公开(公告)号：US20100291278A1

公开(公告)日：2010-11-18

申请号：US12311840

申请日：2007-10-15

Applicant: Danny Lavie ,  Eyal Eliav ,  Shlomo Magdassi

Inventor： Danny Lavie ,  Eyal Eliav ,  Shlomo Magdassi

IPC: A23L1/275

CPC classification number: A23P20/18 ,  A23L5/43 ,  A23V2002/00 ,  C09B61/00 ,  C09B67/0083 ,  C09D11/32

Abstract: The present invention provides a liquid coloring composition comprising of a coffee solution or coffee extract and an ink vehicle. The coloring composition is suitable for use as an ink in a non-impact printing device, including an ink jet type printer. The composition is composed of edible components. The invention further provides a process for applying a design to a food substrate, comprising of providing a non-impact printing device, wherein the ink cartridge or external container contains the coloring composition of the invention.

Abstract translation: 本发明提供一种液体着色组合物，其包含咖啡溶液或咖啡提取物和油墨载体。 着色组合物适合用作非冲击式印刷装置中的油墨，包括喷墨式打印机。 组合物由可食用组分组成。 本发明还提供了一种将设计应用于食品基材的方法，其包括提供非冲击式印刷装置，其中所述墨盒或外部容器含有本发明的着色组合物。

公开(公告)号：US20100291200A1

公开(公告)日：2010-11-18

申请号：US12843958

申请日：2010-07-27

Applicant: Shlomo MAGDASSI ,  Yoram SELA ,  Keren COHEN

Inventor： Shlomo MAGDASSI ,  Yoram SELA ,  Keren COHEN

IPC: A61K9/66 ,  A61K9/28 ,  A61K9/14 ,  A61K9/50 ,  A61K9/107

CPC classification number: A61K9/1682 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1658

Abstract: The present invention provides a drug delivery system comprising nanoparticles or microparticles of a water poorly soluble drug dispersed in a polymeric bead containing essentially only of hydrophilic polymers (i.e. without hydrophobic polymers). The present invention further provides a method of producing the drug delivery system of the invention.

Abstract translation: 本发明提供一种药物递送系统，其包含分散在基本上仅含有亲水性聚合物（即不含疏水性聚合物）的聚合物珠粒中的难溶于水的药物的纳米颗粒或微粒。 本发明还提供了一种制备本发明的药物递送系统的方法。

公开(公告)号：US07758888B2

公开(公告)日：2010-07-20

申请号：US09983229

申请日：2001-10-23

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K9/14 ,  A61K9/00 ,  A61K9/50 ,  A61K8/00 ,  A61K8/02 ,  A61K8/04 ,  A61K8/11 ,  A61K8/64 ,  A61K8/66 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/28 ,  A61K8/29 ,  A61K8/38 ,  A61K6/00 ,  A61K38/00 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/355 ,  A61K31/375 ,  A61K31/51 ,  A61K31/65 ,  A61K31/59 ,  A61K31/525 ,  A61K31/34 ,  A61K31/19 ,  A61K31/07

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/38 ,  A61K8/602 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5115 ,  A61K9/5138 ,  A61K2800/412 ,  A61K2800/75 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945

Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.

Abstract translation: 一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。 微胶囊的直径约为0.1至100微米。 每个微胶囊的核心包括至少一种活性成分并且被包封在微胶囊壳内。 壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。 该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

公开(公告)号：US20050208134A1

公开(公告)日：2005-09-22

申请号：US11067316

申请日：2005-02-24

Applicant: Shlomo Magdassi ,  Frigita Kahana

Inventor： Shlomo Magdassi ,  Frigita Kahana

IPC: A61K9/127 ,  A61K9/24 ,  A61K7/42

CPC classification number: A61K9/0019 ,  A61K9/127

Abstract: The present invention relates to biocompatible polymeric beads and to biocompatible delivery systems comprising same for controlled or sustained release of bioactive molecules. In particular, the invention relates to polymeric beads having a two-phase core and shell structure and to polymeric delivery systems comprising same that provide sustained release of the bioactive compound.

