公开(公告)号：US08592637B2

公开(公告)日：2013-11-26

申请号：US13393251

申请日：2010-08-20

Applicant: Leo Denissen ,  Eckhard Stroefer ,  Jan-Dirk Arndt ,  Torsten Mattke ,  Kerstin Heinen ,  Julia Leschinski

Inventor： Leo Denissen ,  Eckhard Stroefer ,  Jan-Dirk Arndt ,  Torsten Mattke ,  Kerstin Heinen ,  Julia Leschinski

IPC: C07C205/00

CPC classification number: C07C201/08 ,  C07C2603/24 ,  C07C205/06 ,  C07C205/12 ,  C07C205/47

Abstract: The present invention relates to a process for continuously preparing a mononitrated organic compound, especially a process for preparing mononitrobenzene. The invention relates more particularly to an improved continuous adiabatic process for preparing nitrobenzene.

Abstract translation: 本发明涉及连续制备单硝基有机化合物的方法，特别是一种制备单硝基苯的方法。 本发明更具体地涉及用于制备硝基苯的改进的连续绝热方法。

公开(公告)号：US20130245340A1

公开(公告)日：2013-09-19

申请号：US13990352

申请日：2011-12-07

Applicant: Mahesh Ratnakar Sawant ,  Daniel M. Trauth ,  John G. Pendergast

Inventor： Mahesh Ratnakar Sawant ,  Daniel M. Trauth ,  John G. Pendergast

IPC: B01D3/36 ,  C07C201/16

CPC classification number: B01D3/36 ,  C07C201/08 ,  C07C201/16 ,  C07C205/02

Abstract: Disclosed are a process and an apparatus for concentrating an organic acid by using a nitroalkane as an entrainer for the azeotropic removal of water from an aqueous organic acid solution. The nitroalkane may be the same as a nitroalkane that is the product of a high pressure nitration process that produces nitroalkanes and aqueous organic acid.

Abstract translation: 公开了一种通过使用硝基烷烃作为夹带剂浓缩有机酸的方法和装置，用于从有机酸水溶液中共沸除去水。 硝基烷烃可以与硝基烷烃相同，硝基烷烃是产生硝基烷烃和含水有机酸的高压硝化方法的产物。

公开(公告)号：US08519199B2

公开(公告)日：2013-08-27

申请号：US12934810

申请日：2009-04-08

Applicant: Daniel M Trauth ,  Richard L James

Inventor： Daniel M Trauth ,  Richard L James

IPC: C07C201/16

CPC classification number: C07C201/08 ,  C07C201/12 ,  C07C209/34 ,  C07C239/10 ,  C07D263/04 ,  Y02P20/582 ,  C07C205/02 ,  C07C205/15 ,  C07C211/08

Abstract: Provided is a process for the formation of 2-nitropropane and/or 2,2-dinitropropane by the nitration of propane with dilute nitric acid.

Abstract translation: 提供了通过用稀硝酸硝化丙烷来形成2-硝基丙烷和/或2,2-二硝基丙烷的方法。

公开(公告)号：US20130204043A1

公开(公告)日：2013-08-08

申请号：US13812690

申请日：2011-07-26

Applicant: Thomas Knauf ,  Michael Merkel ,  Andreas Karl Rausch ,  Peter Lehner ,  Jürgen Münnig

Inventor： Thomas Knauf ,  Michael Merkel ,  Andreas Karl Rausch ,  Peter Lehner ,  Jürgen Münnig

IPC: C07C201/14

CPC classification number: C07C201/14 ,  C07C201/08 ,  C07C201/16 ,  C07C209/36 ,  C07C205/06 ,  C07C211/46

Abstract: The present invention relates to a continuous process for the production of nitrobenzene by nitration of benzene with nitric acid or mixtures of nitric acid and sulfuric acid to give a crude nitrobenzene, washing of the crude nitrobenzene by means of at least one of each of an acid, alkaline and neutral washing, there being obtained a pre-purified nitrobenzene which, as well as containing nitrobenzene, at least contains also low boilers, optionally middle boilers as well as high boilers and salts, wherein the pre-purified nitrobenzene is purified further by separating off low boilers in a distillation apparatus by evaporation of the low boilers, and separation of nitrobenzene from the resulting further purified nitrobenzene in a distillation apparatus by partial evaporation of nitrobenzene, wherein pure nitrobenzene is removed from the distillation apparatus in gaseous form and is subsequently condensed, and wherein the non-evaporated portion of the further purified nitrobenzene is fed back into the washing at any desired point.

