂层的方法。 描述具有受控形态的医疗装置。
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公开(公告)号：US08367093B2
公开(公告)日：2013-02-05
申请号：US13186207
申请日：2011-07-19
Applicant: Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
Inventor： Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
IPC: A61F2/00
CPC classification number: A61L31/10 , A61L31/14 , C08F8/00 , C08F8/04 , C08F8/40 , C08F8/48 , Y10T428/1393 , C08L101/04 , C08F214/22
Abstract: Provided herein are methods for functionalizing an polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.
Abstract translation: 本文提供了用于官能化用于形成涂层的聚合物和由其形成的涂层和装置或用于官能化包括聚合物的涂层或装置表面的方法。
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公开(公告)号：US08021676B2
公开(公告)日：2011-09-20
申请号：US11178196
申请日：2005-07-08
Applicant: Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
Inventor： Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
IPC: A61F2/00
CPC classification number: A61L31/10 , A61L31/14 , C08F8/00 , C08F8/04 , C08F8/40 , C08F8/48 , Y10T428/1393 , C08L101/04 , C08F214/22
Abstract: Provided herein are methods for functionalizing an polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.
Abstract translation: 本文提供了用于官能化用于形成涂层的聚合物和由其形成的涂层和装置或用于官能化包括聚合物的涂层或装置表面的方法。
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公开(公告)号：US20110208286A1
公开(公告)日：2011-08-25
申请号：US13099095
申请日：2011-05-02
Applicant: Diem Uyen Ta , Caroline Wu , Brenna K. Hearn , Daniel L. Cox , Leonardo D. Barbod , Jessie Delgado , Stephen Dirk Pacetti , Thomas Ray Hatten , David K. Wrolstad , Kenneth Kay Armstrong , Darrin J. Kent
Inventor： Diem Uyen Ta , Caroline Wu , Brenna K. Hearn , Daniel L. Cox , Leonardo D. Barbod , Jessie Delgado , Stephen Dirk Pacetti , Thomas Ray Hatten , David K. Wrolstad , Kenneth Kay Armstrong , Darrin J. Kent
IPC: A61F2/84
CPC classification number: A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/067 , A61F2002/91525 , A61F2002/91575 , A61F2250/006
Abstract: An improved stent design and stent delivery catheter assembly for repairing a main vessel and a side branch vessel forming a bifurcation. The stent includes rings aligned along a common longitudinal axis and connected by links, where the stent has one or more portals for aligning with and partially expanding into the opening to the side branch vessel. The stent is implanted at a bifurcation so that the main stent section is in the main vessel, and the portal section covers at least a portion of the opening to the side branch vessel. A second stent can be implanted in the side branch vessel and abut the expanded central section to provide full coverage of the bifurcated area in the main vessel and the side branch vessel. Radiopaque markers on the stent and on the tip of the delivery catheter assist in aligning the portal section with the opening to the side branch vessel.
Abstract translation: 改进的支架设计和支架输送导管组件，用于修复形成分叉的主血管和侧分支血管。 支架包括沿着共同的纵向轴线对齐并且通过连接件连接的环，其中支架具有用于与侧分支容器的开口对准并部分地扩张的一个或多个门户。 将支架植入分叉处，使得主支架部分在主容器中，并且入口部分覆盖至侧分支容器的开口的至少一部分。 第二支架可以植入侧支血管并且邻接扩张的中心部分以提供主血管和侧支血管中的分叉区域的全面覆盖。 在支架上和输送导管的尖端上的不透射线的标记有助于将门静脉部分与侧支血管的开口对准。
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