Abstract translation: 本发明涉及生物相容性聚合物珠粒和生物相容性递送系统，其包含用于控制或持续释放生物活性分子的递送系统。 特别地，本发明涉及具有两相核心和壳结构的聚合物珠粒以及包含提供生物活性化合物的持续释放的包含其的聚合物递送系统。

公开(公告)号：US06749868B1

公开(公告)日：2004-06-15

申请号：US09316642

申请日：1999-05-21

Applicant: Neil P. Desai ,  Chunlin Tao ,  Andrew Yang ,  Leslie Louie ,  Zhiwen Yao ,  Patrick Soon-Shiong ,  Shlomo Magdassi

Inventor： Neil P. Desai ,  Chunlin Tao ,  Andrew Yang ,  Leslie Louie ,  Zhiwen Yao ,  Patrick Soon-Shiong ,  Shlomo Magdassi

IPC: A61K916

CPC classification number: A61K9/0026 ,  A23L33/40 ,  A61K9/5052 ,  A61K9/5169 ,  A61K47/6929 ,  B82Y5/00

Abstract: In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.

Abstract translation: 根据本发明，提供了用于体内递送基本上不溶于水的药理学活性剂（例如抗癌药物紫杉醇）的组合物和方法，其中药理活性剂以包被的 蛋白质（其作为稳定剂）。 特别地，生物相容性分散介质中的蛋白质和药理学活性剂在没有任何常规表面活性剂的情况下进行高剪切，并且在没有用于颗粒的任何聚合物芯材料的情况下进行。 该方法产生直径小于约1微米的颗粒。 使用特定的组成和制备条件（例如，向有机相中加入极性溶剂）以及仔细选择合适的有机相和相分数使得能够可重复地生产直径小于200nm的异常小的纳米颗粒， 可以无菌过滤。 根据本发明制备的颗粒系统可以转化成可再分散的干粉，其包含用蛋白质包被的水不溶性药物的纳米颗粒，以及结合有药理学分子的游离蛋白质。 这导致独特的递送系统，其中药理活性剂的一部分容易生物利用（以与蛋白质结合的分子的形式），并且部分药剂存在于颗粒内，而其中没有任何聚合物基质。

公开(公告)号：US06582709B1

公开(公告)日：2003-06-24

申请号：US09869827

申请日：2001-10-15

Applicant: Zeev Maor ,  Shaul Yehuda ,  Shlomo Magdassi ,  Galit Meshulam-Simon ,  Yona Gavrieli ,  Zivn Gilad ,  Dov Efron

Inventor： Zeev Maor ,  Shaul Yehuda ,  Shlomo Magdassi ,  Galit Meshulam-Simon ,  Yona Gavrieli ,  Zivn Gilad ,  Dov Efron

IPC: A61K700

CPC classification number: A61Q17/00 ,  A61K8/27 ,  A61K8/494 ,  A61K8/678 ,  A61K8/965 ,  A61K9/06 ,  A61K35/02 ,  A61K2800/75 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/007 ,  A61Q19/008 ,  Y10S514/847 ,  Y10S514/864 ,  Y10S514/865

Abstract: The preset invention relates to a pharmaceutical cream composition for topical application for the treatment of skin disorders and skin diseases, comprising 1-6 wt. % Dead Sea Mud as an active ingredient. Said composition is for use in treating skin disorders and skin diseases such as psoriasis, saborrehic dermatitis, xerosis, attopic dermatitis, eczema, diaper rush, skin burns of stage I and sensitive skin. Said cream composition is also for use as a leave-on cosmetic cream for beautifying and enhancing the skin appearance. In addition to Dead Sea Mud said composition comprises ingredients suitable for the preparation of cosmetic cream. Said cream can further comprises up to 4 wt % Dead Sea water.

Abstract translation: 本发明涉及用于局部应用于治疗皮肤病和皮肤疾病的药用乳膏组合物，其包含1-6wt。 ％死海泥作为活性成分。 所述组合物用于治疗皮肤疾病和皮肤疾病，例如牛皮癣，痉挛性皮炎，干燥症，特应性皮炎，湿疹，尿布冲击，I期皮肤灼伤和敏感皮肤。 所述奶油组合物还可用作美容化妆品，以美化并增强皮肤外观。 除了死海泥以外，所述组合物包含适于制备美容霜的成分。 所述奶油还可包含至多4重量％的死海水。

公开(公告)号：US06528067B1

公开(公告)日：2003-03-04

申请号：US09457085

申请日：1999-12-07

Applicant: Shlomo Magdassi ,  Andrew Yang ,  Chunlin Tao ,  Neil P. Desai ,  Zhiwen Yao ,  Patrick Soon-Shiong

