公开(公告)号：US20210116446A1

公开(公告)日：2021-04-22

申请号：US17254489

申请日：2019-07-01

Applicant: Stellenbosch University

Inventor： Benjamin Loos ,  Jan Hendrik Servaas Hofmeyr ,  Willem Jacobus Perold ,  Andre Du Toit

IPC: G01N33/543 ,  G01N33/68

Abstract: A method, device and system for determining autophagic flux are claimed. The levels of proteins which change with increased or decreased autophagy are determined in a sample. The change in the level of each protein is quantified in order to obtain the autophagic flux. This can be compared to a sample flux range associated with autophagy dysfunction or ageing patterns. Diseases M or conditions which may be diagnosed include neurodegenerative conditions such as Alzheimer's disease and dementia, cancer, heart conditions, immune conditions or aging-related conditions. The device for determining autophagic flux comprises a housing, receiving zones configured for receiving a substrate and a biological sample, and a set of electrodes for each receiving zone. The device is connectable to circuitry that determines an electrical property of each substrate and uses this to determine the autophagic flux.

公开(公告)号：US10883239B2

公开(公告)日：2021-01-05

申请号：US16090202

申请日：2017-03-24

Applicant: Stellenbosch University

Inventor： Michael Rutzen ,  Sara Andreotti ,  Pierre Becker ,  Laurie Barwell

IPC: E02B1/00 ,  B63C9/05 ,  A01M29/30 ,  B63C9/00 ,  F16B1/00

Abstract: A shark barrier that comprises an anchoring assembly having a pair of anchors (9) with a flexible connecting element (11) extending between the anchors. The shark barriers also includes multiple spaced apart buoyant resiliently flexible elongate members (15) that are secured at one end along a length of the connecting element of the anchoring assembly to operatively extend generally upwardly from the connecting element. The buoyant members comprise an elongate flexible spine (32) that extends through a series of tubular members (38).

公开(公告)号：US10154673B2

公开(公告)日：2018-12-18

申请号：US15113053

申请日：2015-01-27

Applicant: Stellenbosch University

Inventor： Amanda Jane Dodd ,  Lubertus Klumperman ,  Pieter Swart

IPC: A23C9/12 ,  B03C1/30 ,  G01N33/543

Abstract: The invention provides protein-functionalized magnetic nanoparticles comprising magnetic nanoparticles (MNPs) to which a lactose-binding protein or enzyme has been immobilized. The protein-functionalized magnetic nanoparticles are particularly suitable for separating lactose from a lactose-containing solution, such as milk, cheese, yoghurt, flavored milk or the like. The protein-functionalized MNPs can be added to the lactose-containing solution and be allowed to bind to the lactose in the solution. The MNPs, to which the lactose is bound, can then be magnetically removed from the solution, e.g. by applying an external magnetic field.

公开(公告)号：US20180258449A1

公开(公告)日：2018-09-13

申请号：US15985042

申请日：2018-05-21

Applicant: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC ,  STELLENBOSCH UNIVERSITY

Inventor： John McBride ,  Elena Brevnova ,  Mark Mellon ,  Allan Froehlich ,  Kristen Deleault ,  Vineet Rajgarhia ,  Riaan Den Haan ,  Merja Penttila ,  Marja Ilmen ,  Matti Siika-Aho ,  Jaana Uusitalo ,  Emily A. Stonehouse ,  Alan Gilbert ,  Haowen Xu ,  Deidre Willies ,  John Bardsley ,  Anu Koivula ,  Sanni Voutilainen

IPC: C12P7/10 ,  C12N15/80 ,  C12P7/14 ,  C12P39/00 ,  C12N9/42

CPC classification number: C12P7/10 ,  C12N9/2437 ,  C12N9/2445 ,  C12N15/80 ,  C12P7/14 ,  C12P39/00 ,  C12Y302/01004 ,  C12Y302/01021 ,  C12Y302/01091 ,  Y02E50/16 ,  Y02E50/17

Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

公开(公告)号：US20180248272A1

公开(公告)日：2018-08-30

申请号：US15757253

申请日：2015-09-04

Applicant: STELLENBOSCH UNIVERSITY

Inventor： David Schalk Van der Merwe PRINSLOO ,  Petrie MEYER ,  Rob MAASKANT ,  Marianna Valerievna IVASHINA

IPC: H01Q25/04 ,  H01Q21/26 ,  H01Q9/28 ,  H01Q1/52

CPC classification number: H01Q25/04 ,  H01Q1/523 ,  H01Q3/247 ,  H01Q3/26 ,  H01Q5/48 ,  H01Q9/28 ,  H01Q13/04 ,  H01Q13/085 ,  H01Q21/26 ,  H01Q25/001 ,  H01Q25/002

Abstract: A multi-mode composite antenna includes two crossed dipole elements each consisting of a bow-tie antenna having two bow-tie antenna segments, and a conductive tube which houses signal transmission lines connected to each bow-tie antenna segment. A conductive flared portion surrounds the conductive tube and forms a monopole element. The bow-tie antenna segments are shaped so that slots extend between each adjacent bow-tie antenna, each slot forming a tapered slot antenna that has a pair of non-linear curved edges that diverge from each other.

