公开(公告)号：US5756809A

公开(公告)日：1998-05-26

申请号：US742074

申请日：1996-11-01

Applicant: Ferdinand Hagedorn ,  Helmut Fiege

Inventor： Ferdinand Hagedorn ,  Helmut Fiege

IPC: C07B53/00 ,  C07C319/14 ,  C07C319/18 ,  C07C323/56 ,  C07C149/40

CPC classification number: C07C319/14 ,  C07C319/18

Abstract: (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4"-methoxyphenyl)-propionic acid methyl ester, an important precursor for the preparation of the pharmaceutical active substance diltiazem, is obtained in a particularly high stereoselectivity and yield by addition of o-aminothiophenol onto 3-(4'-methoxyphenyl)-glycidic acid methyl ester if the reaction is carried out in the presence of alkali metal salts of weak acids in the presence of catalytic amounts of iron compounds.

Abstract translation: （2RS，3RS）-3-（2'-氨基苯硫基）-2-羟基-3-（4“ - 甲氧基苯基） - 丙酸甲酯，是制备药物活性物质地尔硫卓的重要前体 如果反应在弱酸的碱金属盐存在下，在催化量的存在下，在3-（4'-甲氧基苯基） - 缩水甘油酸甲酯中加入邻氨基苯硫酚，则具有特别高的立体选择性和产率 铁化合物。

公开(公告)号：US5679826A

公开(公告)日：1997-10-21

申请号：US735717

申请日：1996-10-23

Applicant: Franz-Josef Mais ,  Thomas Essert ,  Helmut Fiege ,  Friedrich Durholz ,  Guido Steffan

Inventor： Franz-Josef Mais ,  Thomas Essert ,  Helmut Fiege ,  Friedrich Durholz ,  Guido Steffan

IPC: B01J31/02 ,  C07B61/00 ,  C07C253/30 ,  C07C255/10

CPC classification number: C07C253/30

Abstract: 2-Chloroacrylonitrile is prepared in a particularly advantageous and readily industrially practicable manner by chlorinating acrylonitrile and then thermally cleaving the 2,3-diehloropropionitrile formed, by chlorinating acrylonitrile in the presence of a catalyst system comprising dimethylformamide and pyridine and/or pyridine derivatives and subjecting the resulting crude 2,3-dichloropropionitrile to thermal cleavage in the presence of the same catalyst system without the addition of further catalysts.

Abstract translation: 通过氯化丙烯腈，然后在包含二甲基甲酰胺和吡啶和/或吡啶衍生物的催化剂体系存在下，通过氯化丙烯腈热分解形成的2,3-二氯丙腈，制备2-氯丙烯腈， 所得粗制的2,3-二氯丙腈在相同的催化剂体系的存在下进行热裂解而不加入另外的催化剂。

公开(公告)号：US5659088A

公开(公告)日：1997-08-19

申请号：US456839

申请日：1995-06-01

Applicant: Helmut Fiege ,  Ferdinand Hagedorn ,  Wolfgang Eymann ,  Otto Neuner ,  Herbert Muller

Inventor： Helmut Fiege ,  Ferdinand Hagedorn ,  Wolfgang Eymann ,  Otto Neuner ,  Herbert Muller

IPC: C07C313/14 ,  C07C319/06 ,  C07C319/24 ,  C07C323/09 ,  C07C319/02 ,  C07C319/14

CPC classification number: C07C319/06 ,  C07C313/14 ,  C07C319/24

Abstract: 4-Fluorothiophenol is obtained in outstanding purifies and yields if 4-fluorobenzenesulphonyl chloride is reacted with sodium hydrogen sulphite solution to give a solution of sodium 4-fluorobenzenesulphinate, this solution is reduced with sulphur dioxide to give 4,4'-difluorodiphenyl disulphide and finally this is reacted with sodium borohydride in a water-miscible inert organic solvent to give 4-fluorothiophenol (sodium salt). Free 4-fluorothiophenol can be isolated from the sodium salt solution by acidification.

