Liquid Chromatograph System
    21.
    发明申请
    Liquid Chromatograph System 有权
    液相色谱系统

    公开(公告)号:US20120103887A1

    公开(公告)日:2012-05-03

    申请号:US13379603

    申请日:2010-06-28

    Abstract: A channel-switching valve into which a high-pressure liquid and a low-pressure liquid flow is provided. The channel-switching valve includes a stator and a rotor which has a surface in contact with one surface of the stator and rotates while sliding on the contact surface. The stator has a plurality of liquid flow ports open to the contact surface, and the rotor has a plurality of channel grooves for connecting the liquid flow ports. One of the channel grooves is a straight groove passing through the rotational center of the rotor, and the other channel grooves are line-symmetrically arranged with respect to the straight channel groove. Alternatively, among the channel grooves, the channel grooves into which the high-pressure liquid flows are configured to be located on both sides of the rotational center of the rotor. As a result, a local load acting on the rotor during a high-pressure liquid-feeding process is reduced, so that the contact surface is prevented from being scraped off by the edge of the opening of a port during the rotation of the rotor.

    Abstract translation: 一个通道切换阀,其中设有高压液体和低压液体流。 通道切换阀包括定子和转子,其具有与定子的一个表面接触的表面,并且在接触表面上滑动时旋转。 定子具有向接触表面开口的多个液体流动端口,并且转子具有用于连接液体流动端口的多个通道槽。 通道槽中的一个是通过转子的旋转中心的直槽,而另一个通道槽相对于直槽形成线对称布置。 或者,在沟槽中,高压液体流过的沟槽形成为位于转子的旋转中心的两侧。 结果,降低了在高压液体供给过程中作用在转子上的局部负荷,使得在转子旋转期间防止接触表面被端口开口的边缘刮掉。

    Sample Dilution for Chromatography of Multiple Process Streams
    22.
    发明申请
    Sample Dilution for Chromatography of Multiple Process Streams 审中-公开
    多个流程色谱的样品稀释

    公开(公告)号:US20110016955A1

    公开(公告)日:2011-01-27

    申请号:US12919555

    申请日:2009-02-25

    Inventor: Sylvain Cormier

    Abstract: A method of liquid chromatography includes providing an injection valve, drawing a sample and a diluent while mixing, pushing the mixed sample and diluent onto a sample loop of the injection valve, and injecting the mixed sample and diluent. An analytical apparatus includes a proportioning unit, an injection valve having a sample loop, and a sample pump. The injection valve has a draw state and a load state, and has a port in fluidic communication with an outlet port of the proportioning unit. The sample pump is in fluidic communication with the outlet port of the proportioning unit, if the injection valve is in the draw state, to draw both a sample and a diluent through the proportioning unit and the injection valve, and in fluidic communication with the sample loop, if the injection valve is in the load state, to push the drawn sample and diluent onto the sample loop.

    Abstract translation: 液相色谱法包括提供注射阀,在混合时抽取样品和稀释剂,将混合的样品和稀释剂推入注射阀的样品环上,并注入混合的样品和稀释剂。 分析装置包括配料单元,具有样品环的注射阀和样品泵。 注射阀具有抽出状态和负载状态,并且具有与配比单元的出口流体连通的端口。 样品泵与配比单元的出口流体连通,如果喷射阀处于拉伸状态,则通过比例单元和喷射阀将样品和稀释剂抽出,并与样品流体连通 循环,如果进样阀处于负载状态,将抽出的样品和稀释剂推到样品环上。

    CHANNEL SWITCHING VALVE
    23.
    发明申请
    CHANNEL SWITCHING VALVE 有权
    通道开关阀