Abstract translation: 本发明涉及通过用硝酸或硝酸和硫酸的混合物硝化硝酸生产硝基苯的连续方法，得到粗硝基苯，通过以下各项中的至少一种酸洗粗硝基苯 碱性和中性洗涤，得到预纯化的硝基苯以及含有硝基苯，至少还含有低锅炉，任选的中间锅炉以及高锅炉和盐，其中预纯化的硝基苯进一步通过 通过蒸发低沸点锅炉将蒸馏装置中的低锅炉分离出来，并通过硝基苯的部分蒸发在蒸馏装置中将硝基苯与所得到的进一步纯化的硝基苯分离，其中将纯硝基苯以气态从蒸馏装置中除去，随后 冷凝，并且其中进一步纯化的硝基苯的未蒸发部分进料 回到任何想要的点的洗涤。

公开(公告)号：US20130197268A1

公开(公告)日：2013-08-01

申请号：US13812653

申请日：2011-07-26

Applicant: Thomas Knauf ,  Alexandre Racoes ,  Andreas Karl Rausch ,  Dietrich Wulf

Inventor： Thomas Knauf ,  Alexandre Racoes ,  Andreas Karl Rausch ,  Dietrich Wulf

IPC: C07C201/08 ,  C07C209/32

CPC classification number: C07C201/08 ,  C07C209/325 ,  C07C209/36 ,  C07C205/06 ,  C07C211/46

Abstract: The invention relates to a process for the continuous production of nitrobenzene by nitration of benzene with a mixture of nitric acid and sulfuric acid under adiabatic conditions, in which unreacted benzene is separated from the crude product obtained after phase separation before washing thereof, using the adiabatic heat of reaction.

Abstract translation: 本发明涉及一种通过在绝热条件下用硝酸和硫酸的混合物硝化苯来连续生产硝基苯的方法，其中将未反应的苯与洗脱之前相分离后获得的粗产物分离，使用绝热 反应热。

公开(公告)号：US08410323B2

公开(公告)日：2013-04-02

申请号：US12879814

申请日：2010-09-10

Applicant: Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr.

Inventor： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr.

IPC: C07C205/00

CPC classification number: B01D3/141 ,  C07C201/08 ,  C07C205/02

Abstract: Disclosed are a process and apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. Energy and capital costs may be reduced by using a dividing wall column.

Abstract translation: 公开了通过烃原料与硝酸水溶液的反应合成硝基烷烃的方法和装置。 通过使用分隔壁柱可以减少能源和资本成本。

公开(公告)号：US08383832B2

公开(公告)日：2013-02-26

申请号：US13229459

申请日：2011-09-09

Applicant: John Demattei ,  Sagar Shakya ,  Anthony D. Piscopio ,  Bruno P. Hache ,  Matthew Charles Evans ,  James Gair Ford ,  Simon Mark Pointon ,  Koen Peeters ,  Timothy John Lilley ,  John Leonard

Inventor： John Demattei ,  Sagar Shakya ,  Anthony D. Piscopio ,  Bruno P. Hache ,  Matthew Charles Evans ,  James Gair Ford ,  Simon Mark Pointon ,  Koen Peeters ,  Timothy John Lilley ,  John Leonard

IPC: C07D235/04 ,  C07D403/02 ,  C07D235/18

CPC classification number: C07D235/06 ,  C07C201/08 ,  C07C205/58 ,  C07C227/04 ,  C07C227/08 ,  C07C227/18 ,  C07C229/60

Abstract: Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ib-1: wherein Z, X1, X2, X5, R2b and R10 are as defined herein. Compounds of Formula Ib-1 can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.

