公开(公告)号：US20230416801A1

公开(公告)日：2023-12-28

申请号：US18037428

申请日：2021-11-18

Applicant: Beckman Coulter, Inc.

Inventor： Frederick Rupisan CUENCO

IPC: C12Q1/18 ,  G16B40/00

CPC classification number: C12Q1/18 ,  G16B40/00

Abstract: An optimized testing method is used to determine minimum inhibitory concentration (MIC) of a particular antimicrobic for use on a sample. This may include iteratively imaging wells inoculated with the sample and containing various concentrations of the antimicrobic. The images are thereafter processed to identify MIC based on sequences in information provided as input to a machine learning model.

公开(公告)号：US11846616B2

公开(公告)日：2023-12-19

申请号：US16534066

申请日：2019-08-07

Applicant: Beckman Coulter, Inc.

Inventor： Carlos A. Ramirez

IPC: G01N33/00 ,  G16H10/40 ,  G16H10/60 ,  G01D18/00 ,  G01N31/00

CPC classification number: G01N33/00 ,  G01D18/002 ,  G01N31/00 ,  G16H10/40 ,  G16H10/60

Abstract: Improved systems and methods for laboratory instrument calibration. A laboratory instrument retrieves a number of sets of past quality control parameters from a data structure. Each set includes a recovered value and a timestamp. The recovered value is equal to an output value adjusted by an initial calibration factor. The laboratory instrument determines that the number of sets is greater than a threshold and that each of the past quality control parameters has a timestamp that is within a time threshold. The laboratory instrument computes an updated calibration factor such that when the updated calibration factor is applied to a representative value of the recovered values, the representative value equals the expected recovered value. The instrument updates the data structure with the calibration factor such that the calibration factor is used in subsequent testing of patient specimens.

公开(公告)号：US20230399565A1

公开(公告)日：2023-12-14

申请号：US18207983

申请日：2023-06-09

Applicant: Beckman Coulter, Inc.

Inventor： Massimiliano Tomasulo ,  Mukesh Mudgal ,  Arunkumar Easwaran ,  Sergei Gulnik

IPC: C09K11/06

CPC classification number: C09K11/06 ,  C09K2211/1011

Abstract: The present disclosure provides fused dihydrophenanthrene (DHP) monomers and fluorescent fused DHP polymers, water-soluble fluorescent polymers and copolymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample.

公开(公告)号：US11791022B2

公开(公告)日：2023-10-17

申请号：US16488503

申请日：2018-02-28

Applicant: Beckman Coulter, Inc.

Inventor： Carola Schmidt

IPC: G16H10/40 ,  G16H40/67 ,  G16H10/60 ,  G16H50/20

CPC classification number: G16H10/40 ,  G16H10/60 ,  G16H40/67 ,  G16H50/20

Abstract: A middleware device or software may be placed in communication with one or more testing instruments and a lab information system. As samples are collected from patients and tested with the testing instruments, test results pass through the middleware and are analyzed in context with other data, such as patient history, testing instrument history, and test results from other tests of the sample, in order to determine whether a particular result is acceptable, whether retesting is needed, whether additional sample collection or testing is needed, and whether currently ordered testing is still necessary. When the middleware determines a need for additional testing or retesting it may automatically create orders for such testing in order to reduce delays in manual review of testing results.

公开(公告)号：US20230305003A1

公开(公告)日：2023-09-28

申请号：US18014194

申请日：2021-07-09

Applicant: Beckman Coulter, Inc.

Inventor： Gaelle Bouvier ,  Andreas Boehmler ,  David Faye ,  Eduardo Flores-Fuentes ,  Jesus Amundarain ,  Daniel A. Flagler

IPC: G01N33/569 ,  G01N15/14

CPC classification number: G01N33/56972 ,  G01N15/1459 ,  G01N2015/1006

Abstract: The disclosure relates to, among other things, an automated flow cytometric method and system for the analysis and enumeration of at least one of hematopoietic stem cells, hematopoietic progenitor cells, and T-cells.

