公开(公告)号：US3652552A

公开(公告)日：1972-03-28

申请号：US3652552D

申请日：1967-12-18

Applicant: STAMICARBON

Inventor： GARRITSEN JOHAN W ,  HOFMAN JOHANNES H A

IPC: C07D201/10 ,  C07D29/16

CPC classification number: C07D201/10

Abstract: A PROCESS FOR PRODUCING LACTAMS FROM CYCLOALKANES IS DISCLOSED. CYCLOALKANES ARE REACTED WITH NITROSYL CHLORIDE WHILE SUBJECTED TO IRRADIATION, IN THE PRESENCE OF A NITRILE WHICH DOES NOT CONTAIN ANY METHYLENE GROUPS CAPABLE OF REACTING WITH NITROSYL UNDER THE REACTION CONDITIONS. WLACTAMS ARE DIRECTLY PRODUCED BY HEATING THE REACTION PRODUCT.

公开(公告)号：US3449326A

公开(公告)日：1969-06-10

申请号：US3449326D

申请日：1966-11-04

Applicant: HALCON INTERNATIONAL INC

Inventor： NAGLIERI ANTHONY N ,  WINNICK CHARLES N

IPC: C07D201/10 ,  C07D41/04 ,  C07D41/00

CPC classification number: C07D201/10

公开(公告)号：US3427303A

公开(公告)日：1969-02-11

申请号：US3427303D

申请日：1964-07-23

Applicant: ORGANICO SOC

Inventor： GENAS MICHAILAS ,  KERN RENE

IPC: C07D201/10

CPC classification number: C07D201/10

公开(公告)号：US09624242B2

公开(公告)日：2017-04-18

申请号：US14621726

申请日：2015-02-13

Applicant: CTI BIOPHARMA CORP.

Inventor： Brian Dymock ,  Cheng Hsia Angeline Lee ,  Anthony Deodaunia William

IPC: C07D498/08 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

CPC classification number: C07D498/08 ,  C07B2200/13 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

Abstract: The present invention relates to certain salts of a 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.

公开(公告)号：US20050010020A1

公开(公告)日：2005-01-13

申请号：US10883822

申请日：2004-07-06

Applicant: Masashi Yokota ,  Yoshinori Kobayashi ,  Masaru Kitamura

Inventor： Masashi Yokota ,  Yoshinori Kobayashi ,  Masaru Kitamura

IPC: C07D201/10 ,  C07D201/04 ,  C08G69/08 ,  C07D223/10 ,  C08G73/10

CPC classification number: C07D201/04 ,  Y02P20/52

Abstract: ε-Caprolactam is produced by the method comprising the step of introducing a gas comprising cyclohexanone oxime into a layer of solid catalyst particles through a plurality of holes of a gas diffusion plate so that the solid catalyst particles are brought into contact with the gas, while fluidizing the catalyst layer, wherein the holes have an average diameter of about 3 mm or smaller. In accordance with the production method, ε-caprolactam can be produced from a raw material gas comprising cyclohexanone oxime with a high conversion of cyclohexanone oxime and a high selectivity to ε-caprolactam.

Abstract translation: ε-己内酰胺通过包括以下步骤的方法制备：包括环己酮肟的气体通过气体扩散板的多个孔引入固体催化剂颗粒层中，使得固体催化剂颗粒与气体接触，同时 使催化剂层流化，其中孔的平均直径为约3mm或更小。 根据制造方法，ε-己内酰胺可以由包含环己酮肟的高转化率和对ε-己内酰胺的高选择性的环己酮肟的原料气体制备。

公开(公告)号：US4349473A

公开(公告)日：1982-09-14

申请号：US199218

申请日：1980-10-21

Applicant: Pier P. Rossi ,  Mario Catoni

Inventor： Pier P. Rossi ,  Mario Catoni

IPC: C07D201/16 ,  B01J19/18 ,  C07D201/08 ,  C07D201/10

CPC classification number: C07D201/10 ,  B01J19/1862 ,  C07D201/08 ,  B01J2219/00058 ,  B01J2219/00094 ,  B01J2219/00128

Abstract: Process for the preparation of .omega.-lactams (in particular caprolactam)ith improved yields, by reaction of cycloaliphatic derivatives having the general formula: ##STR1## wherein n=3-13 with nitrosating agents in the presence of dehydrating agents, characterized by the fact that the reaction is carried out a low temperature which is constant between stages, and in all the zones of a stage and with particular concentrations of the dehydrating agent.

