公开(公告)号：US09815862B2

公开(公告)日：2017-11-14

申请号：US14653086

申请日：2013-12-18

Applicant: Glycom A/S

Inventor： Benjámin Podányi ,  Gyula Dekany

IPC: C07H15/12 ,  A23L33/10 ,  A61K31/702 ,  C07H13/04 ,  A23L33/00

CPC classification number: C07H15/12 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H13/04

Abstract: A crystalline LNnT polymorph IV, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuKα radiation, at 8.16, 15.41, 39.14, 23.77, 7.77 and 31.15 2Θ angles, and a crystalline LNnT polymorph V, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuKα radiation, at 9.15, 10.26, 19.68, 26.06, 20.61 and 1 1.89 2Θ angles, are provided.

公开(公告)号：US20160367577A1

公开(公告)日：2016-12-22

申请号：US15183404

申请日：2016-06-15

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  Emma Salomonsson

IPC: A61K31/702 ,  A61K9/00

CPC classification number: A61K31/702 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/2054

Abstract: The invention relates to a method for stabilising or reducing insulin resistance in patients having an obesity-related, metabolic disorder, the method comprising administering to the patient an effective amount of one or more human milk oligosaccharides (HMOs).

Abstract translation: 本发明涉及一种用于在具有肥胖相关代谢紊乱的患者中稳定或降低胰岛素抵抗的方法，所述方法包括向患者施用有效量的一种或多种人乳寡糖（HMO）。

公开(公告)号：US20150291642A1

公开(公告)日：2015-10-15

申请号：US14442017

申请日：2013-09-19

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Gyula Dekany

IPC: C07H3/06 ,  A23L1/29 ,  A23L1/30 ,  C07H1/06

CPC classification number: C07H3/06 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H1/06

Abstract: Crystalline 3-O-fucosyllactose, useful in a pharmaceutical composition and a nutritional formulation, is disclosed.

Abstract translation: 公开了可用于药物组合物和营养制剂的结晶的3-O-岩藻糖基乳糖。

公开(公告)号：US20150252400A1

公开(公告)日：2015-09-10

申请号：US14430930

申请日：2013-09-25

Applicant: GLYCOM A/S

Inventor： Pauline Peltier-Pain ,  Gyula Dekany ,  Christophe Pain ,  Pierre Chassagne ,  Nicolas Fierfort ,  Dóra Molnàr-Gàbor

IPC: C12P19/44 ,  C07H15/08 ,  C07H13/04

CPC classification number: C12P19/44 ,  C07H13/04 ,  C07H15/04 ,  C07H15/08 ,  C07H15/26 ,  C12P19/18

Abstract: The invention relates to a method for producing a glycoconjugate comprising an oligosaccharide part covalently linked to a non-sugar moiety selected from the group consisting of amino acids, peptides, proteins, lipids, longer alkyl groups, polyethylene glycols, α,β-unsaturated amido group and polyvinyl alcohols, using a genetically modified cell.

Abstract translation: 本发明涉及一种制备糖缀合物的方法，其包含与非糖部分共价连接的寡糖部分，所述寡糖部分选自氨基酸，肽，蛋白质，脂质，较长的烷基，聚乙二醇，α，β-不饱和 酰胺基和聚乙烯醇，使用转基因细胞。

公开(公告)号：US12258603B2

公开(公告)日：2025-03-25

申请号：US18550209

申请日：2022-03-11

Applicant: Glycom A/S

Inventor： Getachew S. Molla

IPC: C07H1/06 ,  C07H1/08 ,  C12N9/10 ,  C12P19/04

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US12065462B2

公开(公告)日：2024-08-20

申请号：US16626217

申请日：2018-06-27

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin

IPC: C07H1/06 ,  A23L33/00 ,  B01D61/02 ,  B01D61/04 ,  B01D61/14 ,  B01D61/58 ,  B01D69/02 ,  B01D69/12 ,  B01D71/56 ,  B01D71/58 ,  C07H3/06 ,  C08B37/00 ,  C12P19/04 ,  C12P19/12 ,  C12P19/18

CPC classification number: C07H1/06 ,  A23L33/40 ,  B01D61/027 ,  B01D61/04 ,  B01D61/146 ,  B01D61/58 ,  B01D69/02 ,  B01D69/12 ,  B01D71/56 ,  B01D71/58 ,  C07H3/06 ,  C08B37/0003 ,  C12P19/04 ,  C12P19/12 ,  C12P19/18 ,  A23L33/00 ,  A23V2002/00 ,  B01D61/145 ,  B01D2315/16 ,  B01D2325/20

Abstract: The invention relates to a method for separating sialylated oligosaccharides, preferably sialylated human milk oligosaccharides (HMOs), from disaccharides, preferably lactose, produced by a fermentation or enzymatic process.

公开(公告)号：US11998558B2

公开(公告)日：2024-06-04

申请号：US17120881

申请日：2020-12-14

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  David Paul Kronlage

IPC: A61K31/702 ,  A23L33/125 ,  A61P31/04

CPC classification number: A61K31/702 ,  A23L33/125 ,  A61P31/04 ,  A23V2002/00 ,  Y02A50/30 ,  A61K31/702 ,  A61K2300/00

Abstract: The invention relates to a synthetic composition comprising human milk oligosaccharides for use in at least partially restoring the commensal gastrointestinal microbiota and preventing or mitigating antibiotic associated diarrhoea.

公开(公告)号：US20230338403A1

公开(公告)日：2023-10-26

申请号：US17798270

申请日：2019-12-06

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs ,  Gabriela Bergonzelli Degonda ,  Laurent Favre ,  Laurent Ferrier ,  Clara Lucia

IPC: A61K31/702 ,  A61P1/04 ,  A61K9/48

CPC classification number: A61K31/702 ,  A61P1/04 ,  A61K9/4825

Abstract: The application relates to compositions containing 2′-FL and DFL for use in a method of reducing pain and/or the perception of visceral pain in a non-infant human.

公开(公告)号：US20230099060A1

公开(公告)日：2023-03-30

申请号：US18057355

申请日：2022-11-21

Applicant: GLYCOM A/S

Inventor： Benjámin PODÁNYI ,  Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Markus JONDELIUS HEDEROS

IPC: C07H3/06 ,  C07H1/00 ,  C07H3/02

Abstract: It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

公开(公告)号：US20220378809A1

公开(公告)日：2022-12-01

申请号：US17755956

申请日：2020-11-13

Applicant: GLYCOM A/S

Inventor： Louise Kristine VIGSNÆS ,  Bruce MCCONNELL

IPC: A61K31/702 ,  A61K35/745 ,  A61K9/48 ,  A61K9/16 ,  A61P1/12

Abstract: This invention relates to a method and composition for balancing the bile acid profile in the intestine of humans, particularly decreasing primary bile acids and/or increasing production of secondary bile acids.