    公开(公告)号:US20100269936A1

    公开(公告)日:2010-10-28

    申请号:US12747996

    申请日:2008-12-17

    Applicant: Masami Tomita

    Inventor: Masami Tomita

    Abstract: In a preferred embodiment, a channel switching valve has a stator having a connecting surface and a body section having a connecting surface, and the stator and the body section are removably fixed to each other by bolts at their connecting surfaces. Each of the connecting surfaces has a protruding/recessed pattern formed thereon, and the protruding/recessed patterns are designed to be fitted into each other. By rotating the stator and the body section relative to each other, the stroke of a spring is changed between a position where the stator and the body section are fixed to each other in a state where their protruding/recessed patterns are fitted into each other and a position where the stator and the body section are fixed to each other in a state where their protruding/recessed patterns are not fitted into each other. The spring is held in the body section in its compressed state to urge the rotor toward the stator. An urging force for pressing the rotor against the stator is adjusted by changing the stroke of the spring.

    Abstract translation: 在优选实施例中,通道切换阀具有具有连接表面的定子和具有连接表面的主体部分,并且定子和主体部分在其连接表面处通过螺栓可拆卸地彼此固定。 每个连接表面具有形成在其上的突出/凹陷图案,并且突出/凹陷图案被设计成彼此配合。 通过相对于彼此旋转定子和主体部分,弹簧的行程在其突出/凹陷图案彼此嵌合的状态下在定子和主体部分彼此固定的位置之间改变,并且 其中定子和主体部分在它们的突出/凹陷图案彼此不嵌合的状态下彼此固定的位置。 弹簧以其压缩状态保持在主体部分中,以将转子推向定子。 通过改变弹簧的冲程来调节用于将转子压靠在定子上的推动力。

    Novel valve and process for interrupted continuous flow chromatography
    25.
    发明申请
    Novel valve and process for interrupted continuous flow chromatography 有权
    新型阀门和中断连续流色谱法

    公开(公告)号:US20070068873A1

    公开(公告)日:2007-03-29

    申请号:US11234798

    申请日:2005-09-26

    Abstract: A unique valve assembly for simulated bed moving chromatography employs a combination of pressure compatible sealable materials that permit minimal frictional interaction between moving parts, ensures alignment of parts, and provides a method for conducting SMB countercurrent chromatography on a small scale, in which purity and separation efficiency are enhanced. Machine designs are disclosed which embody the SMB concepts. Finally, a quick disconnect connector and adaptor is provided for mounting chromatographic columns in an SMB device. Demonstration of this system in a fructose-glucose isomer separation with purity-recovery trade-off for this device is also presented.

    Abstract translation: 用于模拟床移动色谱的独特阀组件采用压力兼容的可密封材料的组合,其允许运动部件之间的最小摩擦相互作用,确保部件的对准,并提供小规模进行SMB逆流色谱的方法,其中纯度和分离 效率提高。 公开了体现SMB概念的机器设计。 最后,提供快速断开连接器和适配器,用于将色谱柱安装在SMB设备中。 还提出了该系统在用于该装置的纯度恢复权衡的果糖 - 葡萄糖异构体分离中的证明。

    Multiport switching valve for a liquid flow system
    26.
    发明授权
    Multiport switching valve for a liquid flow system 有权
    用于液体流动系统的多端口切换阀

    公开(公告)号:US07096886B2

    公开(公告)日:2006-08-29

    申请号:US10650111

    申请日:2003-08-26

    Applicant: Martin Hofmann

    Inventor: Martin Hofmann

    Abstract: A multiport switching valve for a liquid flow system is described, comprising a first member having a plurality of ports for connecting liquid lines thereto, a second member, connected with a first member and movable relative to the first member, the second member comprising a plurality of channels, wherein the channels are arranged such that, according to a selected relative position between the first and second member, one or more of said channel connect predetermined ones of the ports of the first member with one another in a liquid conducting manner. The first member comprises at least one group of ports arranged in one substantially straight line or at least two adjacent substantially parallel and substantially straight lines, and the second member comprises a plurality of segments, wherein the segments have one or more channels arranged therein, the channel or channels of each segment representing a predetermined connection scheme for connecting predetermined ones of the ports with one another.

