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公开(公告)号：US20120211562A1
公开(公告)日：2012-08-23
申请号：US12134994
申请日：2008-06-06
Applicant: James M. Cook , Robert S. Brinkerhoff , Michael J. Mahnken
Inventor： James M. Cook , Robert S. Brinkerhoff , Michael J. Mahnken
IPC: G06G7/80
Abstract: Methods and apparatus for firing a projectile in response to a threat according to various aspects of the present invention operate in conjunction with a computer coupled to a launch system for the projectile. The computer may be configured to select the projectile from multiple available projectiles and calculate a fire control solution according to a characteristic of the selected projectile. Calculating the fire control solution may comprise deriving the fire control solution from a look-up table according to a predicted intercept point. The computer may initiate a launch of the selected projectile and provide the fire control solution to the selected projectile.
Abstract translation: 根据本发明的各个方面的用于发射威胁的射弹的方法和装置与耦合到用于射弹的发射系统的计算机一起工作。 计算机可以被配置为从多个可用弹丸中选择弹丸，并根据所选弹丸的特征计算消防解决方案。 计算消防解决方案可以包括根据预测的拦截点从查找表导出火控解决方案。 计算机可以启动所选择的弹丸的发射，并向选定的弹丸提供消防控制解决方案。
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32.发明申请Broad Spectrum Gram-Positive Antimicrobials and Anthelmintics with Efficacy Against Drug-Resistant Strains and Mycobacterium Species 有权广谱革兰氏阳性抗菌药物和抗炎药对抗耐药菌株和分枝杆菌属物种有效公开(公告)号：US20110092578A1
公开(公告)日：2011-04-21
申请号：US12973078
申请日：2010-12-20
Applicant: Aaron P. Monte , M. Shahjahan Kabir , Marc A. Rott , William R. Schwan , James M. Cook, III , Jennifer A. Miskowski
Inventor： Aaron P. Monte , M. Shahjahan Kabir , Marc A. Rott , William R. Schwan , James M. Cook, III , Jennifer A. Miskowski
IPC: A61K31/381 , C07D333/56 , C07D333/64 , C07D333/62 , C07D333/16 , C07C43/23 , C07C323/18 , C07C323/16 , A61K31/085 , A61K31/10 , A01N43/12 , A01N43/10 , A01N31/14 , A01N31/08 , A61P31/00 , A61P31/04 , A61P33/10 , A01P5/00 , A01P1/00
CPC classification number: C07D213/30 , A61K31/085 , A61K31/381 , A61K36/185 , C07C43/23 , C07D213/64 , C07D213/65 , C07D213/68 , C07D333/16 , C07D333/56 , C07D333/62 , C07D333/64
Abstract: The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present.
Abstract translation: 本发明提供了化合物和使用该化合物作为抗感染和抗栓剂的方法。 在优选的实施方案中，本发明提供以下式III化合物：其中：当R 1为H时，R 1不为H，且R 1为H时R 2不为H，此外，R 1为OH或CH（2n + 1）O， 其中n为1-10; R2是OH或CH（2n + 1）O，其中n是1-10; W是烷基，苯基，卤代苯基，吡啶基，哌啶基或取代或未取代的芳基，包括未取代和取代的芳族杂环; 并且L是选自O，S，NH，CF 2或CH 2，x = 0或1的任选的接头或连接基团，即如果x = 0，则不存在连接基团。
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公开(公告)号：US20110021533A1
公开(公告)日：2011-01-27
申请号：US12897353
申请日：2010-10-04
Applicant: James M. Cook , David A. Baker , Edward Merle Johnson, III , Wenyuan Yin
Inventor： James M. Cook , David A. Baker , Edward Merle Johnson, III , Wenyuan Yin
IPC: A61K31/497 , C07D241/08 , C07D403/12 , A61K31/4965 , A61P25/30
CPC classification number: C07D241/08
Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。
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公开(公告)号：US20100261711A1
公开(公告)日：2010-10-14
申请号：US12725763
申请日：2010-03-17
Applicant: James M. Cook , Rahul V. Edwankar , Chitra R. Edwankar , Shengming Huang , Hiteshkumar D. Jain , Jie Yang , Felix Rivas , Hao Zhou
Inventor： James M. Cook , Rahul V. Edwankar , Chitra R. Edwankar , Shengming Huang , Hiteshkumar D. Jain , Jie Yang , Felix Rivas , Hao Zhou
IPC: A61K31/5517 , A61K31/5513 , A61P25/00
CPC classification number: A61K31/5513 , A61K31/5517
Abstract: In preferred embodiments, the present invention provides methods of treatment and pharmaceutical compositions for the suppression, alleviation and prevention of seizures. The preferred embodiments of the present invention further relate to methods of treatment and pharmaceutical compositions using benzodiazepine derivatives that provide suppression, alleviation and prevention of seizures with reduced sedative and ataxic side effects.