Inventor： Shlomo Magdassi ,  Andrew Yang ,  Chunlin Tao ,  Neil P. Desai ,  Zhiwen Yao ,  Patrick Soon-Shiong

IPC: A61K3902

CPC classification number: A61K9/0026 ,  A23L33/40 ,  A61K9/5052 ,  B82Y5/00

Abstract: In accordance with the present invention, there are provided stabilized total nutrient admixture (TNA) compositions which are useful for the in vivo parenteral delivery of pharmacologically acceptable lipids or fats, as well as methods for the preparation thereof. In particular, the pharmacologically acceptable lipid or fat is contained within a protein walled shell. In a particular embodiment of the invention, a TNA composition using human serum albumin (HSA) as a stabilizer has been prepared as a convenient three-in-one formulation (i.e., containing a fat emulsion, dextrose, and amino acids plus electrolytes). This “three-in-one” formulation can be prepared in liquid form or in dry form (comprising submicron-sized nanoparticles). The dried material is stable, even under long term storage, and is easily reconstituted immediately before use by simply adding sterile water (with or without vitamin supplementation) This serves to rehydrate the powder into a TNA suitable for injection. The long shelf life, ease of reconstitution, and single-component injectability of invention compositions provide significant cost savings, as such compositions can be reconstituted and administered safely, even in the home. In addition, HSA, the stabilizing agent of choice for use in the practice of the present invention, has been shown to improve survival and wellness when given as a supplement to patients receiving conventional forms of total nutrient admixtures.

Abstract translation: 根据本发明，提供了可用于体内胃肠外递送药理学上可接受的脂质或脂肪的稳定的总营养混合物（TNA）组合物，以及其制备方法。 特别地，药理学上可接受的脂质或脂肪包含在蛋白质壁壳内。 在本发明的一个具体实施方案中，已经制备了使用人血清白蛋白（HSA）作为稳定剂的TNA组合物作为方便的三合一制剂（即，含有脂肪乳剂，葡萄糖和氨基酸加电解质）。 这种“三合一”制剂可以以液体形式或干燥形式（包括亚微米尺寸的纳米颗粒）制备。 干燥的材料即使在长期储存下也是稳定的，并且在使用前立即通过简单地加入无水（有或没有补充维生素）容易地重构，用于将粉末再水合成适合注射的TNA。 本发明组合物的长保存期限，易于重构和单组分可注射性提供显着的成本节约，因为即使在家中也可安全地重构和施用这些组合物。 此外，HSA是用于本发明实践的选择的稳定剂，已经显示出，当给予作为补充常规形式的总营养混合物的患者时，HSA可改善存活和健康。

公开(公告)号：US06436375B1

公开(公告)日：2002-08-20

申请号：US09576962

申请日：2000-05-24

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K742

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/29 ,  A61K8/35 ,  A61K8/37 ,  A61K8/375 ,  A61K2800/412 ,  A61K2800/52 ,  A61Q17/04 ,  Y10S514/844 ,  Y10S514/944 ,  Y10S514/945 ,  Y10S514/972

Abstract: The present invention relates to a method for obtaining improved photostability of a sunscreen composition that contains at least two sunscreen active ingredients, which are photo-unstable when formulated together, by microencapsulating at least one of said active ingredients in an encapsulating material suitable for holding the encapsulated active ingredient material, thus reducing or preventing its leaching out of the capsules; and adding other acceptable components and additives needed for the preparation of said composition. The sunscreen active ingredients can be selected from UVA and UVB absorbers, preferably a combination thereof. In a preferred embodiment of the present invention said active ingredients are encapsulated in separate sol-gel microcapsules.