Abstract translation: 提供了用于合成杂环化合物的方法，例如具有式Ib-1的苯并咪唑羧酸核心结构：其中Z，X1，X2，X5，R2b和R10如本文所定义。 式Ib-1的化合物可用于制备杂环衍生物如苯并咪唑衍生物。

公开(公告)号：US20110306795A1

公开(公告)日：2011-12-15

申请号：US13203360

申请日：2010-02-26

Applicant: Wolfgang Mackenroth ,  Johannes Buettner ,  Eckhard Stroefer ,  Wolfgang Voigt ,  Frank Bok

Inventor： Wolfgang Mackenroth ,  Johannes Buettner ,  Eckhard Stroefer ,  Wolfgang Voigt ,  Frank Bok

IPC: C07C209/02

CPC classification number: C07C201/08 ,  C07C205/06

Abstract: A process for the preparation of mononitroaromatics and dinitroaromatics, in which a hydrate melt of at least one metal nitrate M(NO3)3 is used as a nitrating medium, it being possible for M to be the metals Fe, Cr, Y, La, Ce, Al, Bi and In, and the metal nitrate having a water content of from 4 to 9 mol of water per M(NO3)3, leads to simplifications of the process and improved yields.

Abstract translation: 一种制备单硝基芳族化合物和二硝基溴化物的方法，其中使用至少一种金属硝酸盐M（NO 3）3的水合物熔融物作为硝化介质，M可以是金属Fe，Cr，Y，La， Ce，Al，Bi和In，每M（NO 3）3含水量为4〜9mol的金属硝酸盐导致工艺的简化和提高的产率。

公开(公告)号：US20110263850A1

公开(公告)日：2011-10-27

申请号：US13132001

申请日：2009-11-30

Applicant: Bernard Golding

Inventor： Bernard Golding

IPC: C07D487/04 ,  C07C227/18

CPC classification number: C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C227/16 ,  C07C227/18 ,  C07C303/28 ,  C07C309/66 ,  C07C229/14 ,  C07C205/44 ,  C07C205/26

Abstract: The present invention relates to a novel process for producing quinazoline compounds which are useful in therapy. More specifically, the compounds produced by the process of the invention are useful in the treatment of a number of cardiovascular diseases. The process of the invention provides 6,7-dichloro-1,5- dihydroimidazo [2,1 -b] quinazolin 2 (3H)-one, more commonly known as anagrelide and its analogues in a clean and efficient manner.

Abstract translation: 本发明涉及可用于治疗的喹唑啉化合物的新方法。 更具体地，通过本发明的方法生产的化合物可用于治疗许多心血管疾病。 本发明的方法以清洁和有效的方式提供了6,7-二氯-1,5-二氢咪唑并[2,1-b]喹唑啉2（3H） - 酮，更通常称为阿那格雷及其类似物。

公开(公告)号：US08003831B1

公开(公告)日：2011-08-23

申请号：US12335959

申请日：2008-12-16

Applicant: Joachim C. Ritter

Inventor： Joachim C. Ritter

IPC: C07C205/00

CPC classification number: C07C201/08 ,  C07C205/12

Abstract: A process is provided for the preparation of 1,3-dihalo-4,6-dinitrobenzene by the nitration of 1,3-dihalobenzene. The direct isolation of highly pure 1,3-dihalo-4,6-dinitrobenzene is accomplished without a water or ice quench, and involves the use of at least one equivalent of SO3 during the reaction, slow crystallization, and isolation of product from a cold crystal slurry.

Abstract translation: 提供了通过硝化1,3-二卤代苯制备1,3-二卤代-4,6-二硝基苯的方法。 高纯度的1,3-二卤代-4,6-二硝基苯的直接分离是在没有水或冰骤冷的情况下完成的，并且涉及在反应期间使用至少一当量的SO 3，缓慢的结晶和从 冷结晶浆。