公开(公告)号：US20110053941A1

公开(公告)日：2011-03-03

申请号：US12744860

申请日：2008-12-01

Applicant: Mario Mautino ,  Firoz Jaipuri ,  Agnieszka Marcinowicz-Flick ,  Tanay Kesharwani ,  Jesse Waldo ,  Steven James Collier

Inventor： Mario Mautino ,  Firoz Jaipuri ,  Agnieszka Marcinowicz-Flick ,  Tanay Kesharwani ,  Jesse Waldo ,  Steven James Collier

IPC: A61K31/5375 ,  A61P37/00 ,  A61K31/135 ,  C07D209/14 ,  A61K31/4045 ,  A61K31/404 ,  C07D403/12 ,  C07D401/12 ,  A61K31/4709 ,  C07D405/12 ,  C07D413/12 ,  A61K31/423 ,  C07C333/04 ,  A61K31/27 ,  C07D213/53 ,  A61K31/4406 ,  A61K31/4402 ,  A61K31/36 ,  A61K31/381 ,  A61K31/47 ,  A61K31/357 ,  A61K31/428 ,  A61K31/505

CPC classification number: C07D333/56 ,  A61K31/138 ,  A61K31/506 ,  C07C259/06 ,  C07C311/48 ,  C07C327/44 ,  C07C327/48 ,  C07C333/20 ,  C07D209/14 ,  C07D209/18 ,  C07D213/40 ,  C07D215/26 ,  C07D253/07 ,  C07D261/20 ,  C07D263/22 ,  C07D277/36 ,  C07D277/64 ,  C07D279/06 ,  C07D307/80 ,  C07D307/81 ,  C07D333/58 ,  C07D333/60 ,  C07D335/06 ,  C07D401/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/409 ,  Y02A50/465

Abstract: Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

Abstract translation: 目前提供的是（a）调节吲哚胺2,3-双加氧酶的活性的方法，包括使吲哚胺2,3-双加氧酶与调节有效量的化合物的接触，如本文所述的一个方面所述; （b）在有需要的受试者中治疗吲哚胺2,3-双加氧酶（IDO）介导的免疫抑制，包括施用有效的吲哚胺2,3-双加氧酶抑制量的本文所述方面之一所述的化合物; （c）治疗受抑于吲哚胺-2,3-双加氧酶的酶活性的医学病症，包括给予有效的吲哚胺2,3-双加氧酶抑制量的本文所述方面之一所述的化合物; （d）增强抗癌治疗的有效性，包括给予本文所述方面之一所述的抗癌剂和化合物; （e）治疗与癌症相关的肿瘤特异性免疫抑制，包括施用有效的吲哚胺2,3-双加氧酶抑制量的本文所述方面之一所述的化合物; （f）治疗与感染性疾病例如HIV-1感染相关的免疫抑制，包括给予有效的吲哚胺2,3-双加氧酶抑制量的化合物，如本文所述方面之一所述。

公开(公告)号：US20100299100A1

公开(公告)日：2010-11-25

申请号：US12811538

申请日：2008-12-31

Applicant: Philip G. Bright ,  Steven James Collier-Hallman

Inventor： Philip G. Bright ,  Steven James Collier-Hallman

IPC: G06F15/00 ,  G01P3/00

CPC classification number: G01P3/44 ,  G01P3/489

Abstract: A method of determining velocity of a shaft is provided. The method includes receiving a first shaft position signal and a second shaft position signal. Derivatives of each of the first shaft position signal and the second shaft position signal are computed, as are squares of each of the derivatives, a summation of the squares, and a square root of the summation. The velocity is output as a result of the square root.

Abstract translation: 提供了一种确定轴速度的方法。 该方法包括接收第一轴位置信号和第二轴位置信号。 计算第一轴位置信号和第二轴位置信号中的每一个的导数，如每个导数的平方，平方和的和，以及求和的平方根。 作为平方根的结果输出速度。

公开(公告)号：US07595755B2

公开(公告)日：2009-09-29

申请号：US11161738

申请日：2005-08-15

Applicant: Timothy Newton ,  James Collier ,  Candido Levita

Inventor： Timothy Newton ,  James Collier ,  Candido Levita

IPC: G01S13/10

CPC classification number: G01S11/02 ,  H04B17/27

Abstract: A method for estimating the distance between a transmitter and a receiver, the transmitter being arranged to transmit a signal as a series of bursts, and the carrier frequency of each burst being set according to a predetermined sequence, the method comprising: forming a first series comprising the measured differences between the phases of successive bursts as received at the receiver; forming a second series comprising estimated differences between the phases of successive bursts as received at a supposed time difference between the transmitter and the receiver; and determining the quality of fit between the first series and the second series.