公开(公告)号：US20230288416A1

公开(公告)日：2023-09-14

申请号：US18124224

申请日：2023-03-21

Applicant: Beckman Coulter, Inc.

Inventor： Fabrice Malergue ,  Andreas Van Agthoven

IPC: G01N33/569 ,  G01N33/50

CPC classification number: G01N33/56972 ,  G01N33/5091 ,  G01N33/5094 ,  G01N1/30

Abstract: The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.

公开(公告)号：US11754575B2

公开(公告)日：2023-09-12

申请号：US16314261

申请日：2017-06-30

Applicant: Beckman Coulter, Inc.

Inventor： Mark Holland ,  Conan Dewitt

IPC: G01N35/00 ,  G16B40/00 ,  C12Q1/6851

CPC classification number: G01N35/00693 ,  C12Q1/6851 ,  G16B40/00 ,  G01N2035/00653 ,  G01N2035/00702 ,  G01N2035/00881

Abstract: Methods and systems for determining a dose of an analyte in an unknown sample on an instrument, such as a nucleic acid analyzer, immunoassay analyzer, or clinical chemistry analyzer using a reagent from a selected assay lot are described. The methods and systems use core dose-response information based on measurements of response values to a set of calibrators on a plurality of other instruments and assay lot-specific response information to calibrate the instrument.

公开(公告)号：US11733155B2

公开(公告)日：2023-08-22

申请号：US16671795

申请日：2019-11-01

Applicant: Beckman Coulter, Inc.

Inventor： Michael Kapinsky

IPC: G01N15/14 ,  G01N21/25 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N21/255 ,  G01N15/14 ,  G01N15/1425 ,  G01N15/1434 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2201/12

Abstract: Embodiments of the present invention encompass systems and methods for determining detection limits for various antibody-dye conjugates for flow cytometry. Exemplary techniques involve a linear superpositioning approach of spillover-induced enlargements of normally distributed measurement errors.

公开(公告)号：US20230192943A1

公开(公告)日：2023-06-22

申请号：US18094270

申请日：2023-01-06

Applicant: Beckman Coulter, Inc.

Inventor： Arunkumar Easwaran ,  Sergei Gulnik ,  Massimiliano Tomasulo

IPC: C08G61/10 ,  C09B69/10 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/58

CPC classification number: C08G61/10 ,  C09B69/105 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/582 ,  C08G2261/11 ,  C08G2261/18 ,  C08G2261/78 ,  C08G2261/94 ,  C08G2261/145 ,  C08G2261/228 ,  C08G2261/314 ,  C08G2261/1424 ,  C08G2261/1432 ,  C08G2261/1644

Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

公开(公告)号：US20230165492A1

公开(公告)日：2023-06-01

申请号：US18096449

申请日：2023-01-12

Applicant: Beckman Coulter, Inc.

Inventor： Liliana TEJIDOR ,  Iris CASTRO ,  Diana CAREAGA

IPC: A61B5/145 ,  G16H50/50 ,  G16H50/30 ,  A61B5/0205 ,  A61B5/021 ,  G16H70/60 ,  G16H10/60 ,  G16H50/20 ,  G16H70/20

CPC classification number: A61B5/14546 ,  G16H50/50 ,  G16H50/30 ,  A61B5/0205 ,  A61B5/021 ,  G16H70/60 ,  G16H10/60 ,  G16H50/20 ,  G16H70/20 ,  G01N33/6893

Abstract: Systems and methods of assessing a probability that an individual will develop sepsis are provided. The systems and methods can include obtaining a set of parameters associated with the individual including white blood cell count (WBC) and monocyte distribution width (MDW) value, and determining whether the set of parameters provides an elevated risk status by comparing at least the WBC and the MDW value with respective predetermined criteria. In the event that the set of parameters is determined to provide the elevated risk status, the systems and methods can further include obtaining a secondary parameter associated with the individual; and providing the probability that the individual will develop sepsis.