Abstract translation: 在优选的实施方案中，本发明提供了用于抑制，缓解和预防癫痫发作的治疗方法和药物组合物。 本发明的优选实施方案还涉及使用苯并二氮杂衍生物的治疗方法和药物组合物，其提供抑制，缓解和预防具有降低的镇静和共济失调副作用的癫痫发作。
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Patent Agency Ranking
公开(公告)号：US5924774A
公开(公告)日：1999-07-20
申请号：US712908
申请日：1996-09-12
Applicant: James M. Cook , Jeremy S. Waldrop
Inventor： James M. Cook , Jeremy S. Waldrop
CPC classification number: B60T13/665 , B60T17/228
Abstract: An electronic pneumatic brake system for trains which significantly improves brake cylinder pressure build-up time and facilitates essentially instantaneous and simultaneous braking on all cars of the train. The electronic pneumatic brake system includes electronic pneumatic control valves on the cars which individually control the braking on each car or a pack of cars and which are regulated by an electronic pneumatic controller on each car that receives electronic braking and release signals by way of wireless communication from an electronic head end unit on the lead locomotive, or where no head end unit is provided in the locomotive, receives pneumatic braking signals through the brake pipe.
Abstract translation: 一种用于火车的电子气动制动系统，其显着地提高制动缸压力建立时间，并且有助于在列车的所有车辆上基本上瞬时和同时的制动。 电子气动制动系统包括轿厢上的电子气动控制阀，其分别控制每辆汽车或一包汽车上的制动，并且由每个汽车上的电子气动控制器调节，所述电动气动控制器通过无线通信接收电子制动和释放信号 从机车上的电子头端单元或机车内没有设置头端单元，通过制动管接收气动制动信号。
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公开(公告)号：US09006233B2
公开(公告)日：2015-04-14
申请号：US13458168
申请日：2012-04-27
Applicant: James M. Cook , Terry S. Clayton , Hiteshkumar D. Jain , Sundari K. Rallipalli , Yun Teng Johnson , Jie Yang , Michael Ming-jin Poe , Ojas A. Namjoshi , Zhi-jian Wang
Inventor： James M. Cook , Terry S. Clayton , Hiteshkumar D. Jain , Sundari K. Rallipalli , Yun Teng Johnson , Jie Yang , Michael Ming-jin Poe , Ojas A. Namjoshi , Zhi-jian Wang
IPC: A61K31/5517 , C07D487/04 , C07D487/14 , C07D519/00
CPC classification number: A61K31/695 , A61K31/551 , C07D487/04 , C07D487/14 , C07D519/00
Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.
Abstract translation: 本文描述的是α3或α2或α2/α3GABA能受体亚型选择性配体，药物组合物，以及这些配体和组合物在治疗焦虑症，癫痫和精神分裂症以及降低镇静和共济失调副作用中的应用的方法。 在实施方案中，诸如α3或α2或α2/α3GABA能受体亚型选择性配体缺少酯键，因此可能因酯酶水解而相对不敏感。
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公开(公告)号：US08757486B2
公开(公告)日：2014-06-24
申请号：US12134994
申请日：2008-06-06
Applicant: James M. Cook , Robert S. Brinkerhoff , Michael J. Mahnken
Inventor： James M. Cook , Robert S. Brinkerhoff , Michael J. Mahnken
IPC: G06G7/80
Abstract: Methods and apparatus for firing a projectile in response to a threat according to various aspects of the present invention operate in conjunction with a computer coupled to a launch system for the projectile. The computer may be configured to select the projectile from multiple available projectiles and calculate a fire control solution according to a characteristic of the selected projectile. Calculating the fire control solution may comprise deriving the fire control solution from a look-up table according to a predicted intercept point. The computer may initiate a launch of the selected projectile and provide the fire control solution to the selected projectile.
Abstract translation: 根据本发明的各个方面的用于发射威胁的射弹的方法和装置与耦合到用于射弹的发射系统的计算机一起工作。 计算机可以被配置为从多个可用弹丸中选择弹丸，并根据所选弹丸的特征计算消防解决方案。 计算消防解决方案可以包括根据预测的拦截点从查找表导出火控解决方案。 计算机可以启动所选择的弹丸的发射，并向选定的弹丸提供消防控制解决方案。
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公开(公告)号：US07829709B1
公开(公告)日：2010-11-09
申请号：US12189516
申请日：2008-08-11
Applicant: James M. Cook , David A. Baker , Edward Merle Johnson, II , Wenyuan Yin
Inventor： James M. Cook , David A. Baker , Edward Merle Johnson, II , Wenyuan Yin
IPC: C07D241/02
CPC classification number: C07D241/08
Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。
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公开(公告)号：US5722736A
公开(公告)日：1998-03-03
申请号：US678320
申请日：1996-07-11
Applicant: James M. Cook
Inventor： James M. Cook
CPC classification number: B60T13/665 , B60T17/228
Abstract: An electronic pneumatic brake system for trains which significantly improves brake cylinder pressure build-up time and facilitates essentially instantaneous and simultaneous braking on all cars of the train. The electronic pneumatic brake system includes electronic pneumatic control valves on the cars which individually control the braking on each car or a pack of cars and which are regulated by an electronic pneumatic controller on each car that receives electronic braking and release signals by way of wireless communication from an electronic head end unit on the lead locomotive, or where no head end unit is provided in the locomotive, receives pneumatic braking signals through the brake pipe.
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