Abstract translation: 一种用于估计发射机和接收机之间的距离的方法，所述发射机被布置为按照一系列脉冲串发送信号，并且根据预定的顺序设置每个脉冲串的载波频率，所述方法包括：形成第一系列 包括在接收机处接收的连续突发的相位之间的测量差异; 形成第二系列，其包括在所述发射机和接收机之间的假定时间差处接收的连续突发的相位之间的估计差异; 并确定第一系列和第二系列之间的配合质量。

公开(公告)号：US06498409B1

公开(公告)日：2002-12-24

申请号：US09661657

申请日：2000-09-14

Applicant: Steven James Collier-Hallman ,  William J. Bressette

Inventor： Steven James Collier-Hallman ,  William J. Bressette

IPC: H02K1100

CPC classification number: G01P3/487 ,  G01D5/145 ,  G01D5/2033 ,  G01D5/24461 ,  G01D5/2448 ,  G01D5/24495 ,  Y10S310/06

Abstract: A method and apparatus for determining the velocity of a rotating device is described herein. The apparatus includes sets of sense magnets affixed to a rotating shaft of a rotating device and a circuit assembly. The circuit assembly includes a circuit interconnection having sense coils and sensors affixed thereto. The circuit assembly is adapted to place components thereon in close proximity to the sets of sense magnets on the rotating part.

Abstract translation: 本文描述了用于确定旋转装置的速度的方法和装置。 该装置包括固定到旋转装置的旋转轴和电路组件的感测磁体组。 电路组件包括具有感测线圈和固定于其上的传感器的电路互连。 电路组件适于将组件放置在紧邻旋转部件上的感测磁体组上。

公开(公告)号：US06408235B1

公开(公告)日：2002-06-18

申请号：US09664183

申请日：2000-09-18

Applicant: Eugene Thomas Tanke, II ,  Ashok Chandy ,  Julie Ann Kleinau ,  Steven James Collier-Hallman

Inventor： Eugene Thomas Tanke, II ,  Ashok Chandy ,  Julie Ann Kleinau ,  Steven James Collier-Hallman

IPC: B62D506

CPC classification number: B62D5/0469

Abstract: A system and method for controlling the collisions between elements of an automotive rack and pinion steering apparatus and an end-of-travel stop is presented. The system comprises a sensor for sensing a set of dynamic variables of the rack and pinion steering apparatus and operative thereby to generate as output therefrom a first set of signals indicative of the set of dynamic variables; a controller responsive to the first set of signals and operative thereby to provide as output therefrom a modified torque assist command; and a motor drive assembly drive assembly responsive to the modified torque assist command and operative thereby to provide modified torque assistance to the rack and pinion steering apparatus. In another embodiment, the dynamic data is used to calculate a torque limit to be imposed upon the torque assist command whenever the steering system is close to end-of-stop. The two embodiments may also be superimposed. The invention reduces torque at end-of-travel impacts, and helps preserve the mechanical integrity of the power steering system.

Abstract translation: 提出了一种用于控制汽车齿条和小齿轮转向装置的元件与行程终点之间的碰撞的系统和方法。 该系统包括用于感测齿条和小齿轮转向装置的一组动态变量的传感器，并且由此产生作为其输出的第一组信号，该第一组信号指示该组动态变量; 响应于所述第一组信号并由此操作的控制器提供修改的转矩辅助命令作为其输出; 以及电动机驱动组件驱动组件，其响应于改进的扭矩辅助指令并由此操作，以向齿条和小齿轮转向装置提供修改的扭矩辅助。 在另一个实施例中，只要转向系统接近停止终止，动态数据被用于计算要施加在转矩辅助指令上的转矩极限。 两个实施例也可以叠加。 本发明减少了行程结束冲击时的扭矩，并有助于保持动力转向系统的机械完整性。

