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    Heterocyclic-ring condensed benzothiazine compound
    31.
    发明授权
    Heterocyclic-ring condensed benzothiazine compound 失效
    杂环稠合苯并噻嗪化合物

    公开(公告)号：US06583138B1

    公开(公告)日：2003-06-24

    申请号：US09622458

    申请日：2001-01-04

    Applicant: Mitsuaki Miyamoto ,  Tatsuya Yoshiuchi ,  Keizo Sato ,  Motohiro Soejima ,  Takashi Sato ,  Koichi Kikuchi ,  Hiroyuki Yoshimura ,  Katsuhiro Moriya ,  Yoshinori Sakuma ,  Shigeru Akasofu ,  Koji Yamada

    Inventor： Mitsuaki Miyamoto ,  Tatsuya Yoshiuchi ,  Keizo Sato ,  Motohiro Soejima ,  Takashi Sato ,  Koichi Kikuchi ,  Hiroyuki Yoshimura ,  Katsuhiro Moriya ,  Yoshinori Sakuma ,  Shigeru Akasofu ,  Koji Yamada

    IPC: C07D51304

    CPC classification number: C07D513/04

    Abstract: The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of the present invention or a pharmacologically acceptable salt thereof is effective for prevention or remedy of disease, in which a chemical mediator, such as histamine, leukotriene and the like, participate, for example, asthma, allergic coryza, atopic dermatitis, hives, hay fever, gastrointestinal allergy, food allergy and the like. Further, the heterocyclic ring condensed benzothiazine compound of the present invention, its pharmacologically acceptable salt or hydrates thereof is represented by the following formula: In the formula, the ring Het represents an unsaturated heterocyclic ring; R1 and R2 are the same as or different from each other, and each represents halogen atom, a lower alkyl group that may be substituted with a halogen atom, a lower alkoxy group that may be substituted with a halogen atom, a lower alkyl lower alkoxy group, cyano group; D represents a lower alkylene group and the like that may have a substituent; Q represents, for example, the formula —NR20R2 (in the formula, R20 and R21 are the same as or different from each other, and each represents hydrogen atom, a lower alkyl group that may be substituted with a halogen atom, an aryl group that may have a substituent, an arylalkyl group that may have a substituent, a heteroaryl group that may have a substituent or a heteroarylalkyl group that may have a substituent, or R20 and R21 may form a 3- to 8-membered ring along with the nitrogen atom to which they are bound); and x represents an integer of from 1 to 2.

    Abstract translation: 本发明提供一种新颖的杂环稠合苯并噻嗪化合物，其对组胺，白细胞三烯等参与的疾病的预防或治疗有效。 本发明的杂环稠合苯并噻嗪化合物或其药理学上可接受的盐对于预防或治疗其中化学介质如组胺，白三烯等参与的疾病是有效的，例如哮喘，过敏性鼻炎， 特应性皮炎，荨麻疹，花粉症，胃肠道过敏，食物过敏等。 此外，本发明的杂环稠合苯并噻嗪化合物，其药理学上可接受的盐或其水合物由下式表示：式中，环Het表示不饱和杂环; R1和R2彼此相同或不同，各自表示卤素原子，可以被卤素原子取代的低级烷基，可被卤素原子取代的低级烷氧基，低级烷基低级烷氧基 基团，氰基; D表示可以具有取代基的低级亚烷基等; Q表示例如式-NR20R2（式中，R20和R21彼此相同或不同，各自表示氢原子，可被卤素原子取代的低级烷基，芳基 可以具有取代基的芳基烷基，可以具有取代基的芳基烷基，可以具有取代基的杂芳基或可以具有取代基的杂芳基烷基，或者R20和R21可以与 氮原子）; x表示1〜2的整数。

    Coriolis type mass flow meter
    36.
    发明授权
    Coriolis type mass flow meter 失效
    科里奥利型质量流量计

    公开(公告)号：US5488870A

    公开(公告)日：1996-02-06

    申请号：US307260

    申请日：1994-09-16

    Applicant: Hiroyuki Yoshimura ,  Osamu Kashimura

    Inventor： Hiroyuki Yoshimura ,  Osamu Kashimura

    IPC: G01F1/84 ,  G01F1/78

    CPC classification number: G01F1/8409 ,  G01F1/8413 ,  G01F1/8422 ,  G01F1/8427 ,  G01F1/8431 ,  G01F1/8436 ,  G01F1/8472 ,  G01F1/849

    Abstract: Measurement of a mass flow rate is accomplished by equalizing the output amplitude values of upstream and downstream sensors without causing a lowering of the mechanical Q of a vibration system. One of the upstream and downstream sensors includes a permanent magnet disposed on a side of a tube and an induction coil disposed on a side of a base, the output voltage amplitude of which is fixed. Another sensor includes a ferromagnetic member disposed on the side of the tube and an excitation coil and an induction coil disposed on the side of the base. The output voltage amplitude of the induction coil is controlled to be coincident with the output voltage amplitude of the induction coil by adjusting a DC current flowing through the excitation coil.

    Abstract translation: 通过均衡上下游传感器的输出振幅值而不会导致振动系统的机械Q的降低来实现质量流量的测量。 上游和下游传感器中的一个包括设置在管侧的永磁体和设置在基座侧的感应线圈，其输出电压振幅是固定的。 另一传感器包括设置在管侧的铁磁部件和设置在基座一侧的励磁线圈和感应线圈。 感应线圈的输出电压振幅通过调节流过励磁线圈的直流电流而被控制为与感应线圈的输出电压振幅一致。

    Process for producing flexible polyurethane foam having high air flow property
    38.
    发明授权
    Process for producing flexible polyurethane foam having high air flow property 失效
    具有高空气流动性的柔性聚氨酯泡沫塑料的制造方法

    公开(公告)号：US5306738A

    公开(公告)日：1994-04-26

    申请号：US17437

    申请日：1993-02-12

    Applicant: Hiroyuki Yoshimura ,  Yutaka Tamano ,  Shoji Arai

    Inventor： Hiroyuki Yoshimura ,  Yutaka Tamano ,  Shoji Arai

    IPC: C08G18/18 ,  C08G18/20 ,  C08G101/00 ,  C08J9/02

    CPC classification number: C08G18/2027 ,  C08G2101/0008 ,  C08G2101/0083

    Abstract: Process for producing a flexible polyurethane foam through reaction of a polyol with a polyisocyanate in the presence of an amine catalyst, a blowing agent, and a foam stabilizer, the amine catalyst comprising at least one of the imidazoles represented by the general formula below: ##STR1## wherein R.sup.1 is alkyl of 1 to 4 carbons, dimethylaminopropyl, benzyl, vinyl, or hydroxyalkyl of 1 to 3 carbons; R.sup.2 is hydrogen, alkyl of 1 to 4 carbons, allyl, benzyl, or phenyl; and R.sup.3 and R.sup.4 are respectively hydrogen, alkyl of 1 to 4 carbons, or hydroxymethyl.

    Abstract translation: 在胺催化剂，发泡剂和泡沫稳定剂的存在下通过多元醇与多异氰酸酯的反应制备软质聚氨酯泡沫的方法，所述胺催化剂包含由以下通式表示的至少一种咪唑：（ *化学结构*）其中R 1为1至4个碳的烷基，二甲基氨基丙基，苄基，乙烯基或1至3个碳的羟烷基; R2是氢，1至4个碳的烷基，烯丙基，苄基或苯基; R3和R4分别为氢，1〜4个碳的烷基或羟甲基。

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