    Abstract translation: 描述了一种用于液体流动系统的多端口切换阀,包括具有用于连接液体管线的多个端口的第一部件,与第一部件连接并可相对于第一部件移动的第二部件,第二部件包括多个 的通道,其中所述通道被布置成使得根据所述第一和第二构件之间的选定的相对位置,所述通道中的一个或多个将所述第一构件的所述端口中的预定端口以液体导通方式彼此连接。 第一构件包括布置在一个基本上直线或至少两个相邻的基本上平行和基本上直线的至少一组端口,并且第二构件包括多个段,其中段具有布置在其中的一个或多个通道, 每个段的通道或通道表示用于将预定端口彼此连接的预定连接方案。

    Mobile phase gradient generation microfluidic device
    27.
    发明授权
    Mobile phase gradient generation microfluidic device 有权
    流动相梯度生成微流体装置

    公开(公告)号:US06958119B2

    公开(公告)日:2005-10-25

    申请号:US10085598

    申请日:2002-02-26

    Abstract: The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

    Abstract translation: 本发明涉及用于分离流体样品的组分的微流体装置。 盖板布置在衬底的第一表面上,其与形成在第一表面中的微通道组合,限定用于分离流体样品的部件的分离管道。 与分离管道流体连通的入口允许将包含所选流动相组分的梯度的流动相从积分的梯度产生装置引入分离导管。 还提供了一种用于使用包含所选流动相成分的梯度的流动相分离流体样品的组分的方法,其中在少量流动相中产生梯度。

    Rotary valve
    28.
    发明授权
    Rotary valve 有权
    旋转阀

    公开(公告)号:US06537451B1

    公开(公告)日:2003-03-25

    申请号:US09590120

    申请日:2000-06-09

    Applicant: Gérard Hotier

    Inventor: Gérard Hotier

    Abstract: Disclosed is a rotary valve that makes it possible to link several groups of hoses referenced group G1, group G2, and group G3. The valve includes a stator (40) that is provided with means (E, F, R, S) for circulating fluid or fluids of group 1, means (45, 46) for passing at least two fluids F1, F2 that belong to group G3, and a rotor (47) that is equipped with means (9) for passing fluids of group G3 and also means (50) that make possible the linking either of fluids of G1 with group G3 or fluids of group G3 with G3.

    Abstract translation: 公开了一种旋转阀,其使得可以链接几组参考组G1,组G2和组G3的软管。 该阀包括定子(40),该定子设有用于循环流体或组1的流体的装置(E,F,R,S),用于使至少两个属于组的流体F1,F2的装置(45,46) G3和具有用于使组G3的流体通过的装置(9)的转子(47),以及使G1与G3的流体或G3的流体与G3连接的装置(50)的装置(50)。

    Long lifetime fluid switching valve
    29.
    发明授权
    Long lifetime fluid switching valve 有权
    长寿命流体切换阀

    公开(公告)号:US06453946B2

    公开(公告)日:2002-09-24

    申请号:US09800320

    申请日:2001-03-06

    Abstract: A rotary fluid switching valve has facewise adjacent rotor and stator faces of materials that result in an exceptionally long lifetime. One face is of a fluorocarbon-containing polymer, while the other face is Tungsten Carbide/Carbon (WC/C). The WC/C coating is preferably on a metal stator which has machined ports to accept tubing fittings that connect to stator passages that extend to the interface of stator and rotor.

    Abstract translation: 旋转流体切换阀具有面向相邻的转子和材料的定子面,导致特别长的使用寿命。 一面是含碳氟化合物的聚合物,另一面是碳化钨/碳(WC / C)。 WC / C涂层优选在金属定子上,该金属定子具有加工端口以接纳连接到延伸到定子和转子的界面的定子通道的管接头。

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