公开(公告)号：US5982067A

公开(公告)日：1999-11-09

申请号：US650519

申请日：1996-05-20

Applicant: Tomy Sebastian ,  Steven James Collier-Hallman

Inventor： Tomy Sebastian ,  Steven James Collier-Hallman

IPC: B62D5/04 ,  H02K21/16 ,  H02K29/00 ,  H02P6/18 ,  H02K3/00

CPC classification number: B62D5/0403 ,  H02K21/16 ,  H02P6/182 ,  H02P2209/07

Abstract: A brushless DC motor has a permanent magnet rotor comprising p magnetic poles and a stator having an integer multiple of 6*p*n slots containing windings, n being a positive, non-zero integer, and the poles and slots being skewed by one slot pitch with respect to each other. The windings in the slots are electrically connected in two separate groups of three-phase windings with each group having three phase terminals, the windings of each group being distributed in phase belts occupying alternate sectors of 30 electrical degrees and the windings of the first group alternating with the windings of the second group. Since the trapezoidal back EMF voltage curve has a wider top it exhibits less droop, compared with an equivalent three-phase brushless DC motor of the prior art, over the 60 electrical degree period centered on maximum back EMF in which torque producing current is applied. In addition, the maxima of back EMF voltage across pairs of terminals in the two groups of three phase windings are 30 electrical degrees out of phase with each other, so that variations in back EMF voltage in the two groups tend to cancel each other as torque producing current is applied to both groups. The result is significantly less torque ripple due to back EMF variation, compared with an equivalent three-phase brushless DC motor of the prior art, and less vibration coupled to the steering wheel of an electric power steering system in which the motor is used as a power assist actuator.

Abstract translation: 无刷直流电动机具有包括p个磁极的永磁转子和具有包含绕组的6 * p * n个槽的整数倍的定子，n是正的，非零的整数，并且极和槽被歪斜一个槽 相对于彼此的间距。 槽中的绕组以两组独立的三相绕组电连接，每组具有三相端子，每组的绕组分布在相位带中，占相位30度的交替扇形，第一组的绕组交替 与第二组的绕组。 由于梯形反电动势电压曲线具有较宽的顶部，与现有技术的等效三相无刷直流电动机相比，以施加转矩产生电流的最大反电动势为中心的60个电度周期，其下降幅度较小。 此外，两组三相绕组中的两对端子之间的反电动势电压的最大值彼此相差30电角度，使得两组中的反电动势电压的变化趋向于相互抵消作为转矩 生产电流被应用于两组。 结果是与现有技术的等效三相无刷直流电动机相比，由于反EMF变化而导致的转矩波动显着更小，并且较少的振动耦合到电动转向系统的方向盘，其中电动机用作 动力辅助致动器。

公开(公告)号：US5668722A

公开(公告)日：1997-09-16

申请号：US537605

申请日：1995-10-02

Applicant: Timothy Wesley Kaufmann ,  Ashok Chandy ,  Steven James Collier-Hallman

Inventor： Timothy Wesley Kaufmann ,  Ashok Chandy ,  Steven James Collier-Hallman

IPC: B62D5/04

CPC classification number: B62D5/0466

Abstract: An electric power steering control apparatus comprising a torque sensor coupled to a vehicle steering system for measuring steering wheel torque provided by a vehicle operator, a steering angle sensor coupled to the steering system for measuring steering wheel angle, a controller, responsive to the measured steering wheel torque and a vehicle speed, providing a sum return-to-center command, and a motor responsive to the sum return-to-center command, wherein the controller determines a low speed return-to-center command responsive to the measured steering wheel torque and a first predetermined function, determines a high speed return-to-center command responsive to the measured steering wheel torque and a second predetermined function and blends the low and high speed return-to-center commands to obtain the sum return-to-center command.

Abstract translation: 一种电动助力转向控制装置，包括耦合到车辆转向系统的扭矩传感器，用于测量由车辆操作者提供的方向盘转矩，耦合到用于测量方向盘角度的转向系统的转向角传感器，响应于所测量的转向 车轮扭矩和车速，提供总和返回命令，以及响应于归还中心命令的电机，其中控制器响应于测量的方向盘来确定低速返回中心命令 扭矩和第一预定功能，响应于所测量的方向盘转矩和第二预定功能确定高速返回中心命令，并且混合低速和高速返回中心命令以获得和返回 - 中心命令。