公开(公告)号：US20180237653A1

公开(公告)日：2018-08-23

申请号：US15900338

申请日：2018-02-20

Applicant: STELLENBOSCH UNIVERSITY

Inventor： William Cloete ,  Lubertus Klumperman

IPC: C09D123/36 ,  C09D5/14 ,  A61L15/44 ,  C08F8/32

CPC classification number: C09D123/36 ,  A61L15/44 ,  A61L15/46 ,  A61L31/16 ,  A61L2300/208 ,  A61L2300/404 ,  C08F8/14 ,  C08F8/32 ,  C08F8/44 ,  C08F212/08 ,  C08F2810/50 ,  C09D5/14 ,  C09D7/65 ,  C09D125/08 ,  C08F222/06 ,  C08F222/08

Abstract: A solution including an antimicrobial polymer in a polar solvent and a method of producing the solution. The polymer has the structure of Formula (I). The antimicrobial solution may be coated onto a substrate and cured to provide an antimicrobial substrate in which the polymer is covalently bonded to the substrate so that it cannot leach from the substrate.

公开(公告)号：US09915434B2

公开(公告)日：2018-03-13

申请号：US14797662

申请日：2015-07-13

Applicant: Regine Kröger ,  Stellenbosch University

Inventor： Hanno Carl Rudolf Reuter ,  Johann Pierre Terblanche ,  Detlev Gustav Kröger

IPC: F24D11/00 ,  F24D19/10

CPC classification number: F24D11/007 ,  F24D19/109 ,  F24D2200/14 ,  F24D2220/0271 ,  Y02B10/20 ,  Y02B10/70

Abstract: An air temperature regulating assembly is provided having a packed rock bed through which air may flow between outer and inner spaces by way of interstices between rock units in order to transfer heat to or from the rock bed, in use. Dampers control the flow of air between the outer space, the inner space, an enclosed air space the temperature of which is to be regulated by raising or lowering it and the surrounding atmosphere. A fan moves air within the assembly. The rock bed is in the form of a pile of rocks having an upper surface that is inclined and directed in the general direction of the sun to directly absorb solar energy. The outer space is defined between the upper inclined surface of the rock bed and a transparent cover spaced upwardly from the surface of the rock bed.

公开(公告)号：US20180016532A1

公开(公告)日：2018-01-18

申请号：US15649075

申请日：2017-07-13

Applicant: Stellenbosch University

Inventor： Wessel Johannes Du Toit ,  Sebastian Vannevel

IPC: C12G1/02

CPC classification number: C12G1/02 ,  C12C5/00 ,  C12C5/026 ,  C12G1/0203 ,  C12G1/04 ,  C12G3/02 ,  C12G3/08 ,  C12G2200/21 ,  C12P11/00

Abstract: A method for preparing a fermented beverage having a modulated aromatic profile is provided as well as a fermented beverage produced thereby. The method includes preparing a fermentable mixture, such as juice, must, or wort and introducing ammonium sulphide into the fermentable mixture at a predetermined concentration. The fermentable mixture is then subjected to fermentation. A C6 aldehyde, C6 alcohol or a combination thereof may be added to the fermentable mixture in combination with ammonium sulphide to enhance its effect on the aromatic profile of the fermented beverage.

公开(公告)号：US09831743B2

公开(公告)日：2017-11-28

申请号：US14646881

申请日：2013-11-15

Applicant: STELLENBOSCH UNIVERSITY

Inventor： Johan Nico Stander

IPC: H02K5/16 ,  H02K7/08 ,  H02K16/02 ,  H02K7/18 ,  F16C19/50 ,  F16C19/55 ,  H02K1/22 ,  F03D80/70 ,  F03D9/25

CPC classification number: H02K7/088 ,  F03D9/25 ,  F03D80/70 ,  F16C19/507 ,  F16C19/55 ,  F16C2360/31 ,  H02K1/22 ,  H02K5/16 ,  H02K7/083 ,  H02K7/183 ,  H02K7/1838 ,  H02K16/02 ,  H02K2213/12 ,  Y02E10/725

Abstract: A machine having two co-axial and relatively rotatable rotors and a coaxial stator or housing with respect to which both rotors are rotatable is provided wherein two bearing arrangements mutually support the two rotors with respect to each other and with respect to the stator or housing. One of the bearing arrangements comprises multiple support bearings angularly spaced apart with respect to the axis of rotation of the rotors relative to the stator with the support bearings each having an axle or shaft that is fixed relative to one of the rotors or the stator. Each support bearing cooperates with a raceway provided on a concentric adjacent rotor or stator. The machine may be an electromechanical machine such as a wind turbine in which rotational movement of one of the rotors relative to the other and relative to the stator generates electrical energy.

公开(公告)号：US09710586B2

公开(公告)日：2017-07-18

申请号：US14412344

申请日：2013-07-02

Applicant: Stellenbosch University

Inventor： Louis Crouse Muller ,  Coenrad Johann Fourie

IPC: G06F17/50 ,  H03K19/195

CPC classification number: G06F17/5059 ,  G06F17/5022 ,  G06F17/5045 ,  H03K19/1954

Abstract: The invention provides a method and system for extracting a state machine representation of a digital logic superconductive circuit from an alphanumeric representation of the circuit. The alphanumeric representation typically specifies circuit components including inductive elements, their interconnectivity and input and output nodes. The method according to the invention comprising the steps of simulating the circuit in a suitable software environment utilizing the alphanumeric representation; identifying inductive loops in the circuit; identifying inductive loops in the circuit capable of storing one or more magnetic fluxons and discarding all others; and extracting the state machine representation, using only the inductive loops in the circuit capable of storing magnetic fluxons.