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公开(公告)号：US20190275327A1
公开(公告)日：2019-09-12
申请号：US16356639
申请日：2019-03-18
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
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公开(公告)号：US20190209841A1
公开(公告)日：2019-07-11
申请号：US16355306
申请日：2019-03-15
Applicant: ElectroCore, Inc.
Inventor： Joseph P. Errico , Steven Mendez , Bruce J. Simon
CPC classification number: A61N1/36021 , A61B5/0071 , A61B5/066 , A61B5/6898 , A61B5/7425 , A61N1/0456 , A61N1/36014 , A61N1/36025 , A61N1/37217 , A61N1/3756 , A61N1/3787 , H04M1/21 , H04M2250/12
Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
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公开(公告)号：US20250152939A1
公开(公告)日：2025-05-15
申请号：US18935523
申请日：2024-11-02
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , Peter Staats , Jonathan Gardiner , Jeckin Shah , Michael Romaniw
Abstract: Systems, devices and methods are provided for stimulating one or more nerves within a user. A system comprises stimulator having an electrode configured for contacting the outer skin surface at a target location and an energy source coupled to the stimulator, The energy source is configured to generate at least one electrical impulse and to transmit the electrical impulse transcutaneously from the electrode through the outer skin surface of the user to a selected nerve in the user. In certain aspects, the systems and methods are particularly useful for non-medical purposes, such as reducing stress and anxiety, enhancing relaxation, improving sleep, energy, concentration and mood, increasing mental or physical performance, promoting mental health, recovery and wellness, generally improving the health and wellbeing of a user and/or for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and/or sleep efficiency in human beings.
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公开(公告)号：US20250117545A1
公开(公告)日：2025-04-10
申请号：US18983670
申请日：2024-12-17
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Devices and methods are described to produce therapeutic effects in a patient by utilizing an energy source that transmits energy non-invasively to nervous tissue. A device for modulating a nerve within a body of a patient comprises a housing comprising a power supply and a signal generator for generating an electrical impulse. The electrical impulse comprises bursts of 2 to 20 pulses, wherein each of the bursts has a frequency of 15 to 50 Hz. The device further comprises first and second electrodes coupled to the housing and having a contact surface configured for contacting an outer skin surface of a neck of a user. The energy source is configured to transmit the electrical impulse from the first and second electrodes through the outer skin surface of the user to a vagus nerve.
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公开(公告)号：US20240374889A1
公开(公告)日：2024-11-14
申请号：US18779141
申请日：2024-07-22
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
Abstract: Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.
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Patent Agency Ranking
公开(公告)号：US20240316342A1
公开(公告)日：2024-09-26
申请号：US18595282
申请日：2024-03-04
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC: A61N1/36 , A61B5/00 , A61N1/04 , A61N1/372 , A61N1/40 , A61N2/00 , A61N2/02 , G06Q10/10 , G16H20/30 , G16H20/40 , G16H40/20
CPC classification number: A61N1/36021 , A61N1/36034 , G06Q10/10 , G16H20/30 , G16H20/40 , G16H40/20 , A61B5/4836 , A61B2560/0456 , A61N1/0456 , A61N1/37235 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
Abstract: Devices, systems, and methods are provided for treating various symptoms, disorders and medical conditions through noninvasive stimulation of a nerve. A system comprises a stimulator having an interface configured to contact an outer skin surface of a user and an energy source coupled to the interface. The energy source transmits an electrical signal comprising a plurality of electrical impulses through the interface transcutaneously through the outer skin surface of the user to a nerve of the user such that the nerve is modulated. The system further comprises a downloadable software application downloadable onto a mobile device configured for wireless coupling to the stimulator to transmit data from the software application to the stimulator. The downloadable software application controls a duration of time in which the stimulator generates the electrical signal.
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公开(公告)号：US20240198086A1
公开(公告)日：2024-06-20
申请号：US18593513
申请日：2024-03-01
Applicant: ElectroCore, Inc.
Inventor： Bruce J. Simon , Joseph P. Errico
CPC classification number: A61N1/0456 , A61N1/04 , A61N1/0492 , A61N1/0551 , A61N1/36014 , A61N1/36025 , A61N1/36034 , A61N1/0472 , A61N1/36017 , A61N1/36114 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
Abstract: Devices and methods are disclosed for treating one or more symptoms of a central nervous system disorder in a patient, such as fibromyalgia, anxiety, traumatic brain injury or post-traumatic stress disorder (PTSD). A device comprises one or more electrodes configured for contacting an outer skin surface of the patient and an energy source coupled to the electrodes. The energy source generates at least one electrical impulse and transmits the electrical impulse transcutaneously from the electrodes through the outer skin surface of the patient to a vagus nerve in the patient. The electrical impulse comprises a burst period and a constant period. Each burst period comprises 2 to 20 pulses that alternate between a positive and negative electric field charge and at least a portion of each constant period comprises zero pulses. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the disorder are reduced.
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公开(公告)号：US11944807B2
公开(公告)日：2024-04-02
申请号：US17481510
申请日：2021-09-22
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico
CPC classification number: A61N1/0456 , A61N1/04 , A61N1/0492 , A61N1/0551 , A61N1/36014 , A61N1/36025 , A61N1/36034 , A61N1/0472 , A61N1/36017 , A61N1/36114 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
Abstract: Devices, systems and methods are disclosed for treating one or more symptoms of central nervous system disorders in a patient, such as anxiety disorders, fibromyalgia, traumatic brain injury, PTSD, and others. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of the central nervous system disorder are reduced. For chronic treatment of such disorders, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms.
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公开(公告)号：US20240058605A1
公开(公告)日：2024-02-22
申请号：US18386242
申请日：2023-11-01
Applicant: ElectroCore, Inc.
Inventor： Joseph P. Errico , Steven Mendez , Bruce J. Simon
CPC classification number: A61N1/36021 , A61N1/0456 , A61N1/36025 , A61N1/3603 , A61N1/36034 , A61N1/37217 , A61N1/3756 , A61N1/3787 , H04M1/21 , A61B5/6898
Abstract: Systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like. The system comprises a stimulator configured for wireless coupling to a mobile device and comprising a signal generator that generates an electrical impulse and an energy source. The stimulator includes a contact surface configured to contact an outer skin surface of a head of a patient and a user interface for selecting a therapy regimen. The stimulator transmits the electrical impulse transcutaneously through the outer skin surface to a nerve at a target region of the head, wherein the electrical impulse is sufficient to modulate the nerve and modify the medical condition. The system further comprises a software program downloadable onto the mobile device and configured to communicate with the stimulator.
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公开(公告)号：US11850056B2
公开(公告)日：2023-12-26
申请号：US17874364
申请日：2022-07-27
Applicant: ELECTROCORE, INC
Inventor： Bruce J. Simon , Joseph P. Errico
CPC classification number: A61B5/394 , A61B5/4035 , A61B5/4041 , A61B5/4803 , A61B5/4836 , A61B5/7264 , A61B5/7267 , A61N1/36021 , A61N1/36031 , A61N1/36034 , A61B5/02405 , A61B5/687 , A61B2090/3941 , A61N1/40
Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
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