Abstract translation: 通过在脱水剂存在下，通过使具有以下通式的脂环族衍生物（其中n = 3-13）与亚硝化剂反应制备具有改善产率的ω-内酰胺（特别是己内酰胺）的方法，其特征在于： 反应进行阶段之间恒定的低温，在一个阶段的所有区域和特定浓度的脱水剂中进行。

公开(公告)号：US4211700A

公开(公告)日：1980-07-08

申请号：US12495

申请日：1979-02-15

Applicant: Jean-Claude Michel ,  Philippe Potin

Inventor： Jean-Claude Michel ,  Philippe Potin

IPC: C07D201/10 ,  C07D201/04

CPC classification number: C07D201/04

Abstract: The invention relates to a process for the preparation of lactames according to the so-called "Beckmann rearrangement" which consists in isomerizing oximes in a sulfuric solution, the weight ratio percentage of sulfuric acid to the combined amount of sulfuric acid and water being raised to a value above that of the sulfuric solution feed.

Abstract translation: 本发明涉及一种根据所谓的“贝克曼重排”制备内酰胺的方法，该方法包括在硫酸溶液中异构化肟，硫酸与硫酸和水的混合量的比例百分比提高至 值高于硫酸溶液进料的值。

公开(公告)号：US3816404A

公开(公告)日：1974-06-11

申请号：US20619771

申请日：1971-12-08

Applicant: TEXACO INC

Inventor： KABLAOUI M ,  LOVE R ,  DURANLEAU R

IPC: C07C205/51 ,  C07D201/02 ,  C07D201/10 ,  C07D41/06

CPC classification number: C07D201/02 ,  C07C201/12 ,  C07C201/14 ,  C07D201/10 ,  Y02P20/582 ,  C07C205/45 ,  C07C205/51

Abstract: A METHOD FOR PREPARING CAPROLACTAM BY THE STEPS OF (1) NITRO-OXIDIZING CYCLOHEXENE TO 2-NITROCYCOLHEXANONE, (2) CLEAVING AND ESTERIFYING 2-NITROCYCLOHEXANONE WITH AN ALCOHOL TO FORM AN ALKYL 6-NITROHEXANOATE AND (3) CATALYTICALLY HYDROGENATING AND CYCLIZING THE NITROESTER TO CAPROLACTAM.

公开(公告)号：US3733317A

公开(公告)日：1973-05-15

申请号：US3733317D

申请日：1970-06-30

Applicant: SNIA VISCOSA

Inventor： GIUFFRE L ,  SIOLI G

IPC: C07D201/10 ,  C07D41/06

CPC classification number: C07D201/10

Abstract: THERE IS DESCRIBED A PROCESS FOR THE PREPARATION OF OMEGA-LACTAMS HAVING THE GENERAL FORMULA:

O=C
WHEREIN N= FROM 2 TO 13, AND/OR OF THEIR LACTAMIZABLE PRECURSORS, WHICH MAY BE CYCLOALIPHATIC OXIMES OR CYCLOALIPHATIC NITROSO DERIVATIVES, MONOMERS OR DIMERS CHARACTERIZED BY THE FACT THAT THE CORRESPONDING CYCLOMETHYLENE KETENE, HAVING THE GENERAL FORMULA

O=C=C
WHERE N HAS THE AFOREMENTIONED VALUE, IS SUBJECTED TO NITROSATION WITH A NITROSATING AGENT OF THE FORMULLA NOX, WHERE X CAN BE -HSOBJ4, -CL, -NO2, -OR (IN WHICH R INDICATES AN ALKYL OR ARYL ORGANIC SUBSTITUENT), AT A TEMPERATURE COMPRISED BETWEEN -60*C. AND + 100*C.

公开(公告)号：US3712887A

公开(公告)日：1973-01-23

申请号：US3712887D

申请日：1970-10-02

Applicant: RHONE POULENC SA

Inventor： COLLEUILLE Y ,  GARDON R

IPC: C07D201/10 ,  C07D201/02 ,  C07D41/06

CPC classification number: C07D201/02

Abstract: E-CAPROLACTAM IS PREPARED FROM A CYCLOHEXANE OXIDATION PRODUCT CONTAINING CYCLOHEXYL HYDROPEROXIDE AND OXIDATION BY-PRODUCTS INCLUDING 6-HYDROPEROXY-HEXANOIC ACID, WHICH HAS BEEN OBTAINED BY LIQUID PHASE OXIDATION OF CYCLOHEXANE, WITHOUT A METAL CATALYST, USING A MOLECULAR OXYGEN CONTAINING GAS, BY WASHING THE OXIDATION PRODUCT WITH WATER, SEPARATING THE RESULTING AQUEOUS PHASE CONTAINING 6-HYDROPEROXYHEXANOIC ACID AND HEATING THE ACID UNDER PRESSURE WITH AMMONIA AND HYDROGEN IN THE PRESENCE OF A HYDROGENATION CATALYST.