Abstract translation: 说，当配制在一起，通过微胶囊化中的至少一个在封装材料的活性成分适合用于保持本发明涉及用于获得改进的包含至少两种防晒活性成分，其是光不稳定的防晒组合物的光稳定性的方法 包封的活性成分材料，从而减少或防止其从胶囊中浸出; 并加入制备所述组合物所需的其它可接受的组分和添加剂。 防晒活性成分可以选自UVA和UVB吸收剂，优选其组合。 在本发明的优选实施方案中，所述活性成分被包封在单独的溶胶 - 凝胶微胶囊中。

公开(公告)号：US5916596A

公开(公告)日：1999-06-29

申请号：US720756

申请日：1996-10-01

Applicant: Neil P. Desai ,  Chunlin Tao ,  Andrew Yang ,  Leslie Louie ,  Tianli Zheng ,  Zhiwen Yao ,  Patrick Soon-Shiong ,  Shlomo Magdassi

Inventor： Neil P. Desai ,  Chunlin Tao ,  Andrew Yang ,  Leslie Louie ,  Tianli Zheng ,  Zhiwen Yao ,  Patrick Soon-Shiong ,  Shlomo Magdassi

IPC: A61J3/00 ,  A23L33/00 ,  A61K9/00 ,  A61K9/14 ,  A61K9/38 ,  A61K9/50 ,  A61K9/51 ,  A61K31/337 ,  A61K45/00 ,  A61K47/30 ,  A61K47/42 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61P29/00 ,  A61P35/00

CPC classification number: A61K9/5169 ,  A23L33/40 ,  A61K9/0019 ,  A61K9/5192 ,  B82Y5/00 ,  A61K9/1075 ,  A61K9/19 ,  Y10S977/907 ,  Y10S977/915 ,  Y10S977/927

Abstract: In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful selection of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.

Abstract translation: 根据本发明，提供了用于体内递送基本上不溶于水的药理学活性剂（例如抗癌药物紫杉醇）的组合物和方法，其中药理活性剂以包被的 蛋白质（其作为稳定剂）。 特别地，生物相容性分散介质中的蛋白质和药理学活性剂在没有任何常规表面活性剂的情况下进行高剪切，并且在没有用于颗粒的任何聚合物芯材料的情况下进行。 该方法产生直径小于约1微米的颗粒。 使用特定的组成和制备条件（例如，向有机相中加入极性溶剂）以及仔细选择合适的有机相和相分数使得能够可重复地生产直径小于200nm的异常小的纳米颗粒，其中 可以无菌过滤。 根据本发明制备的颗粒系统可以转化成可再分散的干粉，其包含用蛋白质包被的水不溶性药物的纳米颗粒，以及结合有药理学分子的游离蛋白质。 这导致独特的递送系统，其中药理活性剂的一部分容易生物利用（以与蛋白质结合的分子的形式），并且部分药剂存在于颗粒内，而其中没有任何聚合物基质。

公开(公告)号：US5518736A

公开(公告)日：1996-05-21

申请号：US266025

申请日：1994-06-27

Applicant: Shlomo Magdassi ,  Kosta Mumcuoglu ,  Uri Bach

Inventor： Shlomo Magdassi ,  Kosta Mumcuoglu ,  Uri Bach

IPC: A01N25/04 ,  A01N25/28 ,  A61K9/50 ,  A61K9/52 ,  A61K36/61 ,  A61K47/36 ,  B01J13/02 ,  A01N65/00 ,  A61K35/78

CPC classification number: B01J13/02 ,  A01N25/04 ,  A01N25/28 ,  A01N49/00 ,  A01N65/00 ,  A01N65/22 ,  A01N65/28 ,  A01N65/44 ,  A61K47/36 ,  A61K9/5036 ,  Y10S424/10 ,  Y10S514/88 ,  Y10S514/881 ,  Y10S514/919 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/963 ,  Y10S514/975

Abstract: The invention relates to sustained-release biodegradable lice repelling preparations comprising as active ingredient a lice repelling agent comprising at least one natural oil selected from the group consisting of citronella oil, rosemary oil and eucalyptus oil, or at least one natural oil component selected from the group consisting of citronellal and geraniol or mixtures thereof and further comprising an anionic emulsifier and chitosan, optionally further comprising dermatologically acceptable additives, carriers or diluents. The preparations may be in the form of an aqueous emulsion or chitosan microcapsules, preferably prepared by the processes of the invention.

Abstract translation: 本发明涉及持续释放的可生物降解的虱子排斥制剂，其包含作为活性成分的虱子排斥剂，其包含至少一种选自由香茅油，迷迭香油和桉树油组成的组的天然油，或至少一种选自以下的天然油成分： 由香茅醛和香叶醇或其混合物组成的组，并且还包含阴离子乳化剂和壳聚糖，任选地还包含皮肤病学上可接受的添加剂，载体或稀释剂。 制剂可以是水乳剂或壳聚糖微胶囊的形式，优选通过本发明的方法制备。