Abstract translation: 如果将4-氟苯磺酰氯与亚硫酸氢钠溶液反应，得到4-氟苯磺酸钠溶液，得到4-氟苯硫酚，该溶液用二氧化硫还原得到4,4'-二氟二苯基二硫化物 将其与硼氢化钠在水混溶惰性有机溶剂中反应，得到4-氟苯硫酚（钠盐）。 游离的4-氟代苯硫酚可以通过酸化从钠盐溶液中分离出来。

公开(公告)号：US5629441A

公开(公告)日：1997-05-13

申请号：US514277

申请日：1995-08-11

Applicant: Helmut Kraus ,  Horst Behre ,  Helmut Fiege

Inventor： Helmut Kraus ,  Horst Behre ,  Helmut Fiege

IPC: C07D213/74 ,  C07C253/30 ,  C07C255/61 ,  C07C319/20 ,  C07C323/45 ,  C07D239/28 ,  C07C255/00

CPC classification number: C07D239/28 ,  C07C255/61

Abstract: 2-(Arylimino-methyl)-3-dialkylaminoacrylonitriles can be obtained by reaction of .beta.-anilino-acrylonitriles with ortho-formamides. They are suitable as starting substances for the preparation of 4-amino-5-iminiummethylene-2-pyrimidines or 4-amino-5-formyl-2-pyrimidines.

Abstract translation: 2-（芳基亚氨基 - 甲基）-3-二烷基氨基丙烯腈可以通过β-苯胺基丙烯腈与邻甲酰胺的反应获得。 它们适用于制备4-氨基-5-亚氨基亚甲基-2-嘧啶或4-氨基-5-甲酰基-2-嘧啶的起始物质。

公开(公告)号：US5523481A

公开(公告)日：1996-06-04

申请号：US347660

申请日：1994-12-01

Applicant: Michael Pies ,  Helmut Fiege ,  Josef Kasbauer ,  Gebhard Merz

Inventor： Michael Pies ,  Helmut Fiege ,  Josef Kasbauer ,  Gebhard Merz

IPC: B01J31/02 ,  C07B61/00 ,  C07C68/02 ,  C07C69/96 ,  C07C51/56 ,  C07C51/54

CPC classification number: C07C68/02

Abstract: Dialkyl dicarbonates are obtained particularly advantageously from halogenoformic esters by reaction with alkalis in the presence of water-immiscible organic solvents and in the presence of a catalyst, if the catalyst used is benzylalkyldimethylammonium halides. The catalyst is then particularly easy to separate off and to recycle from the reaction mixture.

Abstract translation: 如果所用的催化剂是苄基烷基二甲基卤化铵，则在与水不混溶的有机溶剂的存在下和在催化剂存在下，通过与碱反应，特别有利地从卤代甲酸酯获得二烷基二烷基酯。 然后催化剂特别容易分离并从反应混合物中再循环。

公开(公告)号：US5384059A

公开(公告)日：1995-01-24

申请号：US110343

申请日：1993-08-20

Applicant: Alfons Klein ,  Rudolf Kron ,  Helmut Fiege ,  Klaus-Christian Paetz

Inventor： Alfons Klein ,  Rudolf Kron ,  Helmut Fiege ,  Klaus-Christian Paetz

IPC: C09K5/08 ,  C07C2/86 ,  C07C5/11 ,  C07C13/28 ,  C07C2/66 ,  C07C13/18

CPC classification number: C07C13/28 ,  C07C2/864 ,  C07C5/11 ,  C07C2101/14 ,  C07C2521/08

Abstract: Mixtures consisting essentially of cyclohexylbiphenyls, dicyclohexylbenzenes, phenylbicyclohexyls and tercyclohexyls are outstandingly suitable as heat transfer media. The mixtures can be prepared from biphenyl and cyclohexanol in the presence of bleaching earths and subsequent hydrogenation.

Abstract translation: 基本上由环己基联苯，二环己基苯，苯基双环己基和三环己基组成的混合物非常适合作为传热介质。 混合物可以在漂白土和随后的氢化存在下由联苯和环己醇制备。

公开(公告)号：US5157170A

公开(公告)日：1992-10-20

申请号：US805433

申请日：1991-12-11

Applicant: Franz-Josef Mais ,  Helmut Fiege

Inventor： Franz-Josef Mais ,  Helmut Fiege

IPC: B01J23/50 ,  B01J23/72 ,  C07B61/00 ,  C07C17/00 ,  C07C17/12 ,  C07C25/02

CPC classification number: C07C17/00

Abstract: The halogen of a polyhalogenated aromatic compound can be transferred to a monohalogenated or nonhalogenated aromatic compound by reaction in the presence of ruthenium as the element or in the form of compounds and if desired with one or more metal compounds from subgroups I and II of the Periodic Table.

Abstract translation: 多卤代芳族化合物的卤素可以通过在钌作为元素或化合物的形式存在下反应而转化为单卤代或非卤代芳族化合物，如果需要，可以与周期表的第I和II族的一种或多种金属化合物 表。

公开(公告)号：US5105036A

公开(公告)日：1992-04-14

申请号：US651715

申请日：1991-02-06

Applicant: Franz-Josef Mais ,  Helmut Fiege

Inventor： Franz-Josef Mais ,  Helmut Fiege

IPC: B01J31/02 ,  B01J31/28 ,  C07B61/00 ,  C07C17/12 ,  C07C25/02

CPC classification number: C07C17/12

Abstract: Aromatic hydrocarbons monosubstituted by straight-chain or branched C.sub.1 -C.sub.12 -alkyl or by Chd 3-C.sub.8 -cycloalkyl can be chlorinated in the aromatic ring in the liquid phase in the presence of Friedel-Crafts catalysts if cyclic amidines which are oxy-sustituted on the exocyclic N atom are employed as co-catalysts. An increased proportion of the p-isomer is obtained in this reaction.

Abstract translation: 在Friedel-Crafts催化剂存在下，通过直链或支链C1-C12烷基或由Chd 3-C8-环烷基单取代的芳族烃可以在芳烃环中被氯化，如果环状脒被羟基维持在 外环N原子用作助催化剂。 在该反应中获得了比例增加的对异构体。

公开(公告)号：US4956505A

公开(公告)日：1990-09-11

申请号：US375761

申请日：1989-07-05

Applicant: Franz-Josef Mais ,  Helmut Fiege ,  Karl-Wilhelm Henneke

Inventor： Franz-Josef Mais ,  Helmut Fiege ,  Karl-Wilhelm Henneke

IPC: C07C45/00 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C45/78 ,  C07C45/82 ,  C07C49/223 ,  C07C49/233 ,  C07C49/235 ,  C07C67/00

CPC classification number: C07C49/235 ,  C07C45/62 ,  C07C45/73 ,  C07C45/74 ,  C07C45/78 ,  C07C45/82 ,  C07C49/223

Abstract: 4,4-Dimethyl-1-(p-chlorophenyl)pentan-3-one can be prepared by condensation of pinacolone and p-chlorobenzaldehyde in an alcohol as solvent in the presence of an inorganic base and by subsequent hydrogenation, in which the reaction mixture obtained in the condensation is hydrogenated directly without isolation of the intermediate 4,4-dimethyl-1-(p-chlorophenyl)-1-penten-3-one after the addition of a hydrogenation catalyst at elevated temperature and superatmospheric pressure to give 4,4-dimethyl-1-(p-chlorophenyl)pentan-3-one, after the hydrogenation catalyst has been separated off from the liquid hydrogenation mixture, the alcohol is largely distilled off, and the water content of the bottom product of the distillation is adjusted in such a manner that it separates into an aqueous and an organic phase, and the 4,4-dimethyl-1-(p-chlorophenyl)pentan-3-one is recovered from the organic phase.

Abstract translation: 4,5-二甲基-1-（对氯苯基）戊-3-酮可以通过频多卡酮和对氯苯甲醛在醇作为溶剂中，在无机碱存在下并通过随后的氢化进行缩合来制备，其中反应 在高温和超大气压下加入氢化催化剂后，在冷凝中获得的混合物直接氢化直接分离中间体4,4-二甲基-1-（对氯苯基）-1-戊烯-3-酮，得到4 ，4-二甲基-1-（对氯苯基）戊-3-酮，在氢化催化剂与液体氢化混合物分离后，大部分蒸馏除去醇，蒸馏塔底产物的含水量 以分离成水相和有机相的方式进行调节，从有机相中回收4,4-二甲基-1-（对氯苯基）戊-3-酮。

公开(公告)号：US4925994A

公开(公告)日：1990-05-15

申请号：US342500

申请日：1989-04-24

Applicant: Franz-Josef Mais ,  Helmut Fiege

Inventor： Franz-Josef Mais ,  Helmut Fiege

IPC: B01J31/30 ,  C07B61/00 ,  C07C17/00 ,  C07C17/12 ,  C07C25/02 ,  C07C25/18 ,  C07C67/00

CPC classification number: C07C17/12

Abstract: Aromatic hydrocarbons which are monosubstituted by straight-chain or branched C.sub.1 -C.sub.12 -alkyl or by C.sub.3 -C.sub.8 -cycloalkyl can be chlorinated in the presence of Friedel-Crafts Catalysts in liquid phase on the aromatic ring if 1,6-benzothiazocins are used as co-catalysts. This makes it possible to obtain a higher proportion of p-isomers.

Abstract translation: 通过直链或支链的C 1 -C 12 - 烷基或C 3 -C 8 - 环烷基单取代的芳族烃可以在芳环上的液相中的Friedel-Crafts催化剂存在下进行氯化，如果使用1,6-苯并噻唑作为 助催化剂。 这使得可以获得